Axial T2-weighted Turbo Spin Echo Research Articles

Analysis of the relationship between meniscal tears and medial patellofemoral rupture according to the treatment method and gender

Objective: The aim of this study was to make a detailed anatomical analysis of the parameters of patellar height, the congruence angle, the lateral patellofemoral angle in patients with medial patellofemoral rupture, according to the treatment method (surgical or conventional), gender and whether or not there is a lateral and medial meniscus tears.
 Methods: This study was planned as retrospective study between January 2010 and January 2021. Magnetic resonance images (MRI) of 61 knees (61 individuals) were obtained for analysis. Of those, 38 knees were left, and 23 were right. One orthopaedic surgeons and two anatomist independently measured patellar morphology, patellar height and patellar alignment and evaluation lateral and medial meniscus tears. Knee MRI protocol including axial T2-weighted turbo spin echo (TR:3600, TE:87 ms; slice thickness 5 mm; gap 1.5 mm) was used.
 Results: There was a significant difference patellar height (surgery; 1.21±0.27 and conventional; 0.99±0.16), the congruence angle (surgery; -4.94±4.72 and conventional; 4.93±5.72), the lateral patellofemoral angle (surgery; -35.61±16.62 and conventional; 10.93±15.00), except for age parameter (surgery; 27.06±6.20 and conventional; 27.47±5.33) between the conventional and surgical treatment groups (p

Diagnostic value of gadolinium contrast administration for spinal cord magnetic resonance imaging in multiple sclerosis patients and correlative markers of lesion enhancement

BackgroundMagnetic resonance imaging is essential for monitoring people with multiple sclerosis, but the diagnostic value of gadolinium contrast administration in spine magnetic resonance imaging is unclear.ObjectiveTo assess the diagnostic value of gadolinium contrast administration in spine magnetic resonance imaging follow-up examinations and identify imaging markers correlating with lesion enhancement.MethodsA total of 65 multiple sclerosis patients with at least 2 spinal magnetic resonance imaging follow-up examinations were included. Spine magnetic resonance imaging was performed at 3 Tesla with a standardized protocol (sagittal and axial T2-weighted turbo spin echo and T1-weighted post-contrast sequences). T2 lesion load and enhancing lesions were assessed by two independent neuroradiologists for lesion size, localization, and T2 signal ratio (T2 signallesion/T2 signalnormal appearing spinal cord).ResultsA total of 68 new spinal T2 lesions and 20 new contrast-enhancing lesions developed during follow-up. All enhancing lesions had a discernable correlate as a new T2 lesion. Lesion enhancement correlated with a higher T2 signal ratio compared to non-enhancing lesions (T2 signal ratio: 2.0 ± 0.4 vs. 1.4 ± 0.2, ****p < 0.001). Receiver operating characteristics analysis showed an optimal cutoff value of signal ratio 1.78 to predict lesion enhancement (82% sensitivity and 97% specificity).ConclusionGadolinium contrast administration is dispensable in follow-up spine magnetic resonance imaging if no new T2 lesions are present. Probability of enhancement correlates with the T2 signal ratio.

MRI Findings of Arachnoiditis, Revisited. Is Classification Possible?

Prior imaging studies characterizing lumbar arachnoiditis have been based on small sample numbers and have reported inconsistent results. To review the different imaging patterns of lumbosacral arachnoiditis, their significance, and clinical implications. Retrospective. A total of 96 patients (43 women; average age 61.3 years) with imaging findings of arachnoiditis (postsurgical: N=49; degenerative: N=29; vertebral fracture: N=6; epidural and subdural hemorrhage: N=3, infectious: N= 1; other: N=8) from January 2009 to April 2018. Sagittal and axial T2-weighted Turbo Spin Echo at 1.5 T and 3 T. Chart review was performed to assess the cause of arachnoiditis, and imaging was reviewed by two musculoskeletal and three neurology radiologists, blinded to the clinical data and to each other's imaging interpretation. Previous classification included a three-group system based on the appearance of the nerve roots on T2-weighted images. A fourth group was added in our review as "nonspecified" and was proposed for indeterminate imaging findings that did not fall into the classical groups. The presence/absence of synechiae/fibrous bands that distort the nerve roots and of spinal canal stenosis was also assessed. The kappa score was used to assess agreement between readers for both classification type and presence/absence of synechiae. Postsurgical (51%) and degenerative changes (30%) were the most common etiologies. About 7%-55% of arachnoiditis were classified as group 4. There was very poor classification agreement between readers (kappa score 0.051). There was also poor interreader agreement for determining the presence of synechiae (kappa 0.18) with, however, strong interreader agreement for the presence of synechia obtained between the most experienced readers (kappa 0.89). This study demonstrated the lack of consensus and clarity in the classification system of lumbar arachnoiditis. The presence of synechia has high interreader agreement only among most experienced readers and promises to be a useful tool in assessing arachnoiditis. 3 TECHNICAL EFFICACY: Stage 2.

Yttrium-90 radioembolization for hepatocellular carcinoma: Outcome prediction with MRI derived fat-free muscle area

PurposeSarcopenia is associated with adverse outcomes in several gastrointestinal malignancies and liver cirrhosis. We aimed to study the utility of magnetic resonance imaging (MRI) derived fat-free muscle area (FFMA) to predict clinical outcome in patients receiving yttrium-90 radioembolization (RE) for treatment of hepatocellular carcinoma (HCC). MethodsFifty-eight patients with unresectable HCC and pre-interventional liver MRI undergoing salvage RE were retrospectively evaluated. Using axial T2-weighted turbo spin echo sequences, FFMA was calculated by subtraction of the intramuscular adipose tissue area from the total cross-sectional area of paraspinal skeletal muscles at the superior mesenteric artery level. FFMA values lower than 3582 mm2 in male and 2301 mm2 in female patients were defined as low FFMA. Main outcomes were progression-free survival (PFS) and overall survival (OS). For outcome analysis, the Kaplan-Meier method with log rank test and multivariate cox regression analysis were used. ResultsMean time from pre-interventional MRI to RE was 27 ± 20 days. Median OS and PFS after RE were 250 (range: 21–1230 days) and 156 days (range: 21–674 days), respectively. Patients with low FFMA showed significantly reduced OS (197 vs. 294 days, P = 0.024) and tended to have shortened PFS (109 vs. 185 days, P = 0.068). Low FFMA (HR 2.675; P = 0.011), estimated liver tumor burden (HR 4.058; P = 0.001), and Eastern Cooperative Oncology Group (ECOG) performance status (1.763; P = 0.009) were independent predictors of OS on multivariate analysis. ConclusionsFFMA as a measure of sarcopenia predicts OS and might represent a promising new biomarker for survival prognosis in patients undergoing RE for treatment of unresectable HCC.

Analysis of ovarian volume of Korean children and adolescents at magnetic resonance imaging.

Knowledge of ovarian volume is important for diagnostic evaluations; however, normal ovarian volume studies on children and adolescents are lacking. This study aimed to analyze age-specific ovarian volume and identify the diverse factors that contribute to ovarian diagnoses. We retrospectively enrolled 180 patients (0-18years of age) with normal ovaries who underwent magnetic resonance imaging (MRI) between 2010 and 2018. MRI sequences included coronal and axial T2-weighted turbo spin echo (TSE) images and coronal T1-weighted TSE images. Ovarian volume was calculated by the standard ellipsoid formula. Age-specific ovarian volume, height, weight, height-adjusted total ovarian volume and body mass index were obtained. Linear regression analysis was used to predict ovarian volume. Six age groups (infant; early and late child, and early, middle and late adolescent) were described. The early adolescent group (10-12years) had the highest rate of increase. In the middle adolescent period (13-15years), the curve of ovarian volume appeared flat. Our findings provide age-specific references for ovarian volume.

Radiographic Study of Lumbar Sympathetic Trunk in Oblique Lateral Interbody Fusion Surgery

Oblique lateral interbody fusion (OLIF) surgery provides a convenient and minimal access to the lesion disc with few complications; however, the left lumbar sympathetic trunk (LST) lies in the surgical field with a certain incidence of injury. The aim of this study was to describe the anatomic structures of the left LST at risk for injury during OLIF at different lumbar segment levels based on radiologic evaluations. Forty-four healthy young people (22 men and 22 women) were recruited, and routine lumbar magnetic resonance radiograph was performed. The LST, abdominal aorta (AA), and psoas muscle (PM) were observed, and all parameters were acquired using axial T2-weighted turbo spin echo sequence images. Independent-samples t test, 1-way analysis of variance test, and Least significant difference test were used to explore the LST's tract and the anatomic relationship with the adjacent anatomic landmarks at different levels. The distance from the left lateral border of the AA to the anterior medial border of the left PM was significantly narrowing from the L2-3 to L4-5 segment levels (13.72 ± 3.00, 11.78 ± 2.69, and 9.18 ± 3.43 mm). The distance from the left lateral border of the AA to the left LST was also significantly decreased from the L2-3 to L4-5 segment levels (11.14 ± 2.89, 9.36 ± 2.79, and 6.63 ± 2.94 mm). However, the distance from the leading edge of the left PM to the left LST had no statistical differences among all adjacent segment levels (2.96 ± 0.62, 2.83 ± 0.62, and 3.07 ± 0.86 mm). The location of the left LST is more backward and lateral at level L2-3, whereas it is inside front at levels L3-4 and L4-5. The practical risk of LST injury in different segment levels varied with specific anatomic conditions. The segment level L2-3 could provide a safer surgical space for OLIF, and the risk of the left LST injury might be greater during OLIF at level L4-5.

MRI Determination of Knee Effusion Volume: A Cadaveric Study

ABSTRACT Background There is currently limited literature on quantitative determination of knee effusion volume using magnetic resonance imaging (MRI). Purpose To describe a method of knee effusion volume determination using MRI generated models and to demonstrate accuracy of this technique. Materials and methods Using axial T2-weighted turbo spin echo and sagittal SPACE sequences, MRIs of three cadaver knees with multiple saline loads were obtained. Effusions models were created and effusion volumes were estimated using the Rhinoceros software. Estimated and known effusion volumes were compared using a bivariate correlation analysis. Results The SPACE sequence and T2WTSE estimates were highly correlated with the known volumes (R = 0.996 and 0.993 respectively, p &lt; 0.001). Conclusion MRI-generated models of knee effusions provide accurate estimates of knee effusion volumes. Clinical relevance MRI determination of knee effusion volume may provide a useful clinical outcomes tool. Wittstein J, Spritzer C, Garrett WE. MRI Determination of Knee Effusion Volume: A Cadaveric Study. The Duke Orthop J 2013;3(1):67-70.

Detection of focal hepatic lesions with 3-T MRI: comparison of two-dimensional and three-dimensional T2-weighted sequences

To evaluate whether incorporation of a 3D turbo spin-echo sequence during T2-weighted MR imaging improves the detection of focal hepatic lesions by 3T MR imaging. Seventy-nine consecutive patients including 67 patients with 62 malignant and 71 benign lesions and 12 patients having no hepatic lesion underwent respiratory-triggered fat-suppressed axial T2-weighted turbo spin-echo imaging using two-dimensional (2D-TSE) and 3D (3D-TSE) sequences. Coronal multiplanar reformatted images (MPR-3D-TSE) were generated from 3D-TSE images. Breath-hold fat-suppressed 2D axial T2-weighted half-Fourier turbo spin-echo (HF-2D-TSE) images were combined for reading. Two independent radiologists reviewed three imaging sets, (1) 2D-TSE and HF-2D-TSE, (2) 3D-TSE and HF-2D-TSE, and (3) 3D-TSE, HF-2D-TSE and MPR-3D-TSE, for detection of malignant and benign lesions. Lesion-to-liver contrast ratio (CR) and the conspicuity of anatomical boundaries were assessed. For benign lesions, lesion-to-liver CRs with 3D-TSE (2.77 ± 1.91, p = .0002) and MPR-3D-TSE (2.47 ± 1.42, p = .012) were higher than with 2D-TSE (2.13 ± 1.80). Sensitivity for lesions of ≤ 10-mm was higher with 3D-TSE (86 %, p = .0039) and MPR-3D-TSE (84 %, p = .0078) than with 2D-TSE (72 %). However, the edge of left lateral lobe was less conspicuous with 3D-TSE (p < .0001) and MPR-3D-TSE (p = .0003) than with 2D-TSE because of susceptibility artifacts. Incorporation of 3D T2-weighted sequence may incrementally improve the detection of focal hepatic lesions.

Functional MR imaging of the Eustachian tube in patients with clinically proven dysfunction: correlation with lesions detected on MR images

To visualise the function of the Eustachian tube by MRI and assess the effect of surrounding lesions. Using 1.5 T MRI, 32 Eustachian tubes of 16 patients with clinically proven dysfunction (clinical symptoms, such as autophonia and fullness and non-opening at tympanometry) were investigated. For depiction of the anatomy and associated abnormalities, coronal and axial T2-weighted turbo spin echo sequences and a T1-weighted-2D-gradient echo sequences were acquired. Eustachian tube opening was analysed with real time turbo-gradient echo sequences during a Valsalva manoeuvre. Dysfunction, that is, failure of opening of the Eustachian tube as shown by MRI, correlated in all patients with tympanometry. Lesions detected included nasopharyngeal carcinoma in 4 patients. Mucosal swelling in the paranasal sinus was present in 9 patients. One patient had postoperative defects. In two patients both pharyngotympanic tubes did not open although no structural abnormalities could be depicted. The opening of the Eustachian tubes during the Valsalva manoeuvre is assessable on MRI. Failure of opening may be due to swelling of the mucosa and may be also associated with tumours. MRI assessment may be helpful in patients with chronic otitis media, where the information about tubal function is important in preoperative planning. •Eustachian tube opening during Valsalva manoeuvre can be visualised with MRI •Lesions hampering tubal opening can be delineated at the same MRI examination •Functional MRI of the Eustachian tubes might determine the cause of dysfunction.

Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma

BackgroundHepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The molecular mechanisms underlying hepatocarcinogenesis are still poorly understood. Genetically modified mice are powerful tools to further investigate the mechanisms of HCC development. However, this approach is limited due to the lack of non-invasive detection methods in small rodents. The aim of this study was to establish a protocol for the non-invasive analysis of hepatocarcinogenesis in transgenic mice using a clinical 1.5 Tesla Magnetic Resonance Imaging scanner.ResultsAs a model system we used hepatocyte-specific c-myc transgenic mice developing hepatocellular carcinoma at the age of 12-15 months. The scans of the murine livers included axial T2-weighted turbo-spin echo (TSE) images, axial T1-weighted and contrast enhanced T1-weighted gradient echo (fast field echo, FFE) and sagittal true Fast Imaging with Steady state Precession (true-FISP) images. Application of contrast agent was performed via tail vein-catheter and confirmed by evaluation of the altered longitudinal relaxation T1 time before and after application. Through technical adaptation and optimization we could detect murine liver lesions with a minimum diameter of approximately 2 mm and provided histopathological evidence that these MR findings correspond to hepatocellular carcinoma. Tumor growth was repeatedly measured using sequential MRI with intervals of 5 weeks and subsequent volumetric analysis facilitating direct comparison of tumor progression between individual animals. We finally demonstrated that our protocol is also applicable in the widely- used chemical model of N-nitrosodiethylamine-induced hepatocarcinogenesis.ConclusionOur protocol allows the non-invasive, early detection of HCC and the subsequent continuous monitoring of liver tumorgenesis in transgenic mice thereby facilitating future investigations of transgenic tumor mouse models of the liver.

Cadaveric and MRI Study of the Musculotendinous Contributions to the Capsule of the Symphysis Pubis

The purpose of this article is to define the relations of the symphysis pubis and capsular tissues to the adductor and rectus abdominis soft-tissue attachments on cadaver dissection and correlate with MRI of the anterior pelvis. Seventeen cadavers (8 males and 9 females; mean age, 80 years) were dissected bilaterally. Rectus abdominis and adductor muscles were traced to the pubis and further attachments to the pubic symphysis were defined. Ten asymptomatic (mean age, 17; age range, 16.5-29 years) male athletes underwent 1.5-T MRI of the anterior pelvis with two surface microcoils (each 42 mm in diameter). An axial T2-weighted turbo spin-echo (TSE) sequence (TR/TE, 2,609/106; voxel size, 0.4 mm) was obtained. Axial and sagittal 3D T1-weighted fast-field echo (FFE) sequences (25/4.9; voxel size, 0.3 mm) were obtained. Sequences were repeated incorporating fat suppression and i.v. gadolinium. The relation of the symphysis pubis, disk, and capsular tissues to the insertions of the rectus abdominis, adductor muscles, and gracilis were independently evaluated by two experienced radiologists blinded to all clinical details. In all 17 cadaver specimens, the adductor longus and rectus abdominis attached to the capsule and disk of the symphysis pubis, whereas the adductor brevis had an attachment to the capsule in seven specimens and the gracilis in one. All adductor tendons attached to the pubis. In all 10 athletes, the adductor longus and rectus abdominis bilaterally contributed to the capsular tissues and disk. This was only the case for the adductor brevis in four athletes. No other tendons involved the capsular tissues. Cadaver and MRI findings show an intimate relationship between the adductor longus; rectus abdominis; and symphyseal cartilage, disk, and capsular tissues.

Improved visualization of collateral ligaments of the ankle: multiplanar reconstructions based on standard 2D turbo spin-echo MR images

The purpose of the study was to evaluate the visualization of the collateral ankle ligaments on multiplanar reconstructions (MPR) based on standard 2D turbo spin-echo images. Coronal and axial T2-weighted turbo spin-echo and MPR angled parallel to the course of the ligaments of 15 asymptomatic and 15 symptomatic ankles were separately analyzed by two musculoskeletal radiologists. Image quality was assessed in the asymptomatic ankles qualitatively. In the symptomatic ankles interobserver agreement and reader confidence was determined for each ligament. On MPR the tibionavicular and calcaneofibular ligaments were more commonly demonstrated on a single image than on standard MR images (reader 1: 13 versus 0, P=0.002; reader 2: 14 versus 1, P=0.001 and reader 1: 13 versus 2, P=0.001; reader 2: 14 versus 0, P<0.001). The tibionavicular ligament was considered to be better delineated on MPR by reader 1 (12 versus 3, P=0.031). In the symptomatic ankles, reader confidence was greater with MPR for all ligaments except for the tibiocalcanear ligament (both readers) and the anterior and posterior talofibular ligaments (for reader 2). Interobserver agreement was increased with MPR for the tibionavicular ligament. Multiplanar reconstructions of 2D turbo spin-echo images improve the visualization of the tibionavicular and calcaneofibular ligaments and strengthen diagnostic confidence for these ligaments.

Jaccoud's arthropathy in systemic lupus erythematosus: differentiation of deforming and erosive patterns by magnetic resonance imaging.

To evaluate alterations of the soft tissues, tendons, and bones as detected by magnetic resonance imaging (MRI) in patients with systemic lupus erythematosus (SLE)-associated arthritis of the finger joints. Both hands of 14 patients with SLE of various activities and durations and with arthritis and/or deformities of the finger joints were examined by MRI and conventional radiography. Coronal T1-weighted spin-echo (with and without gadolinium contrast), axial T2-weighted turbo spin-echo, coronal fat-suppressed short tau inversion recovery, and 3-dimensional double-echo steady-state sequences were acquired and analyzed, and the findings were compared with those from conventional radiographs. MRI detected periarticular capsular swelling in all 14 patients, joint effusion in 7, edematous tenosynovitis in 6, proliferative tenosynovitis (flexor and/or extensor tendons) in 4, and intraarticular signs of synovial membrane hypertrophy in 10 patients, 9 of whom showed enhancement after administration of contrast medium. Bony erosions were identified in 8 patients by MRI; conventional radiography missed these erosions in 2 of the 8 patients. Four of the 14 patients were designated as Jaccoud's arthropathy index-positive, and all 4 showed severe edematous tenosynovitis and capsular swelling, but no signs of bony erosions despite longstanding disease (mean 21.5 years). Four of the 10 patients with mild deformity exhibited prominent soft tissue pathology, with minimal destruction of bone; the other 6 patients had bony alterations that resembled rheumatoid arthritis. In SLE patients with arthritis of the finger joints, MRI detects characteristic signs of soft tissue pathology (e.g., capsular swelling, edematous and proliferative tenosynovitis, synovial hypertrophy) and bony alterations (e.g., erosions, some of which are missed by conventional radiography). MRI thus helps to distinguish different types of lupus arthritis/Jaccoud's arthropathy, which allows more differentiated treatment strategies and monitoring.