Automatic Diagnosis Of Diabetic Retinopathy Research Articles

Correction to: Automatic Diagnosis of Diabetic Retinopathy from Retinal Abnormalities: Improved Jaya-Based Feature Selection and Recurrent Neural Network

Correction to: Automatic Diagnosis of Diabetic Retinopathy from Retinal Abnormalities: Improved Jaya-Based Feature Selection and Recurrent Neural Network

Роботизированные инструменты и обучаемые алгоритмы в офтальмологии

In recent years, robotic tools and machine learning algorithms have become increasingly popular in ophthalmology. These technologies reduce the risk of errors during surgical procedures and improve treatment outcomes, as well as enable automation. one of the most common robotic systems in ophthalmology is the Femto-laSIK system, which is used to correct vision by changing the shape of the cornea. Machine learning algorithms have also found wide application in ophthalmology. they are used to analyze medical images, such as photographs of the eye or retina scans. These algorithms automatically detect and classify various eye diseases, such as glaucoma, diabetic retinopathy, and macular degeneration. This helps doctors diagnose diseases more quickly and accurately, and prescribe appropriate treatment. One of the most interesting examples of using machine learning algorithms in ophthalmology is the Eyeart system, which is used for automatic diagnosis of diabetic retinopathy. This article describes approaches and developments that allow for the diagnosis and treatment of glaucoma, tools for automating cataract treatment using machine learning algorithms and a robotic manipulator. It also describes a digital microscope that enables the use of these technologies in the operating process. Overall, robotic tools and machine learning algorithms have become an integral part of ophthalmology. they improve treatment outcomes and reduce the risk of errors. the future of ophthalmology is linked to the development of these technologies, which will become increasingly accurate and intelligent. Keywords: robotic tools, machine learning, ophthalmology

Hybrid Fusion of High-Resolution and Ultra-Widefield OCTA Acquisitions for the Automatic Diagnosis of Diabetic Retinopathy.

Optical coherence tomography angiography (OCTA) can deliver enhanced diagnosis for diabetic retinopathy (DR). This study evaluated a deep learning (DL) algorithm for automatic DR severity assessment using high-resolution and ultra-widefield (UWF) OCTA. Diabetic patients were examined with 6×6 mm2 high-resolution OCTA and 15×15 mm2 UWF-OCTA using PLEX®Elite 9000. A novel DL algorithm was trained for automatic DR severity inference using both OCTA acquisitions. The algorithm employed a unique hybrid fusion framework, integrating structural and flow information from both acquisitions. It was trained on data from 875 eyes of 444 patients. Tested on 53 patients (97 eyes), the algorithm achieved a good area under the receiver operating characteristic curve (AUC) for detecting DR (0.8868), moderate non-proliferative DR (0.8276), severe non-proliferative DR (0.8376), and proliferative/treated DR (0.9070). These results significantly outperformed detection with the 6×6 mm2 (AUC = 0.8462, 0.7793, 0.7889, and 0.8104, respectively) or 15×15 mm2 (AUC = 0.8251, 0.7745, 0.7967, and 0.8786, respectively) acquisitions alone. Thus, combining high-resolution and UWF-OCTA acquisitions holds the potential for improved early and late-stage DR detection, offering a foundation for enhancing DR management and a clear path for future works involving expanded datasets and integrating additional imaging modalities.

Automatic diagnosis of diabetic retinopathy using vision transformer based on wide-field optical coherence tomography angiography

Diabetic retinopathy (DR) is one of the major causes of visual impairment in adults with diabetes. Optical coherence tomography angiography (OCTA) is nowadays widely used as the golden criterion for diagnosing DR. Recently, wide-field OCTA (WF-OCTA) provided more abundant information including that of the peripheral retinal degenerative changes and it can contribute in accurately diagnosing DR. The need for an automatic DR diagnostic system based on WF-OCTA pictures attracts more and more attention due to the large diabetic population and the prevalence of retinopathy cases. In this study, automatic diagnosis of DR using vision transformer was performed using WF-OCTA images (12[Formula: see text]mm × 12[Formula: see text]mm single-scan) centered on the fovea as the dataset. WF-OCTA images were automatically classified into four classes: No DR, mild nonproliferative diabetic retinopathy (NPDR), moderate to severe NPDR, and proliferative diabetic retinopathy (PDR). The proposed method for detecting DR on the test set achieves accuracy of 99.55%, sensitivity of 99.49%, and specificity of 99.57%. The accuracy of the method for DR staging reaches up to 99.20%, which has been proven to be higher than that attained by classical convolutional neural network models. Results show that the automatic diagnosis of DR based on vision transformer and WF-OCTA pictures is more effective for detecting and staging DR.

Overview of global publications on machine learning in diabetic retinopathy from 2011 to 2021: Bibliometric analysis.

To comprehensively analyze and discuss the publications on machine learning (ML) in diabetic retinopathy (DR) following a bibliometric approach. The global publications on ML in DR from 2011 to 2021 were retrieved from the Web of Science Core Collection (WoSCC) database. We analyzed the publication and citation trend over time and identified highly-cited articles, prolific countries, institutions, journals and the most relevant research domains. VOSviewer and Wordcloud are used to visualize the mainstream research topics and evolution of subtopics in the form of co-occurrence maps of keywords. By analyzing a total of 1147 relevant publications, this study found a rapid increase in the number of annual publications, with an average growth rate of 42.68%. India and China were the most productive countries. IEEE Access was the most productive journal in this field. In addition, some notable common points were found in the highly-cited articles. The keywords analysis showed that "diabetic retinopathy", "classification", and "fundus images" were the most frequent keywords for the entire period, as automatic diagnosis of DR was always the mainstream topic in the relevant field. The evolution of keywords highlighted some breakthroughs, including "deep learning" and "optical coherence tomography", indicating the advance in technologies and changes in the research attention. As new research topics have emerged and evolved, studies are becoming increasingly diverse and extensive. Multiple modalities of medical data, new ML techniques and constantly optimized algorithms are the future trends in this multidisciplinary field.

Automatic Diagnosis of Diabetic Retinopathy from Fundus Images Using Neuro-Evolutionary Algorithms.

Due to the presence of high glucose levels, diabetes mellitus (DM) is a widespread disease that can damage blood vessels in the retina and lead to loss of the visual system. To combat this disease, called Diabetic Retinopathy (DR), retinography, using images of the fundus of the retina, is the most used method for the diagnosis of Diabetic Retinopathy. The Deep Learning (DL) area achieved high performance for the classification of retinal images and even achieved almost the same human performance in diagnostic tasks. However, the performance of DL architectures is highly dependent on the optimal configuration of the hyperparameters. In this article, we propose the use of Neuroevolutionary Algorithms to optimize the hyperparameters corresponding to the DL model for the diagnosis of DR. The results obtained prove that the proposed method outperforms the results obtained by the classical approach.

Performance Analysis of Deep-Neural-Network-Based Automatic Diagnosis of Diabetic Retinopathy.

Diabetic retinopathy (DR) is a human eye disease that affects people who are suffering from diabetes. It causes damage to their eyes, including vision loss. It is treatable; however, it takes a long time to diagnose and may require many eye exams. Early detection of DR may prevent or delay the vision loss. Therefore, a robust, automatic and computer-based diagnosis of DR is essential. Currently, deep neural networks are being utilized in numerous medical areas to diagnose various diseases. Consequently, deep transfer learning is utilized in this article. We employ five convolutional-neural-network-based designs (AlexNet, GoogleNet, Inception V4, Inception ResNet V2 and ResNeXt-50). A collection of DR pictures is created. Subsequently, the created collections are labeled with an appropriate treatment approach. This automates the diagnosis and assists patients through subsequent therapies. Furthermore, in order to identify the severity of DR retina pictures, we use our own dataset to train deep convolutional neural networks (CNNs). Experimental results reveal that the pre-trained model Se-ResNeXt-50 obtains the best classification accuracy of 97.53% for our dataset out of all pre-trained models. Moreover, we perform five different experiments on each CNN architecture. As a result, a minimum accuracy of 84.01% is achieved for a five-degree classification.

Validation of an Automated Screening System for Diabetic Retinopathy Operating under Real Clinical Conditions.

Background. Retinopathy is the most common microvascular complication of diabetes mellitus. It is the leading cause of blindness among working-aged people in developed countries. The use of telemedicine in the screening system has enabled the application of large-scale population-based programs for early retinopathy detection in diabetic patients. However, the need to support ophthalmologists with other trained personnel remains a barrier to broadening its implementation. Methods. Automatic diagnosis of diabetic retinopathy was carried out through the analysis of retinal photographs using the 2iRetinex software. We compared the categorical diagnoses of absence/presence of retinopathy issued by family physicians (PCP) with the same categories provided by the algorithm (ALG). The agreed diagnosis of three specialist ophthalmologists is used as the reference standard (OPH). Results. There were 653 of 3520 patients diagnosed with diabetic retinopathy (DR). Diabetic retinopathy threatening to vision (STDR) was found in 82 patients (2.3%). Diagnostic sensitivity for STDR was 94% (ALG) and 95% (PCP). No patient with proliferating or severe DR was misdiagnosed in both strategies. The k-value of the agreement between the ALG and OPH was 0.5462, while between PCP and OPH was 0.5251 (p = 0.4291). Conclusions. The diagnostic capacity of 2iRetinex operating under normal clinical conditions is comparable to screening physicians.

Automatic Diagnosis of Diabetic Retinopathy from Retinal Abnormalities: Improved Jaya-Based Feature Selection and Recurrent Neural Network

Abstract Accurate diagnosis of lesions bears the highest significance in the early detection of diabetic retinopathy (DR). In this paper, the combination of intelligent methods is developed for segmenting the abnormalities like ‘hard exudates, hemorrhages, microaneurysm and soft exudates’ to detect the DR. The proposed model involves seven main steps: (a) image pre-processing, (b) optic disk removal (c) blood vessel removal, (d) segmentation of abnormalities, (e) feature extraction, (f) optimal feature selection and (f) classification. The pre-processing of the input retinal fundus image is performed by two operations like contrast enhancement by histogram equalization and filtering by average filtering. For the segmentation of abnormalities, the same Circular Hough Transform followed by Top-hat filtering and Gabor filtering is used. Next, the entropy-scale-invariant feature transform (SIFT), grey level co-occurrence matrices and color morphological features are extracted in feature extraction. The optimally selected features are subjected to the classification part, which uses a modified deep learning algorithm called optimized recurrent neural network (RNN). As the main novelty, the optimal feature selection and optimized RNN depends on an improved meta-heuristic algorithm called fitness oriented improved Jaya algorithm. Hence, the beneficial part of the optimization algorithm improves the feature selection and classification.

Automatic Detection of Genetics and Genomics of Eye Disease Using Deep Assimilation Learning Algorithm.

Diabetic retinopathy (DR) is one of the most prevalent genetic diseases in human and it is caused by damage to the blood vessels in the eye retina. If it is undetected and untreated at right time, it can lead to vision loss. There are many medical imaging and processing technologies to improve the diagnostic process of DR to overcome the lack of human experts. In the existing image processing methods, there are issues such as lack of noise removal, improper clustering segmentation and less classification accuracy. This can be accomplished by automatic diagnosis of DR using advanced image processing method. The cotton wool spot (CWS), hard exudates (HE) contains a common manifestation of many diseases in retina including DR and acquired immunodeficiency syndrome. In the present work, super iterative clustering algorithm (SICA) is proposed to identify the CWS, HE on retinal image. Feature-based medical image retrieval (FBMIR) datasets are utilized for this purpose. Noises present on the images and histogram-filtering technique is used to convert red, green, and blue (RGB) images into a perfect greyscale image without noise. After pre-processing, SICA is used to identify the CWS, HE detection on retinal images and eliminates unnecessary areas of interest. In the third stage, after detecting CWS and HE, various statistical features are extracted for further classification using deep assimilation learning algorithm (DALA). The performance of DALA technique is examined with various classification parameters like recall, precision, and F-measure. Finally, the false classification ratios are computed to compare the performance of the trained networks. The proposed method produces accurate detection of affected regions with an accuracy ratio of 98.5% and it is higher than the other conventional methods. This method may improve the accuracy of automatic detection and classification of eye diseases.

Automatic diagnosis of diabetic retinopathy with the aid of adaptive average filtering with optimized deep convolutional neural network

AbstractThe most effective treatment for diabetic retinopathy (DR) is the early detection through regular screening, which is critical for a better prognosis. Automatic screening of the images would assist the physicians in diagnosing the condition of patients easily and accurately. This condition searches out for special importance of image processing technology in the way of processing the retinal fundus images. Accordingly, this article plans to develop an automatic DR detection model with the aid of three main stages like (a) image preprocessing, (b) blood vessel segmentation, and (c) classification. The preprocessing phase includes two steps: conversion of RGB to Lab, and contrast enhancement. The Histogram equalization process is done using the contrast enhancement of an image. To the next of preprocessing, the segmentation phase starts with a valuable procedure. It includes (a), thresholding the contrast‐enhanced and filtered images, (b) thresholding the keypoints of contrast‐enhanced and filtered images, and (c) adding both thresholded binary images. Here, the filtering process is performed by proposed adaptive average filtering, where the filter coefficients are tuned or optimized by an improved meta‐heuristic algorithm called fitness probability‐based CSO (FP‐CSO). Finally, the classification part uses Deep CNN, where the improvement is exploited on the convolutional layer, which is optimized by the same improved FP‐CSO. Since the conventional CSO depends on a fitness probability in the improved algorithm, the proposed algorithm termed as FP‐CSO. Finally, valuable comparative and performance analysis has confirmed the effectiveness of the proposed model.

Automated diabetic retinopathy detection using radial basis function

Diabetic mellitus is a major reason of visual impairment an around the world. Early automatic diagnosis of diabetic retinopathy (DR) may avoid vision loss and blindness. The goal of this paper is to automatically detect retinal image as Non DR or DR based on radial basis function (RBF) neural network classifier. This experiment address to explore ophthalmic features such as blood vessels, exudates & microaneurysms and it’s segmented from retinal background using A-IFS histon based segmentation method. This obtained feature set delivers to train RBF neural network. The Receiver operation characteristics (ROC) curve is plotted based on evaluated result. The projected experiment has been done on 130 DIARETDB0 & 89 DIARETDB1 retinal images database by using RBF neural network. The experiment perceive the accuracy of 71.2%, Sensitivity 0.83 & Specificity 0.043 for DIARETDB0 and the accuracy of 89.4% Sensitivity 0.94 & Specificity 0.16 for DIARETDB1.

IDRiD: Diabetic Retinopathy - Segmentation and Grading Challenge.

Diabetic Retinopathy (DR) is the most common cause of avoidable vision loss, predominantly affecting the working-age population across the globe. Screening for DR, coupled with timely consultation and treatment, is a globally trusted policy to avoid vision loss. However, implementation of DR screening programs is challenging due to the scarcity of medical professionals able to screen a growing global diabetic population at risk for DR. Computer-aided disease diagnosis in retinal image analysis could provide a sustainable approach for such large-scale screening effort. The recent scientific advances in computing capacity and machine learning approaches provide an avenue for biomedical scientists to reach this goal. Aiming to advance the state-of-the-art in automatic DR diagnosis, a grand challenge on "Diabetic Retinopathy - Segmentation and Grading" was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI - 2018). In this paper, we report the set-up and results of this challenge that is primarily based on Indian Diabetic Retinopathy Image Dataset (IDRiD). There were three principal sub-challenges: lesion segmentation, disease severity grading, and localization of retinal landmarks and segmentation. These multiple tasks in this challenge allow to test the generalizability of algorithms, and this is what makes it different from existing ones. It received a positive response from the scientific community with 148 submissions from 495 registrations effectively entered in this challenge. This paper outlines the challenge, its organization, the dataset used, evaluation methods and results of top-performing participating solutions. The top-performing approaches utilized a blend of clinical information, data augmentation, and an ensemble of models. These findings have the potential to enable new developments in retinal image analysis and image-based DR screening in particular.

Automatic diabetic retinopathy diagnosis using adjustable ophthalmoscope and multi-scale line operator

Diabetic Retinopathy (DR), the most common one of diabetic eye diseases that cause loss of vision and blindness, has become one of major health problems today. However, DR can be eased through timely treatment and periodical screening. In this paper, we proposes an automatic diabetic retinopathy diagnostic system to help patients know about their retinal conditions. We design a portable ophthalmoscope, which is composed of a retinal lens, a smartphone and a frame between them to help patients take fundus images anywhere and anytime. Then the images are transmitted to be analyzed, including localization of optic disk and macular, vessel segmentation, detection of lesions, and grading of DR. We use a multi-scale line operator to improve accuracy in segmenting small-scale vessels, a binary mask and image restoration to reduce the effect of the existence of the vessels on optic disk localization. After the analysis, the fundus image are then graded as normal, mild Non-Proliferative Diabetic Retinopathy (NPDR), moderate NPDR or severe NPDR. The grading process uses region segmentation to improve the efficiency. The final grading results are tested based on the fundus images provided by the hospitals. We evaluate our system through comparing our grading result with those graded by experts, which comes out with an overall accuracy of up to 85%.

An enhanced PSO-DEFS based feature selection with biometric authentication for identification of diabetic retinopathy

Recently, automatic diagnosis of diabetic retinopathy (DR) from the retinal image is the most significant research topic in the medical applications. Diabetic macular edema (DME) is the major reason for the loss of vision in patients suffering from DR. Early identification of the DR enables to prevent the vision loss and encourage diabetic control activities. Many techniques are developed to diagnose the DR. The major drawbacks of the existing techniques are low accuracy and high time complexity. To overcome these issues, this paper proposes an enhanced particle swarm optimization-differential evolution feature selection (PSO-DEFS) based feature selection approach with biometric authentication for the identification of DR. Initially, a hybrid median filter (HMF) is used for pre-processing the input images. Then, the pre-processed images are embedded with each other by using least significant bit (LSB) for authentication purpose. Simultaneously, the image features are extracted using convoluted local tetra pattern (CLTrP) and Tamura features. Feature selection is performed using PSO-DEFS and PSO-gravitational search algorithm (PSO-GSA) to reduce time complexity. Based on some performance metrics, the PSO-DEFS is chosen as a better choice for feature selection. The feature selection is performed based on the fitness value. A multi-relevance vector machine (M-RVM) is introduced to classify the 13 normal and 62 abnormal images among 75 images from 60 patients. Finally, the DR patients are further classified by M-RVM. The experimental results exhibit that the proposed approach achieves better accuracy, sensitivity, and specificity than the existing techniques.

An application of image processing to the diagnosis of diabetic retinopathy for the automatic detection of microaneurysms and hemorrhages in fundus images of the human retina

This study focused on developing a new algorithm for segmenting lesions in retinal images, in order to prepare for lesion feature extraction, in the automatic diagnosis of Diabetic Retinopathy (DR) using computer vision. Tests conducted to evaluate algorithm performance included a sensitivity-and-specificity test, a ground-truth-based test and a subjective fidelity-criteria test. Sensitivity and specificity were 90% and 100%, respectively. Target lesions fell within ground-truth-labeled regions. On a scoring scale of 1 to 5, the subjective fidelity-criteria mean, standard deviation and variance were 3.829, 0.6128 and 0.375, respectively. Tests showed the algorithm has strong potential in helping to detect microaneurysms and hemorrhages, as a means of automatically diagnosing DR’s early symptoms and treating it in a timely manner. Key Words: Blindness, diabetic retinopathy, fundus, retinal blood vessels, microaneurysms, hemorrhages, image processing, image segmentation