BackgroundTo inform training program development and curricular initiatives, quantitative descriptions of the disciplinary training of research teams publishing in top-tier clinical and epidemiological journals are needed. Our objective was to assess whether interdisciplinary academic training and teamwork of authors publishing original research in 15 top-tier journals varied by year of publication (2000/2010/2020), type of journal (epidemiological/general clinical/specialty clinical), corresponding author gender, and time since the corresponding author completed formal training relative to the article publication date (<5/≥5 years).Methods and findingsWe invited corresponding authors of original research articles to participate in an online survey (n = 103; response rate = 8.3% of 1240 invited authors). In bivariate analyses, year of publication, type of journal, gender, and recency of training were not significantly associated with interdisciplinary team composition, whether a co-author with epidemiological or biostatistical training was involved in any research stage (design/analysis/interpretation/reporting), or with participants’ confidence in their own or their co-authors epidemiological or biostatistical expertise (p > 0.05 for each comparison). Exceptions were participants with more recent epidemiological training all had co-author(s) with epidemiological training contribute to study design and interpretation, and participants who published in 2020 were more likely to report being extremely confident in their epidemiological abilities.ConclusionsThis study was the first to quantify interdisciplinary training among research teams publishing in epidemiological and clinical journals. Our quantitative results show research published in top-tier journals generally represents interdisciplinary teamwork and that interdisciplinary training may provide publication type options. Our qualitative results show researchers view interdisciplinary training favorably.