Average Degree Research Articles

Scoping review of magnetic resonance motion imaging phantoms.

To review and analyze the currently available MRI motion phantoms.Publications were collected from the Toronto Metropolitan University Library, PubMed, and IEEEXplore. Phantoms were categorized based on the motions they generated: linear/cartesian, cardiac-dilative, lung-dilative,rotational, deformation or rolling. Metrics were extracted from each publication to assess the motion mechanisms, constructionmethods, as well as phantom validation.A total of 60 publications were reviewed, identifying 48 unique motion phantoms. Translational movement was themost common movement (used in 38% of phantoms), followed by cardiac-dilative (27%) movement and rotational movement(23%). The average degrees of freedom for all phantoms were determined to be 1.42.Motion phantom publications lack quantification of their impact on signal-to-noise ratio through standardizedtesting. At present, there is a lack of phantoms that are designed for multi-role as many currently have few degrees of freedom.

Alteration of multilayer network perspective on gray and white matter connectivity in obstructive sleep apnea.

The objective of this research was to examine changes in the neural networks of both gray and white matter in individuals with obstructive sleep apnea (OSA) in comparison to those without the condition, employing a comprehensive multilayer network analysis. Patients meeting the criteria for OSA were recruited through polysomnography, while a control group of healthy individuals matched for age and sex was also assembled. Utilizing T1-weighted imaging, a morphometric similarity network was crafted to represent gray matter, while diffusion tensor imaging provided structural connectivity for constructing a white matter network. A multilayer network analysis was then performed, employing graph theory methodologies. We included 40 individuals diagnosed with OSA and 40 healthy participants in our study. Analysis revealed significant differences in various global network metrics between the two groups. Specifically, patients with OSA exhibited higher average degree overlap and average multilayer clustering coefficient (28.081 vs. 23.407, p < 0.001; 0.459 vs. 0.412, p = 0.004), but lower multilayer modularity (0.150 vs. 0.175, p = 0.001) compared to healthy controls. However, no significant differences were observed in average multiplex participation, average overlapping strength, or average weighted multiplex participation between the patients with OSA and healthy controls. Moreover, several brain regions displayed notable differences in degree overlap at the nodal level between patients with OSA and healthy controls. Remarkable alterations in the multilayer network, indicating shifts in both gray and white matter, were detected in patients with OSA in contrast to their healthy counterparts. Further examination at the nodal level unveiled notable changes in regions associated with cognition, underscoring the effectiveness of multilayer network analysis in exploring interactions across brain layers.

All-optical polarization scrambler based on polarization beam splitting with an amplified fiber ring

Optical-fiber-based polarization scramblers can reduce the impact of polarization sensitive performance of various optical fiber systems. Here, we propose a simple and efficient polarization scrambler based on an all-optical Mach-Zehnder structure by combining a polarization beam splitter and an amplified fiber ring. To totally decoherence one polarization split beam, a fiber ring together with an amplifier is incorporated. The ratio of two orthogonal beams can be controlled by varying the amplification factor, and we observe different evolution trajectories of the output state of polarizations on the Poincaré sphere. When the amplification factor exceeds a certain threshold, the scrambler system exhibits nearly ideal polarization scrambling behavior. A commercial single wavelength laser with a linewidth of 3 MHz is utilized to characterize the scrambling performance. We found that when the sampling rate is 1.6 MSa/s, a scrambling speed up to 2000krad/s can be obtained for the average degree of polarization being less than 0.1. We also exploit these random polarization fluctuations to generate random binary numbers, indicating that the proposed technique is a good candidate for a random bit generator.

Average Degree of the Essential Variety

AbstractThe essential variety is an algebraic subvariety of dimension 5 in real projective space $$\mathbb R\mathrm P^{8}$$ R P 8 which encodes the relative pose of two calibrated pinhole cameras. The 5-point algorithm in computer vision computes the real points in the intersection of the essential variety with a linear space of codimension 5. The degree of the essential variety is 10, so this intersection consists of 10 complex points in general. We compute the expected number of real intersection points when the linear space is random. We focus on two probability distributions for linear spaces. The first distribution is invariant under the action of the orthogonal group $$\textrm{O}(9)$$ O ( 9 ) acting on linear spaces in $$\mathbb R\mathrm P^{8}$$ R P 8 . In this case, the expected number of real intersection points is equal to 4. The second distribution is motivated from computer vision and is defined by choosing 5 point correspondences in the image planes $$\mathbb R\mathrm P^2\times \mathbb R\mathrm P^2$$ R P 2 × R P 2 uniformly at random. A Monte Carlo computation suggests that with high probability the expected value lies in the interval $$(3.95 - 0.05,\ 3.95 + 0.05)$$ ( 3.95 - 0.05 , 3.95 + 0.05 ) .

Optimization of water supply reservoir scheduling with insufficient regulating capacity

ABSTRACT To make use of a limited regulating reservoir capacity to provide a small amount of water supply benefits, a multiobjective optimal model that considers the water demand and regulating capacity of the pumping station was established, by combining the maximum sequence similarity (F1), maximum pumping station suitability (F2), maximum ecological flow satisfaction (F3) and maximum number of continuous water supply periods (F4), which were solved by NSGA-II algorithm, K-means clustering, and EW-TOPSIS method were used to select the optimal scheme. The results showed that the results of the combination of F1 and F2 were better than that of the list method, with a multiannual average water supply of 3.88 × 107 m3; the occupation of ecological flow significantly increased the water supply efficiency, with a multiannual average water supply of 4.49 × 107 m3, with a multiannual average ecological satisfaction degree of 10.84; the interruption periods were gathered between January and May by accepting the interruption periods regularly occurred, the water supply was 1.10 × 107 m3 with 95% guarantee rate by taking June–December as the water supply period. Our data indicated that reservoirs with insufficient regulation capacity can produce certain water supply benefits, and there were competitive relationships between objectives, and competitiveness increases with the increase of pumping station regulation capacity.

Influence of subsidy policies against insurances on controlling the propagation of epidemic security risks in networks

Subsidies are used to further control the propagation of epidemic security risks as they offer users incentives to practice security investment behaviors. However, previously proposed subsidy policies have typically been studied without insurance, and it is still challenging to build effective subsidy strategies when users can transfer some of the infection loss to the insurer by purchasing insurance, because these external incentives may alter users' decisions to purchase insurance. To this end, we designed three subsidy policies in a scenario where purchasing insurance is one of the available strategies to users: under SPIns and SPInsp, the subsidies are used as the insurance funds and the risk precaution aspect of the insurance funds, respectively, and under SPInsd, a fraction of the subsidies are used to support some free-riding users with high node importance in their purchase of insurance, and the remaining subsidies are used as the precaution aspect of the insurance funds. The subsidy policies are studied with a formulated security investment game model on scale-free networks from the perspectives of the public and insurer. The results show that SPInsd can always work effectively and outperforms others in limiting the extent of an epidemic outbreak with similar or lower social costs, and without a reduction in profit for the insurer. More importantly, an interesting phenomenon emerges in the SPInsp scenario: under specific insurance parameters, the increase in subsidy funding has a negative impact on preventing the risk spread, leading to larger final epidemic sizes. In addition, the effectiveness of SPInsd on scale-free networks with larger average degree or network size and random networks are also studied. We anticipate this work can provide useful insights for policy makers with respect to design and implementation of optimal subsidy policies related to the control of epidemic security risks under an insurance scenario.

Markovian Approach for Exploring Competitive Diseases with Heterogeneity-Evidence from COVID-19 and Influenza in China.

Due to the complex interactions between multiple infectious diseases, the spreading of diseases in human bodies can vary when people are exposed to multiple sources of infection at the same time. Typically, there is heterogeneity in individuals' responses to diseases, and the transmission routes of different diseases also vary. Therefore, this paper proposes an SIS disease spreading model with individual heterogeneity and transmission route heterogeneity under the simultaneous action of two competitive infectious diseases. We derive the theoretical epidemic spreading threshold using quenched mean-field theory and perform numerical analysis under the Markovian method. Numerical results confirm the reliability of the theoretical threshold and show the inhibitory effect of the proportion of fully competitive individuals on epidemic spreading. The results also show that the diversity of disease transmission routes promotes disease spreading, and this effect gradually weakens when the epidemic spreading rate is high enough. Finally, we find a negative correlation between the theoretical spreading threshold and the average degree of the network. We demonstrate the practical application of the model by comparing simulation outputs to temporal trends of two competitive infectious diseases, COVID-19 and seasonal influenza in China.

Modeling Yield of Irrigated and Rainfed Bean in Central and Southern Sinaloa State, Mexico, Based on Essential Climate Variables

The goal was to model irrigated (IBY) and rainfed (RBY) bean yields in central (Culiacán) and southern (Rosario) Sinaloa state as a function of the essential climate variables soil moisture, temperature, reference evapotranspiration, and precipitation. For Sinaloa, for the period 1982–2013 (October–March), the following were calculated: (a) temperatures, (b) average degree days for the bean, (c) cumulative reference evapotranspiration, and (d) cumulative effective precipitation. For essential climate variables, (e) daily soil moisture obtained from the European Space Agency and (f) IBY and RBY from the Agrifood and Fisheries Information Service were used. Multiple linear regressions were significant for predicting IBY–RBY (dependent variables) as a function of essential climate variables (independent variables). The four models obtained were significantly predictive: IBY–Culiacán (Pearson correlation (PC) = 0.590 &gt; Pearson critical correlation (CPC) = |0.349|), RBY–Culiacán (PC = 0.734 &gt; CPC = |0.349|), IBY–Rosario (PC = 0.621 &gt; CPC = |0.355|), and RBY–Rosario (PC = 0.532 &gt; CPC = |0.349|). Due to the lack of irrigation depth data, many studies only focus on modeling RBY; this study is the first in Sinaloa to predict IBY and RBY based on essential climate variables, contributing to the production of sustainable food.

Analysis of the change in human resources of centers for disease control and prevention in different regions of China from 2010 to 2020

Objective: To analyze the change in human resources within China's Centers for Disease Control and Prevention (CDC) from 2010 to 2020. Methods: The self-reported information from provincial, prefectural (city), and county (district) levels of China's CDC, covering employee counts, staff composition, professional qualifications, educational backgrounds, technical titles, and tenure, were extracted from the China Disease Prevention and Control Information System. The demographic context was provided by the annual population figures from the China Statistical Yearbook (2010-2020). The profile of CDC personnel was described, and the average annual percentage rate change (AAPC), average annual percentage rate change (APC), human resource agglomeration degree (HRAD) and the difference between HRAD and population agglomeration degree (PAD) were calculated. The Joinpoint regression model was used to analyze the time trend. Results: The decade under review witnessed a net increase of 17 300 active and 18 300 enrolled personnel in the CDC, surpassing the national population growth rate with AAPCs of 0.93% and 1.03%, respectively. This upward trajectory was statistically significant (P<0.05). The ratio of disease control personnel per 10 000 population escalated from 1.14 to 1.21. An initial decline in active CDC workforce density (from 1.31 to 1.27 per 10 000 population between 2010 and 2017) was followed by an increase (from 1.28 to 1.37 between 2018 and 2020), with APCs of -0.40% and 3.73%, respectively. The proportion of professional and technical staff in 2019 was highest in the eastern region (86.01%), followed by the western (83.75%) and central regions (79.54%). The period also saw an enhancement in the average academic degree (from 1.91 to 2.43 points) and professional title scores (from 1.39 to 1.53 points) of CDC personnel. While the average tenure in the eastern and western regions showed a slight decline, the central region experienced an increase, with HRAD values indicating a higher concentration in the eastern and central regions compared to the western region. The HRAD-PAD discrepancy revealed a negative value in the eastern region, nearing zero in the central and western regions. Conclusion: Between 2010 and 2020, China's CDC experienced notable growth in human resources and underwent structural optimization, albeit with significant regional disparities in concentration.

Формирование образа Ирака в региональных СМИ Германии посредством концептуальных метафор

The article presents the results of the study of productive conceptual metaphors regularly used to create an image of Iraq in the German regional media. Metaphors are characterized with regard to their frequency, the amount of lexical means in metaphorical nominative fields, and the characteristics added to the formed country image. The sources of the material are the regional media Berliner Zeitung, Aachener-Zeitung, Saarbrücker Zeitung, Münchner Merkur, Berliner Morgenpost, Tagesspiegel. The sample includes publications from 2019 to the present. Contextual and definitional analysis and quantitative calculations are used. The following metaphors are identified as the most frequently used (in descending order of productivity): "Iraq is a living being", "Iraq is a non-whole whole", "Iraq is a place of uncontrolled power", "Iraq is a warrior". The listed metaphors are updated in the publications of the German regional media by the lexical units of the semantic fields "speech activity", "mental state", "physical state", "movement", "division", "mental manifestations", "weather manifestations", "war". The highest nominative density distinguishes the personifying metaphor "Iraq is a living being"; the lowest nominative density characterizes the metaphor "Iraq is a warrior". The metaphors "Iraq is a place of uncontrolled power" and "Iraq is a non-whole whole" reveal a similar degree of linguistic detail of the corresponding conceptual metaphorical spaces, an average degree of variability in the designations of the introduced semantic shades. The lexical units leiden, Teil, toben, kämpfen are attributed to the most frequent kernel means which implement the studied metaphors. The kernel of the Iraq image in the regional German media is constituted by such features of the country as suffering, divided, raging, struggling.

Rainbow Cycles in Properly Edge-Colored Graphs

AbstractWe prove that every properly edge-colored n-vertex graph with average degree at least $$32(\log 5n)^2$$ 32 ( log 5 n ) 2 contains a rainbow cycle, improving upon the $$(\log n)^{2+o(1)}$$ ( log n ) 2 + o ( 1 ) bound due to Tomon. We also prove that every properly edge-colored n-vertex graph with at least $$10^5 k^3 n^{1+1/k}$$ 10 5 k 3 n 1 + 1 / k edges contains a rainbow 2k-cycle, which improves the previous bound $$2^{ck^2}n^{1+1/k}$$ 2 c k 2 n 1 + 1 / k obtained by Janzer. Our method using homomorphism inequalities and a lopsided regularization lemma also provides a simple way to prove the Erdős–Simonovits supersaturation theorem for even cycles, which may be of independent interest.

The Impact of Achieving the Fourth Goal of the Sustainable Development Goals (Good Learning) in the First Schools of Irbid Governorate in Raising the Level of Motivation of Teachers Towards Work from Their Point of View

The study aimed to reveal the impact of achieving the fourth goal of the Sustainable Development Goals (good learning) in the first schools of Irbid governorate in raising the level of teachers' motivation towards work from their point of view. To achieve the objectives of the study, the researcher prepared a tool consisting of (26) paragraphs, and the study population consisted of all primary and secondary school teachers in the Jordanian public schools of the Irbid First Directorate, numbering (858) teachers, a simple random sample of (352) teachers was selected during the first semester of the year (2022-2023). The results of the study showed that the total arithmetic averages to achieve the fourth goal in the schools of Irbid Governorate, the first in raising the level of teachers' motivation towards work, came to an average degree and showed that there are differences in the school stage and in favor of secondary school teachers, and the existence of differences due to the difference in the variable years of experience and in favor of more than ten years, and the existence of differences due to the difference in the academic qualification and were in favor of members of the bachelor's qualification. The study recommended the need to prepare educational leaders that achieve the objectives of the strategic plan for education and achieve distinguished administrative systems, and spread awareness of the requirements of employing the fourth goal of sustainable development and ensuring its activation in Jordanian schools, and develop comprehensive and achievable transformational plans to enhance the capabilities of school principals.

The discrimination of tidal- and fluvial-dominated sedimentary systems based on quantifying the degree of serration in gamma-ray logging curves: East China Sea Shelf Basin

Using quantitative methods to distinguish tidal- and fluvial-dominated sedimentary systems is currently a challenge in sedimentological research. This paper establishes and verifies a new quantitative method through the degree of serration of gamma-ray logging curves. This method depends on the fundamentals of core-based and gamma-ray logging pattern interpretation of the depositional environment, using one-dimensional continuous wavelet transform to denoise the initial curve to enhance the effects of tides and rivers processes, and then expands to an analysis of the degree of serration in noise-reduced gamma-ray curves. The results may then be used to constrain a single best-boundary value to distinguish a tidal- or fluvial-dominated area, avoiding subjectivity and uncertainty. A case study of the Pinghu Formation showed that the degree of serration (defined here as DeltaGr) of the fluvial-dominated sediments was less than 10 in the depth dimension and that the average degree of serration (defined here as the average square of DeltaGr) was less than 7 in the layer dimension. Values that deviate from these imply a close relation to tide-dominated sedimentary systems, which provides a quantitative basis for the interpretation of sedimentary environments in both the depth and layer dimensions in the Pingbei Slope. Seismic attribute-based sedimentary analysis, relative sea-level changes, and the basin architecture of the Pingbei Slope clarify the reason for these changes and verify that this method is reliable. However, owing to the limitations of logging and core samples, the criteria remain an approximation of the actual situation. This study may, however, enable the discrimination of other similar sedimentary systems dominated by tidal and fluvial processes and therefore provide a further constraint on the reconstruction of the filling of basins.

Analysis of Research Publications on Pharmacogenomics of Sulphonylurea - A Scientometric Study.

This study analysed pharmacogenomics studies on sulfonylurea research publications using the Pubmed and Scopus databases. In the end, 65 publications from the years 2015 to 2021 were noticed. The objective of this study was to analyse these studies using scientometric tools, such as frequency counts, percentages, relative growth rates, doubling times, and collectively. A maximum of 19 (29.23%) research publications were contributed during the 2020 research period. The relative growth rate tends to decrease from 2015 to 2020 and the doubling time tends to increase and decrease after 2020. Up to 2 (3.08%) research publications were contributed by Ewan R. Pearson and Chen each. The top authors have an average degree of collaboration of 0.90 and 41 (63.83%) of their research publications are articles. The United States is the major contributor with 19 (29.23%) pharmacogenomics research publications on sulfonylureas. Although the United States is the most prolific country in sulfonylurea pharmacogenomics research, there are few Indian institutions that are not listed among the most prolific institutions.

Clinical-radiological results of the tibial osteotomy of valgization by internal addition in Gonarthrosis.

In knee osteoarthritis, medial-opening tibial osteotomy remains a good surgical technique, and have been effective in stabilizing and even improving osteoarthritis, Our study is about 20 cases of gonarthrosis on genu varum, treated by opening wedge valgus high tibial osteotomyconducted within the orthopedic trauma department '' B'' of the University Hospital Mohamed VI of Marrakech, over a period of 4 years. The mean age of our patients was 49 years (39-60), with a sex ratio of 1M/4F. In 55% of cases (11 cases) thegonarthrosis was related to primitive genu varum, while 45% cases (9 cases) was secondary to trauma ormeniscectomy. Clinically the knee pain was the main symptom in all cases, with an intensity level 3 on the simple verbal scale. The imagery was designed to measure angular deviations and surgical correction and monitoring the evolution. Angular deviation adjusted mean was 10.3 ° (6 ° -16 °), stages II and III of Ahlback classification, represent the mostcases of tibiofemoral osteoarthritis (90%).The filling was done by autologous bone graft, and the average degree of varus correction was 9.6 °.The results evaluated by the IKS score were excellent or good in 60% of cases for the knee score and 73% for the function score.

Network pharmacology combined with molecular docking and experimental verification to elucidate the effect of flavan-3-ols and aromatic resin on anxiety

This study investigated the potential anxiolytic properties of flavan-3-ols and aromatic resins through a combined computational and experimental approach. Network pharmacology techniques were utilized to identify potential anxiolytic targets and compounds by analyzing protein–protein interactions and KEGG pathway data. Molecular docking and simulation studies were conducted to evaluate the binding interactions and stability of the identified targets. Behavioral tests, including the elevated plus maze test, open field test, light–dark test, actophotometer, and holeboard test, were used to assess anxiolytic activity. The compound-target network analysis revealed complex interactions involving 306 nodes and 526 edges, with significant interactions observed and an average node degree of 1.94. KEGG pathway analysis highlighted pathways such as neuroactive ligand-receptor interactions, dopaminergic synapses, and serotonergic synapses as being involved in anxiety modulation. Docking studies on EGCG (Epigallocatechin gallate) showed binding energies of −9.5 kcal/mol for MAOA, −9.2 kcal/mol for SLC6A4, and −7.4 kcal/mol for COMT. Molecular dynamic simulations indicated minimal fluctuations, suggesting the formation of stable complexes between small molecules and proteins. Behavioral tests demonstrated a significant reduction in anxiety-like behavior, as evidenced by an increased number of entries into and time spent in the open arm of the elevated plus maze test, light–dark test, open field center activity, hole board head dips, and actophotometer beam interruptions (p < 0.05 or p < 0.01). This research provides a comprehensive understanding of the multi-component, multi-target, and multi-pathway intervention mechanisms of flavan-3-ols and aromatic resins in anxiety treatment. Integrated network and behavioral analyses collectively support the anxiolytic potential of these compounds and offer valuable insights for future research in this area.

A route network resource allocation method based on multi-objective optimization and improved genetic algorithm

In order to solve the problem of imbalance between traffic demand and airspace capacity of high-altitude air route network, reduce unnecessary delay costs, and improve air route operation efficiency, the resource allocation problem of multi-objective air route network for CTOP program is studied. Taking the affected flights in the congested area of air routes as the research object, taking into account the constraints of actual flight operation, FCA time slot resource availability limit, FCA capacity limit, etc., aiming at minimizing the total delay time of each flight and maximizing the fairness of airlines, a multi-objective optimization model for air route network resource allocation is established, and an improved NSGA-II algorithm is designed to solve the model. Based on the actual operation data of air routes in East China, the Pareto optimal solution set is obtained and compared with the traditional RBS algorithm, the average delay time is reduced by 5.49% and the average fair loss degree is reduced by 66.76%. The results show that the proposed multi-objective optimization model and the improved NSGA-II algorithm have better performance, which can take into account the fairness of each airline on the basis of reducing the total delay cost, realize the allocation of optimal flight trajectories and time slot resources, and provide a reference scheme for air traffic control resource scheduling.

Impact of grassland degradation on soil multifunctionality: Linking to protozoan network complexity and stability

Soil protozoa, as predators of microbial communities, profoundly influence multifunctionality of soils. Understanding the relationship between soil protozoa and soil multifunctionality (SMF) is crucial to unraveling the driving mechanisms of SMF. However, this relationship remains unclear, particularly in grassland ecosystems that are experiencing degradation. By employing 18S rRNA gene sequencing and network analysis, we examined the diversity, composition, and network patterns of the soil protozoan community along a well-characterized gradient of grassland degradation at four alpine sites, including two alpine meadows (Cuona and Jiuzhi) and two alpine steppes (Shuanghu and Gonghe) on the Qinghai-Tibetan Plateau. Our findings showed that grassland degradation decreased SMF for 1–2 times in all four sites but increased soil protozoan diversity (Shannon index) for 13.82–298.01 % in alpine steppes. Grassland degradation-induced changes in soil protozoan composition, particularly to the Intramacronucleata with a large body size, were consistently observed across all four sites. The enhancing network complexity (average degree), stability (robustness), and cooperative relationships (positive correlation) are the responses of protozoa to grassland degradation. Further analyses revealed that the increased network complexity and stability led to a decrease in SMF by affecting microbial biomass. Overall, protozoa increase their diversity and strengthen their cooperative relationships to resist grassland degradation, and emphasize the critical role of protozoan network complexity and stability in regulating SMF. Therefore, not only protozoan diversity and composition but also their interactions should be considered in evaluating SMF responses to grassland degradation, which has important implications for predicting changes in soil function under future scenarios of anthropogenic change.

Whole-body muscle magnetic resonance imaging in inflammatory myopathy with mitochondrial pathology.

Inflammatory myopathy with mitochondrial pathology (IM-Mito) is a rare condition described in a few case series, and it is not clear whether it is a specific disease or a variant of Inclusion Body Myositis (IBM). Radiological data of IM-Mito patients has only been evaluated in one study. To analyze whole-body muscle magnetic resonance imaging (MRI) features in patients with IM-Mito compared with individuals with IBM. Fourteen IM-Mito and ten IBM patients were included. IM-Mito was defined by endomysial inflammatory infiltrate, presence of at least 1% of Cytochrome C Oxidase negative fibers, and absence of rimmed vacuoles in muscle biopsy; and IBM was defined by the presence of dystrophic muscular abnormalities, endomysial inflammatory infiltrate, and rimmed vacuoles. Patients underwent clinical evaluation and whole-body muscle MRI to determine the presence of edema, and fatty infiltration in various muscles. Muscle imaging abnormalities were asymmetric in most patients with IM-Mito and IBM. Muscles with the highest average degree of fatty infiltration in both conditions were the quadriceps and medial gastrocnemius. Most patients with IM-Mito and IBM showed imaging patterns of rectus femoris relatively spared compared to other quadriceps muscles. The flexor digitorum profundus was the most affected muscle of the upper limbs in both IBM and IM-Mito. Although the results suggest some similarities in muscle imaging features between IM-Mito and IBM, there remains uncertainty whether these two conditions are part of the same clinical spectrum.

COMBINATION OF REGENERATIVE THERAPY AND FREE GINGIVAL GRAFT IN STAGE IV PERIODONTITIS: CASE REPORT

Introduction: Periodontal regenerative therapy can be used to repair damaged periodontal tissues caused by periodontitis. The combination of regenerative periodontal surgery and FGG (Free Gingival Graft) is expected to accelerate the regeneration of periodontal tissue. Case : A 37-year-old woman came with complaints of loose lower front teeth, frequent bleeding and pain when eating and drinking. The complaint was felt since 1 year ago. Clinical examination obtained an average pocket depth of 6 mm and an average second degree of tooth mobility. On radiographic examination found bone damage horizontally. Case Management: The patient received root planing scaling and occlusion adjustment, followed by dental periodontal surgery 42,41,31,32. Stage II surgery for recession closure therapy with FGG was carried out three months after stage 1 surgery was performed. Discussion: Regenerative periodontal surgery is performed to produce new periodontal tissue growth and restore connective tissue attachment to the teeth. Free Gingival Graft is performed to increase gingival keratinization and improve patient esthetics. Conclusion and Suggestions: The combination of regenerative periodontal surgery and FGG for the treatment of periodontitis cases involving severe bone destruction gives good results of periodontal tissue healing by alveolar bone healing and regeneration and quite good aesthetics.