Globally, the Women and Youth Development Fund, channeled through women's groups, has played a crucial role in fostering economic empowerment for women and youth. In Tanzania, population growth has introduced both opportunities and challenges, with a significant issue being the rise in unemployment and poverty, particularly among women and youth. To address these challenges, the Women, Youth, and People with Disabilities Revolving Fund (WYDF) was established within Local Government Authorities (LGAs) to provide accessible loans to the poor, who are often excluded from conventional financial institutions. This study investigates the effectiveness of economic empowerment initiatives in alleviating poverty among youth and women's groups in the Arusha Region, Tanzania. Specifically, it examines the impact of start-up capital provision, financial literacy training, and business capacity-building on poverty reduction. The study employed a survey research design with a quantitative approach, collecting data from 95 respondents through questionnaires. Purposive sampling was used to select the sample. The data were analyzed using descriptive statistics and SPSS software, with regression analysis employed to explore the relationships between variables influencing poverty reduction among the targeted groups. The findings reveal that start-up capital provision, financial literacy training, and business capacity-building significantly contribute to poverty reduction among youth and women's groups. The study recommends enhanced financial literacy programs to enable entrepreneurs to save and accumulate sufficient capital for business investments. Additionally, the government, through youth and women empowerment programs, should continue providing training, particularly to those without technical skills, focusing on new production techniques, efficient fund allocation, and marketing strategies to ensure sustainable impacts.