Recent global disruptions, such as the COVID-19 pandemic and the ongoing geopolitical conflicts, have profoundly exposed vulnerabilities in traditional supply chains, requiring exploration of more resilient alternatives. Among various solution offerings, Autonomous supply chains (ASCs) have emerged as key enablers of increased integration and visibility, enhancing flexibility and resilience in turbulent trade environments through the widespread automation of low level decision making. Although ASC solutions have been discussed and trialled over several years, they still lack well-established theoretical foundations. This paper addresses this research gap by presenting a formal definition of ASC along with its defining characteristics and auxiliary concepts. We propose a layered conceptual framework, called the MIISI model. An illustrative case study focusing on the meat supply chain demonstrates an initial ASC implementation based on this conceptual model. Furthermore, we introduce a seven-level supply chain autonomy reference model, delineating a trajectory towards achieving full supply chain autonomy. Recognising that this work represents an initial endeavour, we emphasise the need for continued exploration in this emerging domain. This work is designed to stimulate further research, both theoretical and technical, and contribute to the continual evolution of ASCs.
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