Auxiliary Diagnosis System Research Articles

Expert consensus on the clinical application of efficient intelligent chromosomal karyotyping precise auxiliary diagnosis system

Chromosomal karyotyping analysis has been considered as the gold standard for cytogenetic diagnosis and an effective measure for preventing birth defects. However, conventional karyotyping analysis relies heavily on manual recognition, which is time-consuming and labor-intensive. The application of an efficient intelligent chromosomal karyotyping precise auxiliary diagnosis system in clinical practice can significantly reduce the analysis time and greatly improve the efficiency, increase the detection rate for low-percentage mosaicisms, and promote homogenization between laboratories. This can effectively enhance the capacity and level of cytogenetic diagnosis. With the continuous application of such system in the field of karyotyping analysis, a substantial amount of clinical application data and experience has been accumulated. This consensus has been formulated after multiple rounds of discussion by experts from the clinical application collaboration group of the efficient intelligent chromosomal karyotyping precise auxiliary diagnosis system. It aims to provide a reference for peers to better utilize intelligent auxiliary diagnosis systems during chromosomal karyotyping analysis and promote the standardized development of karyotyping analysis technology.

A knowledge graph based intelligent auxiliary diagnosis and treatment system for primary tinnitus using traditional Chinese medicine

Primary tinnitus is a disabling disease with an unknown pathogenesis and a high incidence rate in China. Its diagnosis and treatment are complex and difficult to control. Although many treatments are available for primary tinnitus, their efficacy is often unsatisfactory. This paper proposes a new diagnosis and treatment method using knowledge graphs, and an intelligent assistant decision system is developed. To support diagnosis, a knowledge graph is created as a decision support tool using traditional Chinese medicine (TCM). Based on the knowledge graph, a model for the syndrome differentiation of tinnitus in TCM is built. At tinnitus treatment, an intelligent recommandation model for pentatonic music using knowledge graph based heterogeneous label propagation is then used to provide patients with personalized treatment plans. According to evaluation results, the proposed method achieves an accuracy of 87.1 % in tinnitus diagnosis. Compared with the control group, the recommended pentatonic music had a more obvious effect, and the efficacy of the five types of tinnitus was increased by 33.34 %, 33.33 %, 20 %, 26.67 %, 33.34 %, respectively. The system developed in this paper will help clinicians improve the diagnosis and treatment of tinnitus while reducing unnecessary medical expenses and offering significant social and economic benefits.

A Parkinson's Auxiliary Diagnosis Algorithm Based on a Hyperparameter Optimization Method of Deep Learning.

Parkinson's disease is a common mental disease in the world, especially in the middle-aged and elderly groups. Today, clinical diagnosis is the main diagnostic method of Parkinson's disease, but the diagnosis results are not ideal, especially in the early stage of the disease. In this paper, a Parkinson's auxiliary diagnosis algorithm based on a hyperparameter optimization method of deep learning is proposed for the Parkinson's diagnosis. The diagnosis system uses ResNet50 to achieve feature extraction and Parkinson's classification, mainly including speech signal processing part, algorithm improvement part based on Artificial Bee Colony algorithm (ABC) and optimizing the hyperparameters of ResNet50 part. The improved algorithm is called Gbest Dimension Artificial Bee Colony algorithm (GDABC), proposing "Range pruning strategy" which aims at narrowing the scope of search and "Dimension adjustment strategy" which is to adjust gbest dimension by dimension. The accuracy of the diagnosis system in the verification set of Mobile Device Voice Recordings at King's College London (MDVR-CKL) dataset can reach more than 96%. Compared with current Parkinson's sound diagnosis methods and other optimization algorithms, our auxiliary diagnosis system shows better classification performance on the dataset within limited time and resources.

Study on the difference and regularity of tongue images in 309 patients with different pathological stages of non-small cell lung cancer.

Tongue diagnosis is a crucial traditional Chinese medicine (TCM) inspection method for TCM syndrome differentiation and treatment. The primary research focus was on tongue image characteristic parameters of patients with non-small cell lung cancer (NSCLC). Analysis of the tongue image parameters of various pathological stages of NSCLC provides technical support for establishing an integrated Chinese and Western auxiliary diagnosis and efficacy evaluation medicine system for lung cancer that integrates tongue image features. Tongue image characteristics of 309 patients with NSCLC and 206 controls were collected and analyzed clinically. The T-test or rank sum test and logistic regression analysis were applied to analyze the characteristics of tongue image indicators of different pathological stages of NSCLC. There were differences in tongue image characteristics in the NSCLC group compared to the control group. The tongue quality and brightness of the tongue coating in the NSCLC group increased, the red component was reduced, the tongue coating thickened, and the yellow component increased compared to the healthy control group. A comparison of tongue image indexes of NSCLC in different pathological stages showed that stage IV had lower TB-b and higher TB-a than stage I. In addition, stage IV had lower TB-b than stage II + III, showing an increase in the blue and red components of the tongue in stage IV and the appearance of cyanotic tongue features. The tongue image characteristics of NSCLC patients differed from those of the control group. Tongue imaging indicators can reflect the characteristics of tongue images of patients with NSCLC. The tongue image characteristics of patients with stage IV lung cancer are bluish and purple compared with those with stage I, II, and III. It is suggested that the tongue's image characteristics can be used as a reference for the pathological classification of NSCLC and judgment of the disease process.

Artificial intelligence auxiliary diagnosis and treatment system for breast cancer in developing countries.

In many developing countries, a significant number of breast cancer patients are unable to receive timely treatment due to a large population base, high patient numbers, and limited medical resources. This paper proposes a breast cancer assisted diagnosis system based on electronic medical records. The goal of this system is to address the limitations of existing systems, which primarily rely on structured electronic records and may miss crucial information stored in unstructured records. The proposed approach is a breast cancer assisted diagnosis system based on electronic medical records. The system utilizes breast cancer enhanced convolutional neural networks with semantic initialization filters (BC-INIT-CNN). It extracts highly relevant tumor markers from unstructured medical records to aid in breast cancer staging diagnosis and effectively utilizes the important information present in unstructured records. The model's performance is assessed using various evaluation metrics. Such as accuracy, ROC curves, and Precision-Recall curves. Comparative analysis demonstrates that the BC-INIT-CNN model outperforms several existing methods in terms of accuracy and computational efficiency. The proposed breast cancer assisted diagnosis system based on BC-INIT-CNN showcases the potential to address the challenges faced by developing countries in providing timely treatment to breast cancer patients. By leveraging unstructured medical records and extracting relevant tumor markers, the system enables accurate staging diagnosis and enhances the utilization of valuable information.

Applying Object Detection and Large Language Model to Establish a Smart Telemedicine Diagnosis System with Chatbot: A Case Study of Pressure Injuries Diagnosis System.

Background: The scarcity of medical resources and personnel has worsened due to COVID-19. Telemedicine faces challenges in assessing wounds without physical examination. Evaluating pressure injuries is time consuming, energy intensive, and inconsistent. Most of today's telemedicine platforms utilize graphical user interfaces with complex operational procedures and limited channels for information dissemination. The study aims to establish a smart telemedicine diagnosis system based on YOLOv7 and large language model. Methods: The YOLOv7 model is trained using a clinical data set, with data augmentation techniques employed to enhance the data set to identify six types of pressure injury images. The established system features a front-end interface that includes responsive web design and a chatbot with ChatGPT, and it is integrated with a database for personal information management. Results: This research provides a practical pressure injury staging classification model with an average F1 score of 0.9238. The system remotely provides real-time accurate diagnoses and prescriptions, guiding patients to seek various medical help levels based on symptom severity. Conclusions: This study establishes a smart telemedicine auxiliary diagnosis system based on the YOLOv7 model, which possesses capabilities for classification and real-time detection. During teleconsultations, it provides immediate and accurate diagnostic information and prescription recommendations and seeks various medical assistance based on the severity of symptoms. Through the setup of a chatbot with ChatGPT, different users can quickly achieve their respective objectives.

Image classification and auxiliary diagnosis system for hyperpigmented skin diseases based on deep learning

Background and aimMelasma (ML), naevus fusco-caeruleus zygomaticus (NZ), freckles (FC), cafe-au-lait spots (CS), nevus of ota (NO), and lentigo simplex (LS), are common skin diseases causing hyperpigmentation. Deep learning algorithms learn the inherent laws and representation levels of sample data and can analyze the internal details of the image and classify it objectively to be used for image diagnosis. However, deep learning algorithms that can assist clinicians in diagnosing skin hyperpigmentation conditions are lacking. MethodsThe optimal deep-learning image recognition algorithm was explored for the auxiliary diagnosis of hyperpigmented skin disease. Pretrained models, such as VGG-19, GoogLeNet, InceptionV3, ResNet50V2, ResNet101V2, ResNet152V2, InceptionResNetV2, DesseNet201, MobileNet, and NASNetMobile were used to classify images of six common hyperpigmented skin diseases. The best deep learning algorithm for developing an online clinical diagnosis system was selected by using accuracy and area under curve (AUC) as evaluation indicators. ResultsIn this research, the parameters of the above-mentioned ten deep learning algorithms were 18333510, 5979702, 21815078, 23577094, 42638854, 58343942, 54345958, 18333510, 3235014, and 4276058, respectively, and their training time was 380, 162, 199, 188, 315, 511, 471, 697, 101, and 144 min respectively. The respective accuracies of the training set were 85.94%, 99.72%, 99.61%, 99.52%, 99.52%, 98.84%, 99.61%, 99.13%, 99.52%, and 99.61%. The accuracy rates of the test set data were 73.28%, 57.40%, 70.04%, 71.48%, 68.23%, 71.11%, 71.84%, 73.28%, 70.39%, and 43.68%, respectively. Finally, the areas of AUC curves were 0.93, 0.86, 0.93, 0.91, 0.91, 0.92, 0.93, 0.92, 0.93, and 0.82, respectively. ConclusionsThe experimental parameters, training time, accuracy, and AUC of the above models suggest that MobileNet provides a good clinical application prospect in the auxiliary diagnosis of hyperpigmented skin.

A Depression Recognition Method Based on the Alteration of Video Temporal Angle Features

In recent years, significant progress has been made in the auxiliary diagnosis system for depression. However, most of the research has focused on combining features from multiple modes to enhance classification accuracy. This approach results in increased space-time overhead and feature synchronization problems. To address this issue, this paper presents a single-modal framework for detecting depression based on changes in facial expressions. Firstly, we propose a robust method for extracting angle features from facial landmarks. Theoretical evidence is provided to demonstrate the translation and rotation invariance of these features. Additionally, we introduce a flip correction method to mitigate angle deviations caused by head flips. The proposed method not only preserves the spatial topological relationship of facial landmarks, but also maintains the temporal correlation between frames preceding and following the facial landmarks. Finally, the GhostNet network is employed for depression detection, and the effectiveness of various modal data is compared. In the depression binary classification task using the DAIC-WOZ dataset, our proposed framework significantly improves the classification performance, achieving an F1 value of 0.80 for depression detection. Experimental results demonstrate that our method outperforms other existing depression detection models based on a single modality.

Cattle Disease Auxiliary Diagnosis System Based on Data Analysis

The primary goal of the proposed system is to identify the symptoms of cattle diseases and then forecast the relationship between symptoms, diseases, and treatments. The suggested method combines data science techniques to recognize the signs of cow sickness and forecast patterns. The proposed system employs the "Eclat algorithm" data science technique to identify the patterns. The system is intended to be developed as a real-time application that helps veterinarians treat cattle diseases.

Electret-based flexible pressure sensor for respiratory diseases auxiliary diagnosis system using machine learning technique

Respiratory diseases have been increasingly affecting people worldwide, posing a major public health challenge due to rising morbidity and mortality rates. Subtle abnormal respiratory sounds s may present early in the pulmonary or respiratory tract diseases, therefore urging an instant intervention in critical clinical conditions. However, the current monitoring and signal analysis technologies pose significant challenges in achieving real-time, convenient, and accurate respiratory disease monitoring. Here, we propose a novel automatic auxiliary diagnosis system that utilizes a flexible electret-based self-powered sensor (FESS), signal processing technology, and machine learning algorithms. The FESS is based on a strain-enhanced laminated electret with an edge-to-edge hollow hemisphere array structure, which enables the system to detect and prevent various respiratory diseases with high accuracy rates of 99.43%, sensitivity of 98.30%, and specificity of 99.02%. Our system holds immense potential in reducing medical burden and improving the overall health of individuals.

Diagnostic value of a dynamic artificial intelligence ultrasonic intelligent auxiliary diagnosis system for benign and malignant thyroid nodules in patients with Hashimoto thyroiditis.

A dynamic artificial intelligence (AI) ultrasonic intelligent assistant diagnosis system (dynamic AI) is a joint application of AI technology and medical imaging, which can conduct real-time synchronous dynamic analysis of nodules from multiple sectional views with different angles. This study explored the diagnostic value of dynamic AI for benign and malignant thyroid nodules in patients with Hashimoto thyroiditis (HT) and its significance in guiding surgical treatment strategies. Data of 487 patients (154 with and 333 without HT) with 829 thyroid nodules who underwent surgery were collected. Differentiation of benign and malignant nodules was performed using dynamic AI, and diagnostic effects (specificity, sensitivity, negative predictive value, positive predictive value, accuracy, misdiagnosis rate and missed diagnosis rate) was assessed. Differences in diagnostic efficacy were compared among AI, preoperative ultrasound based on the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS), and fine needle aspiration cytology (FNAC) diagnoses. The accuracy, specificity and sensitivity of dynamic AI reached 88.06%, 80.19%, and 90.68%, respectively; besides, there was consistency with postoperative pathological consequences (κ=0.690; P<0.001). The diagnostic efficacy of dynamic AI was equivalent between patients with and without HT, and there were no significant differences in sensitivity, specificity, accuracy, positive predictive value, negative predictive value, missed diagnosis rate, and misdiagnosis rate. In patients with HT, dynamic AI had significantly higher specificity and a lower misdiagnosis rate than did preoperative ultrasound based on the ACR TI-RADS (P<0.05). Compared with FNAC diagnosis, dynamic AI had a significantly higher sensitivity and a lower missed diagnosis rate (P<0.05). Dynamic AI possessed an elevated diagnostic worth of malignant and benign thyroid nodules in patients with HT, which can provide a new method and valuable information for the diagnosis and development of management strategy of patients.

Neural network-based model for evaluating inert nodules and volume doubling time in T1 lung adenocarcinoma: a nested case-control study.

The purpose of this study is to establish model for assessing inert nodules predicting nodule volume-doubling. A total of 201 patients with T1 lung adenocarcinoma were analysed retrospectively pulmonary nodule information was predicted by an AI pulmonary nodule auxiliary diagnosis system. The nodules were classified into two groups: inert nodules (volume-doubling time (VDT)>600 days n=152) noninert nodules (VDT<600 days n=49). Then taking the clinical imaging features obtained at the first examination as predictive variables the inert nodule judgement model <sn</sn>>(INM) volume-doubling time estimation model (VDTM) were constructed based on a deep learning-based neural network. The performance of the INM was evaluated by the area under the curve (AUC) obtained from receiver operating characteristic (ROC) analysis the performance of the VDTM was evaluated by R2(determination coefficient). The accuracy of the INM in the training and testing cohorts was 81.13% and 77.50%, respectively. The AUC of the INM in the training and testing cohorts was 0.7707 (95% CI 0.6779-0.8636) and 0.7700 (95% CI 0.5988-0.9412), respectively. The INM was effective in identifying inert pulmonary nodules; additionally, the R2 of the VDTM in the training cohort was 0.8008, and that in the testing cohort was 0.6268. The VDTM showed moderate performance in estimating the VDT, which can provide some reference during a patients' first examination and consultation. The INM and the VDTM based on deep learning can help radiologists and clinicians distinguish among inert nodules and predict the nodule volume-doubling time to accurately treat patients with pulmonary nodules.

Using less annotation workload to establish a pathological auxiliary diagnosis system for gastric cancer

Pathological diagnosis of gastric cancer requires pathologists to have extensive clinical experience. To help pathologists improve diagnostic accuracy and efficiency, we collected 1,514 cases of stomach H&E-stained specimens with complete diagnostic information to establish a pathological auxiliary diagnosis system based on deep learning. At the slide level, our system achieves a specificity of 0.8878 while maintaining a high sensitivity close to 1.0 on 269 biopsy specimens (147 malignancies) and 163 surgical specimens (80 malignancies). The classified accuracy of our system is 0.9034 at the slide level for 352 biopsy specimens (201 malignancies) from 50 medical centers. With the help of our system, the pathologists' average false-negative rate and average false-positive rate on 100 biopsy specimens (50 malignancies) are reduced to 1/5 and 1/2 of the original rates, respectively. At the same time, the average uncertainty rate and the average diagnosis time are reduced by approximately 22% and 20%, respectively.

Retracted: An Orthopedic Auxiliary Diagnosis System Based on Image Recognition Technology

Retracted: An Orthopedic Auxiliary Diagnosis System Based on Image Recognition Technology

Exploring robust computer-aided diagnosis of Parkinson’s disease based on various voice signals

As the voice disorder is a typical early symptom of Parkinson, some researchers attempt to diagnose this disease based on voice data collected from suspected patients. Although existing methods can provide acceptable results, they just work in partial scenarios. In other words, they are not generable and robust enough. To this end, we present a Parkinson’s auxiliary diagnosis system based on human speech, which can adaptively build a suitable deep neural network based on sound features. The system includes two modules: hybrid features extraction and adaptive network construction. We extract kinds of information from the voice data to form a new compound feature. Furthermore, particle swarm optimization (PSO) algorithm is employed to build the corresponding 1D convolution network for features classification. Extensive experiments on two datasets consisting of English and Italian are conducted for evaluation purposes. Experimental results show that our method improves the accuracy of voice-based Parkinson’s disease detection to some extent.

Identification of benign and malignant thyroid nodules based on dynamic AI ultrasound intelligent auxiliary diagnosis system.

BackgroundDynamic artificial intelligence (AI) ultrasound intelligent auxiliary diagnosis system (Dynamic AI) is a joint application of AI technology and medical imaging data, which can perform a real-time synchronous dynamic analysis of nodules. The aim of this study is to investigate the value of dynamic AI in differentiating benign and malignant thyroid nodules and its guiding significance for treatment strategies.MethodsThe data of 607 patients with 1007 thyroid nodules who underwent surgical treatment were reviewed and analyzed, retrospectively. Dynamic AI was used to differentiate benign and malignant nodules. The diagnostic efficacy of dynamic AI was evaluated by comparing the results of dynamic AI examination, preoperative fine needle aspiration cytology (FNAC) and postoperative pathology of nodules with different sizes and properties in patients of different sexes and ages.ResultsThe sensitivity, specificity and accuracy of dynamic AI in the diagnosis of thyroid nodules were 92.21%, 83.20% and 89.97%, respectively, which were highly consistent with the postoperative pathological results (kappa = 0.737, p < 0.001). There is no statistical difference in accuracy between people with different ages and sexes and nodules of different sizes, which showed the good stability. The accuracy of dynamic AI in malignant nodules (92.21%) was significantly higher than that in benign nodules (83.20%) (p < 0.001). The specificity and positive predictive value were significantly higher, and the misdiagnosis rate was significantly lower in dynamic AI than that of preoperative ultrasound ACR TI-RADS (p < 0.001). The accuracy of dynamic AI in nodules with diameter ≤ 0.50 cm was significantly higher than that of preoperative ultrasound (p = 0.044). Compared with FNAC, the sensitivity (96.58%) and accuracy (94.06%) of dynamic AI were similar.ConclusionsThe dynamic AI examination has high diagnostic value for benign and malignant thyroid nodules, which can effectively assist surgeons in formulating scientific and reasonable individualized diagnosis and treatment strategies for patients.

Classification of Monkeypox Skin Lesion using the Explainable Artificial Intelligence Assisted Convolutional Neural Networks

The World Health Organization (WHO) has given people various protective warnings for Monkeypox. If monkeypox spreads rapidly, it becomes a serious public health problem. In this case, it creates a serious congestion in hospitals. Therefore, auxiliary systems can be needed in hospitals. In this study, explainable artificial intelligence (xAI) assisted convolutional neural networks (CNNs) based a decision support system was proposed. The data set was used for this task consists of 572 images in two classes, such as Monkeypox and Normal. 12 different CNN models were used for Monkeypox and Normal skin classification. MobileNet V2 model achieved best performance with the accuracy of 98.25%, sensitivity of 96.55%, specificity of 100.00% and F1-Score of 98.25%. This model was supported by explainable AI methods. As a result, an artificial intelligence (AI) assisted auxiliary diagnosis system has been proposed for Monkeypox skin lesion.

Diagnosis of Breast Cancer with Strongly Supervised Deep Learning Neural Network

The strongly supervised deep convolutional neural network (DCNN) has better performance in assessing breast cancer (BC) because of the more accurate features from the slice-level precise labeling compared with the image-level labeling weakly supervised DCNN. However, manual slice-level precise labeling is time consuming and expensive. In addition, the slice-level diagnosis adopted in the DCNN system is incomplete and defective because of the lack of other slices’ information. In this paper, we studied the impact of the region of interest (ROI) and lesion-level multi-slice diagnosis in the DCNN auxiliary diagnosis system. Firstly, we proposed an improved region-growing algorithm to generate slice-level precise ROI. Secondly, we adopted the average weighting method as the lesion-level diagnosis criteria after exploring four different weighting methods. Finally, we proposed our complete system, which combined the densely connected convolutional network (DenseNet) with the slice-level ROI and the average weighting lesion-level diagnosis after evaluating the performance of five DCNNs. The proposed system achieved an AUC of 0.958, an accuracy of 92.5%, a sensitivity of 95.0%, and a specificity of 90.0%. The experimental results showed that our proposed system had a better performance in BC diagnosis because of the more precise ROI and more complete information of multi-slices.

High-Accuracy Oral Squamous Cell Carcinoma Auxiliary Diagnosis System Based on EfficientNet.

It is important to diagnose the grade of oral squamous cell carcinoma (OSCC), but the current evaluation of the biopsy slide still mainly depends on the manual operation of pathologists. The workload of manual evaluation is large, and the results are greatly affected by the subjectivity of the pathologists. In recent years, with the development and application of deep learning, automatic evaluation of biopsy slides is gradually being applied to medical diagnoses, and it has shown good results. Therefore, a new OSCC auxiliary diagnostic system was proposed to automatically and accurately evaluate the patients’ tissue slides. This is the first study that compared the effects of different resolutions on the results. The OSCC tissue slides from The Cancer Genome Atlas (TCGA, n=697) and our independent datasets (n=337) were used for model training and verification. In the test dataset of tiles, the accuracy was 93.1% at 20x resolution (n=306,134), which was higher than that at 10x (n=154,148, accuracy=90.9%) and at 40x (n=890,681, accuracy=89.3%). The accuracy of the new system based on EfficientNet, which was used to evaluate the tumor grade of the biopsy slide, reached 98.1% [95% confidence interval (CI): 97.1% to 99.1%], and the area under the receiver operating characteristic curve (AUROC) reached 0.998 (95%CI: 0.995 to 1.000) in the TCGA dataset. When verifying the model on the independent image dataset, the accuracy still reached 91.4% (95% CI: 88.4% to 94.4%, at 20x) and the AUROC reached 0.992 (95%CI: 0.982 to 1.000). It may benefit oral pathologists by reducing certain repetitive and time-consuming tasks, improving the efficiency of diagnosis, and facilitating the further development of computational histopathology.

An efficient glomerular object locator for renal whole slide images using proposal-free network and dynamic scale evaluation method

In the diagnosis of chronic kidney disease, glomerulus as the blood filter provides important information for an accurate disease diagnosis. Thus automatic localization of the glomeruli is the necessary groundwork for future auxiliary kidney disease diagnosis, such as glomerular classification and area measurement. In this paper, we propose an efficient glomerular object locator in kidney whole slide image(WSI) based on proposal-free network and dynamic scale evaluation method. In the training phase, we construct an intensive proposal-free network which can learn efficiently the fine-grained features of the glomerulus. In the evaluation phase, a dynamic scale evaluation method is utilized to help the well-trained model find the most appropriate evaluation scale for each high-resolution WSI. We collect and digitalize 1204 renal biopsy microscope slides containing more than 41000 annotated glomeruli, which is the largest number of dataset to our best knowledge. We validate the each component of the proposed locator via the ablation study. Experimental results confirm that the proposed locator outperforms recently proposed approaches and pathologists by comparing F 1 and run time in localizing glomeruli from WSIs at a resolution of 0.25 μm/pixel and thus achieves state-of-the-art performance. Particularly, the proposed locator can be embedded into the renal intelligent auxiliary diagnosis system for renal clinical diagnosis by localizing glomeruli in high-resolution WSIs effectively.