Abstract The origin of mid–high-latitude intraseasonal oscillations (ISOs) was investigated through both observational and theoretical studies. It was found that maximum intraseasonal variability centers appear near 60°N, which is at odds with maximum synoptic variability centers that are located along the upper-tropospheric jet stream (∼45°N). The ISO along 60°N is characterized by a typical zonal wavelength of 7700 km and a westward phase speed of −3 m s−1. A marked feature of the mid–high-latitude ISO is a tight coupling among moisture and precipitation and circulation. Motivated by this observational discovery, a moist baroclinic theoretical model was constructed. The analysis of this model indicates that under a realistic background mean state, the model generates the most unstable mode along the reference latitude (60°N), which has a preferred zonal wavelength of 7000 km, a westward phase speed of about −3 m s−1, a westward tilted vertical structure, and a zonal structure of perturbation moisture/precipitation being located to the east of the low-level trough, all of which resemble the observed. The cause of the instability arises primarily from the moisture–precipitation–circulation feedback under a moderate background vertical shear.