Motion In Axial Rotation Research Articles

Role of intra-lamellar collagen and hyaluronan nanostructures in annulus fibrosus on lumbar spine biomechanics: insights from molecular mechanics-finite element-based multiscale analyses.

Annulus fibrosus' (AF) ability to transmit multi-directional spinal motion is contributed by a combination of chemical interactions among biomolecular constituents-collagen type I (COL-I), collagen type II (COL-II), and proteoglycans (aggrecan and hyaluronan)-and mechanical interactions at multiple length scales. However, the mechanistic role of such interactions on spinal motion is unclear. The present work employs a molecular mechanics-finite element (FE) multiscale approach to investigate the mechanistic role of molecular-scale collagen and hyaluronan nanostructures in AF, on spinal motion. For this, an FE model of the lumbar segment is developed wherein a multiscale model of AF collagen fiber, developed from COL-I, COL-II, and hyaluronan using the molecular dynamics-cohesive finite element multiscale method, is incorporated. Analyses show AF collagen fibers primarily contribute to axial rotation (AR) motion, owing to angle-ply orientation. Maximum fiber strain values of 2.45% in AR, observed at the outer annulus, are 25% lower than the reported values. This indicates native collagen fibers are softer, attributed to the softer non-fibrillar matrix and higher interfibrillar sliding. Additionally, elastic zone stiffness of 8.61 Nm/° is observed to be 20% higher than the reported range, suggesting native AF lamellae exhibit lower stiffness, resulting from inter-collagen fiber bundle sliding. The presented study has further implications towards the hierarchy-driven designing of AF-substitute materials.

Posterior atlantoaxial fixation of osteoporotic odontoid fracture: biomechanical analysis of the Magerl versus harms techniques in a cadaver model

BACKGROUND CONTEXTOdontoid fractures are among the most common cervical spine fractures in the elderly and are associated with increased morbidity and mortality. Clinical evidence suggests improved survival and quality of life after operative intervention compared to nonoperative treatment. PURPOSEThis study seeks to examine the stability of an osteoporotic Type II odontoid fracture following posterior atlantoaxial fixation with either the Magerl transarticular fixation technique or the Harms C1 lateral mass screws C2 pedicle screw rod fixation. STUDY DESIGNBiomechanical cadaveric study. METHODSEighteen cadaveric specimens extending from the cephalus to C7 were used in this study. Reflective marker arrays were attached to C1 and C2 and a single marker on the dens to measure movement of each during loading with C2–C3 and occiput-C1 being allowed to move freely. A biomechanical testing protocol imparted moments in flexion-extension, axial rotation, and lateral bending while a motion capture system recorded the motions of C1, C2, and the dens. The spines were instrumented with either the Harms fixation (n=9) or Magerl fixation (n=9) techniques, and a simulated Type II odontoid fracture was created. Motions of each instrumented spine were recorded for all moments, and then again after the instrumentation was removed to model the injured, noninstrumented state. RESULTSBoth Harms and Magerl posterior C1–C2 fixation allowed for C1, C2, and the dens to move as a relative unit. Without fixation the dens motion was coupled with C1. No significant differences were found in X, Y, Z translation motion of the dens, C1 or C2 during neutral zone motions between the Magerl and Harms fixation techniques. There were no significant differences found in Euler angle motion between the two techniques in either flexion-extension, axial rotation, or lateral bending motion. CONCLUSIONSOur findings suggest that both Harms and Magerl fixation can significantly reduce dens motion in Type II odontoid fractures in an osteoporotic cadaveric bone model. CLINICAL SIGNIFICANCEBoth Harms and Magerl posterior atlantoaxial fixation techniques allowed for C1, C2, and the dens to move as a relative unit following odontoid fracture, establishing more anatomic stability to the upper cervical spine.

Effect of Distal Tibiofibular Destabilization and Syndesmosis Compression on the Flexibility Kinematics of the Ankle Bones: An In Vitro Human Cadaveric Model.

Overcompression of the distal tibiofibular syndesmosis during open reduction and internal fixation of ankle fracture may affect multidirectional flexibility of the ankle bones. Ten cadaveric lower limbs (78.3±13.0 years, 4 female, 6 male) underwent biomechanical testing in sagittal, coronal, and axial rotation with degrees of motion quantified. The intact force (100%) was the force needed to compress the syndesmosis just beyond the intact position, and overcompression was defined as 150% of the intact force. After intact testing, the anterior inferior tibiofibular ligament (AITFL), interosseus membrane (IOM), and posterior inferior tibiofibular ligament (PITFL) were sectioned and testing was repeated. The IOM and AITFL were reconstructed in sequence and tested at 100% and 150% compression. Overcompression of the syndesmosis did not significantly reduce ROM of the ankle bones for any loading modality (P > .05). IOM+AITFL reconstruction restored distal tibiofibular axial rotation to the intact condition. Axial rotation motion was significantly lower with AITFL fixation compared with IOM fixation alone (P < .05). The proximal tibiofibular syndesmosis demonstrated significantly higher motion in axial rotation with all distal reconstruction conditions. As assessed by direct visualization, overcompression of the distal tibiofibular syndesmosis did not reduce ROM of the ankle bones. Distal tibiofibular axial rotation was significantly lower with IOM+AITFL fixation compared with IOM augmentation alone. Distal tibiofibular axial rotation did not differ significantly from the intact condition after combined IOM+AITFL fixation. Dynamic fixation of the distal tibiofibular syndesmosis resulted in increased axial rotation at the proximal tibiofibular syndesmosis. These biomechanical data suggest that inadvertent overcompression of the distal tibiofibular syndesmosis when fixing ankle fractures does not restrict subsequent ankle bone ROM. The AITFL is an important stabilizer of the distal tibiofibular syndesmosis in external rotation. controlled laboratory study.

Prevertebral Anchored Kevlar Band to Recover Intact Spine Movement Ranges in Lumbar Disc Arthroplasty

Anterior longitudinal ligament and annulus fibrosus removal in total disc replacement induces excessive spinal mobility with zygapophyseal joint overload and osteoarthritic changes causing chronic back pain. To control disc arthroplasty-induced hypermobility with a Kevlar® band. A 3 × 3 cm Kevlar® band implanted in twelve human lumbar cadaveric spines substituted the anterior longitudinal ligament and annulus in disc arthroplasty. Biomechanical studies compared the intact spine, after discectomy, post-disc arthroplasty, and with the Kevlar® band inserted. The Kevlar® band recovered the extension and axial rotation movement ranges without regaining the intact status. Improvement was moderate in lateral bending. The Instantaneous Axis of Rotation improved the discectomy and total disc prosthesis conditions without recovering the initial state. The disc above the operated one also showed increased mobility, particularly in extension and axial rotation, improved by Kevlar® band insertion without recovering the intact spine values. The Kevlar® band improves excess mobility ranges induced by anterior longitudinal ligament and anterior annulus removal in disc arthroplasty in the operated and supra-adjacent discs without recovering the baseline status.

Comparative finite element analysis of posterior short segment fixation constructs with or without intermediate screws in the fractured vertebrae for the treatment of type a thoracolumbar fracture

Six-screw short-segment posterior fixation for thoracolumbar fractures, which involves intermediate screws at the fractured vertebrae has been proposed to reduce the rates of kyphosis recurrence and implant failure. Yet, little is known about the mechanisms and biomechanical responses by which intermediate screws at the fracture vertebrae enhance fixation strength. The objective of this study was to investigate the biomechanical properties that are associated with the augmentation of intermediate screws in relation to the severity of type A thoracolumbar fracture using finite element analysis. Short-segment stabilization models with or without augmentation screws at fractured vertebrae were established based on finite element model of moderate compressive fractures, severe compressive fractures and burst fractures. The spinal stiffness, stresses at the implanted hardware, and axial displacement of the bony defect were measured and compared under mechanical loading conditions. All six-screw stabilization showed a decreased range of motion in extension, lateral bending, and axial rotation compared to the traditional four-screw fixation models. Burst thoracolumbar fracture benefited more from augmentation of intermediate screws at the fracture vertebrae. The stress of the rod in six-screw models increased while decreased that of pedicle screws. Our results suggested that patients with more unstable fractures might achieve greater benefits from augmentation of intermediate screws at the fracture vertebrae. Augmentation of intermediate screws at the fracture vertebrae is recommended for patients with higher wedge-shaped or burst fractures to reduce the risk of hardware failure and postoperative re-collapse of injured vertebrae.

Development, calibration and validation of a comprehensive customizable lumbar spine FE model for simulating fusion constructs.

Instrumentation alters the biomechanics of the spine, and therefore prediction of all output quantities that have critical influence post-surgically is significant for engineering models to aid in clinical predictions. Geometrical morphological finite element models can bring down the development time and cost of custom intact and instrumented models and thus aids in the better inference of biomechanics of surgical instrumentation on patient-specific diseased spine segments. A comprehensive hexahedral morphological lumbosacral finite element model is developed in this work to predict the range of motions, disc pressures, and facet contact forces of the intact and instrumented spine. Facet contact forces are needed to predict the impact of fusion surgeries on adjacent facet contacts in bending, axial rotation, and extension motions. Extensive validation in major physiological loading regimes of the pure moment, pure compression, and combined loading is undertaken. In vitro, experimental corridor results from six different studies reported in the literature are compared and the generated model had statistically significant comparable values with these studies. Flexion, extension and bending moment rotation curves of all segments of the developed model were favourable and within two separately established experimental corridor windows as well as recent simulation results. Axial torque moment rotation curves were comparable to in vitro results for four out of five lumbar functional units. The facet contact force results also agreed with in vitro experimental results. The current model is also computationally efficient with respect to contemporary models since it uses significantly smaller number of elements without losing the accuracy in terms of response prediction. This model can further be used for predicting the impact of different instrumentation techniques on the lumbar vertebral column.

Assessment of axial rotation movement in cervical dystonia using cone-beam computed tomography

BackgroundCervical dystonia is a neurological disorder characterized by involuntary muscle contractions and abnormal postures of the head and neck. Botulinum neurotoxin injection is the first-line treatment. Imaging determination of the cervical segments involved (lower or upper according to the torticollis-torticaput [COL-CAP] Classification) is an aid in determining the muscles to be injected. We aimed to clarify the impact of dystonia on posture and rotational movement of cervical vertebrae in the transverse plane. MethodsA comparative study was conducted in a movement disorders department. Ten people with cervical dystonia and 10 matched healthy subjects (without cervical dystonia) were recruited. 3-D images of posture and cervical range of motion in axial rotation in the sitting position were recorded by using a cone-beam CT scanner. Range of rotational motion of the upper cervical spine from the occipital bone to fourth cervical vertebra was measured and compared between the two groups. FindingsThe head posture analysis showed that the total cervical spine position was more significantly distant from the neutral position for people with dystonia than healthy subjects (p = 0.007). The rotational range of motion of the cervical spine was significantly lower in cervical dystonia participants than in healthy subjects for the total (p = 0.026) and for upper cervical spine (p = 0.004). InterpretationWe demonstrated, by means of cone-beam CT, that the disorganization of movements due to cervical dystonia affected the upper cervical spine and mostly the atlantoaxial joint. The involvement of rotator muscles at this cervical level should be considered more in treatments.

Stress analysis of the screw of atlantoaxial posterior screw fixation C1LM-C2PS and C1LM-C2PARS with and without rod: A FEM based study

Human cervical spine consists of three vertebrae C0-occiput, C1-atlas, & C3-axial in its upper part. The atlantoaxial complex is the most portable segment of the cervical spine and is accountable for half of the flexion, extension, and axial rotation movements of the neck. Atlantoaxial cervical spine injuries are serious injuries since there is a likely risk of harm to the spinal cord. Sustaining stability of the atlantoaxial joint following a neck injury is a difficult task because both vertebrae have complicated anatomy. Thus, the strength of a bone screw is especially significant in the early post-operative stages. Different stabilization procedures have been accounted for C1-C2 injury fixation, out of which fixation with transarticular screws is considered as the gold standard procedure. But screw malposition and high riding transverse foramen of the C2 vertebra are some limitations of this fixation technique. Current FE-based study provides a comparison of the biomechanical stability of the two different atlantoaxial posterior screw fixation techniques (C1Lateral Mass-C2 Pedicle screws, C1Lateral Mass-C2PARS screws).In this work, a C1-C2 cervical spine model of a male patient is developed using MRI CT scan data using a 3-d slicer software and biomechanical stability comparison is done for C1LM-C2PS & C1LM-C2PARS screws fixed once with a supporting posterior screw fixation rod and once without rod under the physiological loading conditions of flexion, extension, lateral bending, and axial rotation using ANSYS WORKBENCH 16.2. The effects of the engaging supporting rod on the cervical spine were evaluated in the form of von-mises stresses induced in screws. Result shows reduction in screw stress values when implanted with supporting rods. C1LM-C2PS screw fixation with rod might be thought of as the best fixation solution for fractured C1-C2 vertebrae as it showed minimum stress values in the analysis as compared to C1LM-C2PARS with and without rod.

The Characterization of Wave Parameters in Laboratory Scale of Wave Simulator Using Video Tracking Analysis

Understanding the wave parameters in the ocean wave phenomenon is necessary to learn and develop the potential of ocean wave energy. Therefore, this study created a simple laboratory-scale of wave simulator that was developed using an electric motor. The various wave parameters obtained by different treatments were carried out using variations in the angle of the wedge inclination and the rotational speed of the wave generator. In this system, two pulleys of different sizes were used, a large pulley with a diameter of 20 cm and a small pulley with a diameter varying between 1.25 cm and 1.98 cm. Changing the size of the pulleys uses the principle of axial rotational motion to produce different rotational speeds. Moreover, the video tracker analysis application was used to characterize the parameters of the waves generated in the simulator that has been designed. The parameters obtained include wave height, amplitude, frequency, wave period, wavelength, and wave propagation speed. In the examination and analysis that have been carried out, it has been found that increasing wave height and amplitude correlates with increasing the inclination of wedges. The frequency and speed of the waves are linearly related to changes in the rotation speed of the wave generator. For the characteristic wavelength, there is inverse relation to the rotational speed. Based on this study, the wave simulator system and video tracking analysis application can be used to increase the understanding of wave parameters. In addition, this research can also be used as preliminary research on developing a prototype for an ocean wave energy converter on the laboratory scale.

Cervical Range of Motion Assessment through Inertial Technology: A Validity and Reliability Study

Inertial technology has spread widely for its comfortable use and adaptability to various motor tasks. The main objective of this study was to assess the validity of inertial measurements of the cervical spine range of motion (CROM) when compared to that of the optoelectronic system in a group of healthy individuals. A further aim of this study was to determine the optimal placement of the inertial sensor in terms of reliability of the measure, comparing measurements obtained from the same device placed at the second cervical vertebra (C2), the forehead (F) and the external occipital protuberance (EOP). Twenty healthy subjects were recruited and asked to perform flexion–extension, lateral bending, and axial rotation movements of the head. Outcome measurements of interest were CROM and mean angular velocities for each cervical movement. Results showed that inertial measurements have good reliability (0.75 &lt; ICC &lt; 0.9). Excellent reliability (ICC &gt; 0.9) was found in both flexion and right lateral bending angles. All parameters extracted with EOP placement showed ICC &gt; 0.62, while ICC &lt; 0.5 was found in lateral bending mean angular velocities both for F and C2 placements. Therefore, the optimal sensor’s positioning emerged to be EOP. These results suggest that inertial technology could be useful and reliable for the evaluation of the CROM.

An investigation of range of motion preservation in fusionless anterior double screw and cord constructs for scoliosis correction.

To evaluate the motion-preserving properties of vertebral body tethering with varying cord/screw constructs and cord thicknesses in cadaveric thoracolumbar spines. In vitro flexibility tests were performed on six fresh-frozen human cadaveric spines (T1-L5) (2M, 4F) with a median age of 63 (59-to-80). An ± 8 Nm load was applied to determine range of motion (ROM) in flexion-extension (FE), lateral bending (LB), and axial rotation (AR) in the thoracic and lumbar spine. Specimens were tested with screws (T5-L4) and without cords. Single (4.0mm and 5.0mm) and double (4.0mm) cord constructs were sequentially tensioned to 100 N and tested: (1) Single 4.0mm and (2) 5.0mm cords (T5-T12); (3) Double 4.0mm cords (T5-12); (4) Single 4.0mm and (5) 5.0mm cord (T12-L4); (6) Double 4.0mm cords (T12-L4). In the thoracic spine (T5-T12), 4.0-5.0mm single-cord constructs showed slight reductions in FE and 27-33% reductions in LB compared to intact, while double-cord constructs showed reductions of 24% and 40%, respectively. In the lumbar spine (T12-L4), double-cord constructs had greater reductions in FE (24%), LB (74%), and AR (25%) compared to intact, while single-cord constructs exhibited reductions of 2-4%, 68-69%, and 19-20%, respectively. The present biomechanical study found similar motion for 4.0-5.0mm single-cord constructs and the least motion for double-cord constructs in the thoracic and lumbar spine suggesting that larger diameter 5.0mm cords may be a more promising motion-preserving option, due totheir increased durability compared to smaller cords. Future clinical studies are necessary to determine the impact of these findings on patient outcomes.

Biomechanical Analysis of Multilevel Posterior Cervical Spinal Fusion Constructs.

Controlled Laboratory Study. To compare multilevel posterior cervical fusion (PCF) constructs stopping at C7, T1, and T2 under cyclic load to determine the range of motion (ROM) between the lowest instrumented level and lowest instrumented-adjacent level (LIV-1). PCF is a mainstay of treatment for various cervical spine conditions. The transition between the flexible cervical spine and rigid thoracic spine can lead to construct failure at the cervicothoracic junction. There is little evidence to determine the most appropriate level at which to stop a multilevel PCF. Fifteen human cadaveric cervicothoracic spines were randomly assigned to 1 of 3 treatment groups: PCF stopping at C7, T1, or T2. Specimens were tested in their native state, following a simulated PCF, and after cyclic loading. Specimens were loaded in flexion-extension), lateral bending, and axial rotation. Three-dimensional kinematics were recorded to evaluate ROM. The C7 group had greater flexion-extension motion than the T1 and T2 groups following instrumentation (10.17±0.83 degree vs. 2.77±1.66 degree and 1.06±0.55 degree, P <0.001), and after cyclic loading (10.42±2.30 degree vs. 2.47±0.64 degree and 1.99±1.23 degree, P <0.001). There was no significant difference between the T1 and T2 groups. The C7 group had greater lateral bending ROM than both thoracic groups after instrumentation (8.81±3.44 degree vs. 3.51±2.52 degree, P =0.013 and 1.99±1.99 degree, P =0.003) and after cyclic loading. The C7 group had greater axial rotation motion than the thoracic groups (4.46±2.27 degree vs. 1.26±0.69 degree, P =0.010; and 0.73±0.74 degree, P =0.003) following cyclic loading. Motion at the cervicothoracic junction is significantly greater when a multilevel PCF stops at C7 rather than T1 or T2. This is likely attributable to the transition from a flexible cervical spine to a rigid thoracic spine. Although this does not account for in vivo fusion, surgeons should consider extending multilevel PCF constructs to T1 when feasible. Not applicable.

Comparing the Efficacy of Long Spinal Board, Sked Stretcher, and Vacuum Mattress in Cervical Spine Immobilization; a Method-Oriented Experimental Study.

Inadequate spinal motion restriction in patients suffering from spinal injuries could lead to further neurological damage, ultimately worsening their prognosis. This study aimed to investigate the efficacy of long spinal boards (LSB), ske stretcher, and vacuum mattress for cervical spine immobilization during transportation of patients by measuring the angular motion of the cervical spine following lifting, transferring, and tilting. We conducted an experimental study using a box of three randomizations and crossover designs without a washout period effect for the long spinal board, sked stretcher, and vacuum mattress. We concealed the randomization with sequentially numbered, opaque, sealed envelopes (SNOSE). Kinematic data were collected using eight optoelectronic cameras at 200 Hz (BTS Bioengineering, Milan, Italy) in triangular planes (lateral bending, flexion-extension, and axial rotation) while performing all three motions (static lift-hold, transfer, and 90° tilt). 12 cases (7 males and 5 females) with the mean age of 20 ± 3.03 (range: 18-28) years were studied. The three highest angular motions were observed in the axial rotation plane during patient's tilting under immobilization on all devices (Vacuum mattress having the highest value of 99.01±8.93, followed by the LSB at 89.89±34.35 and the sked stretcher at 86.30±7.73 degrees). During patient lifting, a higher angular motion was observed with vacuum mattress immobilization in flexion extension (Coefficient = 4.45; 95%CI: 0.46 - 8.45; p =0.029) and axial rotation (Coefficient = 3.70; 95%CI: 0.58 - 6.81; p =0.020) planes. During patient transfer, a higher angular motion was observed with sked stretcher in the flexion-extension plane (Coefficient = 2.98; 95%CI: 0.11 - 5.84; p = 0.042). During patient tilting to 90 degrees, a higher angular motion was observed with vacuum mattress immobilization in lateral bending (Coefficient = -4.08; 95%CI: -7.68 - -0.48; p = 0.026) for the vacuum mattress. Based on the finding of the present study, patients on the vacuum mattress experience significantly higher angular motion in flexion extension and axial rotation during lifting, as well as lateral bending during 90-degree tilting. In addition, patients on the sked stretcher showed significantly higher angular motion in flexion-extension during the transferring. However, the predictive margins for immobilization across all devices did not demonstrate clinically significant differences among the three immobilization devices.

Impact of Multifidus Muscle Morphometry on the Clinical Evolution of Chronic Low Back Pain

Purpose: The multifidus muscle is an important extensor muscle of the lumbar spine. It plays a major role in the stability and realization of axial rotation movements of the thoraco-lumbar spine. Its atrophy by fatty degeneration would be at the origin of the occurrence of chronic low back pain which constitutes a public health problem in Senegal. Taking into account its anatomy is essential for the etiopathogenic analysis and the treatment of low back pain. The purpose of our work was to investigate the impact of multifidus muscle morphometry on the anatomy-clinical evolution of low back pain. Material and method: this was a prospective study over a period of 30 months from November 2019 to May 2022. It involved 100 patients seen in the neurology department of Fann Hospital for chronic low back pain and who had already had a scanner falling within the criteria for low back pain. We used 3D Slicer, SPSS 20, Excel 2016 software to model and analyze the morphometric data of the multifidus muscle after physiotherapy and control lumbar scans. Results: The sex ratio was 2.23. The average age of the patients was 45 ± 7 years. On the initial CT scan, according to the Hadar classification, we noted a predominance of grade 2 with 56% in L5/S1, followed by grade 1 with 32% and grade 3 with 14%. In L4/L5, the majority of patients, 67%, had grade 1. A conflicting circumferential disc bulge with the roots predominating in L5/S1 was present in 94% of men (p-value = 0.02). Before physiotherapy, the average volume of the multifidus was 193 mm3 ± 39, after physiotherapy it was 203 mm3 ± 42 with a progression rate of 5.2%. Clinically, severe type pain had regressed from 86% before physiotherapy to 0% after physiotherapy (p-value = 0.03). Conclusion: Taking into account the morphometry of the multifidus is an essential element in the management of chronic low back pain.

Yeditepe spine mesh: Finite element modeling and validation of a parametric CAD model of lumbar spine

Finite element analysis is a powerful tool that is often used to study the biomechanical response of the spine. The primary objective of this study was to illustrate the mechanical behavior of a previously proposed parametric CAD spine model in comparison with a segmented FSU model and the literature. In this study, two finite element models of the L4-L5 spinal level were developed from the same patient's CT scan data. The first was developed using well-known segmentation methods, whereas the second was developed from the new by using a novel parametric CAD model. Both models were subjected to the same loading and boundary conditions to perform flexion, extension, lateral bending and axial rotation motions. The segmented finite element model was observed to be in good agreement with the literature. The parametric finite element model results were also observed to be in good agreement with the segmented finite element model and with the literature except under extension.

33. Comparison of the biomechanics of lumbar spine instrumented with standalone interbody fixation constructs vs interbody with supplemental fixation: a finite element investigation

<h3>BACKGROUND CONTEXT</h3> Low fusion rates and cage subsidence have been reported as the main drawbacks of lumbar fixation with static interbody cages. Although several clinical and biomechanical studies have evaluated the efficacy of 360 interbody fixation constructs (anterior cage plus posterior fixation), no study has reported the biomechanical comparison between such constructs and more novel techniques which use standalone fixation implants. A cadaver validated computational model of lumbar spine was used to compare the biomechanics of spine instrumented with 360 fixations vs standalone cage and screw and cage with lateral plate systems. <h3>PURPOSE</h3> To compare the mechanical stability of different interbody fixation techniques in lumbar spinal segments with standalone interbody vs static cage with posterior fixation or lateral plate system. <h3>STUDY DESIGN/SETTING</h3> Finite element modeling. <h3>OUTCOME MEASURES</h3> Range of motion across instrument segments and load sharing on vertebral endplate. <h3>METHODS</h3> An experimentally validated finite element (FE) model of L1-pelvic segment was used to simulate ALIF and LIF lumbar fixation techniques including: ALIF cage at L5-S1 plus posterior screw-rod fixation (360 construct) vs ALIF standalone (screw through the cage). LIF cage at L4-L5 vs LIF cage with integrated two-hole lateral plate system. 4WEB Medical's Truss ALIF (27mm x 25mm), Lateral Truss (22mm X 5mm) cages and 2-hole integrated plate systems were used for simulation of the surgical procedure. For 360 constructs, a generic posterior rod and screw system was used. All models were subjected to a 400N compressive pre-load followed by an 8Nm moment to simulation flexion-extension, left and right bending and axial rotation motions. The segmental kinematics and the load sharing at the inferior endplate were compared among cases. <h3>RESULTS</h3> The segmental motion in standalone ALIF construct was 1.1°(Flex-Ext), 0.9° (LB) and 0.4° vs 0.8°, 0.8° and 0.6° in 360 ALIF in the same planes of motion. When comparing lateral cases, the motions were 1.2° (Flex-Ext), 1.4° (LB) and 0.5° (AR) in lateral cage with plate vs 0.9°, 1.0° and 0.8° in the 360 lateral construct for the same loads. The peak stresses in extension for the LIF stand-alone cage were somewhat higher than the posterior instrumented cases, but not significant. When comparing the mechanical stress on the inferior endplate of the index segment, the standalone ALIF had almost 20% higher peak stress compared to the 360 ALIF. In the lateral construct, the cage-plate segment experienced 15% lower stresses on the endplate compared to the 360 lateral construct. <h3>CONCLUSIONS</h3> Our data suggest that standalone ALIF cage with screw through the cage is able to provide kinematic stability in the fixation construct comparable to the cage plus posterior fixation, although the 360 construct is able to provide slightly more stability in the sagittal plane. Also, the standalone cage results in higher stresses applied to the endplate compared the cage in 360 constructs. The lateral cage with integrated plate had superior stability in axial rotation compared to the 360 lateral construct. The loads on the endplate were also slightly lower compared to the 360-fixation case. Standalone ALIF and LIF with lateral plate are biomechanically effecient alternatives to 360-fixation constructs at least under the controlled conditions analyzed in the present study. Clinical data are required to support the findings and define the further role and application of standalone cages. <h3>FDA DEVICE/DRUG STATUS</h3> 4WEB ALIF Truss System (Approved for this indication), 4WEB Lateral Plate System (Approved for this indication), 4WEB Lateral Truss System (Approved for this indication)

In Vivo Evidence of Early Instability and Late Stabilization in Motion Segments Immediately Superior to Anterior Cervical Arthrodesis.

Prospective cohort study. The aim was to identify patient factors that affect adjacent segment kinematics after anterior cervical discectomy and fusion (ACDF) as measured by biplane radiography. The etiology of adjacent segment disease (ASD) may be multifactorial. Previous studies have investigated associations between patient factors and ASD, although few attempted to link patient factors with mechanical changes in the spine that may explain ASD development. Previous studies manually measured intervertebral motion from static flexion/extension radiographs, however, manual measurements are unreliable, and those studies failed to measure intervertebral motion during rotation. Patients had continuous cervical spine flexion/extension and axial rotation movements captured at 30 images per second in a dynamic biplane radiography system preoperatively and 1 year after ACDF. Digitally reconstructed radiographs generated from subject-specific computed tomography scans were matched to the biplane radiographs using a validated tracking process. Dynamic kinematics and preoperative disc height were calculated from this tracking process. Preoperative magnetic resonance imagings were evaluated for disc bulge. Patient age, sex, body mass index, smoking status, diabetes, psychiatric history, presence of an inciting event, and length of symptoms were collected. Multivariate linear regression was performed to identify patient factors associated with 1-year postoperative changes in adjacent segment kinematics. Sixty-three patients completed preoperative and postoperative testing. Superior adjacent segment disc height and disc bulge predicted the change in superior adjacent segment range of motion after surgery. Inferior adjacent segment disc bulge, smoking history, and the use of psychiatric medications predicted the change in inferior adjacent segment flexion/extension range of motion after surgery. Preexisting adjacent segment disc degeneration, as indicated by disc height and disc bulge, was associated with reduced adjacent segment motion after ACDF, while lack of preexisting adjacent disc degeneration was associated with increased adjacent segment motion after ACDF. These findings provide in vivo evidence supporting early instability and late stabilization in the pathophysiology of disc degeneration.

Biomechanical effects of interbody cage height on adjacent segments in patients with lumbar degeneration: a 3D finite element study

ObjectiveTo investigate the biomechanical effects of interbody cage height on adjacent segments in patients with lumbar degeneration undergoing transforaminal lumbar interbody fusion (TLIF) surgery, so as to provide references for selection of interbody cage.MethodsThe finite element model of normal lower lumbar spine (L3–S1) was built and validated, then constructed three different degenerative segments in L3–L4, and the cages with different height (8, 10, 12, 14 mm) were implanted into L4–L5 disc. All the twelve models were loaded with pure moment of 7.5 N m to produce flexion, extension, lateral bending and axial rotation motions on lumbar spine, and the effects of cage height on range of motion (RoM) and intervertebral pressure in lumbar spine were investigated.ResultsThe RoM of adjacent segments and the maximum stress of intervertebral discs increased with the increase in cage height, but this trend was not obvious in mild and moderate degeneration groups. After implantation of four different height cages (8, 10, 12, 14 mm), the RoM of L3/L4 segment reached the maximum during extension. The RoM of mild degeneration group was 2.07°, 2.45°, 2.48°, 2.54°, that of moderate degeneration group was 1.79°, 1.97°, 2.05°, 2.05°, and that of severe degeneration group was 1.43°, 1.66°, 1.74°, 1.74°. The stress of L3–L4 intervertebral disc reached the maximum during flexion. The maximum stress of L3–L4 intervertebral disc was 20.16 MPa, 20.28 MPa, 20.31 MPa and 20.33 MPa in the mild group, 20.58 MPa, 20.66 MPa, 20.71 MPa and 20.75 MPa in the moderate group, and 21.27 MPa, 21.40 MPa, 21.50 MPa and 21.60 MPa in the severe group.ConclusionFor patients with mild-to-moderate lumbar degenerative disease who need to undergo TLIF surgery, it is recommended that the height of fusion cage should not exceed the original intervertebral space height by 2 mm, while for patients with severe degeneration, a fusion cage close to the original intervertebral height should be selected as far as possible, and the intervertebral space should not be overstretched.

A biomechanical study of ligament tethers strengthening for the prevention of proximal junctional kyphosis after posterior long-segment spinal fusion

BackgroundProximal junctional kyphosis is a known complication of posterior long-segment thoracolumbar fusion. Here, the biomechanical effectiveness of ligament tethers strengthening and vertebral body augmentation, in proximal junctional kyphosis prevention was explored using the finite element analysis. MethodsBased on a validated model of T1-L5 with the pedicle screw system instrumented T8-L5, strengthening models with different strategies were created to assess the range of motion in proximal vertebrae, vertebrae stress, pedicle screw stress, and pressure on intervertebral discs during extension, flexion, lateral bending, and axial rotation motions. Strengthening strategies included two- and three-level posterior ligament tethers (TE-T7-T9 and TE-T6-T9), and tethers with T7 &T8 vertebral body augmentation (TECE-T7-T9 and TECE-T6-T9). FindingsCompared to the spinal fusion model, the ligament tethers strengthening significantly reduced the flexion-extension range of motion difference among the proximal vertebrae. During the flexion-extension motion, the T8 vertebra stresses in the TE-T7-T9, TE-T6-T9, TECE-T7-T9, and TECE-T6-T9 models were distinctively reduced, the values decreased by 26.8%, 28.3%, 28.8%, and 9.6%, respectively, during flexion, and by 21.9%, 35.2%, 23%, and 18.6%, respectively, during extension. In the strengthening models, the maximum stresses on the T7/T8 intervertebral disc in the TE-T6-T9 model were reduced by 13.8% during flexion and by 14.7% during extension. InterpretationBased on our results, the ligament strengthening configuration of the three-level posterior tethers produced a more gradual transition in range of motion, vertebrae stresses, and intervertebral discs stress between the fused and non-fused segments, especially during flexion-extension, which may significantly decrease the proximal junctional kyphosis biomechanical risk.

Investigation on the biomechanical behaviour of the lower cervical spine induced by facet tropism with respect to the sagittal plane

Clinic observations have shown that facet tropism with respect to the sagittal plane is associated with cervical degeneration, but their mechanisms haven't been clearly revealed. This study developed different levels of facet tropism musculoskeletal multi-body dynamics cervical models to investigate the biomechanical effect on the intervertebral compressive force (ICF), intervertebral shear force (ISF), facet joint force (FJF) and intervertebral disc displacement (IDD) during head flexion, extension, lateral bending and axial rotation movements. Results showed that the ICFs at the asymmetrical levels of the severe facet tropism models increased by 9.33% and 15.34% respectively during extension and right lateral bending, but did not change significantly during axial rotation. The ISFs at the asymmetrical levels of the severe facet tropism models increased by 56.64% and 164.40% respectively during right lateral bending and right axial rotation. The corresponding IDDs in medial-lateral direction at asymmetrical level also increased greatly during extension, right lateral bending and right axial rotation. The FJFs at asymmetrical level of the severe facet tropism models decreased by 3.41%, 10.55% and 9.19% during extension, right lateral bending and left axial rotation, but increased by 22.62% during right axial rotation. Facet tropism increased the ICFs, ISFs and IDDs of the asymmetrical level, but reduced the protection against cervical excessive motion during certain head movements. The results suggested that facet tropism may contribute to the initiation or enhancement of the process of intervertebral disc degeneration, especially intervertebral disc herniation.