Azo Schiff Base Ligand Research Articles

Synthesis, Characterisation and Biological Evaluation of Metal Complexes from Thiosemicarbazone

A new azo schiff base ligand, together with its metal complexes,was synthesized and characterized from a thiosemicarbazid moiety. The title (E)-2-((2-hydroxy-3-((E)-(3-nitrophenyl)diazenyl)naphthalen-1-yl)methylene)hydrazine-1-carbothioamide)(HL),was synthesized by reacting((-2-hydroxy-3-((3-nitrophenyl)diazenyl) withan thiosemicabazide in a 1:1 molar ratio,HL interacted with different metal ions (Cr,Mn,Co,Ni and Cu) to from monomerci coordination complexes .Arsng of spectroscopic and analytical techniques ,including conductance studies, H1 and C13-NMR,FT-IR, electronic and mass spectroscopy,magnetic susceptibility,and elemental micro-analysis,were used to extensivety characterize these complexes.Coordinate compounds with four and six-coordinate geometries were confirmed to from based on the characterization data .

New Semicarbazone-Schiff Base Coordination; Synthesis, Characterization and Biological Evaluation

The synthesis and characterisation of a new azo Schiff base ligand generated from a semicarbazone moiety are reported in this study, in addition to its metal complexes. The title ligand, (E)-2-((2-hydroxy-3-((E)-(2-nitrophenyl) diazenyl) naphthalen-1-yl) methylene) hydrazine-1-carboxamide (HL), was synthesised by reacting ((E)-2-hydroxy-3-((2-nitrophenyl) diazenyl)-1-naphthaldehyde) with semicarbazidein a 1:1 molar ratio. Afterward, the interplay between HL and other metal ions (CrШ, MnII, CoII, NiII and CuII) produced monomeric coordination complexes in a 1:1 ligand-to-metal ratio. A range of spectroscopic and analytical techniques, such as magnetic susceptibility, conductance tests, 1H and 13C-NMR, FT-IR, electronic and mass spectroscopy, and elemental microanalysis, were used to extensively characterize these complexes. The synthesis of coordination compounds with six-coordinate geometries was verified by the characterization data. The study also assessed the antimicrobial efficacy of the synthesised compounds against various bacterial and fungal species, revealing that After the complex formed, the ligand's antimicrobial activity was greatly increased.

Synthesis, Charecterization, Antibacterial and Cytotoxicity of Novel Metal Complexes Derived from Azomethine Ligand (Bis Azo-Schiff Base) In Vitro and In Silico

Background: Schiff bases, especially Azo-Schiff bases, are significant ligands in organic chemistry due to their coordination capabilities. They find applications in various industrial sectors and biological studies. Metal complexes of Schiff bases, particularly with tetradentate ligands, have gained attention for their potential pharmacological benefits. However, there is limited information on the biological activities of certain Schiff base complexes, such as 1H-indole-3-ethylenesalicyldamine derivatives. Method: The synthesis of bis azo-Schiff base ligands and their metal complexes, including Ni(II), Co(II), Pd(II), and Pt(IV) complexes, was conducted. Various analytical techniques were employed to characterize the compounds using FTIR, NMR, UV-Vis spectroscopy, mass spectrometry, and molar conductivity. Biological activities, including antibacterial and cytotoxicity studies, were evaluated. Results: The synthesized compounds demonstrated stability and structural characteristics consistent with the intended coordination geometries. IR spectra confirmed the coordination of metal ions with the ligands. The complexes were evaluated for the antimicrobial activity against two types strains of Gram-negative Escherichia coli and Gram-positive bacteria Staphylococcus aureus and showed good significant against these bacteria. The Pd(II) complex demonstrated higher efficacy against cancer cells compared to normal cells, highlighting its potential as an anticancer agent. The cytotoxicity of the Pd (II) complex on human malignant melanoma A375 and Normal cell WRL-68 were IC50 23.83 and IC50 153.7, respectively. Molecular docking studies provide insights into the interaction of the complexes with target proteins, offering potential modes of action. Conclusion: The study successfully synthesized and characterized bis azo-Schiff base ligands and their metal complexes, demonstrating their stability and promising biological activities.

Synthesis, characterization, medical activity, and docking prediction of new heterocyclic Azo-Schiff base ligand derived from 2-Amino-5-methyl thiazol and Cr(III), Ni(II), and Cu(II) metal ions

A new heterocyclic Azo-Schiff base dye named 3- (((Z)-4-(dimethylamino) benzylidene) amino)-4-((E)-(5-methylthiazol-2-yl) diazenyl) phenol (HL) 3-aminophenol is produced when 2-amino-5-methyl thiazole reacts with (dimethylamino) benzaldehyde. The azo-Schiff base ligand reacted with some metal ions like Cr(III), Ni (II), and Cu(II) forming a chelate complex. Elements were analyzed by UV, FT-IR, H1-NMR, 13C NMR, molar conductance, mass spectra, GA, X-ray, and FESEM elemental analysis. Spectra reveal the complex's [M:L] ratio was 1:2. This investigation comprised antibacterial and antifungal activities against Escherichia coli (Gram-negative), Streptococcus (Gram-positive), and penicillin. Some complexes have good activity. Azo ligand and Ni(II) complex inhibit HepG2 cancer cells. The results indicated that it can be used as an anti-cancer drug in the fields of medicine and pharmacy. The DPPH test was also used to demonstrate that ligands and their complexes are antioxidants. The docking portion was used to determine cancer cells' physical characteristics and inhibitory activity. The order of inhibition is Ni-Complex > HL > Cr-Complex > Cu-Complex.

Ligational behavior of bidentate NO-donor, 2-(((1H-1,2,4-triazol-5-yl)imino)methyl)-4-(o-tolyldiazenyl)phenol towards VO2+, Fe3+, Ru3+, Co2+, Mn2+, Ni2+, Cu2+ Zn2+ and ions preparation, experimental, theoretical characterization, and microbicidal investigation

Novel bidentate chelator, 2-(((1H-1,2,4-triazol-5-yl)imino)methyl)-4-(o-tolyldiazenyl)phenol was employed for designing and preparation of transition metallic complexes. The synthetics were characterized based on various analytical, spectral, and theoretical tools. Based on the various analysis data, the azo-Schiff base chelator (H2L) linked with metallic cations as a neutral/uni-negative bidentate chelator via the protonated/deprotonated hydroxyl oxygen and azomethine nitrogen atoms adopted a distorted octahedral, tetrahedral, or square planar geometry. The mass spectroscopy confirmed that the molecular weights of azo-Schiff base and some of its complexes closely match with that of the estimated m/z values. Additionally, the structure of the azo-Schiff base ligand and some metallic complexes were studied by Density functional theory (DFT) calculations to assess the molecular orbitals (LUMO&HOMO) as well as the molecules electrostatic potential (MEP) to complete the picture. The synthetics were evaluated for their in vitro activity against Escherichia coli, Aspergillus niger, and Bacillus subtilis. According to this research, unbound ligand molecules are inactive while their metallic complexes have low to moderate activity.

Synthesis and Characterization of a Novel Azo-Dye Schiff Base and Its Metal Ion Complexes Based on 1,2,4-Triazole Derivatives

The study focused on producing and examining the properties of the 2-(((3-mercapto-5-(4-nitrophenyl)-4H-1,2,4-triazol-4-yl)imino)methyl)-4-(((4-mercaptophenyl) diazenyl)phenol) ligand (L) and its complexes with three transition metal ions, namely Ni(II), Co(II), and Cu(II). The ligand was formed through diazotization and coupling reactions between 4-aminobenzenethiol and a coupling Schiff base derived from 1,2,4-triazole. The characterization of the ligand and its metal ion complexes was carried out using analytical techniques such as FTIR, 1H- and 13C-NMR, UV-visible spectroscopy, and thermal analysis (TGA and DTG). Various physical methods were employed to synthesize and analyze the properties of the three mononuclear Co(II), Ni(II), and Cu(II) complexes with the azo-dye Schiff's base ligand. Based on the microanalysis and spectroscopic results, it was determined that the coordination between the azo Schiff base ligand and the central metal ion occurred through the NOS-donating atoms of the ligand. The analysis of the electronic spectra revealed that the synthesized Co(II) and Ni(II) complexes exhibited an octahedral geometry, while the Cu(II) complex had a distorted octahedral geometry. The implications of the finding regarding the octahedral and distorted-octahedral geometries include expanding the structural diversity in coordination chemistry, providing insights into ligand-metal interactions, and understanding the influence of geometry on properties.

Tetradentate azo Schiff base Ni(II), Pd(II) and Pt(II) complexes: Synthesis, spectral properties, antibacterial activity, cytotoxicity and docking studies

A new complexes of Ni(II), Pd(II), and Pt(II) have been synthesized from the reaction of Azo-Schiff base ligand (L1) that was prepared by the condensation firstly of salicylaldehyde with ethylene diamine in a 1:2 molar ratio and the prepared imine compound (S1) reacted with 2,5-dichloro aniline, and were employed in the preparation of complexes containing the metal ions Ni(II), Pd(II), and Pt(II). The structural characteristics of the synthesized compounds were investigated using UV-Vis, IR and NMR, molar conductance, elemental analysis, and mass spectroscopy. The results of the elemental analysis point to a 1:1 [M:L] stoichiometry. According to molar conductance studies, none of the prepared end products are electrolytic in nature. The complexes of Ni(II), Pd(II), and Pt(II) may have square planer geometry, according to spectral investigations. Then Pd(II), Ni(II), and Pt(II) complexes were evaluated for antimicrobial activity against different types strains of Gram-negative [Escherichia coli (ATCC 25922)] and positive bacteria [Staphylococcus aureus (ATCC 25923)] and showed good significant against these bacteria. The cytotoxic effect of the palladium complex on the prostatic malignant cell was examined via the PC3 cell line studied against normal cell WRL-68. The molecular docking of target microorganisms of these complexes will be studied by using MOE software.
 KEY WORDS: Salen ligand, Nickel(II), Palladium(II), Platinum(II), Complexes, bis azo-Schiff base
 Bull. Chem. Soc. Ethiop. 2024, 38(1), 99-111. DOI: https://dx.doi.org/10.4314/bcse.v38i1.8

Synthesis and Spectral identifications of new azo – Schiff base ligand(4Cl-2DIBP) derived from (para-aminobenzylamine) with its some metallic complexes

The New Heterocyclic ligand 4-chloro-2-(((4-((4,5-diphenyl-1H-imidazol-2-yl) diazenyl ) benzyl)imino)methyl) phenol (4Cl-2DIBP) was prepared from the condensation of para-aminobenzylamine with 4,5-diphenyl imidazole, followed by the condensation of the resulting compound with 5- chloro-2- hydroxy benzaldehyde. Different analytical and characterization techniques including (Mass,1HNMR, FT-IR and UV-Vis. spectroscopy and C.H.N elemental analysis) in the investigation of Newly prepared ligand. A series of Novel solid metal complexes of this ligand with Co (II), Ni (II), Cu (II), Zn ((II), Cd (II), and Hg (II) were prepared and all complexes were characterization by techniques above, excluding the Mass and the 1H-NMR spectroscopy of some prepared solid metal complexes and the use of flame atomic absorption spectroscopy to determine the percentages of metal ions in the prepared complexes also studied the magnetic susceptibility and molar conductivity of the metal complexes dissolved in DMSO at 1 × 10-3 M concentration laboratory temperature. The results of this studies showed that the coordination sites for the new Azo-Schiff base ligand with Co (II), Ni (II), Cu (II), Zn ((II) , Cd (II) and Hg(II) were to be through nitrogen of the imidazole ring, and the nitrogen of azo group,. The Electronic spectral and magnetic measurement data predict octahedral structure of the complexes. All complexes showed that Non-electrolytes properties.

Synthesis, physicochemical characterisation and DNA binding study of a novel azo Schiff base Ni(II) complex

The azo Schiff base ligand was synthesised, along with its Ni(II) complex, by diazotisation of salicylaldehyde with 4-nitroaniline in accordance with the accepted literature approach. Using a variety of spectroscopic techniques, the resulting complex is analysed both quantitatively and qualitatively (Elemental analysis, FT-IR spectroscopy, UV-VIS spectroscopy, 1H NMR, etc.). Spectral measurements of the complex revealed a mole ratio of 1:1. The non-electrolytic nature of the complex is confirmed by molar conductance investigation. The unique azo compound had a tetrahedral shape as a result of the tetra coordination of two phenolic oxygen and two imine nitrogen. The ability of the metal complexes to bind DNA was examined using absorption spectroscopy, fluorescence spectroscopy, viscosity tests, and thermal denaturation methods. Experimental research suggests that complexes bind to DNA through intercalation.

Bivalent Metal Chelates with Pentadentate Azo-Schiff Base Derived from Nicotinic Hydrazide: Preparation, Structural Elucidation, and Pharmacological Activity.

Azo-Schiff base ligand (N'-((E)-2-hydroxy-5-((E)-(2-hydroxyphenyl)diazenyl)benzylidene)nicotinohydrazide) and its Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) chelates were prepared and elucidated. The geometrical structures of the prepared chelates were characterized by several spectroanalytical techniques and thermogravimetric analysis. The obtained data revealed that the chelates have (1M:1L), (1M:2L), (1M:3L), and (1M:4L) molar ratios. The infrared spectra displayed that the H2 L ligand behaves in a pentacoordinate fashion in chelates of Mn(II), Ni(II), and Cu(II) ions. However, in Zn(II) and Pd(II) chelates, the ligand is coordinated as a tetradentate species (NONO) through nitrogen atoms of azomethine and azo groups as well as oxygen atoms of phenolic hydroxy, and carbonyl groups. Besides, it was concluded that the oxygen atoms of carbonyl and hydroxy groups along with the azomethine nitrogen atom of the ligand are bounded with Co(II) ion in metal chelate (2). According to the measured molar conductance values, the chelates of Cu(II), Zn(II), and Pd(II) are weak electrolytes, but Mn(II), Co(II), and Ni(II) chelates are ionic. The azo-Schiff base ligand and its prepared metal chelates were tested for their antioxidant and antibacterial properties. The Ni(II) chelate was found to be considered an effective antioxidant agent. In addition, the available antibacterial data suggest that the Ni(II) and Co(II) chelates may be employed as inhibitor agents against Proteus vulgaris, Escherichia coli, and Bacillus subtilis bacteria. Furthermore, the data showed that, in comparison to the ligand and other metal chelates, copper(II) chelate (4) exhibited higher action against Bacillus subtilis bacteria.

Synthesis and Spectral Identification of New Azo-Schiff base Ligand Derivative from Aminobenzylamine and its Novel Metal Complexes with Cu(II), Zn(II) and Hg(II)

Synthesis and Spectral Identification of New Azo-Schiff base Ligand Derivative from Aminobenzylamine and its Novel Metal Complexes with Cu(II), Zn(II) and Hg(II)

New Azo-Schiff Compounds and Metal Complexes Derived from 2-Naphthol Synthesis, Characterization, Spectrophotometric, and Study of Biological Activity

This research involved synthesizing two compounds as derivatives of 2-naphthol by the classical method. The azo coupling compound was prepared via diazonium salt of 4-amino acetophenone followed by 2-naphthole. The azo-Schiff molecule was synthesized through condensation of an azo compound with 5-amino salicylic acid in an acidic medium. Using spectrum approaches, the new compounds are characterized (13C-NMR, 1H-NMR, FT-IR). The acid-base characteristics were investigated at various pH levels (0.67-12), and the ionization and protonation constants were determined. Spectroscopic methods were used to identify new copper (II), nickel (II), and cobalt (II) complexes of the azo-Schiff base ligand. All the compounds were evaluated for antibacterial activity against bacteria such as Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria). It was found that the coordination complexes of Cu and Co had an antibacterial effect on both concentrations against Staphylococcus aureus.

A New Azo-Schiff Base Dual-mode Chemosensor: Colorimetric Detection of Cobalt Ions and Fluorometric Detection of Aluminum Ions in Aqueous Ethanol Solution.

A new Azo-Schiff base ligand (H2L) was designed and synthesized as a cation chemosensor.The chemosensor H2L as dual chemosensor showed selective fluorescence recognition of Al3+ with a noticeable fluorescence enhancement and colorimetric detection of Co2 + in aqueous ethanol solution. The H2L exhibits a linear response toward Al3+ ions in the concentration range of 1.91 × 10-8M to 4.8 × 10-6M with a limit of detection of 1.91 × 10-8M. The sensing mechanism of sensor H2L toward Al3+ was investigated by 1H NMR and IR spectroscopies. Fluorescence switch based on the control of EDTA and Al3+ proved H2L could act as a reversible chemosensor. The molecular structure of [NiL] complex has been determined by X-ray crystallography.

Computational, Experimental and Pharmacological Studies of Cu(II), Co(II) and Ni(II) Metal Complexes containing Azo Schiff base Ligand

The metal complexes containing Cu(II), Co(II) and Ni(II) metal ions were synthesised in the molar ratio of 1:2 [M:L] and azo Schiff base ligand as a primary ligand. The synthesized metal complexes were confirmed by the different analytical and spectroscopic techniques like UV-Visible, FT-IR, NMR, LC-MS and P-XRD techniques. The binding interaction of synthesized metal chelates with CT-DNA has been investigated by absorption spectra, viscosity measurements and thermal denaturation techniques. The mode of binding of the metal complexes with calf-thymus DNA has been explored. The metal complexes [Cu(II), Co(II) and Ni(II)] intercalated between the base pairs of the CT-DNA tightly with intrinsic binding constant (Kb) in Tris - HCl buffer containing 50 mMNaCl buffer. The DNA cleavage activities of the complexes were clearly assayed by using pUC-18 DNA which was monitored by the gel electrophoresis method. The antibacterial activity was carried out by a well-diffusion method against gram-positive bacteria S. aureus and gram-negative bacteria Shigella. Amylase inhibitory activity of pooled fractions was carried out according to the standard method with minor modification (antidiabetic activity). The in silico molecular docking was achieved with the DNA binding receptor PDB ID: 1E3Y taken from RCSB Protein Data Bank (www.rcsb.org/pdb). The receptor structre was prepared before use in docking study using protein preparation module of HEX 8.2 modelling package.

Preparation, spectroscopic characterization and study of biological activity as anticancer of some compounds using a new azo-Schiff base ligand (N,N,O) derived from 2-amino-5-methyl thiazol

The biological activity of the Co(III) complex of azo-Schiff bases derived from 2-amino-5-methylthiazole azo-Schiff bases was studied. Elementary examines, attractive instant volumes, spectroscopy (IR, electronic, 1 H NMR, and XRD), then thermogravimetric investigations described the azo-Schiff bases and their mineral complexes. For the cobalt complex, an octahedral geometry has been proposed. Thermal and infrared data of the mineral complexes confirmed the presence of the collected water. Schiff bases and mineral complexes have been tested for their anti-cancer properties

The ultrafast tunable saturable absorption of three azo-Schiff base ligands and related metal complexes

Three azo-Schiff base ligands with large conjugated systems and five related transition metal complexes were synthesized and investigated by femetosecond open-aperture Z-scan and pump-probe system. The ultrafast tunable saturable absorption of the ligands and their metal complexes were observed at 400 nm wavelength. The obtained third-order nonlinear optical (NLO) absorption coefficients of eight compounds are evaluated to be −8.49 ∼ −80.63 cm/GW. Meanwhile, the ultrafast carrier relaxation time (187–592 fs) of all compounds was observed in the pump-probe experiment. The modulated impacts of metal coordination on NLO responses are analyzed by a five-level energy system. We deem that the performance of metal complexes is determined by the number of shell electrons of central metal. All the results indicate that those compounds have potential applications for tunable saturable absorber in NLO field.

Design and synthesis of a novel azo-Schiff base ligand: Its application as a colorimetric chemosensor for selective detection of Ni2+ and CN– in aqueous-organic media, computational studies, antimicrobial properties, and molecular logic circuits

In this study, an azo-Schiff base ligand was synthesized and then investigated using different analyses. The synthesized ligand as a colorimetric chemosensor was able to detect CN– and Ni2+ based upon the color changes from colorless to yellow. The limit of detection (LOD) for CN– and Ni2+ was determined at 2.19 × 10-6 M and 7.14 × 10-7 M, respectively. By DFT method, the boundary orbitals and energy gaps between them were determined. Using the TD-DFT method, the electronic transitions in the DMSO solvent were then simulated, which agreed with the experimental findings. This ligand revealed antibacterial activity against Staphylococcus aureus bacteria. Practically, this chemosensor functioned as a colorimetric test strip for Ni2+. Furthermore, chemosensor L was applied to detect CN– in apple seeds. By applying CN− (input 1) and Ni2+ (input 2) as chemical inputs and the absorption intensity signal as outputs at particular wavelengths of the chemosensor L, various logic functions such as (AND, OR, XNOR, NOR, INHIBT, IMPLICATION and XOR) were constructed. The chemosensor L could function as a half-subtractror by utilizing optical inputs. The complementary OR/NOR, IMP/INH and XOR/XNOR circuits were elaborated by employing two inputs.

Preparation complexes Co(III), Ni(II), and Cu(II) with novel azo-Schiff base ligand (N, N, O) derived from 2- amino- 6- methoxy benzothiazole with spectral characterization, study biological activity as anti-cancer, anti-oxidant to complexes

The biological activity of the Co (III), Ni (II), and Cu (II) complexes of bidentate azo-Schiff bases derived from the 2-amino-6-methoxy Benzothiazole has been investigated. The azo-Schiff bases and their metal complexes were described using element analyses, magnetic moment measurements, spectroscopic (IR, electronic, 1H NMR, XRD), and thermogravimetric examinations. An octahedral geometry has been postulated for Co (III), Ni (II), and Cu (II) complexes. Coordinated water was established by thermal and infrared data from the metal complexes. The anti-cancer and anti-oxidant capabilities of Schiff bases and their metal complexes have been investigated.

PREPARATION, CHARACTERIZATION AND STUDY OF THE BIOLOGICAL SCREENING OF THE AU (III) COMPLEX WITH NOVEL (AZO -SCHIFF BASE) LIGAND

The Aim: Biological studies carried out of new gold complexes after its preparation.
 Place and Duration of Study: All preparations were carried out in college of education, chemistry lab between (Jan 2021 to May 2022).
 Study Design: New azo –Schiff base ligand 2-amino-3-(2-((3-((2-hydroxy-4-sulfamoylphenyl)imino)-1,5- dimethyl- 2-phenyl- 2,3-dihydro- 1H-pyrazol-4-yl) diazenyl) -1H-imidazol-4-yl)propanoic acid with chelate complexes of Co(II),Ni(II), Cu(II), Zn(II), Cd(II) , Hg(II) and Au(III) were prepared with metal salts in ethanol a solvent in 1:1 ratio (metal : ligand) . The azo-Schiff base ligand has been synthesized from condensation of 2-amino-3- (2-((3-( (2 -hydroxy- 4-sulfamoylphenyl) imino)- 1,5-dimethyl -2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)diazenyl)-1H-imidazol-4-yl)propanoic acid with 4-amino-3-hydroxybenzenesulfonamide.
 Methodology: The prepared azo Schiff ligand and its metal complexes where checked by different spectral technique as, FT-IR ,C.H.N elemental analyses , Atomic absorption, magnetic moment measurements, molar conductance, UV-vis, ,1H-NMR and mass spectra studies.
 Results: The data show that the complexes have the composition of 1:1[M:L] chelates type and octahedral geometry with each of Co(II), Ni(II),Cu(II),Zn(II), Cd(II) and Hg(II) ions, except for Au(III) ion which has square planer geometry. All complexes that non electrolytes and no conductive species but Au(III) complex is 1:2 electrolyte nature. This can support the electrolytic nature of the metal complex.
 Conclusion: Biological activity studies of the ligand and their metal complexes against several organisms, bacteria Gram positive G(+ve)staphylococcus aureus and bacteria Gram negative G (- ve)Escherichia coli, In addition to fungi like Aspergillus Niger, and Aspergillus flavus , are reported. Compounds exhibited the high activity on the growth of all types microorganisms in this study . The results showed the highest inhibitory effect for gold the complex. The effect of biological screening of the gold complex on human colon cancer cell line HT- 29 was investigated. The gold complex was observed to have the highest inhibitory effect.

Novel Schiff base scaffolds derived from 4-aminoantipyrine and 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti-inflammatory.

The synthesis of four new azo-Schiff base ligands from 2-hydroxy-3-methoxy-5-(phenyldiazenyl)benzaldehyde and 4-aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as 1 H and 13 C, as well as FT-IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti-inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1-L4) possessed excellent biological potency.