Maximum Average Concentration Research Articles

ПЛАНИРОВАНИЕ И РЕАЛИЗАЦИЯ СТРОИТЕЛЬНЫХ РАБОТ ПРИ ТОЧЕЧНОЙ ЗАСТРОЙКЕ ДЛЯ ОПРЕДЕЛЕНИЯ УДЕЛЬНЫХ ПЫЛЕВЫХ ВЫБРОСОВ

Abstract. The construction industry is one of the significant sources of environmental damage. The effects of dust pollution have an impact on all stages of the building's life cycle, from the start of work on the construction site to completion, operation and demolition. Despite the fact that the stage of work implementation does not last long in comparison with other stages of the life cycle of an investment and construction project, the construction stage has a number of significant impacts on the environment. The development of the construction industry requires the comprehensive assessment and investigation of the construction site as a source of pollu-tion, identification and evaluation of all sources of dust pollution on the construction site, the processes of dust pollution propagation in an urban environment. 
 The article offers an analysis of data on field studies of the degree of atmospheric air pollution in the territory of Rostov-on-Don, an analysis of the volume of construction dust emissions from construction works, a method for calculating control over the implementation of construction processes and the spread of dust pollution generated in the atmospheric air, indi-cators of the maximum, average daily emission concentration of fine dust PM2.5 and PM10 formed from construction production and the ability to control the level of pollution on the construction site. There are no fundamental studies on the calculation of dust emission from construction works during spot construction. Based on the field studies conducted earlier using the Handheld 3016 particle counter, data on dust emissions from construction processes under various climatic influences were obtained.
 Subject: analysis of data on field studies of the degree of atmospheric air dustiness in the territory of Rostov-on-Don, the volume of emissions of construction dust from construction work on construction sites in urban conditions.
 Materials and methods: conducting systematic measurements of the degree of dust in Rostov-on-Don using the Lighthouse Handheld 3016 IAQ manual particle counter, taking into account typical climatic, heterogeneous factors of the territory on which the city is located. Systematic monitoring of several construction sites where residential complexes similar in technology and conditions were built in the most dusty area of Rostov-on-Don and the selection of five construction sites for the development of a calendar schedule for construction and installation work, taking into account specific emissions of dust particles and climatic conditions for calculating the dust pollution factor.
 Results: an effective approach that can be usefully applied to the determination of dust emissions on the construction site, to calculate the gross emission of dust released on the site from construction work, daily indicators of the maximum single and average daily concentration, as well as to dust dispersion with the determination of zones exceeding the MPC indicators is the use of network modeling with further calendarization to predict these types of indicators during the design and implementation of construction production.
 Conclusions: based on the data obtained, it can be concluded that with the existing implemented organization and technology of work, the concentration of fine dust particles are within the MPC, but given the background concentrations of atmospheric air in Rostov-on-Don, these indicators in a particular area will exceed the permissible MPC. The process of using existing SMR models taking into account specific dust emissions, the development of a schedule of dust pollution of a specific territory taking into account natural and climatic factors and the determination of zones of excess of MPC indicators in the process of modeling the dispersion of fine dust particles beyond the fence boundaries of the construction site will make it possible to draw up a passport of environmental safety of the nearby urbanized territory during spot development. Daily determination of dust pollution indicators will allow you to adjust the schedule of construction work. Modeling the dispersion of construction dust, taking into account the direction and speed of the wind, will make it possible to monitor the zones of exceeding the MPC of the neighboring territory on a daily basis and adjust measures to extinguish dust emissions at the construction site.

Physicochemical parameters and heavy metal in surface water in Central Bangladesh

Pollution of surface water and heavy metals is one of the growing concerns worldwide due to industrialization and unplanned urbanization. The surface water pollution level was studied by assessing the physicochemical properties and heavy metal concentration of collected samples in Gazipur district. Maximum average temperature(35.200C±2.63), EC(1423µs/cm), and TDS(746.5mg/l) were observed in Kaliakoir upazila. These parameters were found minimum in Kapasia upazila. DO was found above 5mg/l in Sreepur, Kapasia and Kaliganj. Cr and Ni were too low to detect by the instrument. The maximum average concentration of Pb(925.6917µg/l), Mn(477.8625µg/l), and Na(11230.17µg/l) was observed in Kaliakoir upazila. However, no Fe was observed in Kaliakoir upazila. The maximum Fe concentration was Sreepur upazila (3531.6µg/l) followed by Sadar (1496.517µg/l) upazila. Maximum average Cd concentration was observed in Kapasia (41.28µg/l) followed by Kaliakoir (30.8767µg/l), Sadar (29.4283µg/l) and Sreepur (28.8042µg/l). Cu concentration was found maximum in Kaliganj (14.205µg/l) followed by Sadar (6.29µg/l) and Kaliakoir (3.893µg/l). However, Cu concentration was found nil in Kapasia. The maximum average concentration of Ca(29197.25µg/l) and Mg(8142.833µg/l) was observed in Kaliganj and the minimum concentration was observed in Sreepur upazila. The order of concentration of heavy metals in the study area is Ca>Na>Mg>Fe>Pb>Mn>Cd>Cu>Ni>Cr. From the findings, the physicochemical parameters of the surface water sources were found higher than the standards in most of the samples.

Spatial Distribution, Risk Assessment, and Provenance of Heavy Metals Contamination in the Sediments of the Gilgit River Basin, Northern Pakistan

ABSTRACT Gilgit River Basin (GRB) is one of the primary fluvial aquatic systems flowing through Gilgit-Baltistan and a water source for recreation, fisheries, irrigation, and drinking to more than 1.8 million people. This study aimed to investigate heavy metals (HM) contamination levels in sediments of GRB, northern Pakistan. Fifty-five samples were picked from the various sections of GRB and examined for HM concentrations. Fe showed the maximum average concentration of 27,743 mg/kg, while Cd was noted with a minimum average of 1.06 mg/kg. HM concentrations were noted within the world river system guidelines except Cd, which also surpassed the sediment quality guidelines set by USEPA. HM concentrations of GRB sediments were used for the geospatial and ecotoxicological risk indices. Geospatial analyses showed higher levels of HM contamination and risk in the sediments of Ishkomen River in GRB. HM contamination in GRB sediments showed low to moderate levels of risk to exposed aquatic ecosystems. Statistical analyses were used for the HM source apportionment in sediments of GRB, suggesting a major contribution from natural activities. This study recommends seasonal variation in HM contamination of water and sediments studies in the GRB.

Measurement of ambient particulate matter (PM1.0, PM2.5 and PM10) in Khulna City of Bangladesh and their implications for human health

Atmospheric particles have been significantly affecting urban air quality and urban-oriented living in an increasing share of the population in Bangladesh. This study assessed the concentration of PM1.0, PM2.5, and PM10 in Khulna, one of the largest cities in Bangladesh located near the Bay of Bengal. The maximum average concentrations were recorded 415 ± 184.01 µg/m3 for PM10, 302 ± 109.89 µg/m3 for PM2.5, and 143 ± 45.05 µg/m3 for PM1.0. These values are several times higher than the World Health Organization air quality standard and Bangladesh National Ambient Air Quality Standard. According to the size and fractional distribution of PM, most of the monitoring locations were dominated by fine particles. Carcinogenic and non-carcinogenic risks due to exposure to ambient PM1.0, PM2.5 and PM10 were also quantified to illustrate the relevant potential human health risks. The excess lifetime cancer risk (ELCR) values of PM1.0 ranged from 8.6E0–4 to 6.0E–07 and PM2.5 varied between 8.6E–04 and 6.0E–07 exceeded the allowable limit at every location indicating the potential cancer-developing risk to the urban population. The health quotient (HQ) values also crossed the least permissible value at most of the locations depicting strong non-carcinogenic risks. Average HQ values of PM2.5 varied from 1.07 to 20.13 while PM10 ranged from 0.44 to 8.3. This research revealed children and elderly people as the most vulnerable age groups with the highest carcinogenic risks through exposure to atmospheric PM in Khulna city. Therefore, air pollution reduction plans and risk mitigation strategies should be developed and implemented by the government authorities.Graphical

2526. Ex Vivo Assessment of Sulbactam-Durlobactam (SUL-DUR) Clearance during Continuous Renal Replacement Therapy (CRRT)

Abstract Background Optimal dosing of antibiotics in patients on CRRT is complicated by factors that can influence drug adsorption and clearance including filter type, CRRT mode, effluent rate (ER), and the drug’s properties itself. SUL-DUR is a novel combination antibiotic under development for management of Acinetobacter baumannii infections. We sought to characterize SUL and DUR adsorption and transmembrane clearance (CLTM) in an ex vivo CRRT model. Methods CLTM was determined in hemofiltration (CVVH) and hemodialysis (CVVHD) modes using the Prismaflex M100 and HF1400 hemofilter sets. One liter of heparinized bovine blood was allowed to circulate in the Prismaflex CRRT system for 10 minutes. SUL and DUR were then added to achieve a plasma concentration of 30 mg/L, the average maximum concentration achieved in humans following SUL-DUR 1g/1g q6h as a 3h infusion. Pre-filter blood, post-filter blood and effluent samples were collected at 0, 10, 30, and 60 minutes to determine SUL and DUR concentrations. Combinations of filters, modes, and replacement fluid were tested in triplicate at effluent rates of 1, 2 and 3 L/h. The sieving coefficient (SC) for CVVH and the saturation coefficient (SA) for CVVHD were calculated to determine CLTM. Adsorption was measured through a closed loop system bypassing effluent elimination. Multiple linear regression was used to determine SUL and DUR CLTM as a function of ER, filter, and mode. Results SUL and DUR adsorption was minimal at 10% for both drugs. Mean ± standard deviation initial SUL and DUR concentrations were 28.6 ± 2.5 and 27.4 ± 1.9 mg/L, respectively. The overall mean SC/SA across different modes, filters, and ERs was 1.0 and 0.9 for SUL and DUR, respectively. Multiple linear regression demonstrated that the ER was the primary driver (p< 0.001) of CLTM for both drugs based on the equations: SUL CLTM (L/h) = -0.0123 + (1 x ER), R2 = 0.998; DUR CLTM (L/h) = 0.0346 + (0.91 x ER), R2 = 0.958. Conclusion SUL and DUR were efficiently cleared by both CVVH and CVVHD through M100 and HF1400 filters. The clearance of both drugs during CRRT was dependent primarily on the ER. When incorporated into established population pharmacokinetic models, these data can be used to estimate CLTM and devise dosing recommendations for SUL-DUR for patients requiring CRRT. Disclosures Xiaoyi Ye, MD, Sanofi Genzyme: Honoraria David P. Nicolau, PharmD, Allergan: Advisor/Consultant|Allergan: Grant/Research Support|Cepheid: Advisor/Consultant|Cepheid: Grant/Research Support|Merck: Advisor/Consultant|Merck: Grant/Research Support|Pfizer: Advisor/Consultant|Pfizer: Grant/Research Support|Shionogi: Advisor/Consultant|Shionogi: Grant/Research Support|Tetraphase: Advisor/Consultant|Tetraphase: Grant/Research Support|Venatorx: Advisor/Consultant|Venatorx: Grant/Research Support|Wockhardt: Advisor/Consultant|Wockhardt: Grant/Research Support Joseph L. Kuti, PharmD, bioMeriuex Inc.: Grant/Research Support|Entasis Therapeutics: Grant/Research Support|Merck & Co, Inc: Grant/Research Support|Shionogi Inc: Advisor/Consultant|Shionogi Inc: Grant/Research Support|Shionogi Inc: Honoraria

Disposition kinetics of meloxicam in green sea turtles (Chelonia mydas) after intravenous and intramuscular administrations.

The pharmacokinetics were described of meloxicam (MLX) in green sea turtles (Chelonia mydas), following a single intravenous (i.v.) and intramuscular (i.m.) administrations at one of two dosages of 0.1 or 0.2 mg/kg body weight (b.w.). The sample of 20 green sea turtles was divided into four groups (n = 5) using a randomization procedure according to a parallel study design. Blood samples were collected at pre-assigned times up to 168 h. MLX in the plasma was cleaned-up and quantified using a validated high-performance liquid chromatography method with UV detection. The concentration of MLX in the experimental green sea turtles with respect to time was pharmacokinetically analyzed using a non-compartment model. MLX plasma concentrations were quantifiable for up to 72 and 120 h after i.v. at dosages of 0.1 and 0.2 mg/kg b.w., respectively, whereas it was measurable for up to 168 h after i.m. administration at both dosages. The long elimination half-life value of MLX (28 h) obtained in green sea turtles after i.v. administration was consistent with the quite slow clearance rate for both dosages. The average maximum concentration (Cmax ) values of MLX were 1.05 μg/mL and 4.26 μg/mL at dosages of 0.1 and 0.2 mg/kg b.w., respectively, with their elimination half-life values being 37.26 h and 30.64 h, respectively, after i.m. administrations. The absolute i.m. bioavailability was approximately 110%. These results suggested that i.m. administration of MLX at a dosage of 0.2 mg/kg b.w. was likely to be effective for clinical use in green sea turtles (Chelonia mydas). However, further studies are needed to determine the pharmacodynamic properties and clinical efficacy of MLX for the treatment of inflammatory disease after single and multiple dosages.

Seasonal and diurnal measurement of ambient benzene at a high traffic inflation site in Delhi: Health risk assessment and its possible role in ozone formation pathways.

Benzene is the most toxic and hazardous pollutant among volatile organic compounds (VOCs), as it comes under group 1 carcinogens recognized by the International Agency for Research on Cancer (IARC). It also plays a significant role in forming secondary pollutants like ozone. The benzene concentration was measured using a charcoal sorbent tube by active sampling at a traffic junction and analysis was done using GC-FID. The maximum average concentration of benzene in ambient air was found to be 33 μg/m3. A diurnal study of benzene measurement shows higher benzene concentrations in the evening compared to the morning. Seasonal variation of benzene is found to be winter > spring > summer > autumn > monsoon and OFP was found to be 21, 19, 14, 13, and 10 respectively. Cancer (ILCR) and non-cancer (HQ) health risk assessment was done to determine the impact of ambient benzene on the residents of urban areas. The yearly average value of ILCR was found to be 2×10-6 ± 1×10-6 which ranges from acceptable value to three times the WHO acceptable value i.e 1×10-6. The correlation of ozone and its precursor, benzene with meteorological parameters is also evaluated. The correlation of benzene and ozone with solar radiation shows the influence of photochemical reactions on the levels of benzene and ozone at the study site, although it is low.

Modeling and Analysis of Air Pollution and Environmental Justice: The Case for North Carolina's Hog Concentrated Animal Feeding Operations.

Concentrated animal feeding operations (CAFOs) emit pollutants that can cause negative impacts on human health. The concentration of hog production in North Carolina raises concerns regarding the disproportionate exposure of vulnerable communities to air pollution from CAFOs. We investigated whether exposure to gaseous ammonia () and hydrogen sulfide () (in 2019) differs between subpopulations by examining demographics, including race/ethnicity, age, educational attainment, language proficiency, and socioeconomic status. We used an Air Monitoring Station (AMS)/Environmental Protection Agency (EPA) Regulatory Model (AERMOD)-based Human Exposure Model (version 3) to estimate ambient concentrations of and from hog farms in Duplin County and its surrounding counties in North Carolina and estimate subsequent exposures of communities within of Duplin County, North Carolina, or the Duplin County Region. We combined estimated exposures with 2016 American Community Summary Census data, at the block group level, using spatial analysis to investigate whether exposures to these pollutants differ by race and ethnicity, age, income, education, and language proficiency. Based on these estimations, we assessed associated exposure risks to the impacted communities and used multivariable regression modeling to evaluate the relationship between average ammonia exposures from Duplin regional hog farms and the presence of vulnerable populations. The average [] annual estimated concentration of and in the Duplin County Region is and , respectively. The maximum average annual ambient concentrations are estimated at and for and , respectively. Our descriptive analysis reveals that people of low income, people of color, people with low educational attainment, and the linguistically isolated in the Duplin Region are disproportionately exposed to higher levels of pollutants than the average exposure for residents. Alternatively, our statistical results suggests that after adjusting for covariates, communities of color are associated with 1.70% (95% CI: , 0.44) lower concentrations per 1-SD increase. One-standard deviation increases in the adults with low educational attainment and children years of age is associated with 1.26% (95% CI: , 3.33) and 1.20% (95% CI: , 3.05) higher exposure per 1-SD increase, respectively. Exposures to and differed by race and ethnicity, educational attainment, language proficiency, and socioeconomic status. The observed associations between exposure to CAFO-generated pollutants and sociodemographic indicators differed among demographics. The disproportionate distribution of hog facilities and resulting pollutant exposures among communities may have adverse environmental and human health impacts, raising environmental justice concerns. https://doi.org/10.1289/EHP11344.

Optimal Extreme Random Forest Ensemble for Active Distribution Network Forecasting-Aided State Estimation Based on Maximum Average Energy Concentration VMD State Decomposition

As the penetration rate of distributed generators (DG) in active distribution networks (ADNs) gradually increases, it is necessary to accurately estimate the operating state of the ADNs to ensure their safe and stable operation. However, the high randomness and volatility of distributed generator output and active loads have increased the difficulty of state estimation. To solve this problem, a method is proposed for forecasting-aided state estimation (FASE) in ADNs, which integrates the optimal extreme random forest based on the maximum average energy concentration (MAEC) and variable mode decomposition (VMD) of states. Firstly, a parameter optimization model based on MAEC is constructed to decompose the state variables of the ADNs into a set of intrinsic mode components using VMD. Then, strongly correlated weather and date features in ADNs state prediction are selected using the multivariate rapid maximum information coefficient (RapidMIC) based on Schmidt orthogonal decomposition. Finally, by combining the set of intrinsic mode functions of the ADNs state, calendar rules, and weather features, an ensemble FASE method based on the extreme random tree (ERT) ensemble for the ADNs based on cubature particle filtering (CPF) is developed. An optimization model based on mean absolute error and root mean square error is established to obtain the optimal integration strategy and final estimation results. Simulation verification is performed on the IEEE 118-bus standard distribution system. The results show that the proposed method achieves higher accuracy compared to other estimation methods, with root mean square errors of 1.4902 × 10−4 for voltage magnitude and 4.8915 × 10−3 for phase angle.

A pretreatment scheme for plasmid extraction contained sugar, high concentration lysozyme and mild lysozyme removal

To address the issue of low efficiency in extracting plasmid DNA (pDNA) from Lactobacillus plantarum by breaking the cell wall, we proposed an effective pretreatment scheme. This study investigated the impacts of lysozyme concentrations and glucose, as well as centrifugal forces during lysozyme removal in the pretreatment system. The efficiency of pDNA extraction was assessed using non-staining method, acridine orange staining method (AO staining) and agarose gel electrophoresis (AGE). Furthermore, the glucose high lysozyme method was compared to the commercial kit method and the lysozyme removal method using L. plantarum PC518, 9L15, JS193 and Staphylococcus aureus USA300. The results indicated that the pDNA extraction concentrations from the four tested strains were increased by 8.9, 7.2, 8.5, and 3.6 times, respectively, compared to the commercial kit method. Furthermore, they increased by 1.9, 1.5, 1.8, and 1.4 times, respectively, compared to the lysozyme removal method. The maximum average concentration of pDNA extraction (from L. plantarum PC518) reached 590.8 ± 31.9 ng/ul. In conclusion, the incorporation of sugar, high concentration lysozyme and mild lysozyme removal proved to be effective enhancements in improving the efficiency of pDNA extraction from L. plantarum. Using the pretreatment scheme, the concentration of pDNA extraction was significantly increased, approaching levels comparable to pDNA extraction from Gram-negative bacteria.

A 2-year study on the spatio-temporal changes in trace metal concentrations in sediment, water and plants within the Walvis Bay Lagoon, Namibia

Most pristine coastal ecosystems are at threat from pollution due to the increasing anthropogenic activities such as mining, recreational activities, and human settlements that discharge waste as effluents. In Namibia, the Walvis Bay Lagoon is regarded as one of the most important wetlands for birds along the Southern African coast and has been designated as wetland of international importance, which makes its protection from pollution very critical. To date, no studies have focused specifically on the potential accumulation of heavy metals in the Walvis Bay Lagoon environment under the current increase in industrial activities around the lagoon. It is therefore imperative to monitor the changes in industrial pollutants such as toxic heavy metals within the Walvis Bay Lagoon, which is critical in evaluating the overall lagoon ecosystem health. Therefore, this study monitored changes in heavy metals (As, Cr, Cd, Ni, Pb and Zn) in sediment, water and Salicornia spp. plants collected from the Walvis Bay Lagoon. The highest concentrations of the heavy metals were found in the sediment in transects located furthest away from the lagoon mouth, though with values below minimum threshold values. For sediment samples, the maximum average concentration recorded was Cr (31.3 mg/kg); Ni (8.03 mg/kg); Pb (27.9 mg/kg); Zn (59.4 mg/kg); As (6.14 mg/kg); whilst for water samples it was As (0.06 gm/L); Cd (0.11 mg/L); Ni (0.68 mg/L) and Pb (1.49 mg/L). It was noted that the stations further away from the lagoon mouth had higher concentrations of most metals, indicating the importance of lagoon recharge and discharge. Sedimentation with clay in areas furthest away from the lagoon mouth could be resulting in higher heavy metal retention within the lagoon and thus periodic monitoring of both heavy metals and clay sedimentation is required. Based on this baseline data, the heavy metal concentrations within the lagoon indicate a healthy lagoon, with no immediate risk posed by the heavy metals. However, this study was only undertaken over two years and more time will be required to monitor the long-term changes in these trace metals to have more policy influencing data, hence continued monitoring is recommended. Monitoring of sediment, water and plants should also be coupled with sampling of organisms like fish, crustaceans and birds, that are found within the lagoon to evaluate any correlations between the source concentrations and that in the organisms.

Measurement of nitrogen oxide (NOx) emissions in fuel-combustion equipment and analysis of their impact on city air condition

The object of the research is to ensure environmental safety and maximum efficiency of fuel burning equipment. Energy facilities (thermal power plant, boiler houses) are among the biggest air polluters in the city. Nitrogen oxides (NO, NO2, NOx) occupy a significant place among the toxic gases contained in the flue gases of fuel-burning equipment. These substances have a negative impact on the ecological state of the city and are regulated by the Order of the Ministry of Natural Resources of Ukraine dated 27.06.2006 No. 309 on the approval of standards for maximum permissible emissions of pollutants from stationary sources. The principles of measurement unity are considered, including the presentation of measurement results in standard units (ppm, mg/m3). Conversion from volume concentration (ppm) to mass (mg/m3) is given. Measurements of the concentration of nitrogen oxides were carried out. In the course of research, instrumental measuring tools were used, which made it possible to obtain the values of nitrogen dioxide concentrations in gas boiler flue emissions. In particular, the average maximum concentrations of the main pollutants exceed 62.58 mg/m3. Analyzing the concentration of flue gases allows to determine the concentration of pollutants and to adjust the optimal operation of the equipment as much as possible, achieving a reduction in emissions and compliance with the approved emission standards. Obtained data on background concentrations of nitrogen dioxide in the city of Kyiv, amounting to 1.33 MPC. Using the data of instrumental measurements with the method of calculating concentrations of harmful substances in the atmospheric air and background concentrations, a map of emission dispersion was created. Fields of surface concentrations were plotted on the scattering map, which makes it possible to compare the obtained values with the hygienic standards of atmospheric air. By combining instrumental measurement methods and calculation methods, the volume of emissions was determined and the impact on atmospheric air pollution of the city was assessed.

Burning of Municipal Solid Waste: An Invitation for Aerosol Black Carbon and PM2.5 Over Mid–Sized City in India

Waste management is the main concern of most cities in developing countries. The proper procedure is needed to reduce Municipal solid waste, that’s why burning is the cheaper way to decrease solid waste. The main aim of this study is to assess the concentration of Black Carbon and PM2.5 during the MSW burning sites in Jamshedpur. The continuous measurement was taken during the burning period in three phases at Industrial, Urban, and Rural waste burning sites having respective average BC concentrations observed as 145 ± 46, 101 ± 33 & 95 ± 33 μg m−3, and PM2.5 as 1391 ± 358, 998 ± 319, 957 ± 313 μg m−3. BC and PM2.5 concentrations show significant diurnal variations with maximum average concentration at the midnight phase due to large temperature fluctuation (lower mixed layer height) in the atmosphere. This evaluation during burning period exceeds regular day estimates by around 5–6 times. The rate distinction of BC by the Aethalometer model indicates that source apportionment of BC is more sensitive in assessing BCBB (biomass burning) with an average fraction of 82% at 880 nm because waste trash burning in the dump yard was mostly solid. Pearson correlation analysis shows strong correlations between BC and PM2.5 concentration that is primarily attributable to well-known nearby sources such as vehicular emissions.

Shifting application dates on cereal reduces pesticide transfer via subsurface drainage based on water flow forecasts during autumn applications.

Thanks to the changes in aquatic risk assessment within the Marketing Authorization (MA) process in France, the contamination of surface water through the subsurface drainage network is better accounted for. The measure adopted by Risk Regulations is to prohibit any use of selected pesticides on drained plots. Herbicide solutions on subsurface-drained plots are becoming scarce due to a limited number of innovations combined with the re-approvals process. Autumn weed management then becomes a major issue for winter cropping systems on drained plots. Unlike runoff prevention, few risk management measures are available to prevent the risks associated with drained plots. We analyzed data from La Jaillière, an ARVALIS experimental site (9 plots, 1993 to 2017), representative of scenario D5 from EU FOCUS Group, for four herbicides (isoproturon, aclonifen, diflufenican, flufenacet). Our study first demonstrates the relevance of the time application management measure by showing the decreasing trend in the transfer of pesticides in drained plots. The second result is to validate, still on the La Jaillière site, the hypothesis of a management measure based on an indicator of soil profile saturation before drainage flow (Soil Wetness Index). A conservative measure consisting in restricting pesticide applications during autumn, when the SWI is < 85% of saturation, reduces the risk by a factor of 4-12 for quantification above the predicted no-effect concentration (PNEC) and values of maximum or flow weight average concentrations (Cmax and CMP) by 70- and 27-fold, ratio of exported pesticide (Rexp) by 20-fold, and total flux by 32. This measure based on SWI threshold appears to be more efficient than those using other restriction factors. SWI could be easily calculated considering local weather data and soil properties for any drained field. This article is protected by copyright. All rights reserved.

Failure to tolerate continuous subcutaneous treprostinil in pediatric pulmonary hypertension patients

Continuous subcutaneous (SubQ) treprostinil is an effective therapy for pediatric patients diagnosed with pulmonary hypertension (PH). To date, the clinical characteristics and factors associated with failure to tolerate this therapy have not been described. The purpose was to describe patient-reported factors contributing to SubQ treprostinil intolerance in pediatric patients with PH. A retrospective descriptive study was performed at 11 participating sites in the United States and Canada for patients younger than 21 years of age diagnosed with PH who failed treatment to tolerate SubQ treprostinil between January 1, 2009, and December 31, 2019. All data were summarized using descriptive statistics. Forty-one patients met the inclusion criteria. The average age at SQ treprostinil initiation, and length of treatment, was 8.6 years and 22.6 months, respectively. The average maximum dose, concentration, and rate were 95.8 ng/kg/min, 6.06 mg/mL, and 0.040 mL/h, respectively. The reasons for failure to tolerate SubQ treprostinil included intractable site pain (73.2%), frequent site changes (56.1%), severe site reactions (53.7%), infections (26.8%), and noncompliance/depression/anxiety (17.1%). Thirty-nine (95.1%) patients transitioned to a prostacyclin therapy with 23 patients transitioning to intravenous prostacyclin, 5 to inhaled prostacyclin, 5 to oral prostacyclin, and 7 to a prostacyclin receptor agonist. A subset of pediatric PH patients failed to tolerate SubQ treprostinil infusions despite advances in SubQ site maintenance and pain management strategies. Intractable site pain, frequent SubQ site changes, and severe localized skin reactions were the most common reasons for failure.

On accounting for emissions of pollutants from autonomous heat supply sources of individual residential buildings when conducting summary calculations of atmospheric air pollution for settlements

Introduction. Autonomous sources of heat supply (ASHS) can make a crucial contribution to the level of atmospheric air pollution in settlements. However, emissions from ASHS in most cases are either not included in the summary calculations of atmospheric air pollution at all or estimated with significant uncertainties. &#x0D; The purpose of this study was a hygienic assessment of methods and results of accounting for emissions of pollutants from the ASHS of individual residential buildings when conducting summary calculations of atmospheric air pollution for settlements. &#x0D; Materials and methods. the original methodology of a phased survey of the city’s ASHS was used and the results of summary calculations of atmospheric air pollution in 18 cities conducted using this methodology are presented. Calculations of single, average seasonal (for the cold period) and average annual surface concentrations of pollutants were carried out in accordance with current regulatory documents using the unified software for calculating atmospheric pollution (UPRZA) “Ecologist-city”. In all the studied cities a significant number of sources of atmospheric air pollution was established to be ASHS. In more than 90% of these sources, coal and firewood were used as energy carriers. The greatest excess of hygienic standards of atmospheric air quality was noted &#x0D; for benz(a)pyrene. In 15 cities, the highest calculated maximum single surface concentration of at least one pollutant created by emissions from ASHS exceeded the maximum allowable single concentration (MACs). &#x0D; Limitations of the study are due to the fact that direct instrumental measurements to determine the characteristics of emissions from ASHS into the atmosphere are impossible. &#x0D; Conclusions. The area of the city’s territory where the estimated maximum single surface concentration of at least one pollutant exceeded the MACs, reached 45%, and the seasonal average concentration exceeded maximum allowable average annual concentration on 50% of the territory. The most effective measure to reduce air pollution by emissions from ASHS is the replacement of solid and liquid mineral fuels with natural gas. Unification of methods of accounting and inventory of ASHS as sources of atmospheric air pollution is required.

On the Association between Fine Dust Concentrations from Sand Dunes and Environmental Factors in the Taklimakan Desert

Dust in sand dunes is an effective and important source of dust emission. The Taklimakan Desert (TD) is one of the main sources of global dust: the sand dunes account for approximately 85% of the total area of the TD. However, the dust concentration, emission characteristics, and physical factors of different parts of the sand dunes in the TD during the day and night, as well as dust and non-dust days, remain unclear. In this study, dust observations were collected over a 3 month period in the TD to investigate the physical processes by which dust moves across a surface and generates PM10 and PM2.5 from the top and bottom of sand dunes. The results showed that the daily average maximum concentrations of particulate matter with diameters below 2.5 and 10 µm (PM2.5 and PM10) in the dune during the observation period reach ~90 and ~190 µg·m−3, respectively. Dust emission generated in the saltation process (maximum emission of PM10 was 3–5 mg·m−2·s−1) in the TD dunes was larger than that in other areas and had a good correlation with u* (friction velocity), where u* = 0.4 m·s−1 was the threshold of sand dune dust emission. The wind speed at the top of dunes was larger than that at the bottom, which was conducive to the accumulation of PM10 at the top of the dune. Furthermore, the MLH (mixed layer height) decreased after sunset and the turbulence weakens, which was conducive to the retention of dust in the air. Moreover, the dust made the solar radiation at the top of the dune −15 W·m−2 (average) lower than at the bottom. These results provided a new understanding of dune emissions in the TD and could be used for dust modeling in regional and global models.

Spatial and Temporal Distribution of Near-Surface Methane Concentration in Northwest China Based on GOSAT Satellite Data

Methane (CH4) is a common greenhouse gas that plays an important role in global warming and affects people’s production and life. In order to study the temporal and spatial distribution situation of methane concentration in northwest China (Shaanxi, Gansu, Ningxia, Xinjiang, Qinghai), this article used L4B level data products monitored by GOSAT satellite from 2009 to 2019 to study the temporal and spatial distribution characteristics of near-surface methane concentration in northwest China. The results of the analysis were as follows. Firstly, the annual average concentration of near-surface methane in northwest China was in a rising state, and the maximum annual average concentration increment was in 2016. Secondly, seasonal variation of methane concentration: Autumn>Summer>Spring>Winter. Finally, spatial variation of the annual average methane concentration: Shaanxi, Ningxia, and southern Gansu>northwest Xinjiang>other northwest China regions. The methane concentration decreased from the bottom to the top gradually.

Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.

Human amniotic and amniochorionic membranes (AM, ACM) represent the most often used grafts accelerating wound healing. Palmitoylethanolamide, oleoylethanolamide and anandamide are endogenous bioactive lipid molecules, generally referred as N-acylethanolamines. They express analgesic, nociceptive, neuroprotective and anti-inflammatory properties. We assessed the distribution of these lipid mediators in placental tissues, as they could participate on analgesic and wound healing effect of AM/ACM grafts. Seven placentas were collected after caesarean delivery and fresh samples of AM, ACM, placental disc, umbilical cord, umbilical serum and vernix caseosa, and decontaminated samples (antibiotic solution BASE 128) of AM and ACM have been prepared. Ultra-high-performance liquid chromatography-tandem mass spectrometry was used for N-acylethanolamines analysis. N-acylethanolamines were present in all studied tissues, palmitoylethanolamide being the most abundant and the anandamide the least. For palmitoylethanolamide the maximum average concentration was detected in AM (350.33 ± 239.26 ng/g), while oleoylethanolamide and anandamide were most abundant in placenta (219.08 ± 79.42 ng/g and 30.06 ± 7.77 ng/g, respectively). Low levels of N-acylethanolamines were found in serum and vernix. A significant increase in the levels of N-acylethanolamines (3.1-3.6-fold, P < 0.001) was observed in AM when the tissues were decontaminated using antibiotic solution. The increase in decontaminated ACM was not statistically significant. The presence of N-acylethanolamines, particularly palmitoylethanolamide in AM and ACM allows us to propose these lipid mediators as the likely factors responsible for the anti-hyperalgesic, but also anti-inflammatory and neuroprotective, effects of AM/ACM grafts in wound healing treatment. The increase of N-acylethanolamines levels in AM and ACM after tissue decontamination indicates that tissue processing is an important factor in maintaining the analgesic effect.

The effect of fine suspended particles in the atmospheric air on the formation and course of the T2 endotype of bronchial asthma: a case-control study

The aim of the study was to investigate the effect of fine suspended particles in the atmospheric air on the formation and course of allergic and non-allergic phenotypes of the T2 endotype of bronchial asthma (BA) using the case-control study. Materials and methods. BA patients were selected in the course of seeking medical help. The groups were formed on the base of matching criteria (gender, age, body mass index, level of education), supplemented by the collection of information about potential cofounders. Based on the data on monitoring the content of fine suspended particles in the atmospheric air of Kazan, the average annual and maximum concentrations of PM2.5 and PM10 fractions were determined in the residential areas. The group of “cases” included forty patients with an allergic phenotype and 42 patients with an eosinophilic non-allergic phenotype of bronchial asthma, the control group included forty eight people. Additionally, sampling of atmospheric air was carried out using an 8-stage impactor to assess the content of bacterial endotoxin, and elemental composition. Results. Higher levels of pollution with fine suspended particles were demonstrated in the areas of residence of BA patients, comparing to the control group. An increase in the average annual concentration of the PM2.5 by 10 µg/m3 increases the odds of the eosinophilic non-allergic BA phenotype in adults by 4.76 times. The odds of the allergic phenotype of bronchial asthma increases in the presence of bacterial endotoxin - 1.32 times per 0.01 EU/m3 of endotoxin in the 3.2-18 µm size fraction. A more severe course of the eosinophilic non-allergic BA phenotype was noted at higher average annual concentrations of the PM2.5. The control of allergic asthma depends on the bacterial contamination of the aerosol. Limitations of the study are related to the use of geospatial approach to assess personalized average annual and maximum annual concentrations. Conclusion. The role of fine suspended particles in the atmospheric air in the development of bronchial asthma in adults has been shown. Various mechanisms were established to be involved in the formation of the clinical picture of the eosinophilic non-allergic and allergic phenotypes of bronchial asthma.