Avenue Du Research Articles

\u201cChronic fatigue, quality of life and long-term side-effects of chemotherapy in patients treated for non-epithelial ovarian cancer: national case-control protocol study of the GINECO-Vivrovaire rare tumors INCa French network for rare malignant ovarian tumors\u201d

BackgroundGerm cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surgery combined with chemotherapy [bleomycin, etoposide and cisplatin (BEP)] depending on the stage and the prognostic factors, as for testicular cancers. As reported in testicular cancer survivors, chemotherapy may induce sequelae impacting quality of life, which has not yet been evaluated in survivors of germ cell tumors and sex cord stromal tumors. The GINECO-VIVROVAIRE-Rare tumor study is a two-step investigation aiming to assess i) chronic fatigue and quality of life and ii) long-term side-effects of chemotherapy with a focus on cardiovascular and pulmonary disorders.MethodsUsing self-reported questionnaires, chronic fatigue and quality of life are compared between 134 ovarian cancer survivors (cancer-free ≥2 years after treatment) treated with surgery and chemotherapy and 2 control groups (67 ovarian cancer survivors treated with surgery alone and 67 age-matched healthy women). Medical data are collected from patient records. In the second step evaluating the long-term side-effects of chemotherapy, a subgroup of 90 patients treated with chemotherapy and 45 controls undergo the following work-up: cardiovascular evaluation (clinical examination, non-invasive cardiovascular tests to explore heart disease, blood tests), pulmonary function testing, audiogram, metabolic and hormonal blood tests. Costs of sequelae will be also assessed. Patients are selected from the registry of the INCa French Network for Rare Malignant Ovarian Tumors, and healthy women by the ‘Seintinelles’ connected network (collaborative research platform).DiscussionThis study will provide important data on the potential long-term physical side-effects of chemotherapy in survivors of Germ Cell Tumors (GCT) and Sex Cord Stromal Tumors (SCST), especially cardiovascular and pulmonary disorders, and neurotoxicity. The identification of long-term side-effects can contribute to adjusting the treatment of ovarian GCT or SCST patients and to managing follow-up with adapted recommendations regarding practices and chemotherapy regimens, in order to reduce toxicity while maintaining efficacy. Based on the results, intervention strategies could be proposed to improve the management of these patients during their treatment and in the long term.Trial registrationThis trial was registered at clinicaltrials.gov: 03418844, on 1 February 2018.This trial was registered on 25 October 2017 under the unique European identification number (ID-RCB): 2017-A03028–45.Recruitment Status: Recruiting.Protocol versionVersion n° 4.2 dated from Feb 19, 2021.Trial sponsorCentre François Baclesse, 3 avenue du Général Harris, F-14076 Caen cedex 05, France.

Deceptive Slanders of Cardiovascular Pathology in Covid-19 Ethnic Minorities

Sayed Nour* Author Affiliations Department of Pediatric Cardio Surgeon, Orleans, France Received: September 04, 2020 | Published: September 15, 2020 Corresponding author: Sayed Nour, Consultant Pediatric Cardio Surgeon, Independent Cardiovascular Researcher, Le LAB’O, Orleans Technopole, 1 avenue du Champs de Mars, 45074, Orleans, France DOI: 10.26717/BJSTR.2020.30.004945

Erratum

Land Degradation & DevelopmentVolume 29, Issue 10 p. 3836-3836 ERRATUMFree Access Erratum This article corrects the following: Discovery and characterization of Coturnix chinensis avian β-defensin 10, with broad antibacterial activity Deying Ma, Lijuan Lin, Kexin Zhang, Zongxi Han, Yuhao Shao, Ruiqin Wang, Shengwang Liu, Volume 18Issue 4Journal of Peptide Science pages: 224-232 First Published online: March 2, 2012 First published: 17 October 2018 https://doi.org/10.1002/ldr.3158AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat After online and print publication of Gilardelli et al. (2017), errors were identified in the author formatting and some affiliations. The authors first names and surnames were transposed. In addition, authors Anne Bonis and Pierre Chanteloup should have been associated with the third affiliation only, which is UMR 6553 ‘ECOBIO’ Université de Rennes 1-CNRS, Avenue du Général Leclerc, Campus de Beaulieu, 35042 Rennes Cedex, France. The online version of the article has now been corrected. REFERENCE Gilardelli, F., Vergani, C., Gentili, R., Bonis, A., Chanteloup, P., Citterio, S., & Enrico, A. C. (2017). Root Characteristics of Herbaceous Species for Topsoil Stabilization in Restoration Projects. Land Degradation Development, 28, 2074– 2085. https://doi.org/10.1002/ldr.2731 Volume29, Issue10October 2018Pages 3836-3836 ReferencesRelatedInformation

PM 7/109 (2) Epitrix cucumeris, Epitrix papa, Epitrix subcrinita, Epitrix tuberis

Specific scopeThis Standard describes a diagnostic protocol for adults of Epitrix cucumeris, Epitrix papa, Epitrix subcrinita and Epitrix tuberis.Specific approval and amendmentFirst approved in 2011‐09.Revision approved in 2016‐01.

PM 7/116 (1)Tetranychus evansi

PM 7/116 (1)<i>Tetranychus evansi</i>

Sarcoidosis Induced by Tocilizumab: A Paradoxical Event?

To the Editor: Tocilizumab (TCZ) is a monoclonal antibody against the interleukin 6 (IL-6) receptor, used in the treatment of rheumatoid arthritis (RA). We describe a case of onset of sarcoidosis under TCZ therapy in a patient with RA. A 40-year-old woman of North African origin had RA for 12 years. Rheumatoid factor and anticitrullinated antibody were negative. Erosions were absent. Nevertheless, she fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) RA classification criteria (7/10). She was refractory to sulfasalazine and then to methotrexate (MTX). Etanercept was introduced in 2008 and stopped in 2010 because of secondary loss of efficacy. TCZ was initiated in April 2010. The response was good, with the 28-joint Disease Activity Score (DAS28) 0.5 and Health Assessment Questionnaire … Address correspondence to Dr. Cohen, Hopital Lapeyronie, Unité d’Immuno-Rhumatologie, 191 Avenue du Doyen Gaston Giraud, Montpellier 34295, France. E-mail: jd-cohen{at}chu-montpellier.fr

Gold-Mediated Synthesis and Functionalization of Chiral Halopyridones

A rapid and efficient one-step halopyridone synthesis has been developed based on gold-catalyzed cyclization of β-amino-ynone intermediates and halodeauration process.

Rapidly growing pancreatic ductal adenocarcinoma in a patient with metastatic melanoma and harbouring CDKN2A germline mutation

Departments of aGeneral Dermatology and Skin Cancer bRadiology, Ambroise Paré Hospital, APHP and University of Versailles SQY, Boulogne-Billancourt, France Correspondence to Sophie Lipowicz, MD, Department of General Dermatology and Skin Cancer, Ambroise Paré Hospital, APHP and University of Versailles SQY, 9 Avenue du Général-de-Gaulle, 92104 Boulogne-Billancourt, Cedex, France Tel: +33 1 49 09 56 73; fax: +33 1 49 09 56 85; e-mail: [email protected] Received September 4, 2012 Accepted March 10, 2013

Clinical safety of rapid sequential administration of moxidectin injection and oral derquantel-abamectin as a quarantine treatment for introduced sheep

Veterinary RecordVolume 172, Issue 16 p. 426-426 Research Clinical safety of rapid sequential administration of moxidectin injection and oral derquantel-abamectin as a quarantine treatment for introduced sheep D. J. Bartram...

Fighting, Negotiating, Laughing: The Use of Humor in the Vietnam War

The scene: A conference room at a private villa in the outskirts of Paris, at Avenue du General Leclerc, Gif sur Yvette, 91 Essonne. Diplomatic delegations of North Vietnam and the United States ar...

MDR3 immunostaining on frozen liver biopsy samples is not a sensitive diagnostic tool for the detection of heterozygous MDR3/ABCB4 gene mutations

Dear Editor, We read with great interest the recent article of Wendum et al. [1] describing histological lesions observed in the liver of 13 adult patients with heterozygous MDR3/ABCB4 gene mutations. They performed multidrug resistance Pglycoprotein 3 (MDR3) immunostaining on formalin-fixed paraffin-embedded sections of 11 patients and reported that the staining had a diffuse and strong canalicular pattern in patients and controls, except in one case who disclosed a faint staining. This finding suggested a lack of sensitivity of this technique for the diagnosis of MDR3/ABCB4 heterozygous mutations. Since we previously suggested that MDR3 immunostaining on frozen liver sections could be useful for the diagnosis of unexplained anicteric cholestasis in adult patients [2], we would like to contribute by providing our experience of MDR3 immunostaining realized on frozen liver biopsy sections of a new series of adult patients with MDR3/ABCB4 mutations. Between April 2007 and March 2011, 32 adult patients with unexplained anicteric cholestasis had ABCB4 gene sequencing, using polymerase chain reaction amplification and DNA sequencing of exons 2 to 28 and all splice junctions. Among these 32 patients, ten carried six different ABCB4 mutations. These ten patients (six females, 17– 72 years of age) displayed various clinical characteristics: three fulfilled the criteria for low phospholipid-associated cholelithiasis syndrome [3]; one had an anteriority of intrahepatic cholestasis of pregnancy; and six had an unexplained anicteric cholestasis—two of them with associated elevated aminotransferase level. Histopathological analysis using Picrosirius red and hematoxylin–eosin-stained liver biopsy sections showed that nine patients had portal fibrosis (three F1, four F2, one F3, and one F4 according to Ishak fibrosis score); six of them displaying a jigsaw pattern of biliary-type fibrosis. Bile duct lesions corresponding to mild cholangitis could be observed in four patients. Ductopenia, defined as a loss of more than 50 % of bile ducts, was seen in two patients. Lastly, six cases showed a mild to moderate ductular reaction. The clinicopathological features are detailed in Table 1. Frozen liver biopsies were available for 14 patients (five cases and nine controls). Immunohistochemistry was performed on 4-μm frozen sections by using MDR3 monoclonal antibody (clone P3II-26) and MRP2 antibody (clone M2III-6) as a control to check tissue immune reactivity. As shown in Fig. 1, we observed a diffuse and intense canalicular staining with MDR3 antibody, in the available frozen liver biopsies of the five patients with heterozygous ABCB4 mutations and in the nine controls. Positive canalicular staining was also observed with MRP2 antibody, confirming the immunoreactivity of our samples. These results are in contradiction with our previous report [2] in which no or faint MDR3 immunostaining was observed in frozen liver biopsies from four patients with A. Sannier (*) :M. Tepper :M. Ziol Service d’Anatomie Pathologique, GHU Paris-Seine-Saint-Denis, Hopital Jean Verdier, AP-HP, Avenue du 14 Juillet, 93143 Bondy Cedex, France e-mail: aureliesannier@free.fr

Advanced Nanohybrid Materials: Surface Modification and Applications

1Department of Chemistry, Portland State University, Portland, OR 97207, USA 2Macromolecular and Supramolecular Photophysics and Photochemistry Laboratory (PPSM Laboratory), CNRS UMR8531, Ecole Normale Superieure de Cachan, 61 Avenue du President Wilson, 94235 Cachan Cedex, France 3Department of Materials Science and Engineering, The University of Tennessee, 306D Dougherty Engineering Building, Knoxville, TN 37996-2200, USA 4Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA 5Department of Chemistry, University of Massachusetts Lowell, Olney Hall 510, Lowell, MA 01854, USA

Clinically asymptomatic adult patient with extensive LBSL MRI pattern and DARS2 mutations

Leukoencephalopathy with brainstem and spinal cord involvement and high brain lactate (LBSL) is defined by (a) a recessive inheritance, (b) a slowly progressive spinocerebellar syndrome, and (c) signal abnormalities of various tracts on magnetic resonance imaging (MRI) involving the corpus callosum, the pyramidal tracts, the brainstem, the cerebellar peduncles, the mesencephalic trigeminal tract, the cerebellar white matter, and the dorsal columns of the spinal cord [1–3]. LBSL is associated with mutation in the DARS2 gene, encoding for mitochondrial aspartyl-tRNA synthetase (mtAspRS) [4]. We report the first asymptomatic adult patient with a typical MRI aspect of LBSL associated with a new DARS2 mutation. The index case, a 23-year-old French Caucasian woman, without medical or family history, had progressive walking difficulties since the age of four. Clinical examination showed spastic paraparesis, mixed proprioceptive and cerebellar ataxia, and intention tremor in both upper limbs. She was able to walk 500 m without help. Brain and spinal MRI revealed a typical aspect of LBSL (Fig. 1a), and the presence of high lactate levels in the abnormal cerebral white matter on magnetic resonance spectroscopy (MRS). Sequence analysis of the DARS2 gene [4] revealed compound heterozygous mutations, i.e. a 228-16C[G mutation located in the stretch of C residues just upstream of exon 3 and a second novel missense mutation c.745C[A in exon 8 (Fig. 2). To study the deleterious effect of the mutations, we further analysed the first degree relatives of the index case (parents, two brothers of age 30 and 36, and one sister of age 28), after the patient’s written consent was obtained. Clinical examination was strictly normal in all relatives including vibration sense in the lower limbs. Direct genomic sequencing of exons 3 and 8 showed a heterozygote state in the father (c.745C[A mutation), the mother (228-16C[G mutation), and the two brothers (c.745C[A mutation). The 28-year-old asymptomatic sister had heterozygote composite mutations (228-16C[G P. Labauge (&) Department of Neurology, CHU Nimes, Hopital Caremeau, 2 Avenue du Pr Debre, 30029 Nimes Cedex 4, France e-mail: labauge@yahoo.fr

Retracted: Trade-off between Virulence and Aggressiveness in Plasmopara halstedii (Sunflower Downy Mildew)

Journal of PhytopathologyVolume 159, Issue 9 p. i-iii Retracted: Trade-off between Virulence and Aggressiveness in Plasmopara halstedii (Sunflower Downy Mildew) Correction(s) for this article Retraction Volume 159Issue 9Journal of Phytopathology pages: 648-648 First Published online: August 3, 2011 Nachaat Sakr, Nachaat Sakr Author’s address: INRA-UBP, 234 Avenue du Brézet, 63100 Clermont-Ferrand, France (correspondence to N. Sakr. E-mail: nsakr@clermont.inra.fr; snachaat@hotmail.com)Search for more papers by this author Nachaat Sakr, Nachaat Sakr Author’s address: INRA-UBP, 234 Avenue du Brézet, 63100 Clermont-Ferrand, France (correspondence to N. Sakr. E-mail: nsakr@clermont.inra.fr; snachaat@hotmail.com)Search for more papers by this author First published: 09 August 2011 https://doi.org/10.1111/j.1439-0434.2010.01733.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume159, Issue9September 2011Pages i-iii RelatedInformation

Diary of forthcoming meetings

Pediatric AnesthesiaVolume 20, Issue 5 p. 477-477 Diary of forthcoming meetings First published: 08 April 2010 https://doi.org/10.1111/j.1460-9592.2010.03295.x Please forward all information concerning congresses relevent to Pediatric Anesthesia and Intensive Care to: Dr Isabelle Murat, Départment d'Aneshésia-Réanimation, Hôpital d'Enfants Armand-Trousseau, 26 avenue du Dr Arnold-Netter, 7751 Paris Cedex, 12, France. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue5May 2010Pages 477-477 RelatedInformation

Diary of forthcoming meetings

Pediatric AnesthesiaVolume 20, Issue 4 p. 381-381 Diary of forthcoming meetings First published: 08 March 2010 https://doi.org/10.1111/j.1460-9592.2010.03282.x Please forward all information concerning congresses relevent to Pediatric Anesthesia and Intensive Care to: Dr Isabelle Murat, Départment d'Aneshésia-Réanimation, Hôpital d'Enfants Armand-Trousseau, 26 avenue du Dr Arnold-Netter, 7751 Paris Cedex, 12, France. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue4April 2010Pages 381-381 RelatedInformation

Diary of forthcoming meetings

Pediatric AnesthesiaVolume 20, Issue 3 p. 294-294 Diary of forthcoming meetings First published: 17 February 2010 https://doi.org/10.1111/j.1460-9592.2010.03288.x Please forward all information concerning congresses relevent to Pediatric Anesthesia and Intensive Care to: Dr Isabelle Murat, Départment d'Aneshésia-Réanimation, Hôpital d'Enfants Armand-Trousseau, 26 avenue du Dr Arnold-Netter, 7751 Paris Cedex, 12, France. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume20, Issue3March 2010Pages 294-294 RelatedInformation

Synthesis of 3,4,5-Trisubstituted-1,2,4-triazoles

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTSynthesis of 3,4,5-Trisubstituted-1,2,4-triazolesAline Moulin†, Mathieu Bibian, Anne-Laure Blayo, Sarah El Habnouni, Jean Martinez, and Jean-Alain Fehrentz*View Author Information Institut des Biomolécules Max Mousseron, UMR 5247 CNRS − Universités Montpellier 1 et Montpellier 2, Faculté de Pharmacie, 15 avenue Charles Flahault, BP 14491, 34093 Montpellier cedex 5, France* To whom correspondence should be addressed. E-mail: [email protected]†Present address: Flamel Technologies, Parc Club du Moulin à Vent, 33 avenue du Docteur Georges Lévy, 69693 Vénissieux, France.Cite this: Chem. Rev. 2010, 110, 4, 1809–1827Publication Date (Web):February 12, 2010Publication History Received19 March 2009Published online12 February 2010Published inissue 14 April 2010https://doi.org/10.1021/cr900107rCopyright © 2010 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views7214Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSUBJECTS:Alkyls,Amides,Phenyls,Precursors,Triazole Get e-Alerts

Diary of forthcoming meetings

Pediatric AnesthesiaVolume 20, Issue 1 p. 115-115 Diary of forthcoming meetings First published: 27 December 2009 https://doi.org/10.1111/j.1460-9592.2009.03239.x Please forward all information concerning congresses relevent to Pediatric Anesthesia and Intensive Care to: Dr Isabelle Murat, Départment d'Aneshésia-Réanimation, Hôpital d'Enfants Armand-Trousseau, 26 avenue du Dr Arnold-Netter, 7751 Paris Cedex, 12, France. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume20, Issue1January 2010Pages 115-115 RelatedInformation

Choice of baseline in a multiple-dose thorough QT study (TQTS) &amp;ndash; effect on analysis of moxifloxacin-induced QTc prolongation

Correspondence: Benoit Tyl MDs Pharma services, 1-3, Avenue du Bosquet, 95560 Baillet en France Tel +33 13408 3864 Fax +3 13408 3323 email tyl@noos.fr Background: The primary endpoint of a thorough QT study (TQTS) is the change from baseline in QT corrected (QTc) measured on electrocardiograms (ECG) tracings. It has been suggested that during a crossover study, the time-matched or predose baseline could be recorded. The choice of method for baseline ECG collection may influence the results and the cost of the TQTS. Objective: The objective of our study was to compare the collection of a time-matched baseline before each period (TM EACH ), an average of all the time-matched baseline (TM MEAN ), a time-matched baseline before period 1 (TM P1 ) and a predose baseline (PD EACH ) on QT interval prolongation induced by moxifloxacin, in a 30 subjects, 5 arm cross-over TQTS. Results: Moxifloxacin induced a similar significant increase in QT corrected using Fridericia’s formula (QTc) (lower limit of the confidence interval excluded 5 ms) at all time-points between 0.5 hours and 12 hours with all baseline methods. TM EACH was associated with a lower within subject variability (SD 5.59 ms) than TM MEAN and TM P1 (5.90 and 6.90 ms, respectively). PD EACH was associated with the highest variability (7.41 ms). Conclusion: The collection of ECG tracings during a full baseline day before each period was associated with the lowest variability. However, the two more cost effective designs (TM P1 and PD EACH ) were sufficient, in this small TQTS, to significantly detect moxifloxacin.