Osteoarthritis (OA) of the knee poses a significant public health challenge, with its prevalence escalating globally. This study addresses a critical knowledge gap by investigating the awareness and perceptions of knee OA in the Northern Borders Region, Saudi Arabia, focusing on demographic factors that may influence community perspectives. The primary aim of this cross-sectional study is to comprehensively examine the awareness and perceptions of knee OA, exploring the influence of demographic variables, including region, gender, age, nationality, and educational levels. A total of 501 participants from various cities in the Northern Borders Region, Saudi Arabia, were enrolled in this study. Demographic characteristics, including region, gender, age, nationality, and educational levels, were documented. A structured survey instrument was utilized to collect data on awareness and perceptions of knee OA. Statistical analyses included descriptive statistics, chi-square tests, and logistic regression to explore associations. Demographic insights revealed a predominance of participants from Arar (37.50%) and Rafha (36.50%), with a nearly equal gender distribution (52.90% male, 47.10% female). The majority fell within the 31-45 age group (37.50%), and 97.60% were Saudi nationals. Educational levels varied, with 55.30% holding a bachelor's degree. Awareness levels indicated that 75.40% recognized obesity as a significant factor in knee OA. Significant associations were found between gender and acknowledgment of obesity (p = 0.021), as well as between age and awareness of obesity (p = 0.040). Non-Saudi participants exhibited a higher awareness of knee injury as a reason for arthritis (p = 0.028). Educational levels demonstrated significant associations with awareness of rheumatoid arthritis (p = 0.012), growing old as a reason for knee arthritis (p = 0.002), and various preventive measures and treatment options. This study provides a nuanced understanding of knee OA awareness and perceptions in the Northern Borders Region, Saudi Arabia. The high recognition of obesity as a risk factor, coupled with demographic variations, highlights the need for tailored health education interventions. Addressing gender-specific, age-related, and educational disparities is crucial for promoting effective community-wide initiatives to prevent and manage knee OA.
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