Bandage Lens Research Articles

Preliminary clinical evaluation of the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs.

To preliminarily evaluate the treatment efficacy of a temperature-adjustable cryotherapy device for chronic, recurrent blepharitis in dogs. Five dogs (eight eyes) of different breeds with blepharitis, which was unresponsive to systemic steroids. The dogs were subjected to ophthalmic examination, including Schirmer tear test-1 (STT-1), tear film break-up time (TFBUT) test, and slit-lamp biomicroscope examination. Cryotherapy was performed using a device featuring precise low-temperature control. A bandage lens and ointment (2% hypromellose) were applied before cryotherapy to protect the cornea. Carbon dioxide gas at 0°C was sprayed on the lesion for 10 s. In all patients, only topical antibiotics and corticosteroid were applied twice a day; systemic corticosteroids were not used. Pruritus and ocular discharge were scored based on the visual analog scale (VAS) before and 3 weeks after cryotherapy. Qualitative changes in tear film were measured using STT-1 and a TFBUT test. The effects on erythema and swelling were evaluated by ophthalmic examination. Pruritus improvement was confirmed in all eight eyes (five dogs). After cryotherapy, the average VAS score of pruritus significantly decreased from 4.12 ± 2.64 to 0.37 ± 0.51 (p < .001), and the average TFBUT significantly increased from 5.75 ± 4.80 to 13.75 ± 4.43 (p = .010). STT-1 and the VAS score of ocular discharge did not significantly differ. Erythema and swelling were improved in three out of eight eyes. Cryotherapy is effective in treating blepharitis with pruritus and may become a new treatment option in patients in whom systemic corticosteroids are difficult to administer.

Ag/Cu nanoparticles-loaded glycocalyx biomimetic corneal bandage lenses for combatting bacterial keratitis

Bacterial keratitis is a major cause of blindness, hindered by the rising threat of antibiotic resistance. Although corneal bandage lenses (CBLs) are widely utilized in ophthalmic treatment, their effectiveness in treating bacterial keratitis remains limited due to risks of secondary infections, patient discomfort, and complications. In this study, we developed a novel biomimetic coating on CBLs by grafting Ag/Cu bimetallic nanoparticles (Ag/Cu-NPs) and thiol-functionalized heparin (Hep-SH) using a rapid polydopamine (PDA) deposition technique, effectively mimicking the ocular surface glycocalyx structure. The resulting Ag/Cu-NPs/Hep-SH coated CBLs (PNH-CBLs) exhibited significant antibacterial activity, with over 80 % reduction in Staphylococcus aureus (S. aureus) and 70 % in Escherichia coli (E. coli) due to the sustained release of Ag+ and Cu2+, along with displaying favorable in vitro biocompatibility. Animal experiments conducted on New Zealand white rabbits with bacterial keratitis demonstrated successful treatment therapeutic outcomes, with PNH-CBLs leading to a significant decrease in clinical score. These biomimetic lenses also exhibited selective anti-protein adsorption properties, minimizing inflammation and promoting surface lubrication. Overall, this innovative approach addresses critical challenges in antibiotic resistance and offers a promising therapeutic strategy for managing ophthalmic infectious diseases.

Topical Application of 0.05% Cyclosporine for the Treatment of Neurotrophic Keratopathy Secondary to Herpes Simplex Keratitis

The purpose of this study was to assess the effectiveness and tolerability of 0.05% cyclosporine A (CsA) eye drops for neurotrophic keratopathy (NK) secondary to herpes simplex keratitis (HSK). Fifteen patients (15 eyes) with prior HSK and secondary NK, classified as stage 2 or 3 on the basis of the Mackie classification, were enrolled. All patients received a combined treatment regimen of 0.05% CsA eye drops (1 drop 4 times daily), a silicone hydrogel bandage contact lens, and 0.15% ganciclovir ophthalmic gel (1 drop 3 times daily). For patients achieving corneal healing, CsA was continued at a reduced dosage of twice daily for an additional 2 months and other treatments were discontinued. Follow-ups were scheduled at weeks 1, 2, 3, and 4 and at months 2 and 3 after treatment initiation, followed by a 3-month follow-up period. Key outcomes, including best-corrected visual acuity, Schirmer I test, and corneal sensitivity, were assessed at each visit before and after treatment. Significant reductions were observed in the area of corneal defects, expressed as proportion of total corneal area, throughout follow-up period. Complete corneal healing was achieved by 13.3% of patients by week 2, 60.0% by week 3, 86.7% by week 4, and 100.0% by week 8, with the mean (SD) time to healing being 3.8 (1.8) weeks (range, 2-8 weeks). Additionally, significant improvements were noted in diseased eyes for best-corrected visual acuity, tear secretion (Schirmer I test values), and corneal sensitivity after treatment. CsA eye drops, with bandage lenses and ganciclovir, effectively resolve NK from HSK, without adverse effects. This combination therapy shows promise for future clinical use and research. Our study is a retrospective observational study because it involves the analysis of previously collected data, so the study was not registered prior to its commencement. However, if it is necessary for publication, we are willing to proceed with retrospective registration.

Analysis of association of bandage contact lens with serious vision-threatening diseases and their management

BackgroundBandage contact lenses are important aids for aftercare following ocular surgery and for a wide variety of ocular surface conditions. However, bandage contact lenses also bear the risk of fostering microbial infections of the cornea. We herein report the safety profile of bandage contact lenses from a comprehensive review of medical records in a tertiary care eye hospital in Germany.MethodsWe identified 638 consecutive patients who had been prescribed at least one bandage lens during the past 10 years. For these, we performed a computerized search for the following adverse events: (1) endophthalmitis, (2) emergency keratoplasty and (3) vision loss of at least 2 lines according to the Early Treatment Diabetic Retinopathy Study (ETDRS). We manually assessed the relatedness of each event to the bandage lens. Events later than 100 days following the bandage lens prescription were not considered to be related to bandage contact lenses.ResultsWe observed 267 adverse events, with 120 occurring within 100 days after bandage lens prescription. This left a total of 18 endophthalmitis events, 21 penetrating keratoplasties and 81 eyes with vision loss of at least 2 ETDRS lines (for individual review of relatedness). Only two episodes of endophthalmitis could be linked to bandage lens wear. All other adverse events were due to causative conditions that had already been present prior to bandage contact lens insertion.ConclusionsSevere adverse events after bandage contact lens wear are not uncommon because lenses are used in patients suffering from preexisting ocular conditions. However, severe adverse events were almost never caused by the bandage contact lenses directly in our hands. We therefore conclude that bandage contact lenses are safe given proper ophthalmological supervision.

GIANT INTRAOPERATIVE CORNEAL BULLA MANAGED WITH BANDAGE LENS TECHNIQUE DURING VITRECTOMY SURGERY.

To report a case of giant intraoperative corneal bulla formation in a patient with a history of recent phacoemulsification with clear corneal incision that was managed with a bandage contact lens intraoperatively. Retrospective case report with anterior segment optical coherence tomography. A 77-year-old woman with a history of recent complicated cataract surgery with retained lens fragments underwent pars plana vitrectomy and scleral-fixated intraocular lens placement. During pars plana vitrectomy, a large corneal bulla formed at the site of the main corneal incision, confirmed with anterior segment optical coherence tomography. A bandage contact lens with viscoelastic was used to overcome visualization challenges and safely proceed with the surgery. This is the first report of corneal bullae formation during pars plana vitrectomy that is confirmed by anterior segment optical coherence tomography and successfully managed with a bandage contact lens intraoperatively.

Superficial keratectomy for the treatment of spontaneous chronic corneal epithelial defects in dogs.

To report the outcome of superficial keratectomy with bandage contact lens placement for the treatment of spontaneous chronic corneal epithelial defects (SCCEDs) in dogs. Patients that underwent a superficial keratectomy with bandage lens placement for the treatment of one or more SCCEDs were retrospectively included in the study. Signalment, eye(s) affected, prior medical therapy and any procedures performed, post-operative medical therapy, healing rate, and any post-operative complications were recorded. Superficial keratectomy was performed to approximately one-fifth of corneal depth under operating microscope guidance and a bandage lens was placed immediately post-operatively. Corneas were considered healed when the fluorescein stain was negative. One hundred and seven dogs met the inclusion criteria with 121 SCCEDs. The mean age of patients was 8.34 ± 2.89 years (1-15). Ninety-nine percent (120/121) of SCCEDS healed with no additional treatment within 21 days of surgery. One eye had a diamond burr debridement performed on Day 14 post-operatively and healed 2 weeks following the additional procedure. No post-operative complications were noted. This study found superficial keratectomy with bandage lens placement to be an effective treatment for SCCEDs.

Bowman Layer Onlay Grafting as a Minimally Invasive Treatment for the Most Challenging Cases in Keratoconus

PurposeTo analyze the clinical outcomes after Bowman layer (BL) onlay grafting for the treatment of progressive, advanced keratoconus. DesignProspective, interventional case series. MethodsTwenty-one eyes underwent BL onlay grafting. After removing the epithelium, a single or double BL-graft was “stretched” onto the corneal surface, allowed to dry-in, and a soft bandage lens was placed until the graft was re-epithelialized. Best spectacle- and/or best contact lens-corrected visual acuity (BSCVA/BCLVA), corneal tomography, and postoperative complication rates were analyzed for the total group and two subgroups [Group 1: preoperative maximum keratometry (Kmax) <69D (n=7), Group 2: preoperative Kmax ≥69D (n=14)]. Follow-up ranged from 6-36 months (mean 21±11 months). ResultsAll 21 surgeries were uneventful. Overall, Kmax changed from 76±12D preoperatively to 72±9D at 6-36 months postoperatively (P=0.015). Kmax decreased by 6D in Group 2 (P=0.002) but did not change in Group 1. Average BSCVA remained stable for Group 1 and improved from preoperatively 0.8±0.4 to 0.4±0.2 LogMAR postoperatively in Group 2 (P=0.032); BCLVA remained stable (P>0.05). Within the first postoperative weeks, two eyes required BL-graft re-positioning after inadvertent bandage lens removal and four eyes underwent BL re-transplantation for incomplete re-epithelialization. One eye underwent BL-regrafting 12-month postoperative after traumatic corneal erosion. All eyes showed a completely re-epithelialized graft at the last available follow-up. ConclusionsBL onlay grafting is a completely extraocular, minimally invasive surgical technique, providing up to -6D of corneal flattening in eyes with advanced progressive keratoconus, allowing for continued (scleral) contact lens wear and therefore preserving the BCLVA.

Central corneal distortion after small-incision lenticule extraction.

A 33-year-old woman with a prior history of small-incision lenticule extraction (SMILE) presented with gradual deterioration of vision in her right eye since the surgery. She had undergone bilateral SMILE for myopic correction (-7.00 diopters [D] in the right eye and -6.00 D in the left eye) 3 weeks prior. SMILE was performed with a Zeiss VisuMax femtosecond laser system, with a cap thickness of 120 µm, a cap diameter of 7.50 mm, and a lenticule diameter of 6.50 mm. At the completion of the surgery, loose epithelium was noted at the SMILE incision bilaterally, and bandage contact lenses were placed in both eyes. On the first postoperative day, the patient's uncorrected distance visual acuity (UDVA) was 20/40 in both eyes. The bandage lenses were removed from both eyes, with the epithelium intact. At the first-week postoperative visit, her visual acuity was recorded as 20/30 in the right eye and 20/20 in the left eye. She noticed her vision in the right eye was not as sharp as that in her left eye. She denied experiencing any pain, redness, or ocular surface irritations. She was advised to return to the clinic for a 1-month postoperative visit and continue with aggressive lubrication in both eyes. However, a week later, the patient returned for an emergency visit, citing significant central visual distortion in the right eye and difficulty working on the computer. At this visit, her UDVA and corrected distance visual acuity (CDVA) was 20/50 in the right eye and 20/15 in the left eye at both near and far distances. A slitlamp examination revealed mild central changes in the right eye. She once again denied any pain, redness, or irritation. She was advised to continue with artificial tears and return to the office in 1 week for further observation of the central distortion in her right eye. Upon returning to the clinic at the third postoperative week, the patient still complained of central visual changes in the right eye, with a visual acuity of 20/70. Further slitlamp examination revealed a nonspecific central haze in the same eye, but there was no corneal staining or signs of epithelial defects. Anterior segment ocular coherence tomography (AS-OCT) and NIDEK topography were performed, showing the same central distortion in the right eye (Figures 1 and 2JOURNAL/jcrs/04.03/02158034-202311000-00016/figure1/v/2023-10-18T004638Z/r/image-tiffJOURNAL/jcrs/04.03/02158034-202311000-00016/figure2/v/2023-10-18T004638Z/r/image-tiff). Based on the examination and images provided, what is your working medical diagnosis? What other medical conditions are in your differential diagnosis? What medical and/or surgical interventions would you recommend, if any?

Kontaktlinsen als vielversprechende Therapiemittel

Purpose. Insights into the scientific research about contact lenses and their development, and information about their use as therapeutic tools for various eye diseases are provid- ed. The specificities of the human eye due to its particular physiology and anatomy are outlined and the relation with the resulting therapeutic difficulties is presented. Therapeutic lenses as bandage and as drug-delivering contact lenses are described. Material and Methods. The topics of the selected literature include relevant developments in biomaterials for contact lenses. Reports and publications on worldwide ocular dis- eases, global current market analysis in the field of eye drops, as well as publications on modern drug release methods for ocular systems tend to depict the topic. Results. As a result of a long-lasting development, contact lenses are worldwide successful on the optical device market. Therapeutic contact lenses as bandage lenses are effective tools in ophthalmic surgery and therapy. Conclusions. Novel therapeutic contact lenses used for ocular drug delivery significantly improve the bioavailability and thus perform better as conventional eye treatments. Keywords copolymers, protein adhesion, vision threatening disorders, blood ocular barrier, therapeutic and bandage contact lenses, ocular drug delivery systems

The Use of Soft Contact Bandage Lenses for Corneal Ulcer in Dogs and Cats: A Review

A corneal ulcer is the characteristic of the destruction of the corneal epithelium layer and loss of the stroma layer at various depths. At present time, soft bandage contact lenses are used in many countries for corneal ulcers in dogs and cats to protect their cornea, increase contact time with topical eyes solutions, and support corneal reepithelialization. This article aimed to review information on the use of soft contact bandage lenses to treat corneal ulcers in dogs and cats interms of their efficacy and precaution. The results of the present review have revealed that soft contact bandage lenses are used to protect the cornea, enhance contact time with topical eye treatments, reduce median healing time, and provide comfort in dogs and cats with corneal ulcers. In the case of serious infections and dry eyes, soft contact bandage lenses are not recommended. Keywords: Corneal ulcer, Incidence, Soft contact bandage lenses, Treatment

Surgical treatment options for congenital/infantile corneal opacities and anterior segment dysgenesis

Due to the risk of amblyopia congenital and infantile corneal opacities have anarrow therapeutic window, frequently with a complex surgical treatment. The present study gives an overview of the current treatment options for congenital and infantile corneal opacities. The results of aliterature search are presented and own clinical data and examples are shown. In children ophthalmologic operations are surgically more demanding and the prognosis is generally worse. Surgical options include phototherapeutic keratectomy, crosslinking, corneal sutures, sectoral iridectomy, block excision and lamellar, penetrating, and auto-keratoplasty. An equally important part of the treatment is conservative treatment, when necessary with bandage lenses, glasses, contact lenses and occlusion. Whenever possible treatment of congenital and infantile corneal opacities should be limited to the affected layers/areas. Nevertheless, children and parents have to be prepared for many examinations, sometimes with the patient under anesthesia and should be well-informed about the prognosis and the risks.

Comparison of efficacy of two different silicone hydrogel bandage contact lenses after T-PRK.

To compare the efficacy between two different silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy (T-PRK). In this randomized controlled trial, a total of 89 patients (178 eyes) who underwent T-PRK at the Qingdao Eye Hospital from October to December 2019 were selected. One random eye wore a Senofilcon A bandage contact lens after surgery, and the other eye a Balafilcon A bandage contact lens. Pain scores, uncorrected visual acuity (UCVA), spherical equivalent (SE), corneal epithelial healing status, epithelial thickness, bandage lenses deposits, lenses movement, and ocular surface conditions were measured and compared. There were no differences between the two groups in UCVA, SE, corneal epithelial healing status, corneal epithelial thickness, tear river heights and tear film rupture time at each follow-up visit. However, postoperative pain scores in the Senofilcon A group were significantly lower than those of the Balafilcon A group (F intergroups=67.833, P<0.001; F time=383.773, P<0.001; F interaction=57.344, P<0.001). The duration of pain in eyes in the Senofilcon A group was shorter than that of the Balafilcon A group (t=-3.326, P=0.001). The surface deposition scores and movement scores of Senofilcon A bandage lenses on the first and fourth days after surgery were lower than those of Balafilcon A bandage lenses (Z=-5.385, -6.782, P<0.001; Z=-8.336, -8.906, P<0.001). Both Senofilcon A and Balafilcon A bandage lenses have good efficacy after T-PRK. Senofilcon A lenses are associated with less pain and more comfort compared to Balafilcon A.

Bowman Layer Onlay Grafting: Proof-of-Concept of a New Technique to Flatten Corneal Curvature and Reduce Progression in Keratoconus.

The aim of this study was to describe a new surgical technique for flattening the corneal curvature and to reduce progression in eyes with advanced progressive keratoconus (KC) by using Bowman layer (BL) onlay grafting and to report on the preliminary outcomes of this procedure. In this prospective interventional case series, 5 patients with advanced progressive KC underwent BL onlay grafting. After removal of the epithelium, a BL graft was placed and "stretched" onto the stroma, and a bandage lens was placed to cover the BL graft. In 1 case, BL onlay grafting could be performed immediately after ultraviolet corneal crosslinking; all other eyes were ineligible for ultraviolet corneal crosslinking. Best spectacle- and/or best contact lens-corrected visual acuity, refraction, biomicroscopy, corneal tomography, anterior segment optical coherence tomography, and complications were recorded at 1 week and at 1, 3, 6, 9, and 12 to 15 months postoperatively. All 5 surgeries could be performed successfully. Average maximum keratometry went from 75 diopters (D) preoperatively to 70 D at 1 year postoperatively. All eyes showed a completely reepithelialized and a well-integrated graft. Best spectacle-corrected visual acuity improved at least 2 Snellen lines (or more) in 3 of 5 cases and best contact lens-corrected visual acuity remained stable, improving by 3 Snellen lines in case 1 at 15 months postoperatively. Satisfaction was high, and all eyes again had full contact lens tolerance. BL onlay grafting may be a feasible surgical technique, providing up to -5 D of corneal flattening in eyes with advanced KC.

Masked comparison of two silicone hydrogel bandage contact lenses after photorefractive keratectomy

PurposeTo compare the efficiency and safety of two bandage contact lenses after photorefractive keratectomy (PRK). MethodsIn this double-blind study, 45 patients (90 eyes) received PRK in both eyes and wore bandage contact lenses (BCLs), PureVision (Bausch & Lomb, Rochester, NY, USA) in one eye and PureVision2 (Bausch & Lomb, Rochester, NY, USA) in the other eye, randomly assigned. The medication regimen after surgery was the same for both eyes. The epithelial defect's size, conjunctival hyperemia and lens centration were graded objectively using slit-lamp biomicroscopy on days 1, 3 and 5 after surgery. Also ocular symptoms of discomfort including tearing, photophobia, foreign body sensation and visual fluctuations were assessed subjectively at each visit. ResultsThe mean epithelial defect size on the first day after operation was similar in eyes fitted with PureVision (30.08 ± 5.30 mm²) and PureVision2 (30.25 ± 5.72 mm2) lenses. (p = 0.79) Contact lens deposits and bulbar hyperaemia on days 1 and 3 after PRK were similar between the two eyes, but were significantly greater on day 5 for PureVision2 lenses. (p = 0.02; p = 0.04 respectively) There was no difference in contact lens decentration, and discomfort symptoms including pain, tearing, foreign body sensation, photophobia and visual fluctuations between the eyes fitted with PureVision and PureVision2. (p > 0.05) ConclusionsPureVision and PureVision2 contact lenses are equivalent as bandage lenses in important aspects such as corneal re-epithelialization and subjective comfort., although PureVision2 led to a higher incidence of contact lens deposits and conjunctival hyperemia early post-PRK.

Surgical treatment of keratoglobus: key techniques of bridge-shaped flap penetrating keratoplasty and whole lamellar keratoplasty with corneoscleral limbal

Objective: Introduce the surgical techniques of bridge-shaped flap penetrating keratoplasty and whole lamellar keratoplasty with corneoscleral limbal and the comparison of therapeutic effects on keratoglobus. Methods: Five patients (eight eyes) with keratoglobus from January 2010 to December 2015 were included. Three eyes received bridge-shaped flap penetrating keratoplasty (two eyes with corneal penetrating injury due to trauma, one eye with descemet's membrane detachment) and five eyes received whole lamellar keratoplasty with corneoscleral limbal. Results: The patients (four male, one female) aged 3 to 67 years old. Three younger patients were complicated with blue sclera. The visual acuity of all the patients pre-operation were lower than 0.05. The average visual acuity after whole lamellar keratoplasty (LKP) surgery was 0.2, while the average visual acuity after bridge-shaped flap penetrating keratoplasty (PKP) was 0.5. The corneal epithelium of the three eyes received bridge-shaped flap PKP surgery was completely healed within a week with no recurrence of corneal epithelial defect. Whereas one eye after whole LKP surgery arised persistent corneal epithelial defect and healed after blepharorrhaphy. The corneal epithelial of another eye after whole LKP surgery healed slowly and was completely healed after wearing a bandage lens on corneal for 2 months. The corneal epithelial of the remaining three eyes after whole LKP surgery was completely healed within a week. Two eyes received bridge-shaped flap PKP surgery arised corneal graft rejection 2 months after operation and recovered after anti-rejection treatment. No corneal graft rejection arised in the patients receiving whole LKP surgery. Conclusions: The whole lamellar keratoplasty with corneoscleral limbal could effectively reinforce corneal, avoid corneal penetrating injury caused by minor trauma, and improve visual acuity in keratoglobus whose corneas were gradually thinning and corrected vision cannot be improved. The patients with corneal perforating injury or descemet's membrane detachment could obtain good visual prognosis receiving bridge-shaped flap penetrating keratoplasty. (Chin J Ophthalmol, 2019, 55:916-922).

Effect of bandage lens after pterygium excision combined with corneal stem cell transplantation

Effect of bandage lens after pterygium excision combined with corneal stem cell transplantation

Making a difference in quality of life with scleral lenses – Two clinical cases with neurotrophic ulcers

The main use for scleral lenses is visual aid in irregular corneas. However, they are also beneficial as bandage lenses in severe ocular surface disease. Following cases illustrate two different ways to improve quality of life in patients with neurotrophic ulcers, a condition associated with hypoesthesia or anaesthesia of the cornea due to damage to the trigeminal nerve. Case 1 is a male patient who, at age 58 had a stroke that among other things resulted in a slow healing corneal ulcer. To shield the cornea a partial tarsorrhaphy was performed and soft bandage lenses were tried with little or no result. At age 71, he presented at the clinic with a central ulcer and BCVA 0.13. A scleral lens was fitted and two months later the ulcer was completely healed and BCVA had recovered to 0.6. The patient has now worn the scleral lens successfully for two years and the tarsorrhaphy has been reversed. Case 2 is a female patient who, at age 40, had an aneurysm causing an oculomotor nerve palsy leading to semi ptosis, inability to close the eyelid and total lagoftalmus. Over time an ulcer with neovascularisation caused by the corneal exposure developed. Not being able to move the eye, she also suffered from double vision and cosmetically the ptosis was disturbing. At age 48, she was referred to the clinic and a scleral lens was fitted. The ulcer healed completely after 6 weeks. Thanks to an excessive sagittal depth, the eyelid was elevated masking the ptosis. There was a possibility of improving BVCA from 0.05 to 0.3 but the vision was blurred intentionally with a high minus power to relief the double vision. The patient has now worn the lens successfully for two years.

Protective efficacy of bandage lens on corneal flap of patients with retinal detachment after LASIK surgery

Objective To evaluate the protective efficacy of bandage contact lens on corneal flap for retinal detachment patients with LASIK history. Methods A prospective, self-controlled clinical study. Nine eyes of 9 patients with retinal detachment who had history of LASIK were enrolled. All cases underwent vitreoretinal surgery with non-contact wide-angle lens. Corneal bandage lenses were used to completely cover the surface of the corneal flap during surgery. The visual acuity, IOP, corneal fluorescein sodium staining, tear function, corneal thickness and corneal endothelial cell density at 1 d, 1 week and 1 month postoperatively were recorded. Results No corneal flap displacement or loss occurred in 9 cases. Before surgery corneal fluorescein staining showed scattered cornea around the next spot color in 7 cases. The score of corneal fluorescein staining was (2.00±0.87) 1 d after surgery, it was higher than that before surgery (t=-5.547, P=0.001). The score returned to preoperative level at 1 week after surgery. BUT was agreement with results of corneal fluorescein sodium staining. The corneal thickness at 1 week after surgery was (531.78±24.17)μm, it was thicker than that before surgery(t=-4.918, P=0.001). The difference of corneal thickness was not statistically significant between before and 1 month after surgery. The difference of Schirmer Ⅰtest and corneal endothelial cell density were not statistically significant between before and after surgery. Conclusion Application of corneal bandage lens for retinal detachment patients with history of LASIK can protect corneal flap, recovery early of tear film stability, effectively protect the corneal function. Key words: Retinal detachment, after surgery, laser in situ keratomileusis(LASIK); Vitreoretinal surgery; Bandage contact lens; Corneal flap

In vitro and in vivo effects of ophthalmic solutions on silicone hydrogel bandage lens material Senofilcon A

BackgroundAcuvue Oasys silicone hydrogel contact lenses (Senofilcon A) are used as bandage lenses and often combined with ophthalmic solutions in the treatment of ocular diseases. Concerns have been raised regarding the compatibility and effect of eye‐drop solutions on the bandage lenses, which have led to frequent replacement of lenses causing clinical problems. Some patients experience pain or discomfort during treatments and the accumulation of drugs and preservatives in lenses has been suggested as a possible reason. The aim with this study was to investigate the effect of ophthalmic solutions on silicone hydrogel bandage lens material Senofilcon A in vitro and in vivo.MethodsThe effect of three common ophthalmic solutions Isopto‐Maxidex, Timosan and Oftaquix on Acuvue Oasys (Senofilcon A) bandage lenses was evaluated. An in vitro model method was developed where drug and preservative uptake by Acuvue Oasys was monitored with ultraviolet–visible spectroscopy and laser desorption ionisation mass spectrometry. Surface morphology changes of the lenses were evaluated using scanning electron microscopy. The method was then implemented for the in vivo pilot study evaluating lenses worn by patients.ResultsIn vitro model study monitoring the drug and preservatives uptake showed that the active ingredients from all the eye drops together with preservatives were taken up by the lenses in significant amounts. For the in vivo study no traces of active ingredients or preservatives could be found on the worn and treated lenses regardless of time being worn or dosage profiles. The surface morphology changes in the in vivo study were also minor in contrast to the changes observed in the in vitro scanning electron microscopy images.ConclusionThe in vivo results demonstrate minor effects of the ophthalmic solutions on the worn lenses. These results do not support the building up of preservatives and drugs on the contact lenses as the cause of pain or discomfort experienced by some patients, which is encouraging for the use of bandage lenses in combination with ophthalmic solutions.

(Invited) Printed Flexible Sensor-Integrated Wearable Healthcare Patch

Wearable healthcare device allows us to monitor continuous daily health conditions if multiple sensors to detect physical and chemical information from a body can be integrated on a flexible sheet. Simultaneous detections of a variety of health conditions from body during daily life are most likely only realized by attaching the devices directly onto skin. By considering hygiene concerns for the direct attachment, the device should be disposable like a bandage or contact lenses. To spread this concept to many users widely, the device needs to be low cost due to that reason. To realize both multi-functionality and low cost process on a macroscale film, printing techniques to form active materials are promising as a next class of electronics. In fact, recently, many printed flexible sensors and transistors have been reported by using inorganic and/or organic materials. As the one of approaches, in this talk, a printed flexible multi-functional healthcare patch will be introduced. Furthermore, the fundamental properties of each sensor such as skin temperature, motion, and electrocardiogram signal sensors will be discussed. Although there are still a lot of challenges to realize the wearable healthcare patch, this progress may be able to help the progress on this field in near future.