Average Age Of Female Patients Research Articles

Clinical profile in relation to age and gender of patients with temporomandibular disorders: a retrospective study

BackgroundThe present study is to evaluate the clinical characteristics of patients with temporomandibular disorders (TMD).MethodsA total of 3362 TMD patients were included. Each participant had complete medical records according to the diagnostic criteria for temporomandibular disorders (DC/TMD). The clinical characteristics including symptoms and signs in relation to age and gender were analyzed.ResultsThe mean age of the patients seeking care was 29.89 ± 13.73Y, and 68.6% of patients were aged 16–35 years. The female-to-male ratio of patients was 2.2: 1, and the average age of males was significantly lower than that of females. The prevalence of clicking symptoms decreased with age, while the prevalence of pain symptoms and limitations in jaw movement increased with age. Females were more likely to have limitations in jaw movement than males. Among the patients with pain, the average visual analogue scale (VAS) was 2.96 ± 1.23. The average VAS score of acute TMD patients (≤ 3 months) was significantly higher than that of chronic TMD patients (> 3 months).ConclusionsThe majority of TMD patients seeking care were young people. The number and average age of female patients was higher than the males. Female patients were more likely to have limitations in jaw movement than males.

The Frequency of Application of Anesthetic Techniques in the Care of the Injured During the War in Bosnia and Herzegovina (1992-1995)

Background: War is a negative social phenomenon that results in a large number of dead, injured and ill individuals. Choosing an adequate anesthesiology technique with a minimum of anesthesiology equipment, anesthetics, medications and personnel, in often improvised conditions, is an imperative. Most operations in war trauma can be performed under regional, local or dissociative anesthesia. Objective. The aim of this study was to present the most commonly applied anesthetic techniques in the anesthetic-surgical care of the injured during the war in Bosnia and Herzegovina 1992-1995. Methods. The study is retrospective and included 130 patients of both sexes, operated at the Clinical Center in Sarajevo in the three-months period from 05.02.1994. until 05.05.1994. In the study, we analyzed gender, age and types of applied anesthetic techniques. Results. From 130 analyzed patients, 103 were male while 27 were female. The average age of all patients was 40.47 years. The average age of male patients was 38.45 years, and the average age of female patients was 48.18 years. The largest number of patients was in the age group of 30-39 years, both in total number and by gender. The youngest patient was 2 while the oldest one was 87 years old. The largest number of patients were operated under spinal anesthesia. Conclusion. An anesthesiologist in war is required to act quickly and efficiently in caring for a large number of injured patients. Regional, ketamine, and local anesthesia techniques accommodate such requirements and are more commonly used than general anesthesia.

Significance of Early Diagnostic of Carpal Tunnel Syndrome

Carpal tunnel syndrome (CTS) is the most common compressive neuropathy. The conservative treatment remains the first therapeutic choice in the treatment of mild and moderate CTS. The aim of this paper was to examine the average age of female patients with CTS diagnosed by EMNG, the frequency of bilateral CTS and its correlation with the age, and to determine the grade of electrophysiological damage of the nerve when the CTS diagnosis is confirmed for the first time. The retrospective examination included 187 female patients, aged from 27 to 79, with complains on unilateral CTS. All patients underwent EMNG for confirmation of CTS and the degree of damage to median nerve. Statistical analysis was performed by methods of descriptive statistics, Kruskal-Wallis test, and the Student t-test. The value of p 0.05 was considered statistically significant. The average age of the female examinees was 54.53 years. The bilateral CTS was confirmed in 67.9 %, most often of a moderate degree and more often on the right hand. No statistically significant difference was found in grades of CTS between the analysed age groups of patients that had the bilateral CTS (p = 0.206), nor there was a difference in years of life between the patients with unilateral and bilateral CTS (p = 0.638). Bilaterality of CTS, as well as the degree of the damage are not connected with age. The patients report timely for the first examination and diagnostics of CTS when there is still a possibility of the conservative treatment.

Comparison of Questionnaire Scales to Assess the Function of the Shoulder Joint in Patients after Unipolar Arthroplasty

Summary. Unipolar shoulder arthroplasty is the method of choice for multifragmental fractures of the humeral head, aseptic necrosis of the humeral head, and deforming arthrosis of the humeral joint grade 3-4 by Kellgren and Lawrence. There are many rating scales for monitoring the recovery of shoulder joint function after unipolar arthroplasty during the rehabilitation stages. Common and most popular are: UCLA (University of California, Los Angeles) Shoulder Rating; Constant-Murley Score; DASH (Disabilities of the Arm, Shoulder and Hand); ASES (American Shoulder and Elbow Surgeons) Score; Oxford Shoulder Score, Constant Shoulder Score, and others. Each of them has its advantages and disadvantages.
 Objective: to conduct a comparative analysis of modern assessment scales for assessing the function of the shoulder joint in patients after unipolar arthroplasty.
 Materials and Methods. Comparative analysis was performed in 50 patients after unipolar arthroplasty with the consequences of injuries of the shoulder joint of varying severity. Patients filled in the answers to the questions of four proposed rating scales before treatment and further in dynamics 6 and 12 months after the surgical intervention. The share of males in the cohort of respondents was 40.5%; females were 59.5%. Four most common scales in the world practice were chosen. The average age of male patients was 62±11.4 years; the average age of female patients was 66±10.1 years. The patients underwent unipolar prosthesis of the shoulder joint: 30 patients (60%) after traumatic injuries of the proximal epimetaphysis of the humerus, 9 patients (18%) after deforming osteoarthritis, and 11 patients (22%) after aseptic osteonecrosis.
 Results and Conclusions. We analyzed the results of treatment of 50 patients at different times after unipolar arthroplasty using four assessment systems (Oxford Shoulder Score, Constant Shoulder Score, ASES, and SPADI) of shoulder function. According to the results of the analysis, in our opinion, the Constant Shoulder Score was the most informative system, as it includes both subjective and objective parts and not only quantitative characteristics, but also qualitative criteria for evaluating the results of treatment. Other rating scales turned out to be less objective.

The Structure of the Causes of Primary Prosthetics of the Shoulder Joint

Relevance. Shoulder prosthetics is the method of choice in the treatment of patients with traumatic injuries that significantly impair joint function and are accompanied by prolonged pain.
 Objective: to investigate the main causes of injuries of the shoulder joint that led to its prosthetics.
 Materials and Methods. The clinical group consisted of 162 patients who underwent shoulder prosthetics in the Department of Microsurgery and Reconstructive Surgery of the Upper Limb of the SI “Institute of Traumatology and Orthopedics of NAMS of Ukraine”. There were 44.4% male and 55.5% female patients. The average age of male patients was 62±11.4 years; the average age of female patients was 66±10.1 years. The average period of seeking specialized medical care after an acute injury was 24±10.9 days and 50.6±81.1 months in patients with post-traumatic consequences. In most cases, patients underwent unipolar prosthetics of the shoulder joint (126 patients, 78.7%); 27 patients (15.6%) underwent reversible prosthetics and 9 (5.6%) – total prosthetics, respectively.
 Results. In most cases, shoulder prosthetics were performed in patients with acute (up to 3 weeks from the date of injury) and old fractures and fractures of the proximal epimetaphysis of the humerus – 35 (21.6%) and 48 (29.6%) patients, respectively. The number of patients with posttraumatic aseptic necrosis of the humeral head was 49 (30.2%) (p<0.005), which indicates a high frequency of complications after osteosynthesis etc. The number of patients with massive traumatic injuries of the tendons of the rotator cuff who needed shoulder prosthetics was 18 (11.1%) and with false joints – 12 (7.4%). Unipolar prosthesis systems predominated in the general structure of the prosthesis type (126 patients, 78.7%), since reversible and total prosthesis in Ukraine were registered not so long ago.
 Conclusions. The analysis of our observations showed that the causes of shoulder prosthetics are severe injuries that occur with high-energy injuries (101 patients, 62.3%) and post-traumatic aseptic necrosis (49 patients, 30.2%). Acute and old fractures and fractures of the proximal metaepiphysis of the humerus are one of the most common injuries according to the analysis (35 patients, 21.6% and 48 patients, 29.6%), and their number and complexity continues to increase with age. Understanding the etiological factors that led to shoulder endoprosthetics makes it possible to predict long-term functional results and work to reduce the number of such patients.

Polysomnographic, demographic and clinic differences between male and female obstructive sleep apnea patients.

The differences between both genders with Obstructive Sleep Apnea Syndrome (OSAS) which is often seen in males can be explained by means of certain polysomnographical parameters and demographical and clinical features. The aim of this research study is to research the gender differences in Turkish population in terms of polysomnographical parameters and demographical and clinical features, and to compare and contrast the results of this research with the results of literature. This study has been carried out by including 100 females and 116 males, 216 patients in total, who were diagnosed with OSAS in the Sleep Laboratory of the Medicine Faculty, Ankara University between the years of 2011 and 2014. The demographical information like the ages and the genders of all patients and the figures of the height, weight and body-mass index (BMI) have been recorded. The Epworth Sleepiness Scale (ESS) of patients have also been recorded. Acquired by the polysomnography equipment, the polysomnographical data of all patients having the criteria of this study have been evaluated. The average age of female patients, which is 57.2 ± 9.1 (the lowestthe highest), has been found to be meaningfully high (p<0.05) when compared to the average age of male patients (50.9 ± 11.8). The body-mass index (BMI) averages of female patients, which are 35.4 ± 9.2, have been determined to be high (p<0.05) when compared to the body-mass index (BMI) average of male patients (32.5 ± 6.7). The total Apnea Hypopnea Index (AHI) of male patients have been found to be meaningfully higher than of the female patients (p<0.05). Mild and moderate OSAS in female patients have been observed at a higher rate than males. On the other hand, severe OSAS has been observed at a higher rate than females (p<0.05). Likewise, while the average obstructive apnea time in male patients has been for 17 ± 5.8 seconds, the same figure has been for 14.5 ± 4.4 seconds (p<0.05). As a result, in this study, we have observed that females suffering from OSAS are older and obese at a more rate and they have lower Apnea Hypopnea Index (AHI) than the males with OSAS. We have also distinguished that the symptoms related to OSAS of both genders are similar despite the lower Apnea Hypopnea Index of females. Meanwhile we want to emphasize that clinicians need to take these factors into consideration while focusing on the diagnosis of OSAS in female patients.

A CLINICO-PATHOLOGICAL STUDY ON CYTOLOGICAL SCREENING OF BRONCHOALVEOLAR LAVAGE AND SUBSEQUENT CORRELATION WITH ADENOSINE DEAMINASE, GENEXPERT MTB IN SUSPECTED SPUTUM NEGATIVE PULMONARY TUBERCULOSIS

BACKGROUND: Sputum negative pulmonary tuberculosis is a world-wide burden on health budget. Clinico- radiologically suspected sputum negative pulmonary tuberculosis needs to be diagnosed using cytopathology along with ADA levels and GeneXpert MTB tests of BAL fluid obtained through bronchoscopy. AIM: To interpret the cytological screening of bronchoalveolar lavage and subsequent correlation with adenosine deaminase, genexpert mtb in suspected sputum negative pulmonary tuberculosis. METHODS: Patients visiting Pulmonary Medicine outdoor of R.GKAR Medical College Hospital, who are clinico radiologically being suspected as pulmonary tuberculosis but are sputum smear AFB negative on two consecutive samples. The study group includes these patients who are willing to undergo bronchoscopy, in whom there are neither any medical contraindications nor other miscellaneous restraints i.e. the study group contains cases of pulmonary TB as well as other infectious malignant non-infectious lung diseases. RESULT: Of the 61 patients, 41(67.2%) patients were male and 20(32.8%) patients were female. The average age of male patients was 51.71years and the average age of female patients was 39.35years.The mean ADA level of BAL fluid in patients with Pulmonary Tuberculosis was 22.54 U/L (Normal level – less than 30 U/L) and mean ADA level of BAL fluid in patients without Pulmonary Tuberculosis was 4.76 U/L (Normal level – less than 30 U/L). CONCLUSION: Cytology of bronchoalveolar lavage along with adenosine deaminase and GeneXpert MTB are important diagnostic and screening tools in suspected sputum negative pulmonary tuberculosis. As it can detect different kinds of inflammatory and other types of cells, it can also help in choosing the appropriate therapeutic procedure / modality for a disease.

Incidence, risk factors and clinical characteristics of extra-pulmonary tuberculosis patients: a ten-year study in the North of Iran.

To determine the incidence of extra-pulmonary tuberculosis (EPTB) and examine the risk factors and the clinical features of the disease over a ten-year period. Retrospective study of records of patients who were followed and registered in the TB registry programme in the health district of Gorgan, Iran from January 1, 2008, through December 31, 2017. Among 2280TB records, 609 (26.71%) were EPTB. They were mostly female patients (53.7%) and residents in rural areas (56.5%) with a mean age of 40.55years [±16]. The average age of female patients (37.55years [±16.99]) was lower than of male patients (44.07years [±20.59]). The median of the incidence rate was 7.5 per 100000 inhabitants for EPTB; biopsy and pathology were the best methods for the detection of EPTB. The most frequent forms of EPTB were lymphatic TB (193/609=31.7%) and pleural TB (158/609=25.9%). In most cases (245/609=40.2%), one to three months elapsed between occurrence of symptoms and final confirmation of EPTB. The outcome of EPTB was weaker than of pulmonary TB (PTB). Our most important finding was the increasing incidence of EPTB, which shows the importance of attention to this disease. Lymph node and pleural tissue were the most commonly infected tissues. Skeletal TB presents a challenge in the diagnosis and treatment of EPTB.

531 Sex-based Differences in the Skin: Is It Just a Female Problem?

Abstract Introduction Female gender is associated with poorer outcomes in burns, not necessarily related to co-morbid conditions. Our objective was to analyze the effect of gender in biopsy proven Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) spectrum disorders at our institution. Methods Patients were identified using Institutional Burn Center registry, and linked to the clinical and administrative data. All patients admitted with biopsy proven SJS, SJS/TEN overlap, and TEN between January 1, 2009 and December 31, 2018 were eligible for inclusion. Demographics, length of stay, and mortality were evaluated. Statistical analysis was performed with Students’ t-test, chi-squared, and Fischer’s exact test. Results One hundred and sixty-eight patients had biopsy proven SJS, SJS/TEN overlap, or TEN. Sixty-one percent of patients were female. The average age of female patients was 51 years while the average age of male patients was 44 years, p&amp;lt; 0.05. Fifty-sex percent of female patients were black. All American Indian patients were female. Female patients had significantly longer lengths of stay, 34 days versus 22 days, p&amp;lt; 0.05. Female patients had an average SCORTEN (a severity of illness score of TEN) compared to male patients. Thirty-three percent of female patients died compared to 18% of male patients, p&amp;lt; 0.05. Two out of three American Indian patients in this cohort died. Conclusions Female gender is associated with increased mortality in burn patients, as well as in our cohort of patients with SJS/TEN. Females represent 51% of our state’s population, but 61% of patients with biopsy proven SJS, SJS/TEN overlap, and TEN at our institution. Compared to male patients, female patients presented with more severe disease (higher SCORTEN at presentation). Genomic, and proteomic studies looking at sex-based differences may be helpful in elucidating the origin of these differences. Applicability of Research to Practice This study demonstrates sex-based differences related to skin desquamating disorders, and these outcomes, coupled with known disparities in burns, may indicate a need for hypervigilance in inpatient management for women, and a re-evaluation of prognostic scoring tools to include a variable for gender.

Pancreatic Head Carcinoma-Implications and Correlations in a Romanian Population.

Introduction: Pancreatic cancers are often an aggressive type of malignancy, with a 5-year survival rate estimated at around 5%. The main purpose of our study was to determine whether or not tumor dimensions influence the presence of jaundice and the diameters of the CBD and Wirsung duct. Material and methods: The study group included 32 patients (19 males, 13 females) diagnosed with various histological types of pancreatic head cancers who were hospitalized in the Surgery Department of the County Clinical Emergency Hospital of Craiova during 2016-2018. All 32 patients underwent an initial abdominal ultrasonography (US), followed by an abdominal computed tomography (CT) scan and an abdominal magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) sequences. Results: Based on tumor dimensions, 19 (59.38%) were equal to or larger than 30mm, while 13 (40.62%) were smaller than 30mm. The average age of male patients was 65.15 years, while the average age of female patients was 60.07 years. Tumor dimensions ranged between 22mm and 52mm (33.53mm on average). Furthermore, the diameter of the CBD ranged from 5mm to 20mm (13.40mm on average), while the diameter of the Wirsung duct ranged from 3mm to 12mm (5.75 mm on average). Conclusion: In conclusion, our study reached its’ initial purpose and revealed a significant association between the tumor dimensions and the diameter of the Wirsung duct and also between the diameter of the CBD and the presence of jaundice.

Value of a coordinated management of osteoporosis via Fracture Liaison Service for the treatment of orthogeriatric patients.

The prevalence of osteoporosis in female patients over 75years of age is 59.2%. In Germany ~6.3-7.8million patients are affected by osteoporosis. In 77% of german patients osteoporosis is not treated adequately. Even after fragility fractures only 16-21% of female patients and 3% of male patients are supplied with a specific osteoporosis therapy. Establishing a Fracture Liaison Services (FLS) is a possible addition to co-management for an efficient treatment of osteoporosis in orthogeriatric patients. According to a treatment algorithm adapted to the DVO guideline 2014, data of 251 (77 male, 173 female) patients were collected over 3months. For the assessment specific and standardized questionnaires were used. There was also a basic laboratory testing for osteoporosis done. The average age of female patients was 76.1years, in male patients 76.6years. Thirty-seven patients had vertebral fractures, 25 patients proximal humerus fractures, 18 distal radius fractures and a total of 78 proximal femur fractures were recorded. Eighteen percent of the 251 patients have already been treated with a basic and 11% with a specific osteoporosis medication. Approximately 40% of the orthogeriatric patients were diagnosed with osteoporosis for the first time in our clinic. Less than 1% of the patients had a vitamin D level over 40ng/ml and 32% had a vitamin D level under 10ng/ml. Sixty-five percent of the discharged patients received a basic osteoporosis therapy and 25% an additional specific therapy. Due to the demographic development osteoporosis-associated fractures steadily increase. In addition to the surgical treatment of fractures, osteological diagnosis and treatment are essential components of successful treatment and critical to the prevention of further fractures. A combination of orthogeriatric center and fracture liaison service allows a more efficient treatment of osteoporosis by close supervision of orthogeriatric patients by the physicians involved.

Reduction Mammoplasty in a Developing Country: A 10-year Review (2001-2010) at the National Orthopaedic Hospital, Enugu.

Context:Large breast is a major problem because of associated symptomatology and aesthetic concerns. Reduction mammoplasty (RM) resolves the symptom and at the same time improves the aesthetic appearance of the breast, hence improving self-esteem and social integration.Aims:To describe the pattern of RM in a hospital in the developing world and its impact on postgraduate surgical training.Settings and Design:A retrospective review of all the RMs done in the National Orthopaedic Hospital, Enugu (a major plastic surgery training center in Nigeria) over a ten-year period (2001–2010), in the developing country of Nigeria.Subjects and Methods:All RMs done in the hospital were reviewed after retrieving their records from operation register and medical records department. Fifteen (15) cases were retrieved and analyzed.Data Analysis:Data was analyzed with Microsoft excel 2007.Results:Average age of female patients who had RM was 26.5 years and 83.3% were single. The most common complaint was abnormally large breast (macromastia). Inferior pedicle technique was commonly used.Conclusions:The results of RM are remarkable as it impact positively on the quality of life of the patients. However, the level of awareness about the availability of this service is still low in the region as shown by few cases done over the period of review and this impacts negatively on the training. The need for public awareness cannot be overemphasized.

Clinical analysis of 260 cases of hypopituitarism

Objective To review the clinical features,etiology and differential diagnosis of hypopituitarism.Methods The clinical data of 260 patients with hypopituitarism admitted to our hospital during 2007 to 2011 were retrospectively analyzed.Results In 260 patients 96 were males and 164 were females,the average age of female patients was significantly higher than that of males[ (44 ± 16) vs.(32 ± 20) years; t =3.821,P =0.001 ].Patients under 20 years accounted for the highest proportion in male cases (38/96,39.6％) ; while patients aged 40 - 60 years were the highest proportion for female cases (86/164,52.4％).Pituitary tumor and postoperative damage was the most common cause for hypopituitarism accounting for 36.2％ (94/260),followed by Sheehan syndrome (86/260,33.1％).The most common manifestation of hypopituitarism was anemia (102 eases) ; 26 cases presented all pituitary function failure.The causes leading to hypopituitarism usually showed specific manifestations in imaging examinations.The overall misdiagnosis rate was 40.4％ (105/260)in this series,while that of etiological diagnosis was 25.4％ (66/260).Conclusions This study suggests that hypopituitarism caused by different causes can be diagnosed by disease history,clinical manifestations and pituitary imaging examination. Key words: Hypopituitarism; Clinical feature; Diagnosis

PW01-69 - Post-infarct depression in a general hospital: diagnosis and therapy

ObjectivesPost-infarct Depression appears to 15-30% of the patients treated in the Infarction Units, according to the International Standards. It appears 24-72 hours following an Acute Infarction of the Myocardium.MethodsWe studied 300 patients treated in the Infraction Treatment Unit for a period of three months, within the framework of a Liaison Consultation Psychiatry program. 180 patients were men (60%) and 120 patients were women (40%). The average age of male patients was 52 years and the average age of female patients was 58 years. These patients were submitted to the Montgomery-Arnsberg Depression Rating Scale (MADRS) to evaluate Depression. According to the results of the Scale, these 120 patients presented depressive symptomatology, 45 patients presented mild symptomatology, 70 patients presented average symptomatology, and 5 patients presented heavy symptomatology.ResultsAll the above patients were treated with SSRIs. In particular, they received Fluoxetin, Sitalopram, Esitalopram, Fluvoxamine, Sertraline. The MADRS Scale has been evaluated on 15 days, 1, 2, 3, and 6 months following the initiation of therapy. 110 patients (91%) presented a significant reduction of MADRS Scale, while 10 patients (9%) showed resistance to the treatment and had to switch their treatment scheme with SNRIS or NASSAS.ConclusionsThe SSRIs constitute the most advisable treatment for post-infraction depression, due to their low side-effect profile. The rate of positive outcome for post-infarction depression treatment was especially high (91%) during treatment with SSRIs at a level consistent with the international literature reference.

4000 cases of intrafallopian transfer of ova immediately after intracytoplasmic sperm injection (RAPID ICSI-ZIFT) for treatment of severe male factor infertility.

Objective: Gamete Intrafallopian Transfer (GIFT) is a well-established technique of assisted conception and as the technique of choice for infertile couple with patent fallopian tubes although Gift lost popularity because of its requirement of a fully equipped operating room and improving in-vitro embryo culture system. But it still offers a high pregnancy rate in the hands of well trained personnel probably because of more physiologic environment of the tubal epithelium. We presented probably for the first time the treatment of 100 couples with severe Male Factor infertility in 16th world congress and 54th annual meeting of ASRM 1998. We endeavor to show that Gamete Intrafallopian Transfer of ova immediately after intracytoplasmic sperm injection (RAPID ICSI ZIFT) is a treatment for severe Male Factor Infertility.Design: A retrospective study of 4000 consecutive RAPID ICSI ZIFT cases conducted in a private and university ART centers during a 54 month period from July 1996 to December 2000.Materials/Methods: 4000 couples were selected in whom severe Male Factor was the primary infertility diagnosis. Semen was collected after masturbation (N#2300), microscopic epididymal sperm aspiration (MESA) (N#460), percutaneous sperm aspiration from the epididymis (PESA) (N#830) or testical (TESA) (N#215) and vibratone assisted ejaculation (N#195). 2480 semen samples collected, exhibited two or more suboptimal sperm parameters. 2200 samples contained sperm concentration which were < 3 mil, 2000 samples with 15% forward progressive sperm and suboptimal morphology in 2440 samples. Females 25 to 45 years of age exhibited tubal patency as determined by hystrosalpingogram and laparascopy. All patients had been stimulated with LH/RH agonist Buserlin (Suprefact) HMG combinations in the form of a long protocol and transvaginal ultrasound guided oocyte retrieval, ICSI and laparascopic tubal transfer.Results: In average 10 oocyte per collection was retrieved and a mean of 5.5 post ICSI-OVA were transferred the remaining oocyte were fertilized by ICSI and cryopreserved. Clinical pregnancy rate for the above series was 46% (1840/4000) the average age of female patients was 35.4% and multiple pregnancy rate was 22.2%.Conclusions: Success of tubal transfer for post ICSI ova is related to maternal age (ova number and quality) and the programs’ rate of fertilization and embryo development and in the hand of well-trained personnel can afford the severe Male Factor patients high chance of success.Supported By: Grant in the memorial of Navid Sahebkashaf by Navid’s institute of infertility. Objective: Gamete Intrafallopian Transfer (GIFT) is a well-established technique of assisted conception and as the technique of choice for infertile couple with patent fallopian tubes although Gift lost popularity because of its requirement of a fully equipped operating room and improving in-vitro embryo culture system. But it still offers a high pregnancy rate in the hands of well trained personnel probably because of more physiologic environment of the tubal epithelium. We presented probably for the first time the treatment of 100 couples with severe Male Factor infertility in 16th world congress and 54th annual meeting of ASRM 1998. We endeavor to show that Gamete Intrafallopian Transfer of ova immediately after intracytoplasmic sperm injection (RAPID ICSI ZIFT) is a treatment for severe Male Factor Infertility. Design: A retrospective study of 4000 consecutive RAPID ICSI ZIFT cases conducted in a private and university ART centers during a 54 month period from July 1996 to December 2000. Materials/Methods: 4000 couples were selected in whom severe Male Factor was the primary infertility diagnosis. Semen was collected after masturbation (N#2300), microscopic epididymal sperm aspiration (MESA) (N#460), percutaneous sperm aspiration from the epididymis (PESA) (N#830) or testical (TESA) (N#215) and vibratone assisted ejaculation (N#195). 2480 semen samples collected, exhibited two or more suboptimal sperm parameters. 2200 samples contained sperm concentration which were < 3 mil, 2000 samples with 15% forward progressive sperm and suboptimal morphology in 2440 samples. Females 25 to 45 years of age exhibited tubal patency as determined by hystrosalpingogram and laparascopy. All patients had been stimulated with LH/RH agonist Buserlin (Suprefact) HMG combinations in the form of a long protocol and transvaginal ultrasound guided oocyte retrieval, ICSI and laparascopic tubal transfer. Results: In average 10 oocyte per collection was retrieved and a mean of 5.5 post ICSI-OVA were transferred the remaining oocyte were fertilized by ICSI and cryopreserved. Clinical pregnancy rate for the above series was 46% (1840/4000) the average age of female patients was 35.4% and multiple pregnancy rate was 22.2%. Conclusions: Success of tubal transfer for post ICSI ova is related to maternal age (ova number and quality) and the programs’ rate of fertilization and embryo development and in the hand of well-trained personnel can afford the severe Male Factor patients high chance of success. Supported By: Grant in the memorial of Navid Sahebkashaf by Navid’s institute of infertility.