Optimization of fissile and fusile production in the SOLASE-H laser-fusion fissile-enrichment fuel-factory blanket is carried out. The objective is maximizing fissile breeding with the constraints of maintaining self-sufficiency in tritium production, and realistically accounting in the modeling for structural and coolant compositions and configurations imposed by the thermal-hydraulic and mechanical designs. The effect of radial and axial blanket zone thicknesses on fusile and fissile breeding is studied using a procedure which modifies the zones' effective optical thicknesses, rather than the actual three-dimensional geometrical configurations. A tritium yield per source neutron of 1.08 and a Th (n, γ) reaction yield per source neutron of 0.43 can be obtained in such a concept, where ThO2 Zircaloy-clad fuel assemblies for light water reactors (LWRs) are enriched in the233U isotope by irradiating them in a lead flux trap. This corresponds to 0.77 kg/[MW(th)-year] of fissile fuel production, and 1.94 years of irradiation in the fusion reactor to attain an average 3 w/o fissile enrichment in the fuel assemblies. For a once-through LWR cycle, a support ratio of 2–3 is estimated. However, with fuel recycling, more attractive support ratios of 4–6 may be attainable for a conversion ratio of 0.55, and of 5–8 for a conversion ratio of 0.70. These estimates are lower than those reported, around 20, for related designs.