Autism Treatment Evaluation Checklist Research Articles

The influence of modulation of intestinal microbiota on clinical and immunological parameters and oxytocin levels in children with autism spectrum disorders

Autism spectrum disorders are associated with an imbalance of immune and neurological disorders, starting after the age of two. The study is devoted to studying the role of specialized strains of bacteria Lactobacillus reuteri, which mediate the synthesis of oxytocin in humans and influence inflammation indicators. Bacteria of this strain were part of the biologically active additive “Panbiolact Mental”, developed and presented by NPO ArtLife (Tomsk). The purpose of the work was to assess the effect of specialized strains of bacteria Lactobacillus reuteri on changes in the composition of the intestinal microbiota, oxytocin levels, and immune parameters of children with ASD. The study included 43 children with autism spectrum disorders who took Panbiolact Mental for 90 days. The study materials included venous blood samples and fecal samples. The concentrations of cytokines (IL-4, IL-10, TNF, IFN), immunoglobulins (IgE, IgG, IgA, IgM) and the neuropeptide oxytocin were determined in the blood serum. Fecal samples were used to assess the qualitative and quantitative composition of the colon microbiota. Clinical symptoms of the disease associated with quality of life were assessed using the standard ATEC test scale (Autism Treatment Evaluation Checklist), expressed in scores corresponding to the severity of clinical and neurological parameters of the disease. In children with autism spectrum disorders, after 90 days of regular use of Panbiolact Mental, the number of bacteria of the genera Acinetobacter decreased, the number of Bacteroides species pluralis, Akkermansia muciniphila, Eubacterium rectale, Prevotella species pluralis and Methanobrevibacter smithii increased. Increases in the concentration of oxytocin, the protolerogenic coefficient IL-10/TNFα, immunoglobulins M and G, and a decrease in the concentrations of TNFα and IL-10 were recorded. The results of the study support the hypothesis of a significant role of gut microbiota diversity in the neuro-immune pathogenesis of autism spectrum disorders. “Panbiolact Mental” is presented as a potentially effective remedy for an integrated approach to the correction of ASD in children. These data may form the basis for further research in the field of probiotic therapy, as well as for the development of new strategies based on modulation of the intestinal microbiota.

Unraveling the relative abundance of psychobiotic bacteria in children with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social deficits. Accumulated evidence has shown a link between alterations in the composition of gut microbiota and both neurobehavioural and gastrointestinal symptoms in children with ASD which are related to the genera Lactobacillus and Bifidobacterium. These genera have been recently categorized as “psychobiotics”. Moreover, this study aimed to compare the relative abundance of psychobiotics (L. plantarum, L. reuteri, and B. longum) to the total gut microbiome in typically developing (TD) children and those with ASD in order to correlate the distribution of psychobiotic with the severity and sensory impairments in autism. The ASD children were assessed using the Childhood Autism Rating Scale (CARS), while sensory impairments were evaluated using the Short Sensory Profile (SSP). Furthermore, the gut microbiome was analyzed using the quantitative real-time PCR. The study revealed a statistically significant increase in the relative abundance of L. reuteri and L. plantarum in the TD group in comparison to ASD children. Regarding the SSP total score of ASD children, a statistically significant negative correlation was found between both Lactobacillus and L. plantarum with the under-responsive subscale. For the Autism Treatment Evaluation Checklist (ATEC) score, B. longum and Lactobacillus showed a significant positive correlation with Health/Physical/Behaviour.

A prospective randomized controlled study of neurofeedback combined with learning style profile intervention training in children with high-functioning autism

To explore the application of neurofeedback (NFB) combined with learning style profile (LSP) intervention training in children with high-functioning autism (HFA). A prospective study was conducted to select 86 children with HFA admitted to the hospital from February 2022 to February 2024. They were divided into two groups according to the random number table method, with 43 cases in each group. In this double-blind study, the control group was given LSP intervention training, and the observation group was given NFB intervention on the basis of the treatment used in the control group. Both groups were treated for 6 months. The scores of Autism Behavior Checklist (ABC), Autism Treatment Evaluation Checklist (ATEC), Social Responsiveness Scale (SRS), and Pediatric Quality of Life (PedsQL) were compared between the two groups before intervention and at 6 months after intervention. The relationship of PedsQL score with ABC, ATEC, and SRS scores was analyzed in children with HFA. After 6 months of intervention, the scores of ABC, ATEC, and SRS in the observation group were significantly lower than those in the control group, while the PedsQL score in the observation group was significantly higher than that in the control group (P<0.05). The PedsQL score was negatively correlated with the ABC, ATEC, and SRS scores in children with HFA (r=-0.238, -0.381, -0.219 respectively; P<0.001). NFB combined with LSP can effectively improve the clinical symptoms and social ability, control the development of the disease, and improve the quality of life in children with HFA.

Validation of the Sinhala version of the Autism Treatment Evaluation Checklist (ATEC)

Background: Autism Spectrum Disorder is a neuro developmental disorder which has a trend in its increasing prevalence globally. Measuring the outcome of intervention will have a great value for parents and clinicians. At present, there are no tools validated in the Sri Lankan setting to assess treatment outcomes in Autism Spectrum Disorder. Autism Treatment Evaluation Checklist (ATEC) is a self-administered questionnaire in Sinhala for parents/caregivers that is a feasible method of evaluating outcome in a busy clinic.Aims: This study was conducted to translate and culturally adapt the ATEC to the Sinhala language and to establish the validity and reliability of the translation to the local setting.Methods: Permission was sought from the developers of the ATEC questionnaire and ethical approval was obtained for the study. Study was conducted in two stages. In the first stage, ATEC was translated using the translation-back translation method. An expert panel produced a pre-final questionnaire which was pre-tested prior to formulating the final Sinhala version of ATEC. The second stage of the study was conducted to establish validity and reliability of Sinhala ATEC questionnaire in the Sri Lankan popu-lation. Content validity was assured in each step of the translation by the expert committee. Construct validity of the Sinhala ATEC questionnaire was assessed by comparing the sample of 119 parent/caregiver filled final version of the Sinhala ATEC score against the Consultant Child and Adolescent Psychiatrist assessment of the same children conducted independently and recorded according to DSM-5 (level 1, 2 or 3). Test-retest reliability was determined by the same parent/caregiver filling the Sinhala ATEC one week later, in a sample of 14 children. Intra-rater reliability was taken by com-paring 18 pairs of parents/caregivers Sinhala ATEC scores for the same child.Results: Sinhala ATEC showed high validity and reliability. Its concurrent validity has a strong positive Pearson correlation of 0.856 with the Consultant Psychiatrist assessment. Correlation was higher in total score and as well as in subscale II- Sociability score of the Sinhala ATEC. Internal consistency was revealed by Cronbach’s alpha 0.778. Cut off points to distinguish mild autism spectrum disorder from the rest taken as “48 or less” with sensitivity 82%, specificity 94% and area under the curve 0.968. Cut off to separate severe autism spectrum disorder from the rest were taken as “76 or more” with sensitivity 84%, specificity 90%and area under the curve 0.971. Reliability tests, intra class correlation was 0.98 and 0.96 for test-retest and intra rater reliability showed high reliability of Sinhala ATEC. For developing burnout in this study population.Conclusions: Translated version of Sinhala ATEC is suitable for the use in the Sri Lankan population as it shows high validity and reliability. However, further studies are recommended in other areas of the country to assess its usefulness across diverse subcultures and clinical settings.

Prompt Response, Cues-Pause-Point Therapies and Gender on Management of Echolalia among Children with Autism Spectrum Disorder

The repetitive and delayed nature of echolalia can hinder the development of adaptive behaviors and impact the ability to establish rapport with others. This study investigated the effects of prompt response and cues-pause-point therapies on the management of echolalia among children with autism spectrum disorder. A pre-test, post-test, and control group of a 3x2 factorial matrix of quasi-experimental research design was used to assess the effect of the therapies on children with autism spectrum disorder in Ibadan, Nigeria. 90children with autism spectrum disorder were purposively selected using Diagnostic Statistical Manual- V (DSM-V) for ASD (0.70), Gilliam Autism Rating Scale/Third Edition (GARS-3) (in terms of sensitivity= 0.97, ROU/AUC= 0.93). In contrast, the Autism Treatment Evaluation Checklist (ATEC) (0.90) was used for the pretest and posttest to ascertain the presence of echolalia. Participants were assigned to one of three groups: prompt response, cues-pause-point therapies, or control (N = 90, male = 44, female = 46, age range = 3 –5 years old). Twenty-four prompt response and cues-pause-point therapy were held for each experimental group. The findings showed that the main effect of treatment (prompt response and cues-pause-point therapies) (F (2; 72) = 45.519, p&lt;.05, ƞ2 = .558) on the management of echolalia among children with autism was significant, premised on this, the null hypothesis was rejected. The post hoc estimated marginal mean indicates that prompt response treatment was higher than cues-pause-point therapy; however, this difference was statistically significant. The study findings indicated that the impact of gender on managing echolalia in individuals with ASD was not statistically significant. Based on the findings, it is recommended that speech therapists, caregivers, and parents of children with autism spectrum disorder should seek alternative therapy that will take into cognizance other underlying factors associated with the presence of echolalia.

Impact of parent-delivered traditional Thai massage on children with autism spectrum disorder and parenting stress: a randomized controlled trial

Objectives To evaluate the effects of parent-delivered traditional Thai massage (TTM) on children with autism and its potential influence on parenting stress. Methods Forty-eight children with autism (aged 10.32 ± 1.35 years) were enrolled from Haikou Special Education School (Haikou Province, China) and randomly assigned to either the TTM group or control group in a 1:1 ratio. Alongside their regular school routines, the TTM group underwent 16 sessions of 50-min TTM, twice weekly for 8 weeks. The control group continued their usual daily school routines. Intervention effects and parenting stress were measured using the Autism Treatment Evaluation Checklist and Parenting Stress Index, Fourth Edition Short Form. Results The TTM intervention had a significant positive impact on sociability (p = 0.001, partial ŋ2=0.168) and total scores (p = 0.009, partial ŋ2=0.103). Additionally, the TTM group had significantly reduced parental distress (p = 0.016, partial ŋ2=0.179), parent − child dysfunctional interaction scores (p = 0.008, partial ŋ2=0.206), and total scores (p = 0.001, partial ŋ2=0.179) post-intervention, with a significant rebound observed during the follow-up period. Conclusions Our findings indicate that parent-delivered TTM can effectively improve certain autism symptoms and reduce parenting stress in the short-term. Incorporating parent-delivered massage into family-based interventions offers a convenient, effective, and personalized treatment option for families with limited access to alternative treatment resources. Trial registration Clinical Trials Registry Identifier: ChiCTR2100051355, 2021-09-21

A Case of Autism Spectrum Disorder Treated with Theridion currasavicum Prescribed on the Basis of Group Approach

Abstract Background Autism spectrum disorder (ASD) is a pervasive developmental disorder of unknown aetiology. There is a growing prevalence of ASD globally. Currently, there are no specific treatment that can address the core impairments of ASD. Case Summary A 5-year male child was brought to outpatient department with complaints of irritability, restlessness, howling, repeating words spoken to him, repeating phrases, hand flapping, self-hurting and hurting others, climbing stairs repeatedly, repeated drawing of squares everywhere, poor social interaction, poor peer-play and inappropriate playing with toys. The case was diagnosed as ASD and was assessed with the autism treatment evaluation checklist (ATEC) at baseline and follow-up visits. The case was treated with Theridion currasavicum in centesimal scale. ATEC score at baseline of 118 turned to 69 at the 12th month and 42 after 24 months of treatment. The remedy was repeated during monthly visits in ascending potencies. The child improved in the domains of social interaction, communication, repetitive stereotype movements, restricted interests and general health. The likelihood of causal relationship between intervention and outcome has been discussed as per modified Naranjo criteria for homoeopathy. This case report highlights the usefulness of the group approach and aetiological prescription as one way of arriving at the similimum in children with autism.

Reversal of Autism Symptoms among Dizygotic Twins through a Personalized Lifestyle and Environmental Modification Approach: A Case Report and Review of the Literature

The prevalence of autism has been increasing at an alarming rate. Even accounting for the expansion of autism spectrum disorder diagnostic (ASD) criteria throughout the 1990’s, there has been an over 300% increase in ASD prevalence since the year 2000. The often debilitating personal, familial, and societal sequelae of autism are generally believed to be lifelong. However, there have been several encouraging case reports demonstrating the reversal of autism diagnoses, with a therapeutic focus on addressing the environmental and modifiable lifestyle factors believed to be largely underlying the condition. This case report describes the reversal of autism symptoms among dizygotic, female twin toddlers and provides a review of related literature describing associations between modifiable lifestyle factors, environmental exposures, and various clinical approaches to treating autism. The twins were diagnosed with Level 3 severity ASD “requiring very substantial support” at approximately 20 months of age following concerns of limited verbal and non-verbal communication, repetitive behaviors, rigidity around transitions, and extensive gastrointestinal symptoms, among other common symptoms. A parent-driven, multidisciplinary, therapeutic intervention involving a variety of licensed clinicians focusing primarily on addressing environmental and modifiable lifestyle factors was personalized to each of the twin’s symptoms, labs, and other outcome measures. Dramatic improvements were noted within several months in most domains of the twins’ symptoms, which manifested in reductions of Autism Treatment Evaluation Checklist (ATEC) scores from 76 to 32 in one of the twins and from 43 to 4 in the other twin. The improvement in symptoms and ATEC scores has remained relatively stable for six months at last assessment. While prospective studies are required, this case offers further encouraging evidence of ASD reversal through a personalized, multidisciplinary approach focusing predominantly on addressing modifiable environmental and lifestyle risk factors.

EEG findings and clinical severity and quality of life in non-epileptic patients with autism spectrum disorders

ABSTRACT Electroencephalogram (EEG) abnormalities could be seen in up to 60% of non-epileptic children with autism spectrum disorder (ASD). They have been used as biomarkers of ASD severity. The objective of our study is to identify EEG abnormalities in children with different degrees of ASD severity based on the Autism Treatment Evaluation Checklist (ATEC). We also want to assess the quality of life for children with ASD. All of the children underwent at least one hour of sleep-deprived EEG. Forty-five children were enrolled, of whom 42 were male. EEG abnormalities were found in 10 (22.2%) children, predominantly in the bilateral frontal areas. There were no differences in EEG findings among the mild, moderate, and severe ASD groups. The severity of ASD was associated with female sex (p-value = 0.013), ASD with attention deficit hyperactivity disorder (ADHD) (p-value = 0.032), ASD children taking medications (p-value = 0.048), and a lower Pediatric Quality of Life Inventory (PedsQL) (p-value <0.001). Social and emotional domains were the most problematic for health-related quality of life in ASD children, according to parent reports of PedsQL. Further studies with a larger sample size will help to clarify the potential associations between EEG abnormalities and the severity of ASD, as well as the impact on quality of life.

A Comparison of Parent Reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS).

This study compares two parent reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS). The ATEC consists of four subscales, as follows: (1) expressive language, (2) sociability, (3) sensory awareness, and (4) health. The MSEC is complementary to the ATEC in measuring complex language comprehension. The parents of 143 autistic children, from 2 to 22 years of age (mean 6.7 ± 5.1 years), completed the MSEC and the ATEC questionnaires and a clinician assessed their CARS score. The CARS score correlated strongly with all parent reports, the complex language comprehension MSEC (r = 0.60, p < 0.0001), expressive language (r = 0.66, p < 0.0001), sociability (r = 0.58, p < 0.0001), sensory awareness (r = 0.71, p < 0.0001), and health (r = 0.53, p < 0.0001), as well as the total ATEC score (r = 0.75, p < 0.0001). The strongest correlation was between the CARS score and the composite of all five parent-reported scores (total ATEC + MSEC, r = 0.77, p < 0.0001). These results suggest a high fidelity of the MSEC and ATEC parent reports and especially of their composite score, total ATEC + MSEC.

Relationships between autistic traits, motor skills and socioeconomic status

BackgroundAutism is a neurodevelopmental condition that presents with social and communicative difficulties as well as restricted or repetitive behaviors. Previous research has highlighted the ubiquity of motor impairments in autistic children, but the relationship between the severity of motor impairment and the degree of autistic traits has not yet been adequately researched. The role of socioeconomic status in the development of autism is also poorly understood. MethodWe used the Autism Treatment Evaluation Checklist (ATEC) to assess social and behavioral autistic traits and the Bruininks-Oseretsky Motor Proficiency Test (Second Edition) to assess motor skills in a cohort of 50 children from the central Johannesburg region. A short questionnaire was used to assess socioeconomic status of the family of each participant. ResultsSignificant correlations were found between many motor skill domains and the domains of the ATEC specifically pertaining to sociability, communication and sensory awareness (p < 0.05), but no relationships between autistic traits and socioeconomic status were observed. ConclusionsOur findings support a possible relationship in the aetiology of social and communicative autistic traits, and impairment of motor skills. Therefore, motor interventions could potentially be used to improve social and communicative difficulties, as well as perseverative behaviors in autism.

The relationship between balance and urinary cortisol and neopterin in autistic children

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by stereotyped behavior, restricted interests and social/communicative deficits. The physiological etiology of ASD is not currently understood, however recent research has implicated dysregulation of the immune system as a central feature. The interplay between the stress systems, the immune system and the brain has been well-documented and implicated in other psychiatric and neurological disorders. This interplay suggests a role for the hypothalamic-pituitary-adrenal (HPA) axis in the etiology of ASD. We assessed levels of urinary cortisol and neopterin as markers of immune function and HPA activation in a cohort of 50 children from the central Johannesburg region. Additionally, we used the Autism Treatment Evaluation Checklist to assess autistic symptomatology and the Bruininks-Oseretsky Motor Proficiency Test (Second Edition) (BOT-2) to assess motor skills. No relationships were found between cortisol and autistic symptomatology. No relationships were found between neopterin and any of the other measures. However, a relationship was observed between urinary cortisol and performance on balance-related tasks from the BOT-2 (P < 0.05). Our findings support a theory of neurological interconnectedness between postural modulation and activation of the stress system, which has not previously been documented in children with ASD.

The Relationship between Parental Characteristics and Social Interaction Skills of Autistic Children in SLB Sragen Region

Autism is a disorder that occurs in brain tissue where the condition is a developmental disorder characterized by the inability to carry out social interactions, inability to communicate and repetitive behavior. This causes an autistic child to prefer to be alone and unable to communicate with other people well. Parental involvement in parenting significantly increases the developmental progress of children with autism, including allocating time for joint activities, frequent interaction, financial assistance, active parenting, and being involved in playing with children. Thus, the role of parents is very much needed. to provide care in the development of autistic children. This research aims to determine the relationship between parental characteristics and social interaction abilities for Autistic Children in SLB in the Sargen area. This research used a cross sectional method involving 60 parents who had autistic children at the Sragen Regency Special School which was conducted in September 2023. Social interaction data was measured using ATEC (Autism Treatment Evaluation Checklist). The data analysis used is the data normality test and continued with the Chisquare test to determine the relationship between variables. There is a weak relationship between age, parental education, employment and family income with the social interaction abilities of autistic children in the Sragen Regional Special School. (p 0.04 phi = 0.34, p 0.015 phi 0.282, p 0.007 phi -0.268, p 0.01 phi 0.336). Several parental characteristics have a relationship with the social interaction abilities of autistic children, although the categories are weak.

The Effectiveness of Pivotal Response Treatment Training for Mothers on the Communication Skills of Children with Non-verbal Autism Spectrum Disorder: A Randomized Clinical Trial

Background: Parents of young children with autism spectrum disorder (ASD) regularly seek the support of professionals when the child is diagnosed with ASD. Objectives: This study aimed to investigate the effectiveness of pivotal response treatment (PRT) training for mothers in improving the communication skills of ASD children. Methods: In this double-blind, randomized clinical trial (RCT), 52 mothers of children with ASD were selected and randomly allocated into two groups in 2017 - 2018. The mothers of the intervention group received PRT training, and the children of the intervention and control groups received the applied behavior analysis (ABA) treatment. The children's speech/language/communication and socialization scores were measured by the Autism Treatment Evaluation Checklist (ATEC) before, 1 week after, and 1 month after the intervention. Results: Before the intervention, the mean score of speech/language/communication and socialization did not significantly differ between the two groups. However, 1 week and 1 month after the intervention, the mean scores of speech/language/communication and socialization were significantly lower in the intervention group than in the control group (P &lt; 0.5). Conclusions: The results showed that parental training in PRT can provide permanent and effective therapy for children with ASD in the home environment.

Behavioral intervention in preschool art education for children with autism

BackgroundIn recent years, the world has increasingly focused on a specific group of children with autism. With the rapid development of special education in China, behavioral intervention and rehabilitation training for children with autism have become an important challenge in the field of special education. Many experts and scholars at home and abroad have researched the treatment of autism from various fields, proposing the possibility that art education can provide behavioral intervention for children with autism.Subjects and MethodsIndividual and collective interventions were conducted on 5-year-old children with autism as experimental subjects. The individual intervention plan utilizes the round-robin teaching method in Applied Behavioral Analysis (ABA) to teach painting skills to children with autism. The collective intervention involves integrating children with autism into a class of 40 children for art teaching. And use the Autism Treatment Evaluation Checklist (ATEC) to evaluate pediatric patients before and after art education behavioral intervention.ResultsThe ATEC scores of patients before art education behavioral intervention were 18 for language disorders, 33 for social disorders, 21 for perceptual disorders, and 33 for physical behavioral disorders. The ATEC scores of patients after art education behavioral intervention were 12 for language disorders, 24 for social disorders, 19 for perceptual disorders, and 29 for physical behavioral disorders.ConclusionsThe ATEC score results before and after art education behavioral intervention showed a significant decrease, indicating that early childhood art education behavioral intervention targeting autistic children has a positive effect.

Dietary Factors Impact Developmental Trajectories in Young Autistic Children.

The purpose of this research was to investigate the impact of dietary factors on developmental trajectories in young autistic children. A gluten-free and casein-free diets, as well as six types of food (meat and eggs, vegetables, uncooked vegetables, sweets, bread, and "white soft bread that never molds") were investigated observationally for up to three years in 5,553 children 2 to 5 years of age via parent-report measures completed within a mobile application. Children had a parent-reported diagnosis of Autism Spectrum Disorder (ASD); 78% were males; the majority of participants resided in the USA. Outcome was monitored on five orthogonal subscales: Language Comprehension, Expressive Language, Sociability, Sensory Awareness, and Health, assessed by the Autism Treatment Evaluation Checklist (ATEC) (Rimland & Edelson, 1999) and Mental Synthesis Evaluation Checklist (MSEC) (Arnold & Vyshedskiy, 2022; Braverman et al., 2018). Consumption of fast-acting carbohydrates - sweets, bread, and "white soft bread that never molds" - was associated with a significant and a consistent Health subscale score decline. On the contrary, a gluten-free diet, as well as consumption of meat, eggs, and vegetables were associated with a significant and consistent improvement in the Language Comprehension score. Consumption of meat and eggs was also associated with a significant and consistent improvement in the Sensory Awareness score. The results of this study demonstrate a strong correlation between a diet and developmental trajectories and suggest possible dietary interventions for young autistic children.

Therapeutic Impacts of Hyperbaric Oxygen Therapy and Risperidone on Children with Autism: A Clinical Trial.

In this research, we investigated any possible effect of receiving hyperbaric oxygen therapy (HBOT) or risperidone on the core symptoms of autism in children diagnosed with autism spectrum disorder (ASD). This study was a randomized, controlled clinical trial in Minia and Assiut University hospitals in Egypt with three parallel groups. One hundred and eighty children with autism, aged 5-8 years were divided into three equal groups (n=60). Group 1 (G1) received 40 sessions of HBOT within two months, group 2 (G2) received risperidone (dose: 0.25 mg per day in children weighing less than 20 kg and 0.5 mg per day in cases weighing more) for six months, and group 3 (G3) as the control group, received a placebo for six months. The assessment was done using childhood autism rating scale (CARS) and autism treatment evaluation checklist (ATEC) at the beginning of the study (baseline) and after one year. The mean total CARS and ATEC scores significantly decreased (improved) by varying degrees in the three groups after a year of follow-up compared to the baseline scores, but the best results were found in G1, G2, and G3, respectively. Using HBOT or risperidone is effective in treating the core symptoms of autism in children diagnosed with autism spectrum disorder, but using HBOT gives better results than risperidone therapy. Non-pharmacologic therapy can be used for the treatment of the core symptoms of autism.Both hyperbaric oxygen therapy and risperidone reduce the core symptoms of autism.Hyperbaric oxygen therapy gives better effects than risperidone in reducing the core symptoms of autism. Since the long-term use of drug therapy in children with autism leads to the occurrence of side effects in addition to the difficulty in complying with the drugs for long-term use, efforts have begun to use non-traditional alternative treatments, such as hyperbaric oxygen therapy. The current study assessed the therapeutic effect of hyperbaric oxygen therapy and risperidone on the core symptoms of autism. The results revealed that both hyperbaric oxygen therapy and risperidone reduced the core symptoms of autism, but hyperbaric oxygen therapy gave better therapeutic results than risperidone.

Maternal Variability of Amplitudes of Frequency Fluctuations Is Related to the Progressive Self-Other Transposition Group Intervention in Autistic Children.

The self-to-other model of empathy (SOME) states that a key reason for the empathic deficiency in autistic individuals is the imbalance of the self-other switch. The existing interventions of theory of mind contain training of self-other transposition ability but combined with other cognitive trainings. The self-other distinction brain areas of autistic individuals have been revealed, but the brain areas of the self-other transposition ability and its intervention have not been investigated. There are normalized amplitudes of low-frequency fluctuations (mALFFs) within 0.01-0.1 Hz and many normalized amplitudes of frequency fluctuations (mAFFs) within 0-0.01, 0.01-0.05, 0.05-0.1, 0.1-0.15, 0.15-0.2, and 0.2-0.25 Hz. Therefore, the current study established a progressive self-other transposition group intervention to specifically and systematically improve autistic children's self-other transposition abilities. The transposition test with a three mountains test, an unexpected location test, and a deception test was used to directly measure autistic children's transposition abilities. The Interpersonal Responsiveness Index Empathy Questionnaire with perspective-taking and fantasy subscales (IRI-T) was used to indirectly measure autistic children's transposition abilities. The Autism Treatment Evaluation Checklist (ATEC) was used to measure autistic children's autism symptoms. The experiment was designed with two (intervention: experimental group vs. control group) independent variables and two (test time: pretest vs. posttest or tracking test) × three (test: transposition test vs. IRI-T test vs. ATEC test) dependent variables. Furthermore, it used eyes-closed resting-state functional magnetic resonance imaging to investigate and compare the relevant maternal mALFFs and average energy rank and energy rank variability of mAFFs of autistic children's transposition abilities, autism symptoms, and intervention effects. The results showed the following: (1) There were many improvements (pretest vs. posttest or tracking test) greater than chance 0 in the experimental group, such as the three mountains, lie, transposition, PT, IRI-T, PT tracking, cognition, behavior, ATEC, language tracking, cognition tracking, behavior tracking, and ATEC tracking improvements. However, there was no improvement greater than chance 0 in the control group. (2) The maternal mALFFs and maternal average energy rank and energy rank variability of mAFFs could predict the autistic children's transposition abilities, autism symptoms, and intervention effects with some overlap and some difference in maternal self-other distinction, sensorimotor, visual, facial expression recognition, language, memory and emotion, and self-consciousness networks. These results indicated that the progressive self-other transposition group intervention successfully improved autistic children's transposition abilities and reduced their autism symptoms; the intervention effects could be applied to daily life and last up to a month. The maternal mALFFs, average energy rank, and energy rank variability of mAFFs were three effective neural indictors of autistic children's transposition abilities, autism symptoms, and intervention effects, and the average energy rank and energy rank variability of mAFFs were two new neural indictors established in the current study. The maternal neural markers of the progressive self-other transposition group intervention effects for autistic children were found in part.

High Phenolic Extra Virgin Olive Oil Influences the Gut-brain Axis in Individuals Diagnosed with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is an umbrella term that incorporates a range of neurodevelopmental disorders which affect behaviour, emotion, and communication. In recent years, the effects of dietary habits in individuals with ASD have been mentioned and a distinct correlation has been observed between ASD and gastrointestinal (GI) disorders. We used the Autism Treatment Evaluation Checklist (ATEC) to evaluate whether we can observe differences in behaviour by administering High Phenolic Extra Virgin Olive Oil (HP EVOO) in combination with a special diet to reduce inflammation and consequently improve behaviour. We hypothesise that ASD symptoms will soothe at a proportional rate relative to their severity. Individuals that followed the protocol showed a decrease in severity of their symptoms. Regarding data analysis, we calculated the p-values to evaluate the significance of our results. Our objective is to establish the beneficial influence that HP EVOO has on the gut-brain axis by soothing ASD symptoms.

Acupuncture for children with autism spectrum disorder: A systematic review and meta-analysis.

The aim of this study was to assess the efficiency and safety of acupuncture in core symptomatic improvement of children with autism spectrum disorder (ASD). We searched the following databases: Cochrane Library, PubMed, Embase, Medline, China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Science and Technology Periodical (VIP) and Chinese Biological Medicine (CBM), from 1 January 2012 to 25 September 2022. The Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), and Autism Treatment Evaluation Checklist (ATEC) were adopted as outcome indicators. Three reviewers independently assessed the risk of bias (ROB) and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)assessment. Utilizing Review Manager (RevMan) 5.3 and Stata 12.0, data were analyzed. A total of 38 trials were included, and 2862 participants participated in qualitative synthesis and meta-analysis. Only 1 trial was assessed as having a low ROB, and 37 trials were assessed as having an overall high ROB. The quality of evidence for most indicators were considered very low by the GRADE criteria. The results showed that acupuncture groups might have a higher clinical effective rate than nonacupuncture groups (relative risk [RR] = 1.33,95% confidence interval [CI] = 1.25-1.41; heterogeneity: x2=18.15, P = .64, I2 = 0%). Regarding changes in ABC scores, the acupuncture groups might exhibit greater decrease than nonacupuncture groups (MMD = -6.06, 95%CI = -7.25 to -4.87, P < .00001; heterogeneity: x2 =73.37, P = .03, I2 = 77%). In terms of changes in CARS score, acupuncture group may benefit more than nonacupuncture group (MMD = -3.93, 95%CI = 4.90 to -2.95, P < .00001; heterogeneity: x2=234.47, P < .00001, I2 = 90%). Additionally, in terms of ATEC score, acupuncture groups showed more benefit than nonacupuncture groups (MMD = -10.24, 95%CI = -13.09 to -7.38, P < .00001; heterogeneity: x2=45.74, P = .04, I2 = 85%). Both subgroup analysis and sensitivity analysis are existing heterogeneity. Only 1 RCT study involved adverse events with mild symptoms that did not interfere with treatment and evaluation. Children with ASD may benefit from acupuncture because of its effectiveness and safety. Nevertheless, given the low quality of the evidence for the assessed outcomes and the high ROB of analyzed trials, the results should be regarded with caution.