Lightning stroke strength, characterized by energy and peak currents, over the Tibetan Plateau (TP), is investigated by utilizing datasets from the World Wide Lightning Location Network and the Chinese Cloud-to-Ground Lightning Location System during 2016–2019. Focused on the south-central (SC) and southeast (SE) of the TP, it reveals that SE-TP experiences strokes with larger average energy and peak currents. Strong strokes (energy ≥ 100 kJ or peak currents ≥ |100| kA), exhibiting bimodal distribution in winter and summer, are more frequent and have larger average values over the SE-TP than the SC-TP, with diurnal distribution indicating peaks in energy and positive strokes in the middle of the night and negative strokes peaking in the morning. Utilizing the ECMWF/ERA-5 and MERRA-2 reanalysis, we find that stronger strokes correlate with thinner charge zone depths and larger CIWCFs but stable warm cloud depths and zero-degree levels over the SC-TP. Over the SE-TP, stronger strokes are associated with smaller CIWCFs and show turning points for warm cloud depths and zero-degree levels. Thicker charge zone depths correlate with stronger negative strokes but weaker positive strokes. Generating strokes of similar strength over the SC-TP requires larger CIWCFs, thinner warm cloud depths, and lower zero-degree levels than over the SE-TP.