Confronted by rising powers with autocratic structures such as China and Russia, it is essential for the United States to be less dependent on nations that do not share its values. Rather than a new era of isolationism, this essay proposes a renewed sense of confidence and determination for America to continue to be the leader of the Free World. To be able to support others, the U.S. first needs to look after its own interests as a nation-state. Specifically, this means: (1) Gaining and maintaining energy independence by investing in an energy mix that is both economically and ecologically sustainable; (2) Revitalizing manufacturing in the U.S. by creating an investment-friendly environment and taking advantage of the innovative technologies of the Third and Fourth Industrial Revolutions; and (3) Reevaluating the nation’s foreign-policy commitments by rebuilding its military capabilities in order to focus on its own defense and a few key allies, rather than spending resources in engagements that are not directly connected to America’s self-interest.