Average False Positive Rate Research Articles

Automatic detection of epileptic seizure based on one dimensional cascaded convolutional autoencoder with adaptive window-thresholding

Objective. Identifying the seizure occurrence period (SOP) in extended EEG recordings is crucial for neurologists to diagnose seizures effectively. However, many existing computer-aided diagnosis systems for epileptic seizure detection (ESD) primarily focus on distinguishing between ictal and interictal states in EEG recordings. This focus has limited their application in clinical settings, as these systems typically rely on supervised learning approaches that require labeled data.Approach. To address this, our study introduces an unsupervised learning framework for ESD using a 1D- cascaded convolutional autoencoder (1D-CasCAE). In this approach, EEG recordings from selected patients in the CHB-MIT datasets are first segmented into 5 s epochs. Eight informative channels are chosen based on the correlation coefficient and Shannon entropy. The 1D-CasCAE is designed to autonomously learn the characteristic patterns of interictal (non-seizure) segments through downsampling and upsampling processes. The integration of adaptive thresholding and a moving window significantly enhances the model's robustness, enabling it to accurately identify ictal segments in long EEG recordings.Main results. Experimental results demonstrate that the proposed 1D-CasCAE effectively learns normal EEG signal patterns and efficiently detects anomalies (ictal segments) using reconstruction errors. When compared with other leading methods in anomaly detection, our model exhibits superior performance, as evidenced by its average Gmean, sensitivity, specificity, precision, and false positive rate scores of 98.00% ± 3.51%, 94.94% ± 6.92%, 99.60% ± 0.30%, 79.92% ± 13.56% and 0.0044 ± 0.0030 h-1respectively for a typical patient in CHB-MIT datasets.Significance. The developed model framework can be employed in clinical settings, replacing the manual inspection process of EEG signals by neurologists. Furthermore, the proposed automated system can adapt to each patient's SOP through the use of variable time windows for seizure detection.

Automated confidence estimation in deep learning auto-segmentation for brain organs at risk on MRI for radiotherapy.

We have built a novel AI-driven QA method called AutoConfidence (ACo), to estimate segmentation confidence on a per-voxel basis without gold standard segmentations, enabling robust, efficient review of automated segmentation (AS). We have demonstrated this method in brain OAR AS on MRI, using internal and external (third-party) AS models. Thirty-two retrospectives, MRI planned, glioma cases were randomly selected from a local clinical cohort for ACo training. A generator was trained adversarialy to produce internal autosegmentations (IAS) with a discriminator to estimate voxel-wise IAS uncertainty, given the input MRI. Confidence maps for each proposed segmentation were produced for operator use in AS editing and were compared with "difference to gold-standard" error maps. Nine cases were used for testing ACo performance on IAS and validation with two external deep learning segmentation model predictions [external model with low-quality AS (EM-LQ) and external model with high-quality AS (EM-HQ)]. Matthew's correlation coefficient (MCC), false-positive rate (FPR), false-negative rate (FNR), and visual assessment were used for evaluation. Edge removal and geometric distance corrections were applied to achieve more useful and clinically relevant confidence maps and performance metrics. ACo showed generally excellent performance on both internal and external segmentations, across all OARs (except lenses). MCC was higher on IAS and low-quality external segmentations (EM-LQ) than high-quality ones (EM-HQ). On IAS and EM-LQ, average MCC (excluding lenses) varied from 0.6 to 0.9, while average FPR and FNR were ≤0.13 and ≤0.21, respectively. For EM-HQ, average MCC varied from 0.4 to 0.8, while average FPR and FNR were ≤0.37 and ≤0.22, respectively. ACo was a reliable predictor of uncertainty and errors on AS generated both internally and externally, demonstrating its potential as an independent, reference-free QA tool, which could help operators deliver robust, efficient autosegmentation in the radiotherapy clinic.

Subcutaneous edema segmentation on abdominal CT using multi-class labels and iterative annotation.

Anasarca is a condition that results from organ dysfunctions, such as heart, kidney, or liver failure, characterized by the presence of edema throughout the body. The quantification of accumulated edema may have potential clinical benefits. This work focuses on accurately estimating the amount of edema non-invasively using abdominal CT scans, with minimal false positives. However, edema segmentation is challenging due to the complex appearance of edema and the lack of manually annotated volumes. We propose a weakly supervised approach for edema segmentation using initial edema labels from the current state-of-the-art method for edema segmentation (Intensity Prior), along with labels of surrounding tissues as anatomical priors. A multi-class 3D nnU-Net was employed as the segmentation network, and training was performed using an iterative annotation workflow. We evaluated segmentation accuracy on a test set of 25 patients with edema. The average Dice Similarity Coefficient of the proposed method was similar to Intensity Prior (61.5% vs. 61.7%; ). However, the proposed method reduced the average False Positive Rate significantly, from 1.8% to 1.1% ( ). Edema volumes computed using automated segmentation had a strong correlation with manual annotation ( ). Weakly supervised learning using 3D multi-class labels and iterative annotation is an efficient way to perform high-quality edema segmentation with minimal false positives. Automated edema segmentation can produce edema volume estimates that are highly correlated with manual annotation. The proposed approach is promising for clinical applications to monitor anasarca using estimated edema volumes.

A model-based brain switch via periodic motor imagery modulation for asynchronous brain-computer interfaces

Objective. Brain switches provide a tangible solution to asynchronized brain-computer interface, which decodes user intention without a pre-programmed structure. However, most brain switches based on electroencephalography signals have high false positive rates (FPRs), resulting in less practicality. This research aims to improve the operating mode and usability of the brain switch. Approach. Here, we propose a novel virtual physical model-based brain switch that leverages periodic active modulation. An optimization problem of minimizing the triggering time subject to a required FPR is formulated, numerical and analytical approximate solutions are obtained based on the model. Main results. Our motor imagery (MI)-based brain switch can reach 0.8FP/h FPR with a median triggering time of 58 s. We evaluated the proposed brain switch during online device control, and their average FPRs substantially outperformed the conventional brain switches in the literature. We further improved the proposed brain switch with the Common Spatial Pattern (CSP) and optimization method. An average FPR of 0.3 FPs/h was obtained for the MI-CSP-based brain switch, and the average triggering time improved to 21.6 s. Significance. This study provides a new approach that could significantly reduce the brain switch’s FPR to less than 1 Fps/h, which was less than 10% of the FPR (decreasing by more than a magnitude of order) by other endogenous methods, and the reaction time was comparable to the state-of-the-art approaches. This represents a significant advancement over the current non-invasive asynchronous BCI and will open widespread avenues for translating BCI towards clinical applications.

Automatic detection of pulmonary embolism on computed tomography pulmonary angiogram scan using a three-dimensional convolutional neural network

ObjectiveTo propose a convolutional neural network (EmbNet) for automatic pulmonary embolism detection on computed tomography pulmonary angiogram (CTPA) scans and to assess its diagnostic performance. Methods305 consecutive CTPA scans between January 2019 and December 2021 were enrolled in this study (142 for training, 163 for internal validation), and 250 CTPA scans from a public dataset were used for external validation. The framework comprised a preprocessing step to segment the pulmonary vessels and the EmbNet to detect emboli. Emboli were divided into three location-based subgroups for detailed evaluation: central arteries, lobar branches, and peripheral regions. Ground truth was established by three radiologists. ResultsThe EmbNet’s per-scan level sensitivity, specificity, positive predictive value (PPV), and negative predictive value were 90.9%, 75.4%, 48.4%, and 97.0% (internal validation) and 88.0%, 70.5%, 42.7%, and 95.9% (external validation). At the per-embolus level, the overall sensitivity and PPV of the EmbNet were 86.0% and 61.3% (internal validation), and 83.5% and 57.5% (external validation). The sensitivity and PPV of central emboli were 89.7% and 52.0% (internal validation), and 94.4% and 43.0% (external validation); of lobar emboli were 95.2% and 76.9% (internal validation), and 93.5% and 72.5% (external validation); and of peripheral emboli were 82.6% and 61.7% (internal validation), and 80.2% and 59.4% (external validation). The average false positive rate was 0.45 false emboli per scan (internal validation) and 0.69 false emboli per scan (external validation). ConclusionThe EmbNet provides high sensitivity across embolus locations, suggesting its potential utility for initial screening in clinical practice.

Set evolution based test data generation for killing stubborn mutants

Mutation testing is a fault-based and powerful software testing technique, but the large number of mutations can result in extremely high costs. To reduce the cost of mutation testing, researchers attempt to identify stubborn mutants and generate test data to kill them, in order to achieve the same testing effect. However, existing methods suffer from inaccurate identification of stubborn mutants and low productiveness in generating test data, which will seriously affect the effectiveness and efficiency of mutation testing. Therefore, we propose a new method of generating test data for killing stubborn mutants based on set evolution, namely TDGMSE. We first propose an integrated indicator to identify stubborn mutants. Then, we establish a constrained multi-objective model for generating test data of killing stubborn mutants. Finally, we develop a new genetic algorithm based on set evolution to solve the mathematical model. The results on 14 programs depict that the average false positive (or negative) rate of TDGMSE is decreased about 81.87% (or 32.34%); the success rate of TDGMSE is 99.22%; and the average number of iterations of TDGMSE is 16132.23, which is lowest of all methods. The research highlights several potential research directions for mutation testing.

A novel deep learning based CBIR model using Convolutional Siamese Neural Networks

Content-Based Image Retrieval (CBIR) is a technique that involves retrieving similar images from a large database by analysing the content features of the query image. The heavy usage of digital platforms and devices has in a way promoted CBIR and its allied technologies in computer vision and artificial intelligence. The process entails comparing the representative features of the query image with those of the images in the dataset to rank them for retrieval. Past research was centered around handcrafted feature descriptors based on traditional visual features. But with the advent of deep learning the traditional manual method of feature engineering gave way to automatic feature extraction. In this study, a cascaded network is utilised for CBIR. In the first stage, the model employs multi-modal features from variational autoencoders and super-pixelated image characteristics to narrow down the search space. In the subsequent stage, an end-to-end deep learning network known as a Convolutional Siamese Neural Network (CSNN) is used. The concept of pseudo-labeling is incorporated to categorise images according to their affinity and similarity with the query image. Using this pseudo-supervised learning approach, this network evaluates the similarity between a query image and available image samples. The Siamese network assigns a similarity score to each target image, and those that surpass a predefined threshold are ranked and retrieved. The suggested CBIR system undergoes testing on a widely recognized public dataset: the Oxford dataset and its performance is measured against cutting-edge image retrieval methods. The findings reveal substantial enhancements in retrieval performance in terms of several standard benchmarks such as average precision, average error rate, average false positive rate etc., providing strong support for utilising images from interconnected devices.

A Prostate Boundary Localization and Edge Denoising Algorithm

This research aimed at presenting a two-step method for prostate segmentation in TRUS images. The research used a prostate boundary localization and prostate edge denoising approach. The proposed method contribution is the use of the optimized Hodge’s method as the boundary operator and the use of the Bidirectional Exponential moving average to perform edge denoising. The results showed that the proposed method is effective in completing the prostate segmentation task. (1) The prostate region is effectively initialized and localized. (2) The recovery of noise points is accomplished and the segmentation result being consistent with the general shape of the prostate. The experimental results showed that this method can improve the overall segmentation accuracy. The process uses a combination of traditional and unsupervised methods, eliminating the need to rely on large data sets compared to current deep learning methods. The proposed method achieved excellent segmentation accuracy, with the Dice similarity coefficient (DICE) value of 0.9679, an average Intersection over Union (IoU) value of 0.9377, and an average False Positive Rate (FPR) of 0.0399. The results obtained from this study have significant implications for clinical practice. Accurate prostate segmentation is crucial for various applications, including radiation therapy planning, image-guided interventions, and computer-aided diagnosis. The proposed method has the potential to improve these applications by providing more precise and reliable prostate segmentations. However, it is important to acknowledge some limitations of this study. First, the proposed method was evaluated on a limited dataset, which may not fully represent the diversity of prostate images encountered in clinical practice. Further validation on larger datasets is necessary to assess its generalizability. Additionally, the proposed method relied on manual annotations for training, which can introduce inter-observer variability. Incorporating automated or semi-automated annotation techniques could enhance the robustness of the method

GBDT-IL: Incremental Learning of Gradient Boosting Decision Trees to Detect Botnets in Internet of Things.

The rapid development of the Internet of Things (IoT) has brought many conveniences to our daily life. However, it has also introduced various security risks that need to be addressed. The proliferation of IoT botnets is one of these risks. Most of researchers have had some success in IoT botnet detection using artificial intelligence (AI). However, they have not considered the impact of dynamic network data streams on the models in real-world environments. Over time, existing detection models struggle to cope with evolving botnets. To address this challenge, we propose an incremental learning approach based on Gradient Boosting Decision Trees (GBDT), called GBDT-IL, for detecting botnet traffic in IoT environments. It improves the robustness of the framework by adapting to dynamic IoT data using incremental learning. Additionally, it incorporates an enhanced Fisher Score feature selection algorithm, which enables the model to achieve a high accuracy even with a smaller set of optimal features, thereby reducing the system resources required for model training. To evaluate the effectiveness of our approach, we conducted experiments on the BoT-IoT, N-BaIoT, MedBIoT, and MQTTSet datasets. We compared our method with similar feature selection algorithms and existing concept drift detection algorithms. The experimental results demonstrated that our method achieved an average accuracy of 99.81% using only 25 features, outperforming similar feature selection algorithms. Furthermore, our method achieved an average accuracy of 96.88% in the presence of different types of drifting data, which is 2.98% higher than the best available concept drift detection algorithms, while maintaining a low average false positive rate of 3.02%.

Progressive Poisoned Data Isolation for Training-Time Backdoor Defense

Deep Neural Networks (DNN) are susceptible to backdoor attacks where malicious attackers manipulate the model's predictions via data poisoning. It is hence imperative to develop a strategy for training a clean model using a potentially poisoned dataset. Previous training-time defense mechanisms typically employ an one-time isolation process, often leading to suboptimal isolation outcomes. In this study, we present a novel and efficacious defense method, termed Progressive Isolation of Poisoned Data (PIPD), that progressively isolates poisoned data to enhance the isolation accuracy and mitigate the risk of benign samples being misclassified as poisoned ones. Once the poisoned portion of the dataset has been identified, we introduce a selective training process to train a clean model. Through the implementation of these techniques, we ensure that the trained model manifests a significantly diminished attack success rate against the poisoned data. Extensive experiments on multiple benchmark datasets and DNN models, assessed against nine state-of-the-art backdoor attacks, demonstrate the superior performance of our PIPD method for backdoor defense. For instance, our PIPD achieves an average True Positive Rate (TPR) of 99.95% and an average False Positive Rate (FPR) of 0.06% for diverse attacks over CIFAR-10 dataset, markedly surpassing the performance of state-of-the-art methods. The code is available at https://github.com/RorschachChen/PIPD.git.

A Wearable Asynchronous Brain-Computer Interface Based on EEG-EOG Signals With Fewer Channels.

Brain-computer interfaces (BCIs) have tremendous application potential in communication, mechatronic control and rehabilitation. However, existing BCI systems are bulky, expensive and require laborious preparation before use. This study proposes a practical and user-friendly BCI system without compromising performance. A hybrid asynchronous BCI system was developed based on an elaborately designed wearable electroencephalography (EEG) amplifier that is compact, easy to use and offers a high signal-to-noise ratio (SNR). The wearable BCI system can detect P300 signals by processing EEG signals from three channels and operates asynchronously by integrating blink detection. The wearable EEG amplifier obtains high quality EEG signals and introduces preprocessing capabilities to BCI systems. The wearable BCI system achieves an average accuracy of 94.03±4.65%, an average information transfer rate (ITR) of 31.42±7.39 bits/min and an average false-positive rate (FPR) of 1.78%. The experimental results demonstrate the feasibility and practicality of the developed wearable EEG amplifier and BCI system. Wearable asynchronous BCI systems with fewer channels are possible, indicating that BCI applications can be transferred from the laboratory to real-world scenarios.

Single-board device individual authentication based on hardware performance and autoencoder transformer models

The proliferation of the Internet of Things (IoT) has led to the emergence of crowdsensing applications, where a multitude of interconnected devices collaboratively collect and analyze data. Ensuring the authenticity and integrity of the data collected by these devices is crucial for reliable decision-making and maintaining trust in the system. Traditional authentication methods are often vulnerable to attacks or can be easily duplicated, posing challenges to securing crowdsensing applications. Besides, current solutions leveraging device behavior are mostly focused on device identification, which is a simpler task than authentication. To address these issues, an individual IoT device authentication framework based on hardware behavior fingerprinting and Transformer autoencoders is proposed in this work. To support the design, a threat model details the security problems faced when performing hardware-based authentication in IoT. This solution leverages the inherent imperfections and variations in IoT device hardware to differentiate between devices with identical specifications. By monitoring and analyzing the behavior of key hardware components, such as the CPU, GPU, RAM, and Storage on devices, unique fingerprints for each device are created. The performance samples are considered as time series data and used to train outlier detection transformer models, one per device and aiming to model its normal data distribution. Then, the framework is validated within a spectrum crowdsensing system leveraging Raspberry Pi devices. After a pool of experiments, the model from each device is able to individually authenticate it between the 45 devices employed for validation. An average True Positive Rate (TPR) of 0.74±0.13 and an average maximum False Positive Rate (FPR) of 0.06±0.09 demonstrate the effectiveness of this approach in enhancing authentication, security, and trust in crowdsensing applications.

Confident learning-based Gaussian mixture model for leakage detection in water distribution networks

Leakage detection in the water distribution system not only helps to reduce water waste but also decreases the risk of drinking water pollution. To reduce reliance on hardware devices and enable real-time detection, the water utilities are transitioning towards the data-driven based approach that relies on the analysis of the flow and pressure data collected from the supervisory control and data acquisition (SCADA) system. Due to the lack of leakage data, most of these methods are unsupervised methods that rely heavily on assumptions about the distribution of anomalies; whereas, the water utility's repair records contain much valid information about the leakage and normal characteristics. To convert this information into available labels and to address the lack of leakage data, this paper proposed a new leakage detection framework to infer the pressure characteristics under normal conditions based on historical data by combining a label cleaning method—confident learning (CL)—with an unsupervised method—Gaussian mixture model (GMM)—for leak detection. The methodology is validated with synthetic and real measured data. Comparisons with four unsupervised methods demonstrate that the GMM method has superior identification of leak features from pressure data. For a real-world water distribution system in K city containing 91 pressure sensors, the average true positive rate is 0.78 and the average false positive rate is 0.11. This methodology is a promising tool to identify signs of leakage in large-scale water distribution networks (WDNs).

Automated Detection, Segmentation, and Tracking of Brain Metastases in Repeated Courses of Stereotactic Radiosurgery Using Integrated Artificial Intelligence.

Salvage stereotactic radiosurgery (SRS) for distant brain metastases has been demonstrated as a safe and effective approach for intracranial recurrences after initial SRS. However, accurate tumor detection and segmentation among responding tumors within the irradiated parenchyma can be challenging. The requirement for the registration and reference to the previous course of SRS is very time-consuming and suffers significant inter and intra-reader variability. Artificial intelligence (AI)-assisted system has been proven to improve the accuracy and efficiency in the clinical flow of de-novo SRS. We hypothesize that an integrated AI system can facilitate an automated tumor contouring process for repeated SRS. Three patients who underwent their third course of SRS to brain metastases were selected for the pioneering works. They have had two sessions of SRS with a mean lesion number of 4 and 3.7, respectively. VBrain, an FDA-approved brain tumor management AI platform, was used to co-registered serial MR scans and automatically identify, track, and contour brain metastases for each course of SRS. The AI also indicated new lesions and treated lesions for each course. Three radiation oncologists experienced in brain SRS contoured the gross tumor volumes (GTVs) of the third course of SRS in two reader modes (assisted then unassisted) with a memory washout period of one week between each section. The segmentation ground truth was established through consensus among the three experts. Lesion-wise sensitivity, contouring accuracy, and consuming time were compared between the two contouring modes. In each patient, there were 15, 11, and 9 metastases, with a median diameter of 4.72 (95% CI: 4.05, 6.91) mm. The mean lesion-wise sensitivity was 96.96±2.47% with AI assistance and 76.90 ± 7.10% without assistance. There were two false-positive lesions in the assisted read, resulting in a low average false-positive rate of 0.67 per patient, while no false positive for the unassisted mode. AI assistance improved contouring accuracy. The median Dice similarity coefficient (DSC) was 0.71 (95% CI: 0.55, 0.87) for assisted contouring and 0.65 (95% CI: 0.46, 0.85) for unassisted contouring. We also use average Hausdorff distance (HD) to measure segmentation results. The mean HD was 0.72± 0.13 mm versus 0.73±0.08 mm for the two contouring modes (p = 0.02) Furthermore, the median contouring time per case was significantly shorter with AI assistance than without assistance (20.8 minutes vs. 29.8 minutes; p < 0.001), corresponding to a 43.2% time-saving. Our results suggest that the integration of an AI-based system into repeated brain SRS can significantly improve the accuracy and efficiency of tumor detection and segmentation. This approach has the potential to streamline the treatment planning process for salvage SRS.

Deep learning for automated detection of generalized paroxysmal fast activity in Lennox–Gastaut syndrome

ObjectivesGeneralized paroxysmal fast activity (GPFA) is a key electroencephalographic (EEG) feature of Lennox–Gastaut Syndrome (LGS). Automated analysis of scalp EEG has been successful in detecting more typical abnormalities. Automatic detection of GPFA has been more challenging, due to its variability from patient to patient and similarity to normal brain rhythms. In this work, a deep learning model is investigated for detection of GPFA events and estimating their overall burden from scalp EEG. MethodsData from 10 patients recorded during four ambulatory EEG monitoring sessions are used to generate and validate the model. All patients had confirmed LGS and were recruited into a trial for thalamic deep-brain stimulation therapy (ESTEL Trial). ResultsThe correlation coefficient between manual and model estimates of event counts was r2 = 0.87, and for total burden was r2 = 0.91. The average GPFA detection sensitivity was 0.876, with an average false-positive rate of 3.35 per minute. There was no significant difference found between patients with early or delayed deep brain stimulation (DBS) treatment, or those with active vagal nerve stimulation (VNS). ConclusionsOverall, the deep learning model was able to accurately detect GPFA and provide accurate estimates of the overall GPFA burden and electrographic event counts, albeit with a high false-positive rate. SignificanceAutomated GPFA detection may enable automated calculation of EEG biomarkers of burden of disease in LGS.

Federated learning for reliable model updates in network-based intrusion detection

Machine Learning techniques for network-based intrusion detection are widely adopted in the scientific literature. Besides being highly variable, network traffic behavior changes over time, demanding proposed schemes to be periodically updated to ensure their reliability. Unfortunately, their efficiency is significantly limited in production environments. This paper proposes a new Federated Learning model for reliable network-based intrusion detection with highly confident model updates over time. Our proposed scheme assesses the classification reliability in an unsupervised fashion and rejects potential misclassifications even when outdated. In addition, it significantly eases the model update cost by conducting it in a Federated Learning rationale. To evaluate the effectiveness of our solution, we conduct an experimental campaign with a new dataset, MAWIFlow, with over 7 TB of real network traffic spanning a year. The achieved results of our proposed model are striking. It respectively improves the average false-positive and false-negative rates by up to 12% and 9.6% when no model updates are conducted. If done so, it can further improve the false-positive rate by up to 13% while rejecting only 3.6% of events and demanding only 0.3% of events for model updates. Further, the comparison against the traditional Federated Learning approach confirms our model's remarkable performance in several scenarios. Finally, the quality and viability of our solution do prove that our approach can be successfully adopted for improving the accuracy and efficiency of classification systems in real-world scenarios where outdated models are prevalent and pave the way for future research in the area.

Deep Learning-assisted Diagnosis of Breast Lesions on US Images: A Multivendor, Multicenter Study.

To evaluate the diagnostic performance of a deep learning (DL) model for breast US across four hospitals and assess its value to readers with different levels of experience. In this retrospective study, a dual attention-based convolutional neural network was built and validated to discriminate malignant tumors from benign tumors by using B-mode and color Doppler US images (n = 45 909, March 2011-August 2018), acquired with 42 types of US machines, of 9895 pathologic analysis-confirmed breast lesions in 8797 patients (27 men and 8770 women; mean age, 47 years ± 12 [SD]). With and without assistance from the DL model, three novice readers with less than 5 years of US experience and two experienced readers with 8 and 18 years of US experience, respectively, interpreted 1024 randomly selected lesions. Differences in the areas under the receiver operating characteristic curves (AUCs) were tested using the DeLong test. The DL model using both B-mode and color Doppler US images demonstrated expert-level performance at the lesion level, with an AUC of 0.94 (95% CI: 0.92, 0.95) for the internal set. In external datasets, the AUCs were 0.92 (95% CI: 0.90, 0.94) for hospital 1, 0.91 (95% CI: 0.89, 0.94) for hospital 2, and 0.96 (95% CI: 0.94, 0.98) for hospital 3. DL assistance led to improved AUCs (P < .001) for one experienced and three novice radiologists and improved interobserver agreement. The average false-positive rate was reduced by 7.6% (P = .08). The DL model may help radiologists, especially novice readers, improve accuracy and interobserver agreement of breast tumor diagnosis using US.Keywords: Ultrasound, Breast, Diagnosis, Breast Cancer, Deep Learning, Ultrasonography Supplemental material is available for this article. © RSNA, 2023.

Design and testing of a decision tree algorithm for early failure detection in steel truss bridges

This paper develops a methodology for damage identification in steel truss bridges that uses vibration-based monitoring data and a model-based decision tree algorithm. The methodology resorts to a calibrated FE model with an optimization-based parameter identification procedure to simulate and analyze all the potential damages that might affect the structure. The effect of environmental conditions on the modal parameters is also accounted for, which is modeled as structure stiffness variations using the Young’s modulus and forecasted using a surrogate modeling strategy. The feasibility of the methodology is demonstrated on a full-scale bridge in Vilagarcía de Arousa, Spain. The underlying hypotheses used in the algorithm implementation were validated, and the error ponderation and selection bound employed to detect and identify damage were optimized. The results show an average success rate of 95.0% and an average false positive rate of 1.0% in identifying damage indicating its robustness to be extrapolated to other case studies.

Improving radiation dosimetry with an automated micronucleus scoring system: correction of automated scoring errors

Radiation dose estimations performed by automated counting of micronuclei (MN) have been studied for their utility for triage following large-scale radiological incidents; although speed is essential, it also is essential to estimate radiation doses as accurately as possible for long-term epidemiological follow-up. Our goal in this study was to evaluate and improve the performance of automated MN counting for biodosimetry using the cytokinesis-block micronucleus (CBMN) assay. We measured false detection rates and used them to improve the accuracy of dosimetry. The average false-positive rate for binucleated cells was 1.14%; average false-positive and -negative MN rates were 1.03% and 3.50%, respectively. Detection errors seemed to be correlated with radiation dose. Correction of errors by visual inspection of images used for automated counting, called the semi-automated and manual scoring method, increased accuracy of dose estimation. Our findings suggest that dose assessment of the automated MN scoring system can be improved by subsequent error correction, which could be useful for performing biodosimetry on large numbers of people rapidly, accurately, and efficiently.

Efficiency of mapping epistatic quantitative trait loci.

Most theoretical studies on epistatic QTL mapping have shown that this procedure is powerful, efficient to control the false positive rate (FPR), and precise to localize QTLs. The objective of this simulation-based study was to show that mapping epistatic QTLs is not an almost-perfect process. We simulated 50 samples of 400 F2 plants/recombinant inbred lines, genotyped for 975 SNPs distributed in 10 chromosomes of 100 cM. The plants were phenotyped for grain yield, assuming 10 epistatic QTLs and 90 minor genes. Adopting basic procedures of r/qtl package, we maximized the power of detection for QTLs (56-74%, on average) but associated with a very high FPR (65%) and a low detection power for the epistatic pairs (7%). Increasing the average detection power for epistatic pairs (14%) highly increased the related FPR. Adopting a procedure to find the best balance between power and FPR, there was a significant decrease in the power of QTL detection (17-31%, on average), associated with a low average detection power for epistatic pairs (8%) and an average FPR of 31% for QTLs and 16% for epistatic pairs. The main reasons for these negative results are a simplified specification of the coefficients of epistatic effects, as theoretically proved, and the effects of minor genes since 2/3 of the FPR for QTLs were due to them. We hope that this study, including the partial derivation of the coefficients of epistatic effects, motivates investigations on how to increase the power of detection for epistatic pairs, effectively controlling the FPR.