Auditory P300 Event-related Potential Research Articles

The Latency of Auditory Event-Related Potential P300 Prolonged in School-Age Students with Unilateral Hearing Loss in a Mandarin Learning Environment.

Our study investigated the differences in speech performance and neurophysiological response in groups of school-age children with unilateral hearing loss (UHL) who were otherwise typically developing (TD). We recruited a total of 16 primary school-age children for our study (UHL = 9/TD = 7), who were screened by doctors at Shin Kong Wu-Ho-Su Memorial Hospital. We used the Peabody Picture Vocabulary Test-Revised (PPVT-R) to test word comprehension, and the PPVT-R percentile rank (PR) value was proportional to the auditory memory score (by The Children's Oral Comprehension Test) in both groups. Later, we assessed the latency and amplitude of auditory ERP P300 and found that the latency of auditory ERP P300 in the UHL group was prolonged compared with that in the TD group. Although students with UHL have typical hearing in one ear, based on our results, long-term UHL might be the cause of atypical organization of brain areas responsible for auditory processing or even visual perceptions attributed to speech delay and learning difficulties.

Evaluation of p300 and spectral resolution in children with attention deficit hyperactivity disorder and specific learning disorder.

This study aims to examine auditory processing, P300 values and functional impairment levels among children with Attention Deficit and Hyperactivity Disorder (ADHD), Specific Learning Disorder (SLD), ADHD+SLD and healthy controls. Children with ADHD (n=17), SLD (n=15), ADHD+SLD (n=15), and healthy controls (n=15) between the ages of 7-12 were evaluated with K-SADS, Weiss Functional Impairment Rating Scale, Turgay DSM-IV Disruptive Behavior Disorders Rating Scale, The Mathematics, Reading, Writing Assessment Scale and Children's Auditory Performance Scale (CHAPS). Auditory P300 event-related potentials and Spectral-Temporally Modulated Ripple Test (SMRT) were applied. Three patient groups were found to be riskier than healthy controls according to the CHAPS. There was no significant difference between the groups in the SMRT. In post-hoc analyses of P300 parietal amplitudes, ADHD, SLD, and ADHD+SLD were found to be significantly lower than the control group. The amplitudes of the ADHD+SLD were by far the lowest. It has been shown that auditory performance skills and p300 amplitudes are lower in children diagnosed with only ADHD or SLD compared to the control group, with the lowest values observed in ADHD+SLD. This study suggests that the difficulties with attention and cognitive functions in the ADHD+SLD are more severe than ADHD and/or SLD without comorbidity.

Effect of alternate nostril breathing on evoked potentials among internet addicts.

Increased availability of smartphones and easy access to the internet among adolescents has resulted in Internet Addiction (IA). Effects of IA and Pranayama on evoked potential are available but studies on the comparison of immediate and 6-week effects of alternate nostril breathing on evoked potentials among medicos with internet addiction are not available as per our search in PubMed, hence the study was chosen. In this comparative study 100 male and female medical students aged between 18-25 years, with internet addiction scores ≥ 50 were included as study participants. P300 auditory event-related potential and pattern reversal visual evoked potential (VEP) were recorded before, immediately, and 6 weeks after practicing pranayama. Repeated measure ANOVA shows statistically significant change (P<0.05) in P300 amplitude, P100 latency, N145 latency, and VEP amplitude. The post hoc Bonferroni test shows that P100 latency and N145 latency significantly reduced immediately after 15 minutes of pranayama. P300 amplitude and VEP amplitude significantly increased only after practicing pranayama for 6 weeks. Pranayama has an immediate effect on latency, but it takes 6 weeks of practice to significantly change amplitude.

Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Depression after Cerebral Infarction

<sec><title>Objective</title> To explore the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on depression, cognitive function and activities of daily living in patients with depression after cerebral infarction. </sec><sec><title>Methods</title> A total of 50 patients with depression after cerebral infarction from the departments of neurology and rehabilitation of the Second Affiliated Hospital of Chongqing Medical University from July 2018 to February 2020, which were randomly divided into the control group and the observation group, with 25 cases in each group. All of the patients received conventional drug therapy, rehabilitation training, and paroxetine antidepressant treatment. On this basis, the control group was given sham stimulation, the coil of magnetic stimulation was placed at 90 degrees perpendicular to the scalp, the stimulation frequency was 10.0 Hz, the stimulation intensity was 80%-90% resting motor threshold (RMT), and the stimulation intensity was adjusted from low to high according to the patients tolerance, two seconds per stimulus, 20 seconds interval, total pulses 1 200, once a day, five days a week, continous treatment for six weeks. The observation group was given high-frequency rTMS treatment, the stimulation site was the left dorsolateral prefrontal cortex (DLPFC), the center point of the coil was tangent to the patients scalp surface, and the treatment parameters and time were the same as those in the control group. Before treatment and after treatment for six weeks, the Montreal cognitive assessment scale (MoCA) was used to evaluate the overall cognitive function of patients; the Hamilton depression scale (HAMD) was used to evaluate the depression of patients; the modified Barthel index (MBI) was used to evaluate the activities of daily living of patients; the auditory event-related potential P300 was used to evaluate cognitive function and the adverse reactions of the two groups were compared. </sec><sec><title>Results</title> There were no significant differences in MoCA, HAMD, MBI scores and P300 between the two groups before treatment (<italic>P</italic>>0.05). Compared with before treatment, MoCA scores, subitem scores of MoCA (such as visuospatial/executive function, attention/calculation) and MBI score of both groups after treatment for six weeks were significantly higher (<italic>P</italic><0.05), HAMD score and P300 latency of both groups were significantly lower, the difference was statistically significant (<italic>P</italic><0.05). Compared with the control group, the MoCA scores and subitem scores of MoCA (such as attention/calculation and delayed memory) of the observation group were significantly higher (<italic>P</italic><0.05), and HAMD score and P300 latency were significantly lower, the difference was statistically significant (<italic>P</italic><0.05). There were no significant differences in MBI score and occurrence of adverse events between the two groups (<italic>P</italic>>0.05). </sec><sec><title>Conclusion</title> High frequency rTMS can effectively improve the depressive state and cognitive function of patients with post-stroke depression, which is worthy of clinical application. </sec>

Auditory event-related potential (P300) in patients with schizophrenia

Background: Schizophrenia is a psychiatric disorder characterized by multiple symptoms such as positive symptoms, negative symptoms, and cognitive symptoms. Cognitive deficit can be detected with specific neurophysiological tests. Among these tests are the measurements of auditory P300 event-related potential which is a neurophysiological method that allows the examination of cognitive functioning of the human brain. Objective: The aim of this article is to assess cognitive deficits in chronic schizophrenia patients by studying the amplitude and latency of P300 potential and to compare findings with those from control subjects. Materials and Methods: The present study was a case–control study extended from January 2020 to May 2020. Forty subjects were enrolled in this study: 20 patients aged 20–50 years comprising 11 males and 9 females diagnosed with schizophrenia and 20 apparently healthy volunteers comprising 11 males and 9 females were analyzed. Results: The results of the current study revealed that a highly significant difference was found in the years of education between patients and controls (P-value <0.001) with no significant difference to be noticed regarding age or gender. When analyzing the P300 component with an unpaired t-test, the patient group showed delayed latency and smaller P300 amplitude than the control group (P<0.001). Conclusion: The present study concludes that P300 indices could be valuable biomarkers to assess changes in cognitive functioning of patients with schizophrenia.

Cognitive function analysis of chronic lead poisoning in adults

Objective: To explore the changes of the auditory event-related potentials P300 and the Montreal Cognitive Assessment (MoCA) in the chronic mild lead poisoning in order to find out the impairment of cognitive function and intervene early. Methods: In February 2020, 50 patients with chronic mild lead poisoning in Wuhan Center for Prevention and Treatment of Occupational Diseases from June 2011 to June 2015 were selected as the case group, and 50 healthy people were selected as the control group. The changes of auditory event-related potential P300 and MOCA of the two groups were analyzed. Results: Compared with the control group, the latency of P300 of auditory event-related potential in the case group was prolonged and the amplitude was decreased (P<0.05) . Compared with the control group, the total score of MoCA in the case group was decreased, the mean score of language, abstract and delayed memory items decreased, and the differences were statistically significant (P<0.05) . Conclusion: The combination of auditory event-related potential P300 and MOCA is helpful to detect the early cognitive impairment in chronic lead poisoning population, and auditory event-related potential P300 is an objective and effective early detection method.

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease.

Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination. Objective To review the literature on the application and findings of P300 as an indicator of PD. Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments. Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.

NORMATIVE DATA OF COGNITIVE ASSESSMENT BY AUDITORY P300 EVENT RELATED POTENTIAL, MONTREAL COGNITION ASSESSMENT AND CHOICE REACTION TIME AND ITS VARIATION WITH AGE AND GENDER IN UTTARAKHAND REGION OF INDIA.

Background: Tests like auditory P300 event related potential, neuro-psychometric pen pencil Montreal Cognition Assessment Test (MOCA) and Choice reaction time have been used as indexes of cognitive function. Thus this study has been planned with the aim to evaluate cognitive ability of a normal adult to nd out normative data and its, variation with age and gender in Uttarakhand region of India. Materials and Method: This cross-sectional study was carried out in the department of Physiology of AIIMS, Rishikesh on 52 healthy with ages ranging from 20 to 40 years, equal number of male &amp; female volunteers with the ability to understand test procedures. Following tests were performed in the given order for uniformity during 11-1 pm timing of a day: 1. Event Related Potential-P300 2. Neuro-psychometric assessment (Hindi Montreal Cognitive Assessment -HMOCA test) and 3. Choice Reaction Time. Results and Conclusion: Mean of P300 Latency is 310 ± 37.14 msec, mean of P300 Amplitude is 14 ± 7.5 uv (from Cz electrode site), mean of Montreal Score is 24.81±3.25, and mean of CRT is 584.5 ±84.06 ms in all the subjects. All the parameters are better in younger age group. All the parameters are better in male except MOCA score

Auditory and visual P300 event-related potentials to detect minimal hepatic encephalopathy.

the diagnosis of minimal hepatic encephalopathy (MHE) requires psychometric tests, although new methods are needed since their sensitivity, specificity, and accuracy are low. The P300 event-related potential (ERP) is obtained by auditory and visual stimuli, although only the auditory P300 has been used to detect MHE. This study aimed to compare the diagnostic features of auditory and visual P300 to detect MHE. sixty patients with liver cirrhosis and thirty-five healthy controls completed the Psychometric Hepatic Encephalopathy Score (PHES), the critical flicker frequency (CFF), and auditory and visual P300 tests. MHE was diagnosed if PHES and CFF scores were abnormal. fifty-three cirrhotic patients (aged 54.5 ± 8.6 years) completed all tests. Abnormal scores were obtained for PHES (49.1 %) and CFF (67.9 %). The proportion of MHE was 21.4 %. The area under the receiver operating (ROC) curves (AUROC) for auditory P300 was better than for visual P300 for distinguishing MHE from controls (AUROC: 0.792 vs 0.725; p < 0.005 for both; accuracy: 73.8 % vs 70.2 %; sensitivity: 72.2 % for both; specificity: 74.2 vs 69.7, respectively). Among cirrhotic patients, only auditory P300 was useful to detect MHE (AUROC: 0.723; p < 0.05; 77.4 % accuracy; 61.1 % sensitivity, and 81.8 % specificity). auditory P300 sensitivity, specificity, and accuracy were similar to those of CFF. Our results showed that only auditory P300 is useful to differentiate patients with MHE, although both modalities, auditory and visual, differentiated patients with cirrhosis from controls. Thus, we consider that visual P300 is not suitable for detecting MHE.

Когнитивный вызванный потенциал Р300 у школьников 16–17 лет, проживающих в регионах Арктической зоны РФ

Living in adverse climatic and geographical conditions of the Arctic zone of the Russian Federation requires mobilization of the adaptive mechanisms of the central nervous system in humans. The parameters of the event-related potential P300 serve as indicators of brain bioelectric processes associated with the mechanisms of information perception and processing. This study aimed to establish the parameters of the event-related potential P300 in 16–17-year-old schoolchildren living in different regions of the Arctic zone of the Russian Federation based on a comparative analysis. The auditory event-related potential P300 was evaluated in subjects living in the Nenets Autonomus Okrug (NAO), Yamalo-Nenets Autonomous Okrug (YNAO) and the Arkhangelsk Region (AR). P300 latency and amplitude were recorded by the Encephalan-131-03 electroencephalograph (Medicom MTD, Russia) in the frontal (F3, F4), central (C4, C3), parietal (P3, P4), mid-temporal (T3, T4), and anterior temporal (F7, F8) areas of the brain using the oddball method. In schoolchildren living in AR and YNAO, the amplitude-latency parameters of P300 did not differ significantly. Subjects living in NAO, the majority of whom are representatives of the indigenous peoples of the North (the Nenets), had a longer P300 latency than their peers from other regions. Р300 amplitudes in schoolchildren from all the regions under study were statistically identical. The author comes to the conclusion that longer information processing time, according to the P300 data, reflects the adaptive psychophysiological characteristics of the population with a long historical experience of living in the North.

N100, N200, and P300 Auditory Event-Related Potentials Depending on Handedness and Response Tasks such as Button Pressing and Mental Counting

Purpose: This study was to determine the effects of response tasks, such as button pressing and mental counting, and handedness on N100, N200, and P300 auditory event-related potential (AERP).Methods: A total of 50 normal-hearing young adults with the average age of 21.6 (±1.5) years participated in this study. Among them, 15 men and 15 women were right-handed and 10 men and 10 women were left-handed. An oddball paradigm was used to deliver 30 stimuli of 2 kHz target tone bursts and 120 stimuli of 1 kHz nontarget tone bursts. The stimuli were presented at 70 dB sound pressure level with the rate of 1/s.Results: The button pressing task elicited significantly smaller N100 and larger P300 amplitudes than the mental counting task. N200 latency was significantly lower and P300 amplitude was higher in left-handed participants than those who are right-handed. Appearance percentages of right-/left-handed participants for N100, N200, and P300 were 80/95%, 85/85%, and 75/75% for the button pressing task and 80/90%, 80/80%, and 70/70% for mental counting task, respectively.Conclusion: The significant difference in appearance percentage between response tasks supported that P300 was a strong endogenous potential. N100 and N200 were thought to have both endogenous and exogenous characteristics. A more sensitive approach in selecting the task of response for the target stimuli and careful consideration for the handedness is necessary for AERP recordings.

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

IntroductionCognitive impairment, an important complication in patients with chronic obstructive pulmonary disease (COPD), seriously affects self-management of the disease and quality of life (QoL). As an exercise-based intervention programme, pulmonary...

Effects of transcranial direct current stimulation on cognitive function in delayed encephalopathy after carbon monoxide poisoning

Objective: To investigate the effect of transcranial direct current stimulation (tDCS) on cognitive function of delayed encephalopathy after carbon monoxide poisoning (DEACMP) . Methods: A total of 58 patients with DEACMP admitted to the Emergency Medicine Department of Hudson International Peace Hospital from January 2018 to January 2020 were included. According to the random number table, the patients were randomly divided into study group and control group, with 29 patients in each group. Patients in both groups were given nutritional nerve therapy, improved microcirculation, adrenal cortical hormone and other drugs, as well as hyperbaric oxygen and rehabilitation training, once per day. The study group was treated with tDCS (electrode pads were placed and current stimulation was given 30 min/time) 1/d on the basis of conventional treatment, while the control group was treated with tDCS pseudo stimulation (electrode pads were placed and current stimulation was given for 10 s) 1/d for 30 days consecutively. The auditory event-related potential P300 (ERP-P300) was tested before and 30 days after treatment, and the Mini-Mental State Examination (MMSE) scale, Barthel index (BI) and the National Institutes of Health Neurological Impairment score (NIHSS) were used to evaluate and analyze the patients. Results: There was no significant difference in scores between the two groups before treatment (all P>0.05) . After 30 days of treatment, the MMSE score, orientation, memory, attention and computing power, and language ability of the study group were all higher than those of the control group, and the differences were statistically significant (P<0.05) . 90 days after treatment, the BI of the study group was higher than that of the control group (P<0.05) . After 30 days of treatment, the NIHSS score of the study group was significantly lower than that of the control group (P<0.05) . The latency of ERP-P300 in the study group was shorter than that in the control group, and the amplitude was higher than that in the control group at 30 days after treatment, and the difference was statistically significant (P<0.05) . The latency of ERP-P300 was negatively correlated with the total MMSE score before and after DEACMP treatment (r=-0.837, -0.819, P<0.05) . The latency of ERP-P300 was negatively correlated with orientation, attention and computing power, and language ability before treatment (r=-0.698, -0.675, -0.742, P<0.05) . Conclusion: TDCS treatment can help improve the cognitive function of DEACMP patients, and ERP-P300 test can help determine the cognitive function severity of patients.

Cognitive impairment in Parkinson's Disease

BackgroundDeterioration of cognitive functions is common as Parkinson’s disease (PD) progresses and it varies from mild cognitive impairment (MCI) to dementia.ObjectiveWe aimed to focus on MCI in PD patients, both newly diagnosed cases and chronic cases.Patients and MethodsOur study was conducted on 50 PD male patients, 25 newly diagnosed, 25 chronic patients as well as 50 healthy persons as matched control group were selected. Participants were subjected to Complete neuropsychiatric examination, Structured Clinical Interview for DSM IV-TR Axis I Disorders (SCID I), Montreal Cognitive Assessment (MoCA), P300( auditory event-related potential).Results27 (54%) of patients score < 26 in the MoCA test compared to 12 (24%) of the control group with high statistical significance. A comparison between newly diagnosed cases & chronic cases of PD regarding the cognitive subarea of the MoCA test shows that there was a statistically significant difference regarding attention, language, and delayed recall. P300 shows that 32 (64%) of patients with PD had prolonged latency & 30 (60%) had low amplitude compared to [14 (28%), 16 (23%) respectively] of the control group with statistical significance. Comparison between newly diagnosed cases & chronic cases of PD regarding P300 shows that 20 (80%) of patients with chronic Parkinson’s disease had prolonged latency and 18 (72%) had low amplitude compared to newly diagnosed cases in which 12 (48%) had prolonged latency and 12 (48%) had low amplitude with a statistically significant difference.ConclusionPD patients are frequently encountered with issues concerning cognitive deficits. Prediction and early diagnosis of these deficits are mandatory.

O10.2. DEFICIENT VISUAL ODDBALL STIMULUS PROCESSING PREDICTS PSYCHOSIS ONSET: RESULTS FROM THE NORTH AMERICAN PRODROME LONGITUDINAL STUDY

BackgroundClinical outcomes vary among young people with the psychosis risk syndrome (PRS), with approximately 20% of individuals progressing to a psychotic disorder over 2–3 years and 30% achieving clinical remission. The identification of neurophysiological abnormalities associated with schizophrenia that predate and predict psychosis onset may enhance the accuracy of clinical outcome prediction in the PRS and help elucidate the pathogenic mechanisms of psychosis onset. Auditory P300 event-related potential (ERP) component amplitude reductions are well established in schizophrenia and reflect early attention-mediated information processing deficits. Recent studies employing auditory oddball tasks have shown that P300 amplitude deficits in PRS individuals are associated with later clinical outcomes, including both conversion to full-blown psychosis and remission from the at-risk state. The present study examined whether these effects extend to P300 in the visual modality using visual oddball task data collected as part of the North American Prodrome Longitudinal Study. Specifically, we evaluated whether visual P300 amplitudes are reduced in the PRS and predict future clinical outcomes.Methods540 individuals meeting PRS criteria and 229 healthy individuals completed baseline EEG recording during a visual oddball task. Visual P300 subcomponents were measured in response to two stimulus types: (1) infrequent target stimuli, reflecting top-down allocation of attention (target P3b), and (2) infrequent non-target novel distractor stimuli, reflecting bottom-up orienting of attention (novelty P3a). P300 amplitudes of PRS participants who converted to psychosis (n=70) were compared with those of PRS non-converters who were followed clinically for 24 months and continued to be symptomatic (n=131) or fully remitted from the PRS (n=87).ResultsGroup comparison effects did not differ by stimulus type. Visual P300 amplitudes were not significantly reduced in the PRS group relative to healthy individuals (p=.25). However, baseline target P3b and novelty P3a amplitudes were reduced in PRS individuals who later converted to psychosis relative to all PRS non-converters, including those who remitted (p=.006, d=.44) and those who remained symptomatic (p=.015, d=.37), as well as healthy individuals (p=.001, d=.44). Baseline P300 amplitudes were similar among healthy controls, PRS remitters, and PRS individuals who remained symptomatic (ps>.45). Moreover, visual P300 amplitudes differentiated future psychosis converters after accounting for PRS symptom severity. Finally, both target P3b and novelty P3a amplitudes predicted the time to psychosis onset in PRS participants (p=.03 and p=.02, respectively), such that more deficient P300 amplitudes were associated with shorter time to conversion.DiscussionBaseline visual P300 amplitudes were reduced in future PRS converters relative to non-converters, with effect sizes comparable to those reported in previous auditory P300 studies of the PRS. Results implicate visual P300 as a neurophysiological vulnerability marker that predicts clinical outcomes among PRS individuals, including future transition to psychosis. Accordingly, together with prior auditory P300 studies, results suggest that P300 may have the potential to contribute to personalized early intervention in the PRS by distinguishing individuals with the greatest risk for psychotic illness, who require the most aggressive treatment, from those who may need minimal intervention.

Gender Differences in Auditory P300 Event-Related Potential in Indian Population.

Gender Differences in Auditory P300 Event-Related Potential in Indian Population.

Repeated transcranial magnetic stimulation combined with Donepezil can improve the cognition of cognitively impaired stroke survivors

Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) combined with donepezil on the cognition of persons with post-stroke cognitive impairment (PSCI) and their ability to perform activities of daily living (ADL). Methods A total of 106 PSCI patients were randomly divided into an observation group and a control group using a random number table. Those in the observation group received 10Hz rTMS (5 seconds on and 25 seconds off for 20 minutes daily) and donepezil daily, 5 days per week for 4 weeks, while those in the control group were provided with donepezil but only sham rTMS on the same schedule. Before and after 4 weeks of treatment, the Montreal cognitive assessment scale (MoCA), the Rivermead behavior memory test (RBMT) and the modified Barthel index (MBI) were used to evaluate the subjects′ cognitive functioning, memory capacity and ADL ability. The latency and amplitude of auditory event-related potential P300 were also assessed using a myoelectric evoked potential apparatus. Results After the treatment, improvement was observed in all the measurements of both groups. After the treatment, the average MoCA, RBMT and MBI scores, as well as the latency and amplitude of P300 in the observation group were all significantly better than among the control group. Conclusions rTMS can supplement donepezil′s ability to improve the cognition and ADL ability of persons with PSCI. Such therapy is worthy of clinical promotion and application. Key words: Stroke; Cognitive impairment; Transcranial magnetic stimulation; Donepezil

Effect of music listening on P300 event-related potential in patients with schizophrenia: A pilot study

Reduced amplitude and increased latency of P300 auditory event-related potential (ERP) in patients with schizophrenia (SZ) indicate impairment in attention. Overall arousal level can determine the amount of processing capacity required for attention allocation. Music evokes strong emotions and regulates arousability. Music has been used to modulate P300, especially in normals. This exploratory study examined the effect of music listening on the amplitude and latency of P300 in SZ patients.EEG/ERP was recorded (32-channels) while SZ patients (n = 20; 18–45 years) performed an auditory oddball P300 task after the eyes-closed rest condition (Condition-A) and ten-minute music listening condition (Condition-B) as per the complete counterbalancing design (AB-BA). Patients listened to the researcher chosen, instrumental presentation of raag-Bhoopali in the North-Indian-Classical-Music, for ten-minutes. All patients rated the music excerpt as a relaxing and positively valenced.A significant increase in accuracy score and reaction time during the oddball task after music listening was noted. There was an increase in amplitude at TP7. A trend of increased amplitude was noted across all electrodes in the music condition compared to the rest condition. Mean amplitude in an apriori defined time window of interest (250 to 750 ms) showed significant changes in the frontal and central electrode sites. Power spectral analysis indicated a slight increase in frontal and central alpha and theta activity during music listening. However, this was not statistically significant.Findings add further impetus to examine the effect of music in chronic psychiatric conditions. Need for systematic studies on a larger cohort is underscored.

A pilot study on salivary cortisol secretion and auditory P300 event-related potential in patients with physical disability-related stress

Objective: To evaluate the stress level and attention in workers with physical disabilities-related stress.Methods: Morning salivary cortisol was used as a stress marker while the event-related potential during the performance of the auditory oddball paradigm was conducted to investigate the attentive ability to sound stimuli. Eighteen injured workers (IP) and eighteen unaffected healthy adults (CP) were recruited for this study with half being men and the other half women (aged 21–55). Behavioral performance measures including reaction time (RT), accuracy rate, and commission error as well as the latency and amplitude of P300 wave over the central (Cz), centroparietal (CPz), and parietal (Pz) electroencephalogram electrode sites were used to compare the two groups.Results: This study demonstrated significantly higher salivary cortisol levels, longer RT, less accuracy to respond to the target during the auditory oddball paradigm in the IP group as compared to CP group. In addition, a significant prolongation of the peak latency of auditory P300 wave over CPz electrodes was also detected in IP group.Conclusion: The increased cortisol levels found in the IP group reflect the alteration of the basal hypothalamic-pituitary-adrenal axis as a result of the stresses of living with a physical disability. Delayed RT and the decreased in accuracy together with changing in peak latencies of auditory P300 wave indicate the impairment of attention networks in IP. Our study revealed that the patients with permanent physical disability.

The P300 auditory event-related potential as a method to assess the benefit of contralateral hearing aid use in bimodal listeners: a proof-of-concept

Objective: Bimodal listeners vary in the amount of benefit they receive from wearing the contralateral hearing aid. This may partially depend on the listener’s auditory processing capacities. The current study explores whether the P300 event-related potential can provide insight into the mechanisms underlying the benefits of wearing a contralateral hearing aid.Design: P300s were recorded using an oddball paradigm with 500 and 250 Hz tone-bursts as standard and deviant stimuli, respectively. Subjects counted the number of deviants – a measure of performance. N2b latencies, P300 latencies, N2b-P300 amplitudes, and performance were assessed during CI-only and bimodal listening.Study sample: Five bimodal listeners.Results: P300s were present in four subjects. Amplitudes were larger during bimodal listening (bimodal: 22.3 ± 4.83 µV, CI-only: 13.1 ± 3.86 µV). Both N2b and P300 latencies were shorter during bimodal (N2b: 265 ± 20.0 ms, P300: 551 ± 129.4 ms) than CI-only listening (N2b: 326 ± 42.2 ms, P300: 402 ± 38.4 ms). While performance often reached ceiling level, the difference between the standard and deviant was generally more salient during bimodal listening.Conclusions: This study provides a proof-of-concept, suggesting that P300s may provide insight into benefits that are not always measurable with behavioural tasks.