Management of innovative activity in technological and industrial territorial systems (TITS) becomes particularly relevant in the context of globalization and increasing competitiveness. This study focuses on exploring methods of innovation management within TITS, including strategic planning, implementation of innovative processes, and cooperation among government structures, the private sector, and scientific institutions. The research aims to develop recommendations for managing innovative activities in technological and industrial territorial systems. The article delves into the essence of managing innovative processes at the territorial and industrial territorial systems level, exemplified by techno and industrial parks. It establishes fundamental principles of management, including the principle of foresight, the principle of integration of innovative processes, the principle of division of labor, specialization, and cooperation, the principle of delineation of competencies, the principle of informatization, and the principle of efficiency in managing innovative activities in a science and technology park. Management of innovative activity in technological and industrial territorial systems is carried out through stages such as forming a complete spectrum of tasks related to organizing innovative activity, providing detailed descriptions according to the chosen methodology, assessing interrelationships between tasks, and systematizing tasks by considering established criteria. The essence of managing innovative processes at territorial-technological structures is thoroughly investigated. Particular emphasis is placed on critical principles of managing innovative activity, which include the ability to forecast the development of innovative processes and adapt management decisions according to future trends; ensuring coordinated work of various innovative initiatives and projects to achieve a synergistic effect; optimizing the distribution of functions and tasks among participants of the innovation process to enhance overall efficiency; clear definition and distribution of authority and responsibility among different management levels and organizations; implementation of modern information technologies to support decision-making and enhance the transparency of innovative processes; focus on achieving maximum results with minimal resource expenditure. The essence of managing innovative activity in technological and industrial territorial systems is substantiated; principles of managing innovative activity are defined: the principle of foresight; the principle of integration of innovative processes; the principle of division of labor, specialization, and cooperation; the principle of delineation of competencies; the principle of informatization; the principle of management efficiency in regional innovation activity. The following stages for managing innovative activity in technological and industrial territorial systems are implemented: construction of a complete set of tasks for organizing innovative activity and their description according to the chosen scheme; assessment of the connection between tasks; grouping of tasks by given criteria. Keywords: innovation, innovative activity, management, technological and industrial territorial systems, social effect, cluster