Abstract Health status assessment is an important measure for maintaining the safety of spacecraft flywheel systems. The influence of noise, sensor quality, and other disturbance factors can lead to a decrease in the reliability of the collected information. This can affect the model accuracy. Moreover, a loss of belief in the model is frequently caused by the opaque nature of the procedure and the incomprehensibility of the outcomes, particularly in fields such as aerospace. It is urgent to maintain the interpretability of the model and successfully identify the unreliability of the observed data. Therefore, this paper proposes a spacecraft flywheel system health status assessment method under perturbation based on interpretable belief rule base with attribute reliability (IBRB-r). First, the attribute reliability is calculated based on the average distance method, and a new fusion method of attribute reliability is proposed to reduce the interference of unreliable information. Then, a new interpretable constraint strategy is proposed to improve the rationality and interpretability of the parameters. Finally, the proposed method is validated by a case study of the health status assessment of a spacecraft flywheel system. Experiments show that the IBRB-r maintains high accuracy and interpretability under unreliable observation data.