Auditory Temporal Discrimination Research Articles

Auditory Temporal Discrimination from the Perspective of Gap

Abstract Gap detection refers to the perceptual ability to detect brief silences in auditory stimuli. This study investigates temporal discrimination in relation to the perception and processing of gaps. Experiments were conducted to measure gap discrimination thresholds using markers of different frequencies. The results reveal that the threshold for gap discrimination varies depending on the frequency separation between the leading and trailing markers. Notably, when the markers have identical frequencies, the threshold increases monotonically up to the study limit of 100 ms, with a slope that deviates from Weber’s law. To better comprehend these findings, a previously proposed neural model of gap detection was expanded to account for discrimination. This model shows good compatibility with the experimental results and is able to unify gap detection with temporal discrimination. The model also provides a possible mechanism for the pacemaker in the internal clock hypothesis.

Individual differences in seated resting heart rate are associated with multisensory perceptual function in older adults.

There is evidence that cardiovascular function can influence sensory processing and cognition, which are known to change with age. However, whether the precision of unisensory and multisensory temporal perception is influenced by cardiovascular activity in older adults is uncertain. We examined whether seated resting heart rate (RHR) was associated with unimodal visual and auditory temporal discrimination as well as susceptibility to the audio-visual Sound Induced Flash Illusion (SIFI) in a large sample of older adults (N = 3232; mean age = 64.17 years, SD = 7.74, range = 50-93; 56% female) drawn from The Irish Longitudinal Study on Ageing (TILDA). Faster seated RHR was associated with better discretization of two flashes (but not two beeps) and increased SIFI susceptibility when the audio-visual stimuli were presented close together in time but not at longer audio-visual temporal offsets. Our findings suggest a significant relationship between cardiovascular activity and the precision of visual and audio-visual temporal perception in older adults, thereby providing novel evidence for a link between cardiovascular function and perceptual function in aging.

Modality-Attention Promotes the Neural Effects of Precise Timing Prediction in Early Sensory Processing.

Precise timing prediction (TP) enables the brain to accurately predict the occurrence of upcoming events in millisecond timescale, which is fundamental for adaptive behaviors. The neural effect of the TP within a single sensory modality has been widely studied. However, less is known about how precise TP works when the brain is concurrently faced with multimodality sensory inputs. Modality attention (MA) is a crucial cognitive function for dealing with the overwhelming information induced by multimodality sensory inputs. Therefore, it is necessary to investigate whether and how the MA influences the neural effects of the precise TP. This study designed a visual-auditory temporal discrimination task, in which the MA was allocated to visual or auditory modality, and the TP was manipulated into no timing prediction (NTP), matched timing prediction (MTP), and violated timing prediction (VTP) conditions. Behavioral and electroencephalogram (EEG) data were recorded from 27 subjects, event-related potentials (ERP), time-frequency distributions of inter-trial coherence (ITC), and event-related spectral perturbation (ERSP) were analyzed. In the visual modality, precise TP led to N1 amplitude and 200-400 ms theta ITC variations. Such variations only emerged when the MA was attended. In auditory modality, the MTP had the largest P2 amplitude and delta ITC than other TP conditions when the MA was attended, whereas the distinctions disappeared when the MA was unattended. The results suggest that the MA promoted the neural effects of the precise TP in early sensory processing, which provides more neural evidence for better understanding the interactions between the TP and MA.

Perceptual, procedural, and task learning for an auditory temporal discrimination task.

Perceptual learning reflects experience-driven improvements in the ability to detect changes in stimulus characteristics. The time course for perceptual learning overlaps with that for procedural learning (acquiring general skills and strategies) and task learning (learning the perceptual judgment specific to the task), making it difficult to isolate their individual effects. This study was conducted to examine the role of exposure to stimulus, procedure, and task information on learning for auditory temporal-interval discrimination. Eighty-three listeners completed five online sessions that required temporal-interval discrimination (target task). Before the initial session, listeners were differentially exposed to information about the target task's stimulus, procedure, or task characteristics. Learning occurred across sessions, but an exposure effect was not observed. Given the significant learning across sessions and variability within and across listeners, contributions from stimulus, procedure, and task exposure to overall learning cannot be discounted. These findings clarify the influence of experience on temporal perceptual learning and could inform designs of training paradigms that optimize perceptual improvements.

Sensory processing in the auditory and olfactory domains is normal in laryngeal dystonia.

Abnormal sensory discriminatory processing has been implicated as an endophenotypic marker of isolated dystonia. However, the extent of alterations across the different sensory domains and their commonality in different forms of dystonia are unclear. Based on the previous findings of abnormal temporal but not spatial discrimination in patients with laryngeal dystonia, we investigated sensory processing in the auditory and olfactory domains as potentially additional contributors to the disorder pathophysiology. We tested auditory temporal discrimination and olfactory function, including odor identification, threshold, and discrimination, in 102 laryngeal dystonia patients and 44 healthy controls, using dichotically presented pure tones and the extended Sniffin' Sticks smell test protocol, respectively. Statistical significance was assessed using analysis of variance with non-parametric bootstrapping. Patients had a lower mean auditory temporal discrimination threshold, with abnormal values found in three patients. Hyposmia was found in 64 patients and anosmia in 2 patients. However, there were no statistically significant differences in either auditory temporal discrimination threshold or olfactory identification, threshold, and discrimination between the groups. A significant positive relationship was found between olfactory threshold and disorder severity based on the Burke-Fahn-Marsden dystonia rating scale. Our findings demonstrate that, contrary to altered visual temporal discrimination, auditory temporal discrimination and olfactory function are likely not candidate endophenotypic markers of laryngeal dystonia.

Evaluation of Auditory Temporal Discrimination Thresholds in Migraine Patients

Introduction: Although vestibular migraine is well defined, the effects of migraine on the auditory system have not been clearly identified yet. The aim of this study was to determine the effect of migraine on the auditory system. Methods: Migraine patients without hearing loss were included in the study. Group 1 consisted of patients with migraine pain, group 2 consisted of patients with migraine in the interictal period, and group 3 consisted of healthy volunteers with similar demographic characteristics to groups 1 and 2. Random gap detection test was applied to all 3 groups. Additionally, group 2 and group 3 patients were evaluated with the auditory cortical potentials and the mismatch negativity test. Results: There was a statistically significant difference between the 3 groups in the random gap detection test. There was no statistically significant difference in auditory cortical potentials between group 2 and group 3; however, a statistically significant difference was found between the groups in terms of mismatch negativity test latency. Conclusion: An auditory pathway may be affected in migraine patients, although hearing tests are normal. This interaction continues between attacks, being more evident during the pain period. Therefore, disorders of hearing or speech perception in migraine patients should be evaluated by further audiological tests.

Differentiating perceptual, procedural, and task learning for an auditory temporal discrimination task

Perceptual or stimulus learning (PL) reflects experience-driven improvements in the ability to detect changes in stimulus characteristics. The time course for PL overlaps with that for procedural learning (acquiring general skills and strategies) and task learning (learning the perceptual judgment specific to the task), making it difficult to isolate their individual effects. This study was conducted to examine the impact of exposure to stimulus, procedure, and task information on learning for auditory temporal-interval discrimination. Eighty-three listeners completed multiple sessions requiring auditory temporal-interval discrimination (target learning task), but before these sessions listeners were exposed to one of three conditions that differed by the information conveyed about the target task’s stimulus, procedure, or task characteristics. Significant learning occurred but an exposure effect was not found when examined across sessions. However, percentage improvement scores (initial to final) revealed that listeners exposed to elements of the target task demonstrated larger percentage improvements on that task compared to naïve listeners without any prior experience in a manner that suggested that stimulus and procedural learning were possible drivers of temporal learning. These findings could clarify the influence of experience on temporal PL and inform future research aimed at developing training paradigms that optimize perceptual improvements.

Age-related sensory decline mediates the Sound-Induced Flash Illusion: Evidence for reliability weighting models of multisensory perception

Perception of our world is proposed to arise from combining multiple sensory inputs according to their relative reliability. We tested multisensory processes in a large sample of 2920 older adults to assess whether sensory ability mediates age-related changes in perception. Participants completed a test of audio-visual integration, the Sound Induced Flash Illusion (SIFI), alongside measures of visual (acuity, contrast sensitivity, self-reported vision and visual temporal discrimination (VTD)) and auditory (self-reported hearing and auditory temporal discrimination (ATD)) function. Structural equation modelling showed that SIFI susceptibility increased with age. This was mediated by visual acuity and self-reported hearing: better scores on these measures predicted reduced and stronger SIFI susceptibility, respectively. Unexpectedly, VTD improved with age and predicted increased SIFI susceptibility. Importantly, the relationship between age and SIFI susceptibility remained significant, even when considering mediators. A second model showed that, with age, visual ‘gain’ (the benefit of congruent auditory information on visual judgements) was predicted by ATD: better ATD predicted stronger visual gain. However, neither age nor SIFI susceptibility were directly associated with visual gain. Our findings illustrate, in the largest sample of older adults to date, how multisensory perception is influenced, but not fully accounted for, by age-related changes in unisensory abilities.

Do Auditory Temporal Discrimination Tasks Measure Temporal Resolution of the CNS?

Rammsayer & Brandler (2002) have proposed that auditory temporal discrimination tasks provide a measure of temporal resolution of the CNS which is argued to be partly responsible for higher order cognitive functioning. We report on two studies designed to elicit the nature of the functions underpinning these auditory tasks. Study 1 assessed whether temporal generalisation (TG) might be better considered as a measure of working memory rather than of temporal resolution of the CNS. In N = 66 undergraduates TG did not predict speed of processing tasks; however, there was evidence of a relationship between TG and working memory. Study 2 reanalyzed pre- viously published data on temporal discrimination tasks and showed that the relationship between auditory tem- poral tasks and intelligence reflects memory functions and processing speed. Auditory temporal discrimination tasks are confounded by speed and memory and should not be considered as measures of temporal resolution of the CNS.

Perceptual learning in auditory temporal discrimination: No evidence for a cross-modal transfer to the visual modality

Perceptual learning was used to study potential transfer effects in a duration discrimination task. Subjects were trained to discriminate between two empty temporal intervals marked with auditory beeps, using a two-alternative forced choice paradigm. The major goal was to examine whether perceptual learning would generalize to empty intervals that have the same duration but are marked by visual flashes. The experiment also included longer intervals marked with auditory beeps and filled auditory intervals of the same duration as the trained interval, in order to examine whether perceptual learning would generalize to these conditions within the same sensory modality. In contrast to previous findings showing a transfer from the haptic to the auditory modality, the present results do not indicate a transfer from the auditory to the visual modality; but they do show transfers within the auditory modality.

Early acoustic discrimination experience ameliorates auditory processing deficits in male rats with cortical developmental disruption

Auditory temporal processing deficits have been suggested to play a causal role in language learning impairments, and evidence of cortical developmental anomalies (microgyria (MG), ectopia) has been reported for language-impaired populations. Rodent models have linked these features, by showing deficits in auditory temporal discrimination for rats with neuronal migration anomalies (MG, ectopia). Since evidence from human studies suggests that training with both speech and non-speech acoustic stimuli may improve language performance in developmentally language-disabled populations, we were interested in whether/how maturation and early experience might influence auditory processing deficits seen in male rats with induced focal cortical MG.Results showed that for both simple (Normal single tone), as well as increasingly complex auditory discrimination tasks (silent gap in white noise and FM sweep), prior experience significantly improved acoustic discrimination performance—in fact, beyond improvements seen with maturation only. Further, we replicated evidence that young adult rats with MG were significantly impaired at discriminating FM sweeps compared to shams. However, these MG effects were no longer seen when experienced subjects were retested in adulthood (even though deficits in short duration FM sweep detection were seen for adult MG rats with no early experience). Thus while some improvements in auditory processing were seen with normal maturation, the effects of early experience were even more profound, in fact resulting in amelioration of MG effects seen at earlier ages.These findings support the clinical view that early training intervention with appropriate acoustic stimuli could similarly ameliorate long-term processing impairments seen in some language-impaired children.

The neural basis of auditory temporal discrimination in girls with fragile X syndrome

Fragile X syndrome (FXS) is a common genetic disorder in which temporal processing may be impaired. To our knowledge however, no studies have examined the neural basis of temporal discrimination in individuals with FXS using functional magnetic resonance imaging (fMRI). Ten girls with fragile X syndrome and ten developmental age-matched typically developing controls performed an auditory temporal discrimination task in a 3T scanner. Girls with FXS showed significantly greater brain activation in a left-lateralized network, comprising left medial frontal gyrus, left superior and middle temporal gyrus, left cerebellum, and left brainstem (pons), when compared to a developmental age-matched typically developing group of subjects who had similar in-scanner task performance. There were no regions that showed significantly greater brain activation in the control group compared to individuals with FXS. These data indicate that networks of brain regions involved in auditory temporal processing may be dysfunctional in FXS. In particular, it is possible that girls with FXS employ left hemispheric resources to overcompensate for relative right hemispheric dysfunction.

Right hemispheric contributions to fine auditory temporal discriminations: High-density electrical mapping of the duration mismatch negativity (MMN)

That language processing is primarily a function of the left hemisphere has led to the supposition that auditory temporal discrimination is particularly well-tuned in the left hemisphere, since speech discrimination is thought to rely heavily on the registration of temporal transitions. However, physiological data have not consistently supported this view. Rather, functional imaging studies often show equally strong, if not stronger, contributions from the right hemisphere during temporal processing tasks, suggesting a more complex underlying neural substrate. The mismatch negativity (MMN) component of the human auditory evoked-potential provides a sensitive metric of duration processing in human auditory cortex and lateralization of MMN can be readily assayed when sufficiently dense electrode arrays are employed. Here, the sensitivity of the left and right auditory cortex for temporal processing was measured by recording the MMN to small duration deviants presented to either the left or right ear. We found that duration deviants differing by just 15% (i.e. rare 115 ms tones presented in a stream of 100 ms tones) elicited a significant MMN for tones presented to the left ear (biasing the right hemisphere). However, deviants presented to the right ear elicited no detectable MMN for this separation. Further, participants detected significantly more duration deviants and committed fewer false alarms for tones presented to the left ear during a subsequent psychophysical testing session. In contrast to the prevalent model, these results point to equivalent if not greater right hemisphere contributions to temporal processing of small duration changes.

Cerebral asymmetry in electrophysiological (mismatch negativity) measures of temporal processing determines performance on a between-channel gap detection task

Event Abstract Back to Event Cerebral asymmetry in electrophysiological (mismatch negativity) measures of temporal processing determines performance on a between-channel gap detection task Juanita Todd1, 2, 3, 4*, U. Schall2, 3, 4, 5 and T. B. Budd1, 2, 3, 4 1 School of Psychology, University of Newcastle, Australia 2 Brain and Mental Health Priority Research Centre, University of Newcastle, Australia 3 Hunter Medical Research Institute, Australia 4 Schizophrenia Research Institute, Australia 5 School of Medicine and Population Health, University of Newcastle, Australia There is evidence of a left-hemisphere advantage for processing temporal information in sound that can be observed as a right-ear advantage on auditory tasks. This study was designed to determine whether a right-ear advantage could be observed in mismatch negativity (MMN) measures of central auditory temporal discrimination, and the extent to which this is related to behavioral measures of temporal discrimination ability. Forty-seven adults (18-73 years) completed behavioral and MMN measures of temporal discrimination for sounds presented monaurally to the left and right ear. Temporal discrimination was assessed using between-channel gap-detection - the ability to detect a gap between non-overlapping frequency bands of sound. Temporal discrimination performance showed a positive function of MMN measures of gap-detection, where larger right-ear advantage in MMN to gap sounds correlated with better temporal discrimination ability (rs= -.51, p<.005). Furthermore, only participants with low gap-detection thresholds exhibited significant right-ear advantage in MMN to gap sounds. The association between right-ear advantage in MMN and temporal discrimination ability may reflect the importance of the left-hemisphere in determining the resolution of auditory temporal processing. The results raise the possibility that groups showing impaired temporal processing (e.g. aged, schizophrenia, language disorders) may exhibit altered functional asymmetry in temporal processing. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Poster Presentation Topic: Poster Presentations Citation: Todd J, Schall U and Budd TB (2009). Cerebral asymmetry in electrophysiological (mismatch negativity) measures of temporal processing determines performance on a between-channel gap detection task. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.045 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Mar 2009; Published Online: 24 Mar 2009. * Correspondence: Juanita Todd, School of Psychology, University of Newcastle, Newcastle, Australia, Juanita.Todd@newcastle.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Juanita Todd U. Schall T. B Budd Google Juanita Todd U. Schall T. B Budd Google Scholar Juanita Todd U. Schall T. B Budd PubMed Juanita Todd U. Schall T. B Budd Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

The neural basis of temporal auditory discrimination

When two identical stimuli, such as a pair of clicks, are presented with a sufficiently long time-interval between them they are readily perceived as two separate events. However, as they are presented progressively closer together, there comes a point when the two separate stimuli are perceived as one. This phenomenon applies not only to hearing but also to other sensory modalities. Damage to the basal ganglia disturbs this type of temporal discrimination irrespective of sensory modality, suggesting a multimodal process is involved. Our aim was to study the neural substrate of auditory temporal discrimination in healthy subjects and to compare it with structures previously associated with analogous tactile temporal discrimination. During fMRI scanning, paired-clicks separated by variable inter-stimulus intervals (1–50 ms) were delivered binaurally, with different intensities delivered to each ear, yielding a lateralised auditory percept. Subjects were required (a) to report whether they heard one or two stimuli (TD: temporal discrimination); or (b) to report whether the stimuli were located on the right or left side of the head mid-line (SD: spatial discrimination); or (c) simply to detect the presence of an auditory stimulus (control task). Our results showed that both types of auditory discrimination (TD and SD) compared to simple detection activated a network of brain areas including regions of prefrontal cortex and basal ganglia. Critically, two clusters in pre-SMA and the anterior cingulate cortex were specifically activated by TD. Furthermore, these clusters overlap with regions activated for similar judgments in the tactile modality suggesting that they fulfill a multimodal function in the temporal processing of sensory events.

Effect of intensive training on auditory processing and reading skills

This study assessed the ability of seven children to accurately judge relative durations of auditory and visual stimuli before and after participation in a language remediation program. The goal of the intervention program is to improve the children’s ability to detect and identify rapidly changing auditory stimuli, and thereby improve their language-related skills. Children showed improved accuracy on a test of auditory duration judgement following the intervention without analogous improvements in the visual domain, supporting the assertion that intensive training with modified speech improves auditory temporal discrimination. However, these improvements did not generalize to reading skills, as assessed by standard measures of phonological awareness and non-word reading.

The Neurobiology of Sensory and Language Processing in Language-Impaired Children

Abstract Clinical, behavioral, and neurophysiological studies of developmental language impairment (LI), including reading disability (RD), have variously emphasized different factors that may contribute to this disorder. These include abnormal sensory processing within both the auditory and visual modalities and deficits in linguistic skills and in general cognitive abilities. In this study we employed the event-related brain potential (ERP) technique in a series of studies to probe and compare Merent aspects of functioning within the same sample of LI/RD children. Within the group multiple aspects of processing were affected, but heterogeneously across the sample. ERP components linked to processing within the superior temporal gyrus were abnormal in a subset of children that displayed abnormal performance on an auditory temporal discrimination task. An early component of the visual ERP was reduced in amplitude in the group as a whole. The relevance of this effect to current conceptions of substreams within the visual system is discussed. During a sentence processing task abnormal hemispheric specialization was observed in a subset of children who scored poorly on tests of grammar. By contrast the group as a whole displayed abnormally large responses to words requiring contextual integration. The results imply that multiple factors can contribute to the profile of language impairment and that different and specific deficits occur heterogeneously across populations of LI/RD children.

Neural mechanisms of an auditory temporal discrimination by the goldfish

1. The capacities of the goldfish (Carassius auratus) auditory system for encoding and processing periodic temporal patterns were characterized using behavioral and neurophysiological analyses. Animals were classically conditioned to detect changes in the rates (20 to 200 Hz) at which tonal and noise signals were amplitude-modulated, at a variety of modulation depths (3 to 100%). For the same stimulus set, the variability with which saccular neurons represent envelope periodicity in inter-spike-intervals was measured. 2. The just discriminable change in envelope period (ΔP) is approximately equal to the variance wich spikes in saccular neurons are phase-locked to modulation envelopes. 3. The error made in detecting changes in modulation rate is highly correlated with the error with which inter-spike-intervals in saccular fibers represent envelope periodicity at a wide variety of modulation rates and depths. This is evidence that the goldfish estimates the duration of acoustic inter-pulse-intervals through information contained in neural inter-spike-intervals. 4. Factors in addition to synchronization error determine envelope period discriminability for amplitude modulated signals. Chief among these may be an informational signal-to-noise ratio, or the number of inter-spike-intervals (ISI) which bear information about envelope period as a proportion of the total ISIs evoked by a given stimulus. 5. There is a clear correspondence between the neural and psychophysical measures of envelope representation in the goldfish auditory system, and the precision with which damselfish recognize vocalizations of their own species on the basis of the time interval between repeated sound pulses.

Laterality, Attention and Rate Effects in the Auditory Temporal Discrimination of Chronic Schizophrenics: The Effect of Treatment with Chlorpromazine

Schizophrenic patients, non-psychotic patients and healthy subjects were required to detect longer target tones from a sequence of short tones presented to either ear. The rate of stimulus presentation and the frequency of switches between the ears were varied. The schizophrenic patients were examined for four weeks while on standard clinical doses of chlorpromazine, for four weeks while on placebo, and for four weeks following reinstatement of medication. Lateral asymmetries in the performance of the schizophrenics were found to diminish in proportion to both the duration and the dosage of medication. The results are consistent with the hypothesis that chlorpromazine causes an improvement of left hemisphere performance relative to the right. The performance of the schizophrenics, relative to that of comparison subjects, deteriorated as the rate of stimulus presentation increased, supporting the hypothesis that schizophrenics have particular difficulties in response selection or organization.

Auditory temporal discrimination by trained listeners

Previous reports from this laboratory have shown that untrained listeners cannot name the order of sounds in extended sequences of unrelated items such as hisses, tones, and buzzes at item durations of 200 msec, even though identification of order for the sounds of speech and music is accomplished readily at much shorter item durations. The present study indicates that under appropriate conditions subjects can be trained to distinguish between and to identify permuted orders within sequences of nonrelated sounds each lasting only 10 msec or less. Evidence is presented suggesting that much of what passes for direct identification of order is actually based on prior identification of a larger pattern. Two principal mechanisms seem to mediate discrimination of auditory temporal order: (1) fine resolution (requiring prior training) permitting identification of over-all patterns and capable of operating with item durations of only a few msec; (2) coarse resolution (special prior training not required) allowing naming of order of items having minimal durations usually above 200 msec for unfamiliar sequences.