A new approach toward reliability based design optimization (RBDO) is proposed based on the response surface augmented moment method (RSMM). In RSMM, the reliability analysis procedure based on design of experiments (DOE) is combined with the response surface method (RSM) for numerical efficiency. It utilizes the Pearson system with four statistical moments to calculate the failure probability, and the progressive update of the response surface facilitates the calculation of these four statistical moments. In this study, a semi-analytic design sensitivity analysis is performed in connection with RSMM for an efficient implementation of RSMM in RBDO. The sensitivity of failure probability with respect to the design variables is calculated by direct differentiation and finite difference method with the Pearson system. It is integrated into a mathematical programming for RBDO and applied to several test examples. It was demonstrated that the proposed method of RBDO based on RSMM is efficient and robust.