SUMMARY Pore pressure oscillations induced by stress variations, including propagating seismic waves from remote earthquakes, have been widely observed in various groundwater systems. The monitored pressure change in wells shows significant water-level oscillations to volumetric strain as well as to S and Love waves. Recent observations demonstrated azimuthal dependence of the pore pressure oscillations with respect to stress indicators and fault zone orientation. Within the fault zone, damage-induced anisotropy is the result of the alignment and orientation of cracks and other internal flaws within the rock. In this work, we provide a complete quantitative description of the pore pressure changes induced by passing seismic waves associated with different orientations and values of principal stress and damage tensor components. The model quantifies the azimuthal dependence of the pore pressure response by a non-dimensional ratio defined as the amplitude of the pressure oscillations induced by a shear strain normalized to the volumetric strain. Three angles and two values are needed to calculate the azimuthal dependence of the pore pressure response: the angle between the directions of the maximum horizontal stress and the seismic event; fault zone orientation; microcrack orientation within the fault zone; and damage and stress values. The model predicts that maximum pore pressure response occurs when microcracks and maximum horizontal stress are in the same orientation, high damage and high stress anisotropy. By adjusting these quantities, we recalculate results of recent seismological studies in the Arbuckle disposal well, Osage County, Oklahoma. The presented model successfully predicts the observed azimuthal dependence in wave-induced fluid pressure response and relates the anisotropic response to tectonic indicators such as the orientations of the maximum horizontal stress, fault zone, and microfractures.