This study introduces a novel approach for the global retrofitting of seismic performance in destructively damaged reinforced concrete (RC) frames through the application of autoclaved aerated concrete (AAC) blocks infill walls to enhance both structural strength and stiffness. Three full-scale RC frames are designed and fabricated, comprising an intact bare frame, a damaged frame strengthened by carbon fiber-reinforced polymer (CFRP), and a damaged frame retrofitted with the same CFRP and AAC blocks infill walls. To verify the cyclic behaviors and working principle of the retrofitted system, the two frames undergo a pre-damage scenario with a maximum inter-story drift ratio (MIDR) of 2.52%, and then both specimens are retrofitted. Afterward, a pseudo-static cyclic test is conducted on three specimens, with a MIDR of 3.36%. The test data is analyzed and discussed in terms of hysteretic responses, secant stiffness, displacement ductility, and energy dissipation capacity. The findings indicate a significant improvement in the lateral strength and stiffness of the seismic-damaged frame through the implementation of AAC blocks infill walls, demonstrating performance comparable to the intact RC frame. Also, the slight local crushing of AAC blocks and their interaction with mortar joints effectively dissipates a considerable amount of input energy, thereby reducing the energy dissipation demands on retrofitted structural components. Moreover, the theoretical deduction of the lateral strength of the retrofitted RC frames is presented. The errors between the predicted and test results fall within 5%, suggesting that the analytical outcomes can reasonably predict the lateral strength of the specimens.