In the wake of climate change and prevailing food insecurity, there has been increased attention on crops that can withstand harsh climatic conditions and have the potential to sustain livelihoods. Sorghum (<i>Sorghum bicolor)</i> is among the cereal crops with the potential to address these unprecedented challenges. It grows in arid and semi-arid regions characterized by unpredictable weather patterns, rising poverty levels, and food insecurity. In Kenya, sorghum ranks third in terms of production and importance. Nevertheless, there is prevailing food insecurity in Makueni County, where sorghum thrives well. Hence, the purpose of this study was to assess the role of sorghum in enhancing food security among smallholder farmers by establishing the potential factors influencing sorghum production and income from sorghum. A multistage sampling method was used to select a sample of 96 respondents. Data analysis involved the use of multiple linear regression model and gross margin analysis. The results indicated that experience, household size, and extension service influence sorghum production positively, while distance to all-weather roads and off-farm income have a negative effect. Gross margin results revealed sorghum is a profitable enterprise with an average net farm income of about 10,760 KES per acre. This suggests that sorghum production improves the income of sorghum-producing households and consequently enhances food security. The study, therefore, proposes strategies such as developing appropriate training facilities and strengthening extension services to boost sorghum production and thus promote food security among smallholder farmers. Furthermore, national and county governments should develop efficient road networks and provide incentives to sorghum producers to enhance access to services and markets, and foster specialization in sorghum enterprise.