In this work, a novel orbital-attitude coupled control framework is developed for the electric solar wind sail (E-sail) spacecraft, aiming to handle the orbital transformation and attitude maneuver simultaneously. In the framework, the desired attitude parameters and the slow-varying voltage component are provided by the orbital control strategy, while the current attitude parameters and the fast-varying voltage component are manipulated by the attitude control strategy to approach their desired values. The orbital-attitude coupled characteristics of the E-sail spacecraft, including the flexibility-induced coupling effect, are fully described by the referenced nodal coordinate formulation. Considering the input saturation conditions, the governing equation for the orbital control strategy is then derived, in which the in-plane and out-of-plane displacement and velocity errors are prescribed as the state variables to be eliminated. An integral sliding mode control (ISMC) scheme is proposed to improve the robustness against the unmeasurable disturbance term. A model predictive control (MPC) scheme is introduced to enhance the convergence efficiency, where a quadratic optimization is performed to plan the desired attitude parameters and voltage components within the prediction horizon. To evaluate the control performance in the orbital transformation and attitude maneuver missions on the displaced non-Keplerian orbit, a series of scenarios with complex initial conditions are simulated under different control schemes, including the ISMC-MPC compound scheme. The results show that the control strategy designed under the rigid-body assumptions may not be feasible for the flexible E-sail spacecraft, while the investigated control strategy realizes the accurate and efficient convergence of the orbital and attitude variables on both the rigid and flexible E-sail spacecraft with the tether deformation stabilized.