This paper introduces a new sensing approach utilizing a solid-solid phononic crystal (PnC) channel drop filter structure for the detection of varying molar fractions of Ethyl lactate within a mixture of Ethyl lactate and 2-butoxy ethanol. The sensor features a two-dimensional PnC constructed from poly methyl methacrylate as the background material, incorporating a regular arrangement of circular Tungsten columns. The design integrates a bus waveguide linked to two interconnected ring resonators, which are coupled to a drop waveguide. Each ring resonator is equipped with three strategically positioned pillars near the coupling region, allowing for the accommodation of varying concentrations of Ethyl lactate. The sensor’s performance is significantly influenced by the ring resonators and the integrated pillars. It identifies specific resonance frequencies that shift in response to changes in Ethyl lactate concentrations within the resonators. The transmission resonance frequency exhibits valuable sensitivity to these concentration variations, reflecting the unique sound velocities and mass densities associated with each level of Ethyl lactate. The effectiveness of the proposed sensor is validated through coupled mode theory, demonstrating a close match with the device’s observed behavior. The measured frequency range spans from 1.972 MHz to 1.979 MHz with a step size of 1 Hz. Notably, the sensor displays considerable characteristics, including an average quality factor of 90,613, an average sensitivity of 3816 Hz, an average figure of merit of 172, an average signal-to-noise ratio of 137, an average resolution of 22 Hz, an average damping ratio of 0.56 × 10− 5, and an average limit of detection of 34 × 10− 5. These results underscore the potential of the channel drop filter for the accurate detection of Ethyl lactate concentrations with high quality factor and sensitivity. The sensor can effectively identify variations in Ethyl lactate levels, which are prevalent in various applications, including pharmaceuticals and food additives.