X-ray Crystallography has been present in Uruguay since the 50's. A project funded by UNESCO brought Prof. S. Furberg to Montevideo and introduced equipment in a laboratory of Universidad de la República, Facultad de Ingeniería where Prof. Stephenson Caticha Ellis worked.[1] During the period 1968-1995 the political and economic situation of the country reduced research in general and crystallography in particular, re-emerging in the late 90's with the acquisition of an automatic single-crystal diffractometer by Facultad de Química. After the opening of the Brazilian Synchrotron Light Laboratory in 1997 several projects in crystallography have also developed with the successful realization of half a dozen postgraduate projects. Currently there are chemical, biological and physical crystallography labs in the country, with a reduced but sufficient pool of research equipment. The main institutions where Crystallography is developed are Universidad de la República (3 groups) and the Institut Pasteur de Montevideo. There has been an explosive growth of crystallography in the country in recent years. From the 4-people group found at F. de Química in 2000 to over 50 people of the Red Uruguaya de Cristalografía recently founded.[2] This development wouldn't have happened without the strong influence of Latin American crystallographers, mainly but not only from Argentina and Brazil, and also collaboration from extra-regional colleagues from USA, the UK, France and Switzerland. Very recently additional impulse has come from Latin America with the formation of the Latin American Cryst. Assoc. LACA[3]. Uruguayan crystallographers are currently involved in dissemination and academic projects for IYCr2014 such as an open-sky photo-gallery in Montevideo, a national crystal growth competition, a protein crystallography school and two UNESCO/IUCr OpenLab Type 1 sponsored by Bruker. A description of on-going projects in Uruguay and the region will be outlined in the presentation