Average Mass Research Articles

Polyhydroxybutyrate (PHB)-Based sustainable bioplastic derived from Bacillus sp. KE4 isolated from kitchen waste effluent

Petrochemical-derived plastics pose a major threat to the biosphere and the environment due to their acute or long-term toxicity. Therefore, to ensure sustainability, it is essential to find an effective replacement for synthetic plastics with natural and ecofriendly biomaterial. In this context, production of polyhydroxybutyrate (PHB) was produced by the Bacillus sp. KE4 using glucose as the carbon source, and a maximum dry cell weight (DCW) of 4.4 g/l with a PHB concentration of 3.1 g/l, PHB yield of 0.15 g/g was obtained, and the PHB content was 70.4% of the DCW. The extracted biopolymer was characterized using FTIR, GC-MS, 1H NMR, and 13C NMR which confirmed the structure of the biopolymer as PHB. The findings of TGA, DTG, DTA and DSC studies corresponded to PHB's excellent thermal stability. PHB biopolymer has a melting temperature of 168.7 °C and a maximum degradation temperature of 273 °C. The weight average molar mass (Mw), number average molar mass (Mn), and polydispersity index (PDI) of the extracted PHB was 1,55,436 g mol−1; 1,43,258 g mol−1; and 1.08, respectively. The XRD analysis validated the material's partly crystalline nature. FESEM-EDS and XPS were employed to determine the elemental composition of the purified PHB film. The Young's modulus, tensile strength and elongation at break showed rigid and brittle nature of PHB. Using open windrow composting method, the extracted PHB biopolymer film was assessed to determine its biodegradability. Within 28 days of soil burial, it was found that the biopolymer film had degraded by 61.34%. Cytotoxicity assessment in HepG2 cells indicated that PHB is non-cytotoxic in nature. The results have showed that the biomaterial is environmentally benign, biodegradable, and biocompatible; therefore, it may find its diverse application covering packaging, medicine, agriculture and allied fields.

Effects of polyoxymethylene dimethyl ethers (PODEn) on soot characteristics in isooctane inverse diffusion flames

Polyoxymethylene dimethyl ethers (PODEn, n = 1–3) such as dimethoxymethane (DMM) and PODE3 are considered highly promising alternative fuels due to their lack of C–C bonds and significant oxygen contents. Particularly, PODE3-blends with diesel have been proven to substantially reduce soot emissions and fuel consumption rates under optimized engine conditions, although the impact on soot nanostructure properties remains unclear. This study explored the effects of DMM and PODE3 on soot characteristics in isooctane (i-octane) inverse diffusion flames, focusing on soot morphology, soot nanostructure, soot nanocrystallite, and soot spectral features. To compare soot particles behavior, DMM and PODE3 blended as the isooctane substitute (by 20% and 40% volumetric fractions) were examined with various diagnostic techniques, including high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS).The results showed that DMM and PODE3 contributed to a reduction in sooting tendency from i-octane flames, whereas the average soot mass decreased significantly as the PODE3 ratio increased, consistent with a higher oxygen concentration. Therefore, 20% PODE3/i-octane exhibited growing disorganized arrangements of soot particles with shorter fringes, smaller crystallite sizes, and a relatively lower degree of graphitization than 20% and 40% DMM additions. However, XPS analysis indicated that soot produced from PODE3/i-octane mixtures had less oxygen atoms because PODE3 has multiple –CH2O- chain groups that can convert oxygen into carbon monoxide with little soot production. Moreover, HRTEM, XRD, and Raman spectra analyses of 40% PODE3-doped flames confirmed an exceptional correlation with turbostratic soot structure, as manifested by the shortest fringe length, longest fringe tortuosity, more amorphous soot with the smallest crystallite dimensions, and least degree of graphitization.

The environmental conditions of endemism hotspots shape the functional traits of mammalian assemblages.

Endemic (small-ranged) species are distributed non-randomly across the globe. Regions of high topography and stable climates have higher endemism than flat, climatically unstable regions. However, it is unclear how these environmental conditions interact with and filter mammalian traits. Here, we characterize the functional traits of highly endemic mammalian assemblages in multiple ways, testing the hypothesis that these assemblages are trait-filtered (less functionally diverse) and dominated by species with traits associated with small range sizes. Compiling trait data for more than 5000 mammal species, we calculated assemblage means and multidimensional functional metrics to evaluate the distribution of traits across each assemblage. We then related these metrics to the endemism of global World Wildlife Fund ecoregions using linear models and phylogenetic fourth-corner regression. Highly endemic mammalian assemblages had small average body masses, low fecundity, short lifespans and specialized habitats. These traits relate to the stable climate and rough topography of endemism hotspots and to mammals' ability to expand their ranges, suggesting that the environmental conditions of endemism hotspots allowed their survival. Furthermore, species living in endemism hotspots clustered near the edges of their communities' functional spaces, indicating that abiotic trait filtering and biotic interactions act in tandem to shape these communities.

Computation of natural convection heat transfer from an infrared suppression device (IRS) with multiple louvered cylindrical funnels

The current computational work investigates the buoyancy-driven flow and heat transfer in and around an Infrared suppression device (IRS) with perforated cylindrical funnels. It reports the effects of three critical parameters: the louver size ( 0.025 ≤ d / D ≤ 0.2 ) , diameter ratio of the funnel ( 1.02 ≤ DR ≤ 1.3 ) , and Rayleigh number ( 10 10 ≤ Ra ≤ 10 12 ) on the heat transfer rate, mass suction rate, thermal plume, and velocity vectors. It also proposes suitable correlations for the average Nusselt number and mass suction rate, having an accuracy of 5%, and 6%, respectively. The study’s outcomes show that the heat transfer rate increases with the louver size, only up to a particular value of diameter ratio, beyond which it reduces. However, the heat transfer rate with a louvered funnel is more than the plane funnels, except when DR =1.15 and 1.2 and d/D = 0.2 (approximately). The work also reports the temperature versus time curve for the IRS.

Association Between a National Behavioral Weight Management Program and Veterans Affairs Health Expenditures.

The association between participation in a behavioral weight intervention and health expenditures has not been well characterized. We compared Veterans Affairs (VA) expenditures of individuals participating in MOVE!, a VA behavioral weight loss program, and matched comparators 2 years before and 2 years after MOVE! initiation. Retrospective cohort study of Veterans who had one or more MOVE! visits in 2008-2017 who were matched contemporaneously to up to 3 comparators with overweight or obesity through sequential stratification on an array of patient characteristics, including sex. Baseline patient characteristics were compared between the two cohorts through standardized mean differences. VA expenditures in the 2 years before MOVE! initiation and 2 years after initiation were modeled using generalized estimating equations with a log link and distribution with variance proportional to the standard deviation (gamma). MOVE! participants (n=499,696) and comparators (n=1,336,172) were well-matched, with an average age of 56, average body mass index of 35, and similar total VA expenditures in the fiscal year before MOVE! initiation ($9662 for MOVE! participants and $10,072 for comparators, standardized mean difference=-0.019). MOVE! participants had total expenditures that were statistically lower than matched comparators in the 6 months after initiation but modestly higher in the 6 months to 2 years after initiation, though differences were small in magnitude (1.0%-1.6% differences). The VA's system-wide behavioral weight intervention did not realize meaningful short-term health care cost savings for participants.

Are New Campus Mobility Trends Causing Health Concerns?

An influx of new mobility trends such as fare-free bus transportation, ride hail, and e-scooter services to improve access and affordability of transportation on campus may be shifting the travel behavior of campus patrons such that it affects their long-term health outcomes. The main research questions explored in this study are as follows: (1) why university patrons choose new modes of travel?; (2) what existing mode did the new modes of travel replace for the riders?; and (3) is the average body mass index (BMI) of users primarily using non-motorized transit options lower than those using motorized or both (referred to as hybrid) for on-campus travel needs? An online survey was administered to a campus community (n = 3309) including students (48%), faculty (15%), and staff (37%) in fall of 2018 when fare-free bus transportation and e-scooters became available on campus, and a gradual increase in ridership of ride-hail services was simultaneously observed. This study found that campus patrons were more inclined to replace active modes of travel with affordable and accessible modes of transportation, thereby substituting their walking or biking routine with app-based transportation services. The mean BMI among travelers who chose motorized transportation modes was more than active travelers, and the BMI was statistically significantly associated with age, gender, race, class standing (undergraduate/graduate), and residence on/off campus. This study concludes with suggestions to prevent substitution of active with non-active transport choices and provides policy guidelines to increase awareness on achieving physical activity levels through active modes of travel for university patrons.

A Comparison between Attitudes and Knowledge Towards Fast-Food and Probiotics of Undergraduates

Consumption of fast-food is increasing rapidly, whereas fast-food does not provide enough nutrients. Probiotics contribute to optimal nutrition and health benefits. This study aims to evaluate the consumption frequency, habits, and knowledge regarding fast-food and probiotics among undergraduates. We used a face-to-face interview method to obtain the data from 405 undergraduates aged 18-24 studying in Konya, Turkey. There were 46.9% of males and 53.1% of females, with an average Body Mass Index (BMI) of 22.3±0.168 kg/m2. A difference was detected in BMI according to gender (p 0.000). There were 84% of the students consuming at least one fast food a day, and 58.5% consumed probiotics daily. Statistically, there was no significance between the frequency of fast-food (p 0.456) and probiotic (p 0.680) consumption for BMI. The fast-food knowledge scores differ according to BMI (p 0.004). Probiotic knowledge scores of the overweight and obese group were lower than the other groups. A negative correlation between fast-food knowledge and BMI was (R2 - 0.011). A positive correlation between probiotic knowledge and BMI was (R2 0.034). Undergraduates consumed fast-food at high frequency, and they also know about probiotics. Nevertheless, the level of knowledge about both fast food and probiotics should be increased.

Sequence analysis and secondary structure prediction of autosomal STR alleles using next generation sequencing (NGS) data

The inception of NGS technology in forensic DNA analysis explores the sequence-based alleles in STR markers. This allows the in-depth analysis of observed STR allelic sequences to understand their nature, stability, inheritance, and possible generation of artifacts during their analysis. In the current study, 100 allelic sequences at 20 STR markers generated using the NGS technique were analyzed for their sequence topographies and prediction of secondary structures. The G + C content of the alleles observed in 20 STR markers used in this study varied from 58.65 ± 1.367% (D2S1338) to 7.62 ± 0.844% (D12ATA63). The average exact mass of one stand and for the opposite stand mass was found to be highest in FGA (25,963.248 ± 1623.271; 27,501.720 ± 1712.691), whereas, D4S2408 generated the lowest exact mass of one stand and for the opposite stand mass (11,136.354 ± 1521.757; 11,582.021 ± 1585.486). As expected, none of the STR markers showed the presence of open reading frames, Codons, and CRISPR sequences. Three STR markers viz. D2S1338, TH01, and D5S2800 showed the presence of restriction sites for Cac8I, TspGWI, TspDTI, AccI, and Hpy8I enzymes. Phylogenetic analysis reveals the close association of alleles between the D12ATA63 and D19S433 markers. Stable pseudoknots were predicted at alleles of D2S1338 showing an average energy of −0.76 with the highest number of nucleotides present in the pseudoknots i.e., 21.33, suggesting this marker is more prone to generate amplification artifacts.

Chemical composition, sources and formation mechanism of urban PM2.5 in Southwest China: a case study at the beginning of 2023

Abstract. Despite significant improvements in air quality in recent years, the Sichuan Basin (SCB) is still facing frequent haze pollution in winter, and the causes of severe haze formation have not yet been fully investigated. In this study, the chemical components of PM2.5 (i.e., particulate matter with an aerodynamic diameter of less than 2.5 µm) in a typical pollution period at the beginning of 2023 in Chengdu, a megacity in the SCB, were characterized by bulk-chemical and single-particle analysis, and the PM2.5 sources and formation mechanism of pollution were analyzed. The average mass concentration of PM2.5 during the study period was 95.6 ± 28.7 µg m−3. Organic matter (OM) was the most abundant component (35.3 %), followed by nitrate (22.0 %), sulfate (9.2 %) and ammonium (7.8 %). The individual aerosol particles were classified into five categories, i.e., mineral, OM, secondary inorganic aerosol (SIA), soot and fly ash/metal particles, and most of them were in the state of being internally mixed. The entire observation period could be divided into two non-pollution periods (NP-1 and NP-2) and two haze periods (Haze-1 and Haze-2). With the evolution of pollution, the bulk-chemical and single-particle analysis exhibited similar characteristics, suggesting that Haze-1 was mainly caused by pollutants related to fossil fuel combustion, especially local mobile sources, while Haze-2 was triggered by the rapidly increasing secondary pollutants, which mainly came from regional transmission. The PM2.5 sources included dust (8.5 %), biomass burning (3.5 %), coal combustion (15.4 %), industrial processes (6.5 %), vehicular emissions (25.6 %) and secondary sources (40.5 %). Analysis of Weather Research and Forecasting model with Chemistry (WRF-Chem) model results showed that the average contributions of local sources and regional transmission to pollution in Chengdu were the same (50 % vs. 50 %). In addition, the source composition and WRF-Chem simulation results in different periods confirmed our analysis of the formation mechanisms of the two haze events. This study confirms that further significant reductions in PM2.5 in Chengdu are still needed, and more effective policies for local emission reduction or joint prevention and control of regional air pollution will be necessary in the future.

Consumption of red and processed meat during early pregnancy and risk of gestational diabetes: a prospective birth cohort study

To investigate the association of red and processed meat intake with the risk of gestational diabetes (GDM) in Iranian mothers. A total of 635 pregnant mothers were included. Dietary intake was assessed by a 90-item food frequency questionnaire during the first trimester of pregnancy. Intakes of total red meat, unprocessed red meat, and processed meat were calculated and then, Cox proportional hazard model was used to calculate the hazard ratios (HR) and 95%CIs of GDM across tertiles of red meat intake while controlling for age, occupation, pre-pregnancy body mass index, physical activities, history of cardiovascular disease, hypertension, hypothyroidism, hyperthyroidism, and pregnancy hypertension, order of pregnancy, nausea during current pregnancy, multivitamin use during current pregnancy, weight gain during current pregnancy and total energy intake. The average age of the mothers was 28.80 ± 5.09 years, the average pre-pregnancy body mass index was 25.13 ± 4.43 kg/m2, and the average weight gain during pregnancy was 13.50 ± 5.03 kg. The multivariable-adjusted HRs of GDM for the third tertiles of red and processed meat, red meat, and processed meat intake were, respectively, 1.92 (95% CI 1.06, 3.49), 1.52 (95% CI 0.85, 2.72) and 1.31 (95% CI 0.73, 2.34) when compared to the first tertiles. Our prospective cohort study suggested that there was a positive association between the consumption of red and processed meat and with risk of GDM in a small sample of Iranian mothers with low red meat intake. More large-scale cohort studies in the Iranian population are needed to present more robust evidence in this regard.

Pain Catastrophizing and Impact on Pelvic Floor Surgery Experience

ABSTRACT Duration, intensity, and management of pain and discomfort may all be affected by experience, personality, and medical and psychosocial comorbidities. A negative cognitive-affective response to actual or anticipated pain, which impacts the pain experience, is called pain catastrophizing. The scale utilized for identifying individuals who magnify, feel helpless to manage, anticipate, or ruminate on pain is known as the Pain Catastrophizing Scale (PCS) and is composed of a 13-question validated measure and 3 subscales. The scale's score ranges from 0 to 52, where scores of 30 and greater indicate pain catastrophizing (30 points is the 75th percentile for PCS score distribution in patients with chronic pain). Pain catastrophizing is associated with increased pain severity, pain persistence, and opioid consumption following surgery, as well as poorer response to endometriosis treatments. Approximately 300,000 prolapse surgical procedures are performed in the United States annually, and because little is known about pain catastrophizing on perioperative pain, pelvic floor symptom distress/impact, and voiding trial (VT) performance following urogynecologic surgery, the authors' primary aim was to assess baseline pain catastrophizing on preoperative pelvic floor symptom impact and distress. The secondary aims included assessing the impact of pain catastrophizing on voiding function and postoperative pain following pelvic floor surgery. The patients for this prospective cohort study included self-identifying female patients undergoing surgery for stress urinary incontinence (SUI) and/or pelvic organ prolapse from March 2020 to December 2021. Inclusion came following completion of appropriate surveys and subsequent surgery. Exclusion was merited through surgery for reasons besides SUI or prolapse. At the baseline patient visit, a PCS score of 30 or greater was defined as pain catastrophizing. The initial visit also included recording data such as body mass index, age, benzodiazepine use, chronic opioid use, anxiety and depression diagnoses, postoperative prolapse stage, bothersome urgency urinary incontinence, and preoperative postvoid residual volume. Charts were used for abstracting surgical data, such as operative time, estimated blood loss, type of pelvic reconstructive surgery performed, and midurethral sling placement. Surgeries were all performed by fellowship-trained reconstructive pelvic surgery providers. Postanesthesia care unit (PACU) nurses and clinic staff were masked to preoperative PCS scores obtained in the PACU and postoperative clinic visits. A standardized void trial was performed. Of 320 participants in this cohort, 46 had a pain catastrophizing score of ≥30. Mean age was 60.0 ± 12.8 years. Bivariate analysis indicated that the pain catastrophizing group had higher average body mass index and greater preoperative use of benzodiazepines. Variants such as SUI rates, urgency urinary incontinence, or prolapse stage had no significant differences between groups, yet preoperative pelvic floor symptom distress and impact scores were clinically and statistically significantly higher in the catastrophizing group. Higher PACU pain scores were associated with pain catastrophizing, but not first postoperative VT failure. A significant association between pain catastrophizing and symptom distress remained following multivariable analysis, as well as a relationship between high PCS scores and symptom impact. All quality-of-life subscales maintained the significant associations. This study, although unique in describing pain catastrophizing in this setting, includes various limitations such as its single-institutional nature, which may limit external generalizability. Furthermore, generalizability may also be limited for those electing nonsurgical management, as the study selected for women choosing surgery. Study strengths include its large number of patients cared for by fellowship-trained providers in a similar manner with uniform surgical practice and timing of measures for assessing pelvic pain and pelvic floor symptoms. Also, a relatively standard VT method was utilized. Although further investigation is warranted for describing pain catastrophizing and its role with pelvic floor symptoms and pain postoperatively, the results of this study support other investigative findings, which indicate the importance of understanding pain catastrophizing and its potential effect on patients undergoing pelvic floor surgery. Future studies around this relationship can potentially enable health care providers to tailor perioperative care for individuals with pain catastrophizing.

Changes in Somatic Indicators, Body Posture and Health-Oriented Fitness among Younger School-Age Female Pupils

Background and Aim of Study: Currently, we are observing a worsening trend in the field of health-oriented fitness and postural health of the school population. The aim of the research was to compare and expand knowledge in the areas of monitoring somatic changes, indicators of health-oriented fitness, motor performance, and body posture among 10-year-old female school populations. Material and Methods: The sample consisted of ????n=292 female pupils, with n=150 from 2012 and n=142 from 2022 at the elementary school in Žilina (ZA), Slovakia. An ex post facto study was applied. Standardized methods of measurement and testing applicable for school practice were used to obtain data. Differences between groups of female pupils were examined using the Kruskal-Wallis H-test and the Mann-Whitney U-test. To determine the effect size and measure the difference in average values, Cohen's d and r were used. The differences found were evaluated at the (p<0.05) level of statistical significance. Results: When comparing the average body weight of female pupils from ZA in 2012 and 2022, we found a significant difference (p<0.05) (H=4.87, p=0.02733) in favor of female pupils from 2012. The same finding in favor of female pupils from 2012 was recorded when comparing the average body mass index (BMI) (H=4.8182, p=0.02816), as well as in evaluating the average health-oriented fitness using the Ruffier test (H=13.1965, p=0.00028). The Beep test was also used to evaluate the endurance abilities of female pupils, where current ZA female pupils in 2022 showed significantly worse results (H=5.752, p=0.01647). Similarly, we also observed significant (p<0.05) worse findings in overall body posture among female pupils from ZA in 2022. Conclusion: On the basis of our findings, we consider the current state of body weight, posture, health-oriented physical fitness and endurance skills in younger school-aged girls to be unsatisfactory and health-threatening. It is necessary to further deal with the stated facts and look for preventive measures. These findings indicate a declining and deteriorating trend in health-oriented fitness in relation to body weight, body posture, and endurance abilities.

Effect of rearing density on female investment in reproduction and melanotic encapsulation response in the sand cricket (Gryllus firmus) (Orthoptera: Gryllidae)

Abstract The density-dependent prophylaxis hypothesis posits that because pathogens are expected to be transmitted among conspecifics in crowded conditions, individuals living in such conditions should minimize their chance of infection and maximize survival by elevating their baseline immunity. Further, if individuals developing in crowded conditions indeed allocate more resources to immunity then resource allocation to other life-history traits, such as reproduction, should decline. We tested these hypotheses by rearing sand crickets (Gryllus firmus) at either low or high density in the laboratory and quantified immune function (melanotic encapsulation response) and reproductive investment (ovary mass, egg size) at adulthood. The results did not support the density-dependent prophylaxis hypothesis, but we did find that rearing density significantly affected investment in two reproductive traits, with average ovary mass and egg size both being larger in low-density crickets. We discuss possible explanations for the lack of a trade-off between immunity and reproduction in our study.

Stellar populations and the origin of thick disks in AURIGA simulations

Context. Recent integral-field spectroscopy observations of edge-on galaxies have led to significant progress in our knowledge of the ages and chemical compositions of thick disks. However, the origin of thick disks and their evolutionary connection with thin disks is still a matter of debate. Aims. We provide new insights into this topic by connecting the stellar populations of thick disks at redshift z = 0 with their past formation and growth in 24 Milky Way-mass galaxies from the AURIGA zoom-in cosmological simulations. We assess the role played by mergers of satellite galaxies in the mass assembly of geometrically defined thick disks. Methods. We projected each galaxy edge on and decomposed it morphologically into two disk components in order to geometrically define the thin and thick disks, as is usually done in observations of external galaxies. We produced age, metallicity, and [Mg/Fe] edge-on maps of the 24 galaxies. We quantified the impact of satellite mergers by mapping the distribution of ex situ stars. Results. Thick disks are on average ∼3 Gyr older, ∼0.25 dex more metal poor, and ∼0.06 dex more [Mg/Fe]-enhanced than thin disks. Their average ages range from ∼6 to ∼9 Gyr, metallicities from ∼ − 0.15 to ∼0.1 dex, and [Mg/Fe] from ∼0.12 to ∼0.16 dex. These properties are the result of an early initial in situ formation, followed by a later growth driven by the combination of direct accretion of stars, some in situ star formation fueled by mergers, and dynamical heating of stars. The balance between these processes varies from galaxy to galaxy and impacts thick-disk ages and metallicities. The oldest thick disks (older than 8 Gyr) are hosted by galaxies with a low mass fraction of accreted stars (below 8%), while the youngest thick disks (younger than 7 Gyr) are found in galaxies with higher accreted fractions (larger than 25%). Mergers play a key role in the mass assembly of thick disks, contributing an average accreted mass fraction of ∼22% in the analyzed thick-disk-dominated regions. In two galaxies, about half of the geometric thick-disk mass was directly accreted. The mass fraction of accreted stars is lower than 10% only in four thick disks. While primordial thick disks form at high redshifts in all galaxies, young metal-rich thin disks, with much lower [Mg/Fe] abundances, start to form later but at different times (at higher or lower redshifts) depending on the galaxy. Conclusions. We conclude that thick disks, although mostly formed in situ, grow thanks to the significant contribution of satellite mergers, especially through the direct accretion of stars. They result from the interplay of external processes with the internal evolution of the galaxy.

Biodrying of municipal solid waste-correlations between moisture content, organic content, and end of the biodrying process time.

Biodrying refers to the decomposition of organic municipal solid waste (MSW) under aerobic conditions. This process usually lasts 14days and requires large amounts of air to be injected into the waste matrix. The efficiency of the biodrying process depends on several geotechnical parameters, including initial moisture content, initial organic content, bulk density, dry density, solid particle density, and porosity. To examine the potential influence of these parameters on the biodrying process, we analyzed 13 biodried MSW samples. The results revealed a strong positive linear relationship between the initial moisture content and the mass loss percentage. In the first three days of the biodrying process, the waste mass rapidly decreased; afterwards, the daily mass loss occurred at a less rapid, more constant rate. The established average mass removal ratio between the volatile solids and water was 1:6.38 with a standard deviation of 1.06. Dry and solid particle densities were preserved in all 13 experiments; thus, the corresponding void ratio remained unchanged. This finding suggests that the settlement and degradation of MSW that occur during the biodrying process did not significantly influence the airflow rate.

Changes in indicators of local and systemic inflammation in patients with uncomplicated diverticular disease in combination with obesity

Changes in indicators of local and systemic inflammation in patients with uncomplicated diverticular disease in combination with obesity

Clinical and Operative Risk Factors Associated With Prolonged Length of Stay After Endoscopic Pituitary Adenoma Resection.

Pituitary adenomas (PAs) are the most common intrasellar tumor. Clinically relevant adenomas have a prevalence of 1 per 1000 in the general population. Transsphenoidal surgery (TSS) is the most common surgical treatment and is the first-line management for most PAs. Most patients fare well postoperatively, but a subset of patients experience a prolonged length of stay (PLOS). In this article, we aim to identify demographic and clinical factors associated with PLOS after TSS for PA. Patients with sellar pathologies surgically treated at a single tertiary center from March 1, 2009, to May 31, 2020, were retrospectively reviewed. All patients older than 18 years receiving nonemergent endoscopic TSS for pituitary adenoma were included. Clinical and demographic characteristics were analyzed using χ2-tests and student t-tests. For those factors with a P-value less than .01, multivariate logistic regression and negative binomial regression models were constructed to estimate the adjusted odds of PLOS across predictive factors. A total of 301 patients were included in the study. This cohort had an average age of 54.65 ± 15.06 years and an average body mass index of 29.47 ± 6.69. The median length of stay was 54.9 hours [25th-75th percentiles: 43.5-72.9]. Postoperative cerebrospinal fluid leak (P < .01), postoperative diabetes insipidus (DI) (P < .01), increased surgery duration (P = .01), and elevated maximal tumor dimension (P = .01) were predictive of PLOS in logistic regression. Increased surgery duration, previous pituitary radiation, intraoperative complications, and postoperative DI (all P < .01) were associated with increased rate of PLOS in negative binomial regression. Patients undergoing endoscopic TSS for PA resection demonstrate prolonged lengths of stay if they have higher tumor burden, have lengthier surgeries with intraoperative complications, or develop postoperative complications such as cerebrospinal fluid leak or DI. Careful monitoring of these factors will allow for better resource optimization, reducing costs to both the hospital and the patient.

Design and investigation of novel gradient flow fields for proton exchange membrane fuel cell

Ensuring sufficient gas supply and high distribution uniformity are crucial issues in the flow field design to improve the performance and durability of proton exchange membrane fuel cell (PEMFC). However, previous studies often ignore the gas-water distribution variations along the flow direction and adopt identical design for the entire flow field, resulting in unsatisfactory performance. To fill in this gap, this paper innovatively proposes two types of gradient flow field (gradient narrowing and gradient droplet) considering the gas-water distribution characteristics. The channel of the gradient narrowing flow field gradually decreases in all directions along the flow direction, and the gradient droplet flow field is composed of staggered droplet blocks, and the distribution density gradually decreases along the flow direction. The Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method is used for the comprehensive evaluation of flow fields. The results demonstrate that the gradient flow field can significantly improve the performance and physical field distribution. The gradient narrowing flow field has the best performance, with 11.39 % improvement in peak power density, 77.96 % increment in average oxygen mass fraction, and 43.11 % improvement in oxygen uniformity compared to parallel flow field. Further, the key geometric parameters sensitivity analysis of gradient narrowing flow field is carried out. This study contributes to understanding the underlying mechanism of mass transfer properties in the novel gradient flow field, and exploring its potential for high-performance flow fields design.

Intraoperative mechanical power and postoperative pulmonary complications in low-risk surgical patients: a prospective observational cohort study

BackgroundInadequate intraoperative mechanical ventilation (MV) can lead to ventilator-induced lung injury and increased risk for postoperative pulmonary complications (PPCs). Mechanical power (MP) was shown to be a valuable indicator for MV outcomes in critical care patients. The aim of this study is to assess the association between intraoperative MP in low-risk surgical patients undergoing general anesthesia and PPCs.MethodsTwo-hundred eighteen low-risk surgical patients undergoing general anesthesia for elective surgery were included in the study. Intraoperative mechanical ventilatory support parameters were collected for all patients. Postoperatively, patients were followed throughout their hospital stay and up to seven days post discharge for the occurrence of any PPCs.ResultsOut of 218 patients, 35% exhibited PPCs. The average body mass index, tidal volume per ideal body weight, peak inspiratory pressure, and MP were significantly higher in the patients with PPCs than in the patients without PPCs (30.3 ± 8.1 kg/m2 vs. 26.8 ± 4.9 kg.m2, p < 0.001; 9.1 ± 1.9 ml/kg vs. 8.6 ± 1.4 ml/kg, p = 0.02; 20 ± 4.9 cmH2O vs. 18 ± 3.7 cmH2O, p = 0.001; 12.9 ± 4.5 J/min vs. 11.1 ± 3.7 J/min, p = 0.002). A multivariable regression analysis revealed MP as the sole significant predictor for the risk of postoperative pulmonary complications [OR 1.1 (95% CI 1.0–1.2, p = 0.036].ConclusionsHigh intraoperative mechanical power is a risk factor for developing postoperative pulmonary complications. Furthermore, intraoperative mechanical power is superior to other traditional mechanical ventilation variables in identifying surgical patients who are at risk for developing postoperative pulmonary complications.Clinical trial registration NCT03551899; 24/02/2017.

Assessing factors that increase dusky gopher frog larval performance in open‐canopy wetlands

AbstractAmphibians are declining worldwide, and research on their habitats and ecology is important for their conservation. The endangered dusky gopher frog (Rana sevosa) breeds exclusively in isolated, open canopy wetlands, usually with extensive herbaceous growth. Larvae of the dusky gopher frog have higher growth and survival under open canopy than under closed canopy conditions. The mechanisms whereby this occurs are poorly understood, however. In the summer of 2021 in Harrison County, Mississippi, USA, we conducted a complete factorial experiment in mesocosms to compare the relative influence of factors differing between open and closed canopy ponds on larvae. A heat and light treatment consisted of one third of tanks being exposed to full sunlight, one third of tanks being shaded with 70% shadecloth, and the final third being shaded with 70% shadecloth but heated to mimic the temperature of the full sun tanks. In addition, tanks received a closed canopy tree leaf litter mixture or an open canopy herbaceous vegetation mixture, and vertical vegetation‐like structure made of polypropylene rope or not. Cool shaded tanks and heated shaded tanks had identical survival to metamorphosis at 74.7% and produced frogs with an average mass of 2.21 g and 2.09 g, respectively, while tanks in full sunlight achieved significantly higher 93.4% survival to metamorphosis and an average mass of 2.64 g. The open canopy vegetation mixture yielded an average tank survival of 88.3% and mass of 2.94 g, compared to closed canopy vegetation tanks with a significantly lower survival of 73.5% and average mass of 1.61 g. Added structure had no effect on survival or mass. These results indicate that sunlight (not heat alone) and herbaceous plants are important in increasing dusky gopher frog survival and mass in open canopy conditions and suggest that management for these characteristics receive priority in captive‐rearing programs and habitat restoration.