Corrosion-related damage due to exposure to environmental conditions is the main cause of costs in the maintenance of transport infrastructure. Because of its high corrosion resistance and the associated higher durability, non-metallic reinforcement offers great potential for preventing such damage, thus reducing maintenance costs. In this article, potential savings for an integral road bridge are studied through a holistic life cycle cost (LCC) analysis considering four different reinforcement materials (steel, glass, basalt, carbon). A fair comparison is enabled by a material-specific design, the calculation of maintenance and user costs and the consideration of the respective disposal scenario. Moreover, environmental costs are recognised by carbon pricing based on life cycle analysis (LCA). The influence of individual parameters is quantified by means of a sensitivity analysis and the probability of savings is studied by Monte Carlo simulation. It is shown that higher investment costs for non-metallic reinforcement can be compensated by lower user costs. This is mainly due to shorter maintenance periods, as less time is required for repair action, whereby potential savings in user costs are particularly evident if the traffic route below the bridge is not disrupted. It is concluded that even from today's perspective, the use of glass and basalt fibre-reinforced polymer (FRP) reinforcement in highway bridges with average traffic volumes very likely offers an economic advantage over corrosion-prone reinforcing steel.