Augmentation Urethroplasty Research Articles

Применение большого количества методов оперативного лечения стриктуры уретры у одного пациента: клинический случай

Introduction. Insufficient surgical experience and inadequate choice of surgical treatment options may be the reasons for the failure of treatment of urethral stricture. In this regard, a clinical case from our practice is very indicative. Case: The article is devoted to the description of a clinical case of urethral injury in a man who, at the age of 22 years, suffered a fracture of the pelvic bones as a result of a traffic accident. From the moment of injury to the final operation, the following types of surgical interventions were sequentially performed in this patient: anastomotic endto-end urethroplasty, augmentation urethroplasty using a skin graft, augmentation urethroplasty using a graft of the tunica vaginalis of the testicle, bougienage of the urethra, urethroplasty with a vascularized radial fasciocutaneous flap on a vascular pedicle, 2-stage urethroplasty using a graft of the buccal mucosa according to the type of Bracka I and II operations, perineal urethrostomy. Urethrostomy became the final option for urine diversion; no recurrence of urethral stricture was observed during 4 years of follow-up after urethrostomy. Conclusion. Until recently, the lack of uniform approaches to the treatment of urethral stricture has led to the use of inadequate methods of surgical treatment in various clinics. The recent approval of federal clinical guidelines for urethral stricture should help optimize the treatment of this disease. Keywords: urethral stricture, urethroplasty, urethrostomy

Urethroplasty- a single centre single surgeon experience.

Male urethral stricture affects 100 in 100,000 men. These are investigated using uroflowmetry, retrograde urethrography and cystourethroscopy. Management is usually endoscopic with urethral dilation or direct visual internal urethrotomy, although they have high failure rates. It is now recommended that urethroplasty is performed earlier. In this study we have reviewed a single surgeons experience with urethroplasty and patient outcomes. We retrospectively reviewed a prospectively maintained database of all urethroplasty operations performed in our hospital over a 5 -year period. Forty-five patients were identified, with a mean age of 46. The most common presenting symptom was poor flow (100%). Uroflowmetry was performed in 31 of 45 patients(69%). More patients had a urethrogram (58%) than flexible cystoscopy (38%). Most strictures were idiopathic (67%). Mean stricture length was 2.6cm. 71% did not require any further intervention. Five patients required repeat surgery. Four required DVIU and one required a repeat urethroplasty. The most popular techniques for urethroplasty in the UK are augmentation urethroplasty using a buccal mucosal graft and anastomotic urethroplasty, both of which we describe. There are variations in what is deemed as successful surgery. The most widely used definition is 'the lack of need for any further operative intervention'. We have recently adopted Patient Reported Outcome Measures using a validated questionnaire to measure the patients perception of a successful outcome. Complex strictures have a higher incidence of complications. 42% of our cohort were complex and we describe results comparable to the published literature.

Preservation of the native urethral plate and corpus spongiosum combined with buccal mucosa graft plus Orandi's penile skin flap as an alternative to staged urethroplasty for narrow penile strictures.

In narrow anterior urethral strictures, the combined buccal mucosa graft (BMG) with pedicled penile skin flap (PSF) represents a well-known effective alternative to staged urethroplasty. We hypothesized that if the native urethral plate and adjacent corpus spongiosum were preserved, a narrower flap would be needed, and reinforced ventral stability could be achieved without compromising the surgical outcome. Twelve patients with narrow penile urethral strictures underwent single-stage augmentation urethroplasty using a combined technique. A BMG was quilted to the corpora cavernosa in a dorsal onlay approach, and a longitudinal ventral PSF was transposed ventrally and sutured to the scarred native urethral mucosa on one side and to the BMG on the other side to form a neourethra of triangular form. The preserved corpus spongiosum was wrapped and fixed around the flap ventrally. The median age was 47 years (IQR 35-59), and the median stricture length was 5 cm (IQR 3, 8-7). The median surgical time was 205 min (IQR 172-236). The overall success rate (SR) was 91.7% without sacculation or diverticula formation after a median follow-up period of 38 months (IQR 33-40). Three transient fistulas healed through prolonged urinary diversion. Five patients (41.7%) reported postvoid dribbling following urethroplasty. Preservation of the native urethral plate is a valuable adjunct to the combination of graft and flap for single-stage augmentation urethroplasty for narrow urethral strictures, with satisfactory mid-term success and an acceptable complication rate.

Urethral reconstruction

Aurethral stricture is an abnormal narrowing of the urethra due to spongiofibrosis of the urethral mucosa and the underlying corpus spongiosum. The diagnostics include uroflowmetry, sonography and radiology. For penile strictures the success rate of endoscopic treatment is low. Therefore, urethroplasty should always be performed, preferably using oral mucosa. Depending on the complexity, reconstruction must be carried out in one or multiple stages. For short bulbous strictures endoscopic treatment can primarily be carried out. In the case of recurrence urethroplasty should be carried out. The indications for urethral reconstruction are primarily given for long bulbous strictures. Depending on the length and extent of the stricture, ascar resection and end-to-end anastomosis, non-transsecting end-to-end anastomosis or augmentation urethroplasty can be performed. Perineal urethrostomy (the so-called boutonnière procedure) is atreatment option for patients with complex strictures or for patients who want astraightforward solution.

Smoking is not associated with wound complications in augmented urethroplasty: a NSQIP analysis.

To investigate if predictors of wound complications differed between patients undergoing excision and primary anastomosis urethroplasty (EPA) and augmented urethroplasty. The National Surgical Quality Improvement Program database from 2006 to 2018 was queried for male patients undergoing urethroplasty. Thirty-day wound complications were identified and categorized (superficial/deep/organ-space surgical site infections and dehiscence). Multivariable logistic regression was performed to determine risk factors associated with wound complications. Smoking history was defined as current smoker within the past year. Urethroplasty was performed in 2251 males, with 25.46% (n = 573) using a flap or graft. There was no significant difference in wound complications for patients undergoing augmented urethroplasty (n = 17, 2.97%) or EPA (n = 45, 2.68%) (p = 0.9). The augmented group had a higher BMI, longer operative time, and longer length of stay. On multivariable logistic regression, risk factors associated with wound complications for patients undergoing EPA were diabetes (OR 2.56, p = 0.03) and smoking (OR 2.32, p = 0.02). However, these factors were not associated with wound complications in patients undergoing augmented urethroplasty. Smoking and diabetes were associated with increased wound complications for men undergoing EPA, but not in patients undergoing augmented urethroplasty. Patients with comorbidities associated with worse wound healing may be more likely to have a wound complication when undergoing EPA.

Одноэтапная уретропластика при протяженных стриктурах передней уретры: лоскут или графт?

Introduction. Penile skin flap and oral mucosal graft are most often used for augmentation urethroplasty for extended anterior urethral strictures. It seems relevant to conduct a study comparing augmentation urethroplasty techniques using these donor materials. Materials and methods. The review is based on articles published throughout history in scientific peer-reviewed journals included in the databases PubMed (https://www.ncbi.nlm.nih.gov/pubmed/), Embase (https://www.embase.com/landing), Cochrane Library (https://www.cochranelibrary.com/), Scientific Electronic Library eLibrary.ru (https://elibrary.ru/). The search was performed on the following keywords: «urethral stricture», «anterior urethra», «penile urethra», «bulbous urethra», «urethroplasty», «augmentation urethroplasty», «penile skin flap», «oral mucosa graft». At the first stage, 445 sources were found, of which 17 articles were included in the review. Results. A total of 17 original studies were identified with a comparative analysis between one-stage augmentation urethroplasty techniques using a penile skin flap and an oral mucosal graft for penile and/or bulbous urethral strictures. 7 (41,2%) studies were a randomized controlled trial, 10 (58,8%) studies were a retrospective cohort study. The total number of patients in whom a flap or graft was used across all studies was 1426. A penile skin flap was used in 638 (44,7%) patients, and an oral mucosal graft was used in 788 (55,3%) patients. The success of treatment using a penile skin flap averaged 77,8%, and an oral mucosal graft averaged 83,7%. Conclusions. Penile skin flap and oral mucosal graft, when used for augmentation urethroplasty, can achieve a similar treatment success rate. When assessing the outcome of urethroplasty in cohorts of patients with long-term postoperative follow-up and a relatively large sample size, the best results were characteristic of oral mucosal grafts.

Surgery for female urethral stricture.

Female urethral stricture (FUS) is a rare entity that causes great morbidity and suffering in those affected. As the available scientific data is sparce, there are no formal guidelines or standard of care for this disease. This is a narrative review of the surgical management for female urethral stricture. The literature review was performed on PubMed. Articles were limited to English, but there was no limitation in terms of date. Management of FUS is divided between endoscopic and open surgical repair. Urethral dilation with or without urethrectomy can be offered as a first-line treatment. However, the rate of success of this procedure remains inferior to open surgical repair, and its efficacy decreases with the number of previous dilations. For distal urethral strictures, distal urethrectomy and advancement meatoplasty may be considered. Vaginal flaps are readily available, easy to harvest, well-vascularized, and allow for a dorsal or ventral orientation urethroplasty. The results of this procedure are promising, but most studies are small and retrospective. Labia flaps are easily accessible, wet, hairless, and elastic. The main limitations with the use of vaginal or labial tissues are co-existing conditions such as lichen sclerosis or vaginal atrophy, which may affect future results. Vaginal and labial graft urethroplasty can be used when it is not possible to mobilize an adequate flap. Stricture-free rates of this technique are variable. In cases of more severe stricture, an augmentation urethroplasty using buccal mucosa graft may be necessary. The techniques used in FUS replicate those for male urethral strictures, where both ventral and dorsal approaches can be utilized. Although there is growing interest in the field, the optimal management of FUS remains to be determined.

Posterior Sagittal Approach Provides Optimal Exposure for Urethral Reconstruction in Children With a History of Anorectal Malformations

ObjectiveTo present a unique series of children with previously repaired anorectal malformations (ARM) with subsequent urethral pathology repaired via a posterior sagittal exposure and highlight the associated technical advantages. MethodsUsing a retrospective review of all procedures performed in our pediatric colorectal and pelvic reconstruction program from January 2020 through December 2022, we compiled a case series of patients with a history of ARM and prior PSARP who had urethral pathology and concurrent indication for redo-PSARP. Clinical features, operative details, and postoperative outcomes were collected. ResultsSix male patients presented at a median age of 4.3 years, all born with an ARM of recto-urinary fistula type, of which three were recto-prostatic, one recto-bladder-neck, and two unknown type. In addition to redo-PSARP, two underwent ROOF excision and four had urethral stricture repair. One required post-operative Heineke-Mikulicz anoplasty. Patients underwent cystoscopy 4-6 weeks post-reconstruction, and none showed urethral stricture requiring treatment. Post-procedurally, five patients were able to void urethrally and one required additional bladder augmentation / Mitrofanoff. ConclusionRedo-PSARP completely mobilizes the rectum, thereby providing excellent exposure to the posterior urethra for repair. This approach also allows the option of a rectal flap for augmented urethroplasty as well as harvest of an ischiorectal fat pad for interposition.

Management Patterns of Male Urethral Stricture Disease among Urologists: What Do the Guidelines Say? What Do Urologists Do?

The aim of the present study is to evaluate and analyze the daily clinical practice for male urethral stricture disease (MUSD) among urologists. Considering the latest guidelines on urethral stricture disease, a survey was developed regarding the various treatment options and preferences in different sites of male urethral stricture disease. The survey was sent to urologists via e-mail and phone application. A total of 266 urologists completed the survey and were included in the final analysis. In regard to workplace, 62 (23.3%), 58 (21.8%), 71 (26.7%), and 75 (28.2%) respondents worked in university hospitals, training and research hospitals, state hospitals, and private practice hospitals, respectively. In regard to the diagnostic method used in male urethral strictures, 88.7% of the participants would choose uroflowmetry + postvoiding residual (UF + PVR), and 64.6% would choose retrograde urethrography (RUG). Direct vision internal urethrotomy (DVIU) was the most frequently chosen method in penile urethral strictures (PUS), being chosen by 72.9%. Direct vision anterior internal urethrotomy was the most common method for both ≤2 cm and >2 cm strictures, 63.1%, and 30.8%, respectively. The most preferred graft for augmentation urethroplasty was buccal mucosa (75.8%). Endoscopic incision/resection (transurethral resection (TUR)) is the most frequently applied treatment method for posterior urethral/vesicourethral anastomotic strictures (86.4%). The present study clearly shows that most urologists still prefer DVIU and urethral dilatation to urethroplasty in MUSD, which contradicts current guidelines. Urologists should be encouraged to perform urethroplasty and/or refer patients to experienced centres for recurrent MUSD.

Mucomucosal anastomotic non-transecting augmentation (MANTA) urethroplasty: a ventral modification for obliterative strictures.

To present a surgical modification for the repair of bulbar urethral strictures containing short, highly obliterative segments and report on long-term objective and patient-reported outcomes. We considered patients undergoing bulbar buccal mucosal graft urethroplasty (BMGU) between July 2016 and December 2019. Eligibility criteria for mucomucosal anastomotic non-transecting augmentation (MANTA) urethroplasty were strictures of ≥2 cm with an obliterative segment of ≤1.5 cm. The stricture is approached ventrally to avoid extensive dissection and mobilisation. Dorsally, the scar is superficially excised and the spongiosum is left intact. Dorsal mucomucosal anastomosis is complemented by ventral onlay graft. Perioperative characteristics were prospectively collected including uroflowmetry data and validated patient-reported outcome measures on voiding, erectile, and continence function. We evaluated functional follow-up, incorporating patient-reported (lower urinary tract symptoms [LUTS] score) and functional success. Recurrence was defined as need of re-treatment. Of 641 men treated with anterior BMGU, 54 (8.4%) underwent MANTA urethroplasty. Overall, 26 (48%) and 45 (83%) had a history of dilatation and urethrotomy, respectively, and 14 (26%) were redo cases. Location was bulbar in 38 (70%) and penobulbar in 16 patients (30%), and the mean (SD) graft length was 4.5 (1.4) cm. At a median (interquartile range) follow-up of 41 (27-53) months, the functional success rate was 93%. Whereas the median LUTS score significantly improved from baseline to postoperatively (13 vs 3.5; P < 0.001), there was no change in erectile function (median International Index of Erectile Function - erectile function domain score 27 vs 24) or urinary continence (median International Consultation on Incontinence Questionnaire - Urinary Incontinence Short Form sum score 0 vs 0; all P ≥ 0.4). All patients were 'satisfied' (27%) or 'very satisfied' (73%) with the outcome of their operation. With excellent long-term objective and patient-reported outcomes, MANTA urethroplasty adds to the armamentarium for long bulbar strictures with a short obliterative segment.

Comparison of oral morbidity and mid-term efficacy of anterior urethroplasty using an autologous tissue-engineered graft (MukoCell®) versus native oral mucosa graft.

Our study aimed to compare surgical success rate (SR) and oral morbidity of augmentation urethroplasty for anterior urethral strictures using autologous tissue-engineered oral mucosa graft (TEOMG) named MukoCell® versus native oral mucosa graft (NOMG). We conducted a single-institution observational study on patients undergoing TEOMG and NOMG urethroplasty for anterior urethral strictures >2 cm in length from January 2016 to July 2020. SR, oral morbidity, and potential risk factors of recurrence were compared between groups were analyzed. A decrease of maximum uroflow rate < 15 mL/s or further instrumentation was considered a failure. Overall, TEOMG (n = 77) and NOMG (n = 76) groups had comparable SR (68.8% vs. 78.9%, p = 0.155) after a median follow-up of 52 (interquartile range [IQR] 45-60) months for TEOMG and 53.5 (IQR 43-58) months for NOMG. Subgroup analysis revealed comparable SR according to surgical technique, stricture localization, and length. Only following repetitive urethral dilatations, TEOMG achieved lower SR (31.3% vs. 81.3%, p = 0.003). Surgical time was significantly shorter by TEOMG use (median 104 vs. 182 min, p < 0.001). Oral morbidity and the associated "burden" in patients' quality of life were significantly less at 3 weeks following the biopsy required for TEOMG manufacture, compared to NOMG harvesting and totally absent at 6 and 12 months postoperatively. The SR of TEOMG urethroplasty appeared to be comparable to NOMG at a mid-term follow-up but taking into account the uneven distribution of stricture site and the surgical techniques used in both groups. Surgical time was significantly shortened, since no intraoperative mucosa harvesting was required, and oral complications were diminished through the preoperative biopsy for MukoCell® manufacture.

Comparison of perineal urethrostomy versus augmentation urethroplasty in anterior urethral stricture disease.

Perineal urethrostomy and urethroplasty are very good options for complex and long anterior urethral strictures. A perineal urethroplasty is usually a neglected option. To our knowledge, a comparative study between augmentation urethroplasty and perineal urethrostomy has been not conducted regarding subjective and patient reported outcome measures. We compared both these groups in a high volume tertiary care hospital. A prospective comparative study of augmentation urethroplasty and perineal urethroplasty for long anterior urethral stricture. it was defined by strictures of more than 3 cm. We compared demographic data, urinary and sexual function; and quality of life using validated PROMs (patient-reported outcome measures) between both above groups. Both groups had 40 patients each. IPSS score improvement for PU and AUP were 20 and 19.6, respectively(p = 0.1223); IIEF-5 score improvement for PU and AUP at baseline and after 6 months were 14.3 and 16.7, respectively(p = 0.1433); QOL score improvement for PU and AUP were 3.45 and 3.05, respectively; which was statistically significant (p ⩽ 0.001). Perineal urethrostomy is a good but neglected option for complex and long anterior urethral strictures and it should be considered one of the reliable treatment option for patients with long-segment urethral strictures.

Pathomorphism of buccal grafts used in surgery of extensive bulbar urethral strictures: immunohistochemical analysis

Introduction. The adverse effects of urine on unadapted tissues are known. This is also entirely relevant for buccal grafts used in augmentation urethroplasty, where these effects have not been thoroughly studied so far.Objective. To assess the ongoing pathomorphosis in buccal grafts used for urethral augmentation of extensive strictures in the bulbous region and to evaluate how much urine influences their histological transformation following surgery.Materials &amp; methods. The study included 15 patients with extensive strictures of the bulbous urethra, who underwent a two-stage augmentation urethroplasty with buccal grafts. The grafts pathomorphosis was studied 6 months after the first surgery stage where urethrotomy had been performed with graft augmentation of the dorsal semicircle and the formation of distal and proximal neomeatuses. Natural urination through the latter was restored on days 14 – 20 following the surgery. During the second stage, six months later, urethral tubularisation was performed with two preliminary biopsies of the proximal and distal segments of the grafts implanted in the areas of the neomeatuses formed earlier. The distal area of the graft had no contact with urine, while this contact has occurred in the proximal segment since restoration of natural urination. In biopsy specimens, pathomorphosis of the grafts was studied using immunohistochemical markers: vimentin, clone SRL33; CD34, clone QBEnd/10; MSA HHF-35; СD3, clone LN10; Bcl-2, clone bcl-2\100\D5; CK-HMW 34BE-12.Results. It was found that inflammation was minimal in areas of grafts implanted that had no contact with urine, while in areas where such contact occurred it was verified to be pronounced even 6 months after the operation. On the submucosal level, this was manifested by an uneven arrangement of collagen fibers, a dysplastically developed vascular network, uneven proliferation of the endothelium with swelling and loss of cellular connectivity, in contrast to areas where there was no contact with urine. In such areas, the graft submucosa had a dense collagen framework with organized microvasculature and uniform epithelial surface.Conclusion. The impact of urine on buccal grafts used in augmentation urethroplasty is characterised by the disorganisation of its collagen framework, with a pronounced inflammatory component and the “reactivity” of the epithelial lining to the “toxic agent” that persists even 6 months after surgery. This may underlie the risk of a stenosis relapse in the proximal anastomosis area.

PD35-10 IMPACT ON POSTOPERATIVE ORAL MORBIDITY AND MID-TERM EFFICACY OF ANTERIOR URETHROPLASTY USING AN AUTOLOGOUS TISSUE-ENGINEERED ORAL MUCOSA GRAFT (MUKOCELL®) VERSUS NATIVE ORAL MUCOSA GRAFT

You have accessJournal of UrologyCME1 Apr 2023PD35-10 IMPACT ON POSTOPERATIVE ORAL MORBIDITY AND MID-TERM EFFICACY OF ANTERIOR URETHROPLASTY USING AN AUTOLOGOUS TISSUE-ENGINEERED ORAL MUCOSA GRAFT (MUKOCELL®) VERSUS NATIVE ORAL MUCOSA GRAFT Leonidas Karapanos, Vincent Knorr, Luisa Halbe, Maximilian Schmautz, Bobirjon Ergashev, Andijan Uzbekistan, and Axel Heidenreich Leonidas KarapanosLeonidas Karapanos More articles by this author , Vincent KnorrVincent Knorr More articles by this author , Luisa HalbeLuisa Halbe More articles by this author , Maximilian SchmautzMaximilian Schmautz More articles by this author , Bobirjon ErgashevBobirjon Ergashev More articles by this author , Andijan UzbekistanAndijan Uzbekistan More articles by this author , and Axel HeidenreichAxel Heidenreich More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003333.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of our study was to compare the outcomes and complication rates of augmentation urethroplasty using autologous tissue-engineered oral mucosa graft (TEOMG) versus native oral mucosa graft (NOMG), aiming to determine the appropriate indications for TEOMG use (MukoCell®) in urethral surgery. METHODS: We conducted a single-institution retrospective study on 153 patients undergoing augmentation urethroplasty for anterior urethral strictures >2 cm in length from January 2016 to July 2020. TEOMG was used in 77 and NOMG in 76 patients, respectively. The success rate, complications including postinterventional oral morbidity, and risk factors of recurrence between both groups were analyzed. Postoperative follow-up (FU) examinations were performed at 6 and 12 months and subsequently yearly. A decrease of Qmax value <15 ml/s or further instrumentation were considered a failure. RESULTS: Overall, TEOMG and NOMG had comparable success rates (68.8% vs. 78.9%, p=0.155) after a median follow-up of 52 (IQR 45-60) months for TEOMG and 53.5 (IQR 43-58) months for NOMG. Subgroup analysis revealed similar success rates according to surgical technique, stricture localization, and length. Only following repetitive urethral dilatations, TEOMG achieved significantly lower success rates (31.3% vs. 81.3%, p=0.003). Surgical time could be reduced through TEOMG use with a median of 104 (IQR 86-130) vs. 182 (IQR 154-214) minutes in the NOMG group (p<0.001). Both early and late oral morbidity were diminished through the biopsy taken for TEOMG manufacture, compared to NOMG harvesting. Twelve months postoperatively, the prevalence of sensory disorders still showed a significant disparity between groups, with occurrence only in the NOMG group (0 vs. 9.2%, p=0.006). CONCLUSIONS: The success rate of augmentation urethroplasty using TEOMG was statistically comparable to NOMG at a mid-term FU. Surgical time was significantly shortened since no intraoperative mucosa harvesting was required, and oral complications were diminished through the preoperative biopsy for MukoCell® manufacture. Source of Funding: No funding © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e978 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Leonidas Karapanos More articles by this author Vincent Knorr More articles by this author Luisa Halbe More articles by this author Maximilian Schmautz More articles by this author Bobirjon Ergashev More articles by this author Andijan Uzbekistan More articles by this author Axel Heidenreich More articles by this author Expand All Advertisement PDF downloadLoading ...

Is colorectal mucosa a reasonable graft alternative to buccal grafts for urethroplasty?: A comparison of graft histology and stretch

To compare the histological properties and stretch of colorectal mucosal grafts (CMG) and buccal mucosal grafts (BMG) and to evaluate the impact of age, medical comorbidity and tobacco use on these metrics. Samples of BMGs from patients undergoing augmentation urethroplasty were sent for pathologic review. CMGs were collected from patients undergoing elective colectomy. CMGs were harvested fresh, at full thickness from normal rectum/sigmoid. Patients with inflammatory bowel disease, prior radiation, or chemotherapy were excluded. Seventy two BMGs and 53 CMGs were reviewed. While BMGs and CMGs were both histologically composed of mucosal (epithelium + lamina propria) and submucosal layers, the mucosal layer in CMG had crypts. The outer epithelial layers differed significantly in mean thickness (BMG 573μm vs. CMG 430μm, p=0.0001). Mean lamina propria thickness and submucosal layer thickness also differed significantly (BMG 135μm vs. CMG 400μm, p<0.0001; BMG 1090μm vs. CMG 808μm, p = 0.007, respectively). Mean delta stretch, as to length and width, was greater for CMG (118% x 72%) compared to BMGs (22% x 8%), both p<0.001. CMGs and BMGs significantly differ histologically in layer composition, width and architecture, as well as graft stretch. Given its elastic properties, CMG may be useful in covering large surface areas, but its thin epithelium, thick lamina propria and additional muscularis mucosal layer could impact graft take and contracture.

“Detubularised Non Augmented Urethroplasty”- A Promising Option for Pananterior Urethral Stricture: A Case Series

Pananterior urethral stricture involving the penile and bulbar urethra is a challenging urological condition in the Indian population. In India, Balanitis Xerotica Obliterans (BXO) or Lichen Sclerosus (LS) is the most common cause of pananterior urethral stricture. Various surgical techniques have been described in the literature for present condition, with varied outcomes. However, there is still a need for a simple and effective procedure to address this problem. Hereby, the authors present a case series that included five male patients with BXO and pananterior urethral stricture who underwent Detubularised Non Augmented (DNA) urethroplasty between January 2022 and December 2022. The median age of the patients was 45 years, with a mean stricture length of 13 cm. The median follow-up period was 11 months. During the procedure, a scroto-perineal incision was made, and the anterior urethra was ventrally cut open from the meatus to the junction of the stricturous and normal urethra. A right-sided Tunica Vaginalis (TV) flap was raised (left is left), and the cut-open anterior urethra was wrapped with the TV flap, creating a “controlled fistula” at the proximal end of the detubularised urethra. The average operative time was 1.5 hours. The success of the procedure was determined by a postoperative peak flow rate of 12 mL/sec or more, with no further need for urethral dilatation or direct vision internal urethrotomy. The procedure was successful in 4 out of 5 cases (80%). One patient developed a narrowed urethra during follow-up and required serial catheter upgradation for urethral dilatation. In conclusion, DNA urethroplasty was found to be a simple and effective treatment option for the notorious pananterior urethral stricture associated with BXO.

Standard Snodgrass urethroplasty versus Snodgrass with glans augmentation urethroplasty for distal hypospadias: A comparative study

Abstract Introduction: Hypospadias is one of the most common congenital anomalies of the male genitourinary system. The Snodgrass urethroplasty is the most common worldwide accepted procedure for distal hypospadias. Various modifications have been made to reduce common complications, such as urethra-cutaneous fistula and meatal stenosis. In this study, we compare the results of hypospadias repair using the standard Snodgrass urethroplasty technique and Snodgrass urethroplasty with glans augmentation. Materials and Methods: This is a single institution series from January 2020 to January 2023. One hundred patients with distal hypospadias were included in the study. Out of these, 50 patients underwent the standard Snodgrass repair (Group 1), whereas another 50 patients underwent the Snodgrass urethroplasty with glans augmentation technique (Group 2). Results: The average follow-up period was 8 months. Four patients in Group 1 developed a fistula, and three had meatal stenosis (two were managed by meatal dilatations, and one with severe meatal stenosis was managed by meatotomy). In comparison, none of the patients in Group 2 developed a fistula, and only one developed meatal stenosis, which was managed by meatal dilatation. Partial skin necrosis was noted in three patients in Group 1 and two patients in Group 2. The final cosmetic appearance was acceptable. Conclusions: Snodgrass urethroplasty with glans augmentation is an effective procedure with a low complication rate and good cosmetic results.

Outcomes of Anterior Urethral Stricture Management in a Tertiary Care Hospital in Eastern Nepal

Introduction: The standard guidelines for the management of anterior urethral strictures categorizes as transurethral procedures like dilatation and urethrotomy; and open surgical procedures like urethroplasty. This study aims to find the extent and outcome of anterior urethral strictures managed in a tertiary care hospital in eastern Nepal. Methods: It was a hospital-based cross-sectional study. Patients were evaluated preoperatively as per institutional protocol. The procedure was done either in local or spinal or general anesthesia with nasal intubation. At the end of the procedure, a 14 Fr Silicon catheter was inserted per urethra and removed either on the next day, 2 weeks or 4 weeks post operatively depending upon the type of procedure done. Patients were asked to follow up postoperatively at 6 weeks and three months. Results: Thirty-six cases were eligible. The mean age of the patients was 39.25±14.02 years. According to the etiology; 36.1% were iatrogenic, 30.6% traumatic, 25% were balanitis xerotica obliterans or genital lichen sclerosus (BXO/LS) associated and 8.3% were infective respectively. Similarly, 61.1% of strictures were bulbar in location, 22.2% panurethral, 11.1% penile and 5.6% meatal. The mean length of the stricture was 4.26± 4.22 cm (range 1-14 cm). Similarly, Visual internal urethrotomy (VIU) was done in 47.2%, augmentation urethroplasty in 44.4% meatoplasty in 5.6% and anastomotic urethroplasty in 2.8% respectively. Complications occurred in 11.1% of cases. Conclusion: Visual internal urethrotomy was the commonly performed procedure for the urethral stricture. Meatal stenosis was the most common complication

Determining the outcomes of urethral construction in phalloplasty.

To evaluate the surgical and functional outcomes of urethral reconstruction associated with phalloplasty, depending on the surgical techniques and patient history. We conducted a single-centre retrospective study including 89 patients who underwent phalloplasty with urethral reconstruction between 2007 and 2018. Patients included were trans-male patients undergoing gender-affirming surgery and cis-male patients undergoing penile reconstruction after trauma, congenital malformation, or cancer. Urethral reconstructions were performed by free flap or skin graft (total or thin). Secondary urethroplasty may include direct vision urethrotomy, excision-anastomosis, or augmentation urethroplasty (skin graft, buccal mucosa graft). Patient demographics, medical history, peri- and postoperative data were collected from patient files. Functional results were evaluated using individual questionnaires. The mean (±sd) follow-up duration was 5.5 (±3.7) years. No significant difference was found for total urethral complication rate (fistula and/or stricture) according to type of urethral construction (70.9% for free flap urethra vs 73.5% for skin graft urethra; P = 0.911), nor according to the patient's grounds for surgery (72.7% for cis-male vs 71.8% for trans-male patients; P = 1). A total of 36 patients (40.5%) answered the functional questionnaire, of whom 80.5% reported usually voiding while standing and 47.5% were comfortable with urinating in public. Urethral construction in phalloplasty is associated with a high complication and revision rate regardless of the type of urethral reconstruction. Voiding in a standing position is generally possible but should not conceal feeble functional results.

Comparison of Single versus Double BMG Urethroplasty in the Treatment of Bulbar Urethral Stricture

Background: Bulbar urethral strictures require comprehensive and careful urological management. Augmentation urethroplasty is the preferred treatment method and buccal mucosa has gained widespread popularity as the graft of choice for bulbar urethroplasty. Objective: To compare the outcomes of single versus double BMG urethroplasty in the treatment of bulbar urethral stricture. Methods: This prospective observational study was conducted in the Department of Urology, National Institute of Kidney Diseases and Urology, Sher-e-Bangla Nagar, Dhaka from July 2018 to December 2019 over a period of one and half years. In this study, 22 patients had single BMG urethroplasty and 38 patients had double BMG urethroplasty. Qmax, dilation requirement, recurrent stricture and postoperative complications were recorded and compared. SPSS 12 was used for analysis. Categorical data were compared with Chi-square test and numerical data were compared with unpaired t test. Results: Maximum patients were more than 40 years old in both groups. Mean age was 40.77 ± 8.52 years &amp; 38.97 ± 10.07 years in single and double BMG group respectively (p&gt;0.05). Most of the patients were either overweight or obese in both groups (p&gt;0.05). In most of the cases aetiology of structure was unknown in both groups. Length of graft was 4.59 ± 0.65 cm and 4.43 ± 0.51 cm in single and double BMG group respectively. Peroperative Qmax was 8.00 ± 1.54 ml/sec and 7.61 ± 1.73 ml/sec in single and double BMG group respectively. Postoperative Qmax after 1 month and after 3 months was significantly higher in double BMG group than single BMG group (23.87 ± 1.79 ml/sec vs 21.73 ± 2.37 ml/sec and 20.71 ± 3.25 ml/sec vs 14.95 ± 1.29 ml/sec). Percent increment of Qmax after 3 months comparing pre-operative was significantly higher in double BMG urethroplasty group than that of single BMG urethroplasty group. Wound infection was higher in single BMG group than that of double BMG group but difference was not statistically significant (27.3% vs 13.2%; p=0.310). Recurrent of stricture was significantly higher in single BMG urethroplasty group than that of double BMG urethroplasty group (45.5% vs 21.1%; p=0.04 Conclusion Double BMG urethroplasty is better than single BMG urethroplasty in the treatment of bulbar urethral strictures. Bangladesh J. Urol. 2021; 24(1): 82-86