Abstract A first-of-its-kind large-eddy simulation (LES) study is conducted to numerically investigate the combustion dynamics as well as aero-thermal phenomena in a full-scale non-premixed hydrogen-air rotating detonation engine (RDE) integrated with nozzle guide vanes (NGV) acting as the turbine stator. The LES framework incorporates hydrogen-air detailed chemical kinetics and adaptive mesh refinement. A comparative analysis is carried out for two operating conditions with different fuel/air mass flow rates but global equivalence ratio of unity. The LES model is validated against experimental data with respect to detonation wave speed/height, wave dynamics, and axial static pressure distribution. Numerical results indicate significant deflagrative combustion occurring in the fill region near the inner wall due to formation of recirculation zones in the injection near-field driven by the backward facing step. The leading detonation wave is found to be trailed by an azimuthal reflected-shock combustion wave, which consumes unburned vitiated reactants that leak through the main detonation wave. The detonation wave characteristics do not change appreciably with the presence of NGV. The exit flow is found to be nearly fully subsonic and supersonic for the low and high mass flux conditions, respectively. The presence of NGV renders the flow more axial, and significantly impacts the exit Mach number and total pressure. The low mass flux operating point, despite exhibiting more deflagrative losses within the combustor, yields overall lower pressure drop from plenum to exhaust, mainly attributed to lower pressure drop across the injectors.