Avocado Leaf Extract Research Articles

Physical Test of Avocado Leaf Extract Cream Formula

Avocado (Perseaamericana Mill) is a plant that grows widely in subtropical and tropical areas, one of which is Indonesia. The leaves of the avocado plant, which we can use as traditional medicine, are reported to be anti-bacterial and can inhibit the growth of several bacteria, including Staphylococcus aurus. The active substances contained in avocado leaves are flavonoids, quercetin and tannin which are useful as anti-bacterials and as a source of natural antioxidants. This study aims to determine the results of the physical test of the avocado leaf extract cream formula. This type of research is quantitative with a descriptive research design. In testing the cream, an organoleptic test, homogeneity test, pH test, spreadability test, absorption test and adhesion test were carried out. The results obtained in the organoleptic test were seen from the yellowish brown color, the semi-solid dosage form, and the distinctive creamy smell of avocado leaves, the homogeneity test of the cream did not occur in phase separation, namely the water phase and the oil phase, the pH test of the cream had a pH of 7, the power test Spread the cream with a diameter of 6.1 cm, the cream's absorption test can absorb water optimally, and the cream's adhesion test obtains an adhesion time of 1.48 seconds. The physical test of the avocado leaf extract cream formula meets the requirements.

Formulation and Evaluation of Face Mask Gel Peel Off Combination of Avocado Leaf Extract (Perssea Americana Mill) and Jicama (Pachyrrhuzul Erosus L.)

Avocado leaves and jicama contain antioxidants. Topical use of antioxidants can reduce UVA radiation which can cause skin darkening. Utilization of avocado leaves and jicama is done by making a peel-off gel facial mask. This research was conducted to formulate and determine the physical quality of a gel peel-off facial mask combination of avocado and jicama leaf extracts. The quantitative experimental method was used and four formulas for varying the concentration of the active substance were prepared, with a comparison of the total extracts used, avocado and jicama leaf extracts. The combination of avocado leaf extract and jicama can be formulated as a gel peel off facial mask, with the results of physical evaluation have met the requirements.

ANTI-HYPERLIPIDEMIA ACTIVITY IN THE VIVO TEST FROM A COMBINATION OF AVOCADO LEAF EXTRACT (Persea americana Mill) AND GINGER RHIZOME (Curcuma xanthorrhiza Roxb) IN MICE WITH HYPERCHOLESTEROLEMIA

Herbal and traditional medicine are two of the main types of treatment in developing countries, including Indonesia. Hyperlipidemia is a condition in which cholesterol levels in the body exceed normal limits, impacting cardiovascular disease. Avocado leaves and temulawak rhizomes have been shown to have antihyperlipidemic effects in animals. This study aimed to determine the anti-hyperlipidemic activity of avocado leaf (Persea americana Mill) and temulawak rhizome (Curcuma xanthorrhiza Roxb) combination extract in cholesterol levels of white male mice Sprague Dawley strain. The subjects of this study consisted of 20 white male mice Sprague Dawley strain (Rattus novergicus) and were divided into five groups: F1 (standard); F2 (hypercholesterolemic group); F3 (1:1 treatment group); F4 (1:2 treatment group); and F5 (2:1 treatment group). The induction was conducted for 14 days, while the treatment was carried out for seven days. All data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The combination extract of avocado and temulawak rhizome has an anti-hyperlipidemic activity. Giving a combination extract of avocado leaf and temulawak rhizome to all treatment groups significantly reduced total cholesterol levels in mice (p = 0.028). Avocado leaves and temulawak rhizomes have potential antihyperlipidemic activity derived from flavonoids. In this study, the potency of the extract efficacy can be achieved when given in combination.

Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats

Histopathological study of renal hypertension with avocado leaf extract and fractional in male wistar rats

Comparison of Antioxidant Activity of Methanol Extract of Young and Old Leaves of Avocado (Persea americana Mill.)

Avocado plants (Persea americana Mill.) are widely grown in tropical and subtropical regions. Avocado leaves contain natural antioxidants for traditional medicine. This study aims to determine the total phenolic content, total flavonoids, and antioxidant activity values of young and old avocado leaves, and analyze the relationship between total phenol content and total flavonoids to the antioxidant activity value of avocado leaf methanol extract (Persea americana Mill.). The macerated avocado leaf extract was quantitatively tested for antioxidant activity using the DPPH method and the total phenolic and flavonoid contents were calculated using the Follin-Ciocalteu and Follin-Ciocalteu methods, respectively.The results showed that the highest total phenolic content of old avocado leaves was 1.682,27mg GAE/100g dry weight. The highest total flavonoid content of avocado old leaves was 3.858,96mg QE/100g dry weight. Antioxidant activity of methanol extract of young avocado leaves has a value of IC50 321.32 ± 80.43 ppm and avocado old leaves amounted to 288.54 ± 33.06 ppm. Total flavonoid content was more influential on antioxidant activity, with a correlation coefficient of 0.856

Antibacterial Test Of Avocado Leaf Ethanol Extract (Persea americana Mill) On Staphylococcus Aureus Bacteria

Avocado leaves are one plant that can be used as an antibacterial. The chemical content of flavonoids, alkaloids, tannins and saponins has the potential to inhibit bacterial growth. This research aims to determine the antibacterial activity of ethanol extract of avocado leaves against Staphylococcus aureus bacteria. This research uses laboratory experiments using samples of avocado leaf extract (Persea viiiegativeviii Mill). With concentrations of 20%, 40%, 60% and 80% using the diffusion method. The ability of avocado leaf extract to inhibit Staphylococcus aureus bacteria can be seen from the size of the inhibition zone, namely positive by looking at the area of the inhibition zone around the disc using a caliper. This research shows that the diameter of the inhibition zone for Staphylococcus aureus at a concentration of 20% has an inhibition zone diameter of 8.81 mm, namely the medium category, a concentration of 40% has an inhibition zone diameter of 10.11 mm, namely the strong category, a concentration of 60% has an inhibition zone diameter. of 10.71 mm, namely the strong category, a concentration of 80% has an inhibitory zone diameter of 12.16 mm, namely the strong category. Based on the research results, it can be concluded that the ethanol extract of avocado leaves has activity to inhibit staphylococcus aureus bacteria

Formulation and Evaluation of Avocado Leaf Extract (Persea americana Mill.) Cream Based on Variations Stearic Acid Concentration

Avocado leaves (Persea americana Mill.) contain flavonoid compounds as high as 8.11 mg, so they have potential in the acne healing process. The aim of this research is to create a formulation and evaluate an avocado leaf extract cream preparation. The method used is experimental. Avocado leaf extract cream preparations are made based on varying stearic acid concentrations of 5%, 10% and 15%. Evaluation of the preparation includes organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and viscosity tests. Based on the organoleptic evaluation, the results showed that FI was slightly runny and contained bubbles, FII was slightly thick and FIII was thick. The FI color is brownish white, FII is yellowish white, and FIII is white, and all formulations have a characteristic creamy odor. The homogeneity test shows that all formulas have the same homogeneous preparation. The pH test of the cream preparation showed the same pH value, namely 6. The spreadability test resulted in good spreadability of the cream, namely between 5 and 6.8 cm. The cream adhesion test has an adhesion between 00.53 and 1.38 seconds. And finally, the viscosity test has a viscosity value between 4500 and 8900 mpa. According to the results of this research, avocado leaf extract cream can be used as a cream preparation, with the best stearic acid concentration being 15%.

Effectiveness of avocado leaf extract (Persea americana Mill.) as antihypertensive

Background Avocado leaves (Persea americana Mill.) have been traditionally used as antihypertensive. Various studies have tested the benefits of the Persea americana Mill. in treating hypertension but still using extracts not yet using nanoparticles. Therefore, this study aims to study the effectiveness of avocado leaf extract, including the nanoparticles, on salt-induced hypertensive Wistar rats in inhibiting the ACE enzyme, which causes decreasing systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as increasing urine volume. Methods This study used an experimental in vivo study design involving 24 white male Wistar rats (Rattus norvegicus), aged 2–3 months, weighing 130–250 g, and of a healthy condition with active movement. The samples were randomly divided into six treatment groups and post-test only research design with control group design. Results The result of the study showed that the extract contained a quercetin of 1129.597 ppm and 10 mineral compounds, including potassium, with the highest content. The analysis of antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl method showed that the antioxidant activity at IC50 was 44.734 ppm. The P. americana leaf extract nanoparticles had the most significant result in reducing blood pressure in Wistar rats induced by 16% NaCl for 14 days SBP to normal was by 68.75 mmHg (175.00±21.57 mmHg to 106.25±9.21 mmHg) and 55.25 mmHg (128.42±25.75 mmHg to 73.17±15.75 mmHg), respectively. Also, avocado leaf extract caused the decrease of SBP from 164.92±7.16 mmHg to 116.83±6.36 mmHg and DBP from 118.42±16.24 mmHg to 82.83±6.47 mmHg. The P. americana leaf extract nanoparticles resulted in the most urine volume at 13.5 ml, with the highest DAI value of 2.25. The ACE inhibitor test using the ELISA method showed that the P. americana leaf extract and the nanoparticle extract inhibition against the ACE enzyme were 60.0±12.1 % and 59.5±3%, respectively. The mean serum nitrate as a result of P. americana leaf extract (K4) and nanoparticles of P. americana leaf extract (K5) were 44.0±9.0 μmol/L and 41.1±11.5 μmol/L, respectively. The mean of serum nitrite was led by P. americana leaf extract (K4), and nanoparticles of P. americana leaf extract (K5) were 83.7±24.0 μmol/L and 81.0±23.2 μmol/L, sequentially. Conclusions The study showed that the leaf extract and nanoparticle extract of Persea americana Mill. was effective as an antihypertensive.

Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate

Background: Most sunscreens contain chemicals that can cause health and environmental problems. Natural actives can be an alternative to minimize the use of chemicals. Avocado leaves (Persea americana Mill.) and mangosteen peel (Garcinia mangostana L.) contain active compounds that have UV absorption. Objective: In this study, the optimal composition of a mixture of ethanol extracts of avocado leaves or mangosteen peel with octyl methoxycinnamate (OMC) was determined based on the Sun Protection Factor (SPF) and adhesive properties using Response Surface Methodology (RSM). Material and method: The optimal formula calculated with RSM was then made and underwent a series of tests, including a hedonic test with a scale of 0-9 on 30 respondents, a freeze-thaw stability test, and an accelerated stability test with the Arrhenius equation. Results: The RSM analysis showed that the optimal concentration of extract and OMC was 10% and 0.75% (avocado leaves) & 0.65% (mangosteen peel). The optimized formula resulted in adhesive properties and SPF of 7.41±0.03 and 16.52±0.16 (avocado leaves) & 7.43±0.04 and 15.84±0.15 (mangosteen peel) respectively. Both optimized formulations were physically stable against freeze-thaw and had a t90 of 29 minutes (avocado leaves) and 17 minutes (mangosteen peel). The average hedonic scale obtained was 7.8 (avocado leaves) and 7.9 (mangosteen peel), indicating that both optimized formulations were preferred by the respondents. Conclusions: The sunscreen formulation with an optimized combination of active ingredients from avocado leaf extract or mangosteen peel extract with OMC using RSM results in preparation with SPF value and physical properties that meet the requirements.

UJI SIFAT FISIKOKIMIA SEDIAAN EKSTRAK DAUN ALPUKAT (Persea americana Mill.) DENGAN VARIASI KONSENTRASI ASAM STEARAT

The content of avocado leaf extract such as polyphenol, saponins, alkaloids, tannins, quercetin and flavonoids can be made anti-acne cream preparations. This study aims to determine the physicochemical properties of avocado leaf extract cream including organoleptic tests, homogeneity tests, pH tests, and spread diameter tests. The research method used is experimental research with a posttest only design methodology. Avocado leaf extract is made in cream preparations using a stearic acid base, namely with variations in concentrations of F1(10%), F2(12.5%), and F3(15%). Data analysis used the oneway ANOVA test and the LSD test to determine the difference between variations in stearic acid concentrations in avocado leaf extract cream. The results of the research on organoleptic and homogeneity tests were carried out descriptively showed that F1 was light green, had a distinctive smell of avocado leaf extract, slightly thick, F2 was green color and F3 was brownish green, both of which have a distinctive odor of avocado leaf extract and are thick. Homogeneity shows the three formulas are not homogeneous. The pH test results were F1(7.85±0.05), F2(6.97±0.03) and F3(6.79±0.02) which had significant differences. The spread diameter results are F1(5.70±0.53cm), F2(5.56±0.35cm) and F3(5.36±0.31cm) have no significant differences. Organoleptic, pH and spread diameter tests meet the requirements whereas homogeneity tests do not meet the requirements. The factor of adding avocado leaf extract to the preparation and the unstable mixing speed, because it is done manually using a mortar and stamper, affects the homogeneity of the cream produced.

The Effect of Giving Avocado Leaf and Seed Extract as Antidiabetes: A Systematic Literature Review

This literature review aimed to determine the effect of giving avocado leaf extract and seeds as an antidiabetic. The literature study was conducted by choosing an experimental research design using experimental animal subjects. The results of a review of 9 articles showed that avocado seed and leaf extract as antidiabetics were that both of them showed potential as promising antidiabetic agents. Research on avocado seed extract showed that administration of avocado seed extract positively improved glycemic control and reduced diabetes symptoms in diabetic rats. On the other hand, research on avocado leaf extract showed that administration of avocado leaf extract could also reduce blood glucose levels and regulate lipid profiles in diabetic rats. These two extracts show different but consistent effects in improving blood glucose regulation and lipid profiles in diabetic conditions. Avocado seed extract showed a more significant effect in reducing diabetes symptoms, while avocado leaf extract showed promising potential in regulating blood glucose levels and lipid profiles.

The Effect of Giving Avocado Leaf and Seed Extract as Antidiabetes: A Systematic Literature Review

The Effect of Giving Avocado Leaf and Seed Extract as Antidiabetes: A Systematic Literature Review

Optimization of Sunscreen Cream Formulation Containing Ethanolic Extract of Avocado Leaves (Persea americana Mill.) or Mangosteen Rind (Garcinia mangostana L.) Combined with Octyl Methoxycinnamate

Background: Most sunscreens contain chemicals that can cause health and environmental problems. Natural actives can be an alternative to minimize the use of chemicals. Avocado leaves (Persea americana Mill.) and mangosteen peel (Garcinia mangostana L.) contain active compounds that have UV absorption. Objective: In this study, the optimal composition of a mixture of ethanol extracts of avocado leaves or mangosteen peel with octyl methoxycinnamate (OMC) was determined based on the Sun Protection Factor (SPF) and adhesive properties using Response Surface Methodology (RSM). Material and method: The optimal formula calculated with RSM was then made and underwent a series of tests, including a hedonic test with a scale of 0-9 on 30 respondents, a freeze-thaw stability test, and an accelerated stability test with the Arrhenius equation. Results: The RSM analysis showed that the optimal concentration of extract and OMC was 10% and 0.75% (avocado leaves) & 0.65% (mangosteen peel). The optimized formula resulted in adhesive properties and SPF of 7.41±0.03 and 16.52±0.16 (avocado leaves) & 7.43±0.04 and 15.84±0.15 (mangosteen peel) respectively. Both optimized formulations were physically stable against freeze-thaw and had a t90 of 29 minutes (avocado leaves) and 17 minutes (mangosteen peel). The average hedonic scale obtained was 7.8 (avocado leaves) and 7.9 (mangosteen peel), indicating that both optimized formulations were preferred by the respondents. Conclusions: The sunscreen formulation with an optimized combination of active ingredients from avocado leaf extract or mangosteen peel extract with OMC using RSM results in preparation with SPF value and physical properties that meet the requirements.

Addition of avocado (persea americana) leaf extract and carrot (daucus carota) leaf extract in starter phase broiler feed for production of low-fat meat for elderly

High-fat meat causes fatty liver, hypertension, stroke, and heart attack becomes less safe for the elderly. The research used plants that have the potential to reduce fat synthesis. This study was conducted in the starter phase to provide an overview of performance and fatty conditions in the finisher phase. In vivo testing of 84 broilers using a completely randomized design with seven treatments used commercial feed as basal feed, avocado leaf extract, and carrot leaf extract. The treatment is as follows: T1: basal feed (control) did not add ALE and CLE; T2: basal feed + (2.5% ALE and 2.5% CLE); T3: basal feed + (5% ALE and 5% CLE), T4: basal feed + (5% ALE and 0% CLE), T5: basal feed + (5% ALE and 2.5% CLE); T6: basal feed + (0% ALE and 5% CLE); T7: basal feed + (2.5% ALE and 5% CLE). The treatment is carried out for 21 days, and the parameters of the study were feed intake, body weight gain, and feed conversion. The diet with a CLE at 5% gave the lowest feed conversion in the first and the third weeks (P<0.05). Feed consumption and body weight gain in the first and second weeks were highest in the use of ALE and CLE at 2.5% respectively increasing the body weight in the first and the second weeks. The avocado leaf extract and carrot leaf extract used in the diet improve the feed conversion of broilers in the starter phase.

Effectiveness of avocado leaf extract (Persea americana Mill.) as antihypertensive

Background Long-term chemical drug consumption to treat hypertension may have side effects because the levels are sometimes difficult for the body to tolerate. Therefore, some people have used plants as herbal medicine, including avocado leaves (Persea americana Mill.) as antihypertensive. This study aims to find out the differences in the effectiveness of modern drugs and natural antihypertensive ingredients in avocado leaf extract (containing flavonoids and quercetin compounds) in inhibiting the ACE enzyme, which causes decreasing systolic blood pressure (SBP) and diastolic blood pressure (DBP) as well as increasing urine volume. Methods This study used an experimental in vivo study design involving 24 white male Wistar rats (Rattus norvegicus), aged 2–3 months, weighing 130–250 g, and of a healthy condition with active movement. The samples were randomly divided into six treatment groups and post-test only research design with control group design. Results The result of the study showed that avocado leaf extract was effective in reducing blood pressure in Wistar rats with hypertension induced by 16% NaCl for 14 days. SBP fell from 164.92 mmHg to 116.83 mmHg and DBP from 118.42 mmHg to 82.83 mmHg. One-way ANOVA test value significance SBP p=0.000 and Kruskal–Wallis test value of DBP p=0.030, Kruskal–Wallis test urine volume value of p=0.002. The statistical test results proved that avocado leaf extract significantly reduced the blood pressure and increased the urine volume in hypertensive rats. The ACE inhibitor test, performed using an ELISA, showed that the extract inhibition against the ACE enzyme was 60.0±12.1%, serum nitrate levels 41.1±11.5. The decrease in blood pressure occurred because the extract contained a quercetin compound discovered by the high-performance liquid chromatography (HPLC) method of 1129.597 ppm. Conclusions The study showed that the leaf extract of Persea americana Mill. was effective as an antihypertensive.

Literature Study: Efficacious Indonesian Herbs for Lowering Cholesterol Levels

High cholesterol is generally suffered by obese people, but it is possible that thin people can also experience it, especially by consuming foods that are low in fiber but high in fat. Cholesterol can settle on artery walls, so blood flow to the heart, brain, and other body parts can be blocked. There are several herbal ways that can reduce cholesterol levels in the blood, namely by administering avocado leaf extract and avocado fruit, soursop leaf extract, red dragon fruit, rambutan leaf extract and chayote stew as alternative therapy so as not to depend on synthetic drugs. The method used in writing this journal uses a literature review approach. The process of collecting journals is done by searching for literature sources based on specified criteria. The inclusion criteria taken include: journals published in the last 10 years. And the research sample used was obtained from Google Scholar. The results of previous studies explained that cholesterol can not only be treated by using synthetic drugs that come from a doctor's prescription but can also use herbal medicines such as avocado, red dragon fruit, and soursop leaf water extract.

Persea Americana Mill Extraction as Antibacteria

Avocado leaves (P. americana ) are a part of plants that can be used as traditional medicines. Avocado leaves contain chemicals such as flavonoids, saponins, tannins and alkaloids which function as pathogenic antibacterial killer. This study aims to describe the antibacterial activity of various concentrations of avocado leaf extract (P. americana) on the growth of Escherichia coli. The extract concentrations were 25%, 50%, 75%, and 100%. This research employed experimental method with post-test group design. Antibacterial activity was measured by the diameter of the clear zone formed. The analysis results, using the Kruskal Walls test with an accuracy level of 0.05, conclude that there are significant differences in the antibacterial power of various concentrations of avocado leaf extract (P. americana ) against E. colibacteria. The most effective concentration to inhibit the growth of E. colibacteria is at concentration 100% with an (inhibition zone) of 6.9 mm including moderate inhibition.

The Avocado (Persea americana Mill.) Leaf Extract on Streptozotocin-induced Pancreatic Cell Regeneration of White Rats (Rattus norvegicus)

Objectibe The rate of pancreatic cell regeneration after avocado leaf extract intervention in a diabetic animal model induced by streptozotocin was investigated in this study. Method: Experimental study was conducted on 18 male white rats as subjects, which were divided into 6 groups, 3 animals of each. Those were G1 (Feed + Streptozotocin + 10% Sucrose + 100 mg/kg b.w. of extract + 0.5% NaCMC), G2 (Feed + Streptozotocin + 10% Sucrose + 150 mg/kg b.w. of extract + 0.5% NaCMC), G3 (Feed + Streptozotocin + 10% Sucrose + 200 mg/kg b.w. of extract + 0.5% NaCMC), G4 (Feed + Streptozotocin + 10% sucrose + 0.5% Na-CMC), G5 (Feed + Streptozotocin + 10% sucrose + Glibenclamid + 0.5% Na-CMC), G6 (Normal healthy animal + Feed). Results: The pancreatic cells damage in animal diabetic model, G1 = 1.67 (moderate cell damage); G2 = 1.00 (mild cell damage); G3 = 0.33 (no damage); G4 = 3.00 (severe cell damage); G5 = 0.33 (no damage); G6 = 0.33 (no damage). Conclusion: The dose of 200 mg/kg b.w. of avocado leaf extract contributed the most significant recovery of pancreatic cell of diabetic animal induced with streptozotocin, equivalent to glibenclamide.

Facile and green fabrication of efficient Au nanoparticles catalysts using plant extract via a mesoporous silica-assisted strategy

In this study, highly dispersed Au nanoparticles supported on mesoporous silica were successfully prepared using avocado leaf extract. Due to the in-situ growth of the Au nanoparticles within the confined geometric space of the silica pores these nanoparticles are on average ≈7.7 nm in diameter, much smaller than those prepared without mesoporous silica (≈20 nm), and within the critical size range required for Au catalysts (<10 nm). The reduction and stabilization of the Au nanoparticles within the silica pores is enabled by aqueous biomolecules from the plant extract. The immobilization of the Au nanoparticles on the silica facilitates their separation and purification from the complex plant extract solution. Excellent catalytic performance and reusability is demonstrated by the reduction of 4-nitrophenol. This approach offers a facile, low-cost and environmentally benign method for synthesis of advanced Au-based catalysts from readily available silica materials and Au complexes with potential application in areas such as drug delivery and chemical/bio-sensing. The design concept can be extended to green synthesis of other metal or metal oxide compositions.

Ameliorative Effect of Administering Avocado (Persea americana) Leaf Extract on Lead Acetate Toxicity in the Brain-cerebellum of Albino Rats

Aim: To investigate whether the aqueous extract of avocado leaves can be used in alternative medicine for the remediation or treatment of lead poisoning in the brain.&#x0D; Study Design: Pure Experiment, using animal models.&#x0D; Place and Duration of Study: Department of Anatomy, College of Medicine and Health Sciences, Abia State University, Uturu, Nigeria; between January 2019 and June 2019.&#x0D; Methodology: Twenty albino Wistar rats including both male and female, and weighing around 155 g were randomly assigned to four groups (designated as A,B,C and D), with each group consisting of five animals. While group A served as the control, group B was administered a daily dose of 500 mg/kg body weight of avocado leaf extract, group C received 150 mg/kg body weight per day of lead acetate, and group D was given 150 mg/kg body weight per day of lead acetate and immediately followed with 500 mg/kg body weight/day of the avocado leaf extract. Treatments were given once daily through the oral route using a syringe with attached micropipette tube for 15 days, while the animals had access to water and chow ad libitum. The rats were euthanized on the 16th day by cervical dislocation and the cranial cavity was carefully exposed in order to dissect the brain and to obtain tissue samples from the cerebellum, which were then prepared for microscopic examination using routine histological techniques, with hematoxylin and eosin (H&amp;E) stains.&#x0D; Results: The findings showed the extract to be ameliorative by reducing histomorphological distortions of lead acetate toxicity in the brain, and thus caused moderate regeneration of the cerebellar tissue.&#x0D; Conclusion: The outcome of this research therefore indicates that the avocado leaf extract has medicinal potentials and could serve as an herbal remedy in the alternative treatment of lead poisoning.