In this paper, the crucial aspect of driver comfort was explored by investigating the prevailing driving postures among individuals, aiming to discern their ergonomic implications and ascertain whether the commonly adopted postures are conducive to musculoskeletal health or pose potential risks. From the last decade vehicle like cars have become one of the common modes of personal transport. Car has high relevance in day-to-day activities like commuting, economic activities and sports etc. The continuous driving of vehicle can lead the driver prone to musculoskeletal disorders such as back pain, spine injury and posture issues. This study is conducted to address the ergonomic aspects of posture of the driver to highlight the risk of Musculoskeletal disorders (MSDs) and to optimize the driving posture. Lower Back Analysis (LBA) and Comfortability Analysis is performed in JACK Software to analyze the driving posture. A DHM (Digital Human Model) is created in JACK Simulation Software according to the collected anthropometric data of an average Pakistani man. A virtual Environment is created in JACK Simulation Software. The posture of the subject is analyzed by taking measurements of the subject’s angle of joints when they are sitting in a driving posture. For Ergonomic Analysis the Driving Posture is evaluated on JACK software to Mitigate Musculoskeletal Disorders. Results show that the subject is having low back compression force of 672 which is below the NIOSH Back Compression Action Limit of 3400N representing a nominal risk of low back injury.