The world's first full-scale, 280 nm UV LED reactor for wastewater disinfection was tested at flows of 545 and 817 m3 day−1. The system achieved a >3 average log reduction of total coliform at 545 m3 day−1 and the 817 m3 day−1 flow rate achieved over a >2.5 average log reduction for all operational conditions. The delivered fluence of the full-scale system ranged from 28-148 mJ cm−2 and aligns with a UV auditing study that was conducted prior to the installation of the wastewater reactor. These results benchmark the performance that can be achieved by UV LED disinfection and further connect bench-scale disinfection results with full-scale performance. The approach established in this manuscript provides a novel tool for utilities when considering emerging UV disinfection technologies. In summary, this study establishes that UV LEDs are an effective wastewater disinfectant at-scale and are comparable to conventional low-pressure UV systems. This is the first instance where the efficacy of UV LEDs for municipal wastewater disinfection has been demonstrated using a large-scale installation at a functioning wastewater facility.