To improve the safety of the children in child seats when a vehicle collision occurs, a finite element model of a child safety seat is established, and LS-DYNA is used for crash simulation. Select backrest inclination, headrest inclination, and seat belt centre height as design variables to establish response surface models. The application of chaotic mutation theory in particle swarm optimisation (PSO) is proposed, and the optimal solution of child seat parameters is obtained by using the chaotic mutation based grouped multi-objective particle swarm optimisation (MOPSO). The optimal solution was used to carry out the simulation experiment again, and compared with the original performance. It turned out that the Head Performance Criterion (HPC) is 47.08% better than the original child seat. Besides, the rib deformation is reduced by 21.30%, the neck shear stress is reduced by 55.74%, and the thigh stress is reduced by 48.55%, which indicate significant improvements. The results suggest that a certain parameter combination of the child seat leads to the optimal overall performance in child injury prevention, which indicates significant improvement in the damage of all parts of the child.