Attention Deficit Hyperactivity Disorder Research Articles

Is hyperactivity in children with attention deficit/hyperactivity disorder (ADHD) a functional response to demands on specific executive functions or cognitive demands in general?

Hyperactivity is a core and impairing deficit in the clinical model of attention-deficit/hyperactivity disorder (ADHD). However, the extent to which hyperactivity in ADHD is evoked by cognitively challenging tasks in general or by demands on specific executive functions remains unclear. A clinically evaluated and carefully phenotyped community-referred sample of 184 children ages 8-13 (M = 10.40, SD = 1.50; 61 girls) with ADHD (n = 119) and without ADHD (neurotypical children and children with psychiatric disorders other than ADHD) were administered multiple, counterbalanced executive (working memory, inhibitory control, set shifting) and nonexecutive tests. Objective measures of gross motor movement (hyperactivity) were obtained using actigraphy. Using bifactor s-1 modeling, results indicate that children with ADHD demonstrate moderately elevated levels of motor movement relative to non-ADHD children. Additionally, findings indicated that hyperactivity in ADHD reflects the outcome of at least two similarly important factors: (a) a baseline level of elevated motor movement that is independent of environmental demands on their executive and nonexecutive cognitive abilities (d = 0.72); and (b) additional elevations attributable to demands placed on specific executive functions, with working memory and inhibition demands evoking similarly large, differential increases in movement for children with ADHD above and beyond their elevated baselines (Δd = 0.80). These findings suggests that executive function demands exacerbate, but do not fully explain, hyperactivity in ADHD, and/or there are at least two pathways to hyperactivity in ADHD-hyperactivity caused by environmental demands that challenge their underdeveloped executive functions, and hyperactivity caused by one or more other factors that need future research to identify. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Attention Deficit Hyperactivity Disorder, Cannabis Use, and the Endocannabinoid System: A Scoping Review.

There is emerging evidence that the endocannabinoid system (ECS) plays a significant role in the pathophysiology of many psychiatric disorders, including attention deficit hyperactivity disorder (ADHD). Increasing evidence suggests that a number of neurobiological correlates between endogenous cannabinoid function and cognitive dysfunction are seen in ADHD, making the ECS a possible target for therapeutic interventions. Cannabis use and cannabis use disorder are more prevalent in individuals with ADHD, compared to the general population, and there is growing popular perception that cannabis is therapeutic for ADHD. However, the relationship between cannabis use and ADHD symptomology is poorly understood. Further understanding of the role of the ECS in ADHD pathophysiology and the molecular alterations that may be a target for treatment is needed. To further the science on this emerging area of research, this scoping review describes the preclinical and clinical evidence seeking to understand the relationship between the ECS and ADHD.

Assessing suicidality in adult ADHD patients: prevalence and related factors

BackgroundThe association between Attention-deficit hyperactivity disorder (ADHD) and suicidality has been subject of growing interest for research in the latest years. Suicidality was generally assessed categorically and without the use of validated instruments, leading to heterogeneous or even conflicting evidence. The prevalence of both suicidal ideation and attempts varies considerably, and the associated risk factors remain unclear. Our study investigated suicidality in ADHD using a dimensional approach and a validated and internationally recognized instrument. Our primary aim was to evaluate the prevalence of suicidal ideation (SI), severe suicidal ideation (SSI), suicidal behavior (SB) and non suicidal self-injury behavior (NSSIB) in a sample of adult patients with ADHD. The second objective was to identify sociodemographic and clinical features associated with increased risk of suicidality in these patients.MethodsThe sample included 74 adult patients with clinical diagnosis of ADHD. Suicidality was assessed by administering the Columbia-Suicide Severity Rating Scale. Logistic regressions were used to examine predictors of SI, SSI, SB and NSSIB.ResultsThe lifetime prevalence of SI and SSI were 59.5% and 16.2%, respectively. The 9.5% of patients showed lifetime SB, while NSSIB was found in 10.8% of the subjects. Lifetime SI was associated with severity of inattentive symptoms during adulthood, low self-esteem and impairment in social functioning. Lifetime SSI appeared related to severity of inattentive symptoms during childhood, attentional impulsiveness and number of hospitalizations, while physical activity appeared to be protective. The prevalence of lifetime SB and NSSIB did not appear significantly related to any socio-demographic or clinical feature.ConclusionsAdults with ADHD should be considered at risk of suicide and it is important to determine which patients are at higher risk, in order to guide preventive interventions. The association between ADHD and suicidal ideation did not appear to be influenced by psychiatric comorbidities, but rather by inattention itself, which represents the core symptom of ADHD.

Diagnosis and Treatment of Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

Attention-deficit/hyperactivity disorder (ADHD) is a mental health diagnosis that affects an individual’s brain development and activity, resulting in inattention and/or hyperactivity-impulsivity that interferes with functioning in many aspects of life. A growing number of adults have a diagnosis of ADHD, with approximately one-third of those being diagnosed in adulthood rather than childhood. Symptoms and treatment of adults with ADHD are different than in the pediatric population. Evidence-based practices on identification, diagnosis, and treatment for adults with ADHD will be explored. Clinicians in primary care must be knowledgeable of treatment for adults with ADHD to meet this growing demand.

Making the most of errors: Utilizing erroneous classifications generated by machine-learning models of neuroimaging data to capture disorder heterogeneity.

Within-disorder heterogeneity complicates mapping the neurobiological features of psychopathology to Diagnostic and Statistical Manual of Mental Disorders conceptualizations. The present study explored the patterns of diagnostic classification errors among disorders with commonly co-occurring features to examine this heterogeneity. Classification analyses were conducted with the University of California, Los Angeles Phenomics Study database using a support-vector classifier to differentiate disorders via whole brain task-based functional connectivity, predicting that model misclassifications would provide insight about brain connectivity characteristics shared across disorders. Whether symptoms and specific brain networks could account for misclassification rates was also explored. The classification model performed better than chance (44% accuracy, p = .01) and revealed that misclassification of schizophrenia (SCZ) as bipolar disorder (BD; 38%) and BD as SCZ (36%) was symmetrical. Attention-deficit/hyperactivity disorder (ADHD) was misclassified as BD at the highest rate (46%) and higher than the converse (17%). SCZ and ADHD were misclassified least (15% SCZ as ADHD and 22% ADHD as SCZ). Considerable variance in misclassification of SCZ as BD (R2 = .83) and BD as SCZ (R2 = .71) could be accounted for by symptoms of both SCZ and BD. Permutation testing revealed disorder- and network-specific effects, with certain networks improving classification accuracy and others hindering it for specific disorders. An approach focused on classification errors replicated known disorder overlap, producing errors in the expected configuration. Further, it identified clinical and neural features within and across diagnostic categories that contribute to disorder misclassification and within-disorder heterogeneity. This approach may facilitate neurobiologically informed phenotypic differentiation within diagnostic groups. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Identifying childhood pesticide exposure trajectories and critical window associated with behavioral problems at 10 years of age: Findings from SMBCS

BackgroundPesticides may impact children’s neurodevelopment. As children’s metabolic function and neural plasticity change throughout their growth and development, the effects of pesticide exposure may also vary. ObjectivesWe aimed to identify the trajectories of combined pesticide exposure during childhood, and examine the associations of the exposure trajectories with children’s neurobehavior at the age of 10. MethodsWe involved repeated measurements of three pesticide metabolites [Pentachlorophenol (PCP), 3,5,6-Trichloro-2-pyridinol (TCPy), and Carbofuran phenol (CFP)], in urine samples collected from children in a cohort study at ages 1, 2, 3, 6, 7, 8, 9, and 10 years. The group-based multi-trajectory model (GBMT) and latent class analysis (LCA) were separately utilized to describe the distinct trajectories and patterns of pesticide mixture exposure during childhood. Meanwhile, the Strengths and Difficulties Questionnaire (SDQ) and attention deficit hyperactivity disorder (ADHD) Criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) list were applied to assess behavioral disorders in children. The associations between exposure trajectories and behavioral problem scores were then examined. ResultsThe GBMT model delineated three distinct trajectories of combined pesticide exposure among children: consistently low, higher levels in early childhood transitioning to lower levels during pre-school age, and lower levels in early childhood followed by higher levels in the middle childhood. The LCA model identified three similar longitudinal exposure patterns. Further, the children in the second trajectory group identified by GBMT, characterized by higher early childhood exposure levels, exhibited significantly elevated hyperactivity/inattention scores of the SDQ compared to the other two groups (β = 0.46, 95 %CI: 0.11, 0.81; β = 0.44, 95 %CI: 0.02, 0.86). ConclusionsOur study revealed that exposure to pesticides during early childhood (especially before the age of two), rather than other age periods, was linked to hyperactivity/inattention problems in children aged 10 years. We also provided a novel perspective on characterizing the fluctuation in repeated measurements of multiple environmental chemicals and identifying the potential critical windows.

Mindfulness, crashes, and risky driving behaviors among adolescents and young adults in the United States

PurposeThe purpose of this study was to examine the association between individual-level mindfulness and a range of risky driving behaviors among U.S. adolescents. MethodsWe conducted a survey of a nationally representative sample of 16–19-year-olds, recruited from the National Opinion Research Center AmeriSpeak panel, a probability-based sample. Participants completed the Mindful Attention Awareness Scale. Risky driving measures were adapted from the Youth Risk Behavior Survey. Spline regression analysis was performed to identify the threshold where mindfulness scores significantly changed driving behaviors. ResultsAfter adjusting for age, gender, and race, adolescents reporting higher mindfulness scores were significantly less likely to engage on all risky driving behaviors and significantly less likely to have been involved in a crash. Spline regression analysis indicated that a mindfulness score of 75 corresponded to the minimum marginal probability change averaged across the outcomes of interest. DiscussionThis paper describes a previously unknown association between mindfulness and risky driving in a vulnerable population which is at higher risk of injury and death from motor vehicle crashes. The strength of the associations across a range of behaviors suggests mindfulness could be a general protective factor for adolescents’ driving behaviors and suggests that mindfulness training may be a promising safety intervention for adolescents. A mindfulness score of 75 could be a potential target for mindfulness training interventions aiming to reduce risky driving behaviors and crashes among teenage drivers.Abbreviations: ADHD, Attention Deficit Hyperactivity Disorder; CI, Confidence Interval; MAAS, Mindful Attention Awareness Scale; NORC, University of Chicago’s National Opinion Research Center; YRBS, Youth Risk Behavior Survey.

An exploration into the prevalence and experience of neurodiversity among staff at a UK high-secure psychiatric hospital.

Whilst there is increasing recognition and interest in how staff who have neurodivergence are represented and contribute to industry, to date, there has been very little exploration of neurodivergence among healthcare staff and none with those working in forensic psychiatric services. To estimate the prevalence of neurodivergence among staff working in a UK high-secure psychiatric hospital and explore their experiences. All staff were invited to complete a confidential online self-report questionnaire consisting of both closed and open questions. A fifth of the staff responded (n=124), but two did not report their neurodivergent status, so were excluded. Nearly 40% of responders reported having some form of neurodivergence, with Attention Deficit Hyperactivity Disorder (ADHD) being the most common, followed by dyslexia, autism and dyspraxia. Over a third (36%) of those reporting neurodivergence said that they had chosen not to disclose this to the organisation and around a quarter (23%) reported not feeling valued or supported by the organisation. Of the staff cohort who responded, most expressed the view that neurodiversity in the workforce is beneficial to patient care, despite the majority being unsure whether neurodivergence is an advantage or a barrier for the individual themselves. Over half of staff completing the survey felt there was not enough awareness of neurodiversity among staff and that more training on the subject would be beneficial. This survey suggests gaps in our recognition and understanding of neurodivergence among hospital staff. Although the prevalence figure should be treated with caution, given the low response rate, in this first survey of neurodivergence among staff in a secure hospital, our findings suggest substantial numbers of staff with neurodivergence and the likelihood that neither they nor the organisation are optimising this situation. The further steps should include the development and evaluation of strategies exploring ways of improving recognition and relevant support for staff, as well as discovering ways in which neurodivergence in staff might inform and optimise care and treatment for patients.

The phenotypic and genotypic spectrum of individuals with mono- or biallelic ANK3 variants.

ANK3 encodes ankyrin-G, a protein involved in neuronal development and signaling. Alternative splicing gives rise to three ankyrin-G isoforms comprising different domains with distinct expression patterns. Mono- or biallelic ANK3 variants are associated with non-specific syndromic intellectual disability in 14 individuals (seven with monoallelic and seven with biallelic variants). In this study, we describe the clinical features of 13 additional individuals and review the data on a total of 27 individuals (16 individuals with monoallelic and 11 with biallelic ANK3 variants) and demonstrate that the phenotype for biallelic variants is more severe. The phenotypic features include language delay (92%), autism spectrum disorder (76%), intellectual disability (78%), hypotonia (65%), motor delay (68%), attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) (57%), sleep disturbances (50%), aggressivity/self-injury (37.5%), and epilepsy (35%). A notable phenotypic difference was presence of ataxia in three individuals with biallelic variants, but in none of the individuals with monoallelic variants. While the majority of the monoallelic variants are predicted to result in a truncated protein, biallelic variants are almost exclusively missense. Moreover, mono- and biallelic variants appear to be localized differently across the three different ankyrin-G isoforms, suggesting isoform-specific pathological mechanisms.

Problematic issues of the impact of microplastics on the human body and the environment: A review

Currently, the widespread use of plastic has become a serious problem for the environment and human health. Microplastics, being an artificial polymer created by man, are highly resistant to external influences and their decomposition requires a significant amount of time. The article provides information on the distribution of microplastics and their impact on the environment and the human body, issues of detecting microplastics in the blood, heart, lungs, placenta and meconium, in breast milk, hypothetical mechanisms by which microplastics penetrate into human tissues and the metabolism of plasticizers in children with autism spectrum disorder and attention deficit hyperactivity disorder. In the modern world, plastic has become an integral part of our daily lives, the presence of microplastics in plastic bags for storing breast milk, in baby formula and polypropylene bottles has been demonstrated, the relationship between microplastics and postpartum depression, the relationship between fecal microplastics and the status of inflammatory bowel diseases has been described. Making the decision to limit the use of plastic products in your home is an important step that can play a key role in reducing environmental pollution and protecting the health of future generations.

Linguistic, Metalinguistic and Psychiatric Characteristics of Children with Speech Sound Disorder

Abstract: Comparing the linguistic and metalinguistic profiles in common developmental speech and language disorders is important in advancing our understanding of their clinical symptoms, as well as potentially informing the conceptual basis of novel interventions. The purpose of the present review article is summarizing linguistic, metalinguistic and psychiatric characteristics of children with speech sound disorder (SSD). Clinically and theoretically, it is important that we can understand different error pattern uses among children with SSD only and children with co-occurring SSD and language impairment (LI). Identifying differences in error pattern use will help to discovering the underlying causes of the different types of patterns. In comparison with children with SSD, children with co-occurring SSD and LI use certain patterns more frequently that suggest more global linguistic deficits. The early identification of children who are at risk for development of co-occurring SSD and LI as well as later literacy problems needs to distinguish these patterns. Identification of speech error patterns and their underlying cognitive-linguistic processing deficits will contribute to diagnosis of children at risk of co-occurring SSD and LI and reading problems. Mounting studies have reported that children with SSD, with and without language impairment have differences in phonological processing, literacy skills, and speech production patterns. Children with both speech sound and language disorders are likely to have more severe literacy problems than those with isolated speech sound disorders. In addition, this paper focuses on the comorbidity between psychiatric disorders specially attention deficit/hyperactivity disorder (ADHD) symptoms and SSD.

Role of adenosine in the pathophysiology and treatment of attention deficit hyperactivity disorder.

Attention deficit hyperactivity disorder (ADHD) is a complex neurodevelopmental condition characterized by persistent inattention, hyperactivity, and impulsivity. Although its precise etiology remains unclear, current evidence suggests that dysregulation within the neurotransmitter system plays a key role in the pathogenesis of ADHD. Adenosine, an endogenous nucleoside widely distributed throughout the body, modulates various physiological processes, including neurotransmitter release, sleep regulation, and cognitive functions through its receptors. This review critically examines the role of the adenosine system in ADHD, focusing on the links between adenosine receptor function and ADHD-related symptoms. Additionally, it explores how adenosine interacts with dopamine and other neurotransmitter pathways, shedding light on its involvement in ADHD pathophysiology. This review aims to provide insights into the potential therapeutic implications of targeting the adenosine system for ADHD management.

Attention-Deficit/Hyperactivity Disorder (ADHD) as a Predictor of Prolonged Functional Recovery from Sports-Related Concussion in High School Athletes.

Attention-Deficit/Hyperactivity Disorder (ADHD) has been speculated to prolong concussion recovery; however, the evidence regarding concussion recovery for individuals with ADHD is limited. To examine the concussion recovery time based on ADHD status, sex, and age. Cross-Sectional Study. High school. 935 (female n=382, 40.1%) concussions including 78 (female n=13, 20.0%) self-identified ADHD data were analyzed. A Poisson regression was utilized to estimate the Return- to-Learn (RTL) and Return-to-Sport (RTS) recovery outcomes with three predicting variables: ADHD status, sex, and age. The mean RTL days of the ADHD and non-ADHD groups were 12.86 ± 10.89 (Median 11.0; IQR=8; 7.0-15.25) and 1.43 ± 8.39 (Median 9.0; IQR=9.0; 6.0-14.0), respectively. The mean RTS days of the ADHD and non-ADHD groups were 20.82 ± 15.25 days (Median 17.0; IQR=9; 12.0-21.0) and 18.03 ± 11.42 days (Median 15.0; IQR=10.0; 11.0-21.0), respectively. For RTL, the ADHD status (RR=1.16, 95%CI:1.08, 1.24, p<.001) and female sex (RR=1.13, 95%CI: 1.08, 1.17, p<.001) were significant variables for longer recovery, while the age was not (RR=0.995, 95%CI: 0.98, 1.01, p=.056). For RTS, the ADHD status (RR=1.17, 95%CI:1.12,1.23, p<.001), female sex (RR=1.07, 95%CI:1.04, 1.11, p<.001), and younger age (RR=0.98, 95%CI:0.96, 0.99, p<.001) were all significant variables for longer recovery. Healthcare providers must be aware of the elevated risk of prolonged concussion recovery among high school athletes with ADHD.

Effects of active breaks on educational achievement in children with and without ADHD: study protocol and rationale of the Break4Brain project

The Break4Brain project aims to elucidate the effects of both acute and chronic physical activity (PA) on educational achievement in children with and without Attention Deficit Hyperactivity Disorder (ADHD). This study will be conducted in two phases: a cross-over design followed by a hybrid type 1 implementation-effectiveness trial, which includes both a cluster randomized controlled trial (RCT) and a qualitative study. In phase I, 60 children aged 10–12, with 30 each from ADHD and non-ADHD groups, will participate in a laboratory-based study over 4 days within 1 month. They will participate in three counterbalanced experimental conditions: (i) PA with cognitive engagement, (ii) PA without cognitive engagement, and (iii) a cognitively engaging control. This phase will assess acute changes in brain function, academic performance, working memory, inhibitory control, and sustained attention. Phase II will involve 600 children aged 10–12, randomly assigned to either a video-based PA program or a control group (300 children per group) in an 8-week cluster RCT. This phase will also incorporate a qualitative approach to explore the implementation context through pre- and post-intervention semi-structured interviews with teachers and school staff, and questionnaires for students. The outcomes of interest in this phase will include working memory, cognitive flexibility, selective attention, and academic performance. For the cross-over study, we hypothesize that PA conditions will enhance the studied outcomes compared to the control condition. In the RCT, we anticipate that the 8-week active breaks program will result in significant improvements in the selected outcomes compared to the control group. This study is expected to make pioneering contributions by including novel variables and focusing on the ADHD population. Furthermore, if the cluster RCT proves effective, it could offer a practical and cost-effective resource for integrating active breaks into daily school routines.

Telehealth implementation for children with attention deficit hyperactivity disorder: a scoping review

The objective of this research was to examine current telehealth practices in managing children with attention deficit hyperactivity disorder (ADHD) and to map existing implementations using the American Medical Association’s Virtual Care Value Framework. A scoping review was conducted following the Arksey and O’Malley framework. The databases, CINAHL, PsycINFO, and PubMed, were searched with specific keywords related to telehealth and ADHD. The screening process followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. In­clusion criteria were restricted to articles published in English between January 2000 and July 2024, focusing on children with ADHD, their parents, caregivers, family members, teachers, healthcare professionals, and articles implementing telehealth interventions. As a result, out of 389 initially identified articles, 22 met the inclusion criteria. The studies were predominantly conducted in the United States. The most common telehealth meth­ods included videoconferencing and telephone-based communications. Key areas of fo­cus in these studies included clinical outcomes, access to care, patient and family experi­ence, caregiver experience, clinician experience, and financial and operational impact. However, none of the studies addressed health equity. In conclusion, telehealth has shown effectiveness in improving ADHD assessment, treatment adherence, and parental education, leading to positive patient outcomes and experiences. However, the financial impact of telehealth remains uncertain. Further research is needed, particularly outside the United States, to explore emerging telehealth technologies and areas overlooked by the Virtual Care Value Framework, such as health equity.

Gambaran Penerapan Pola Asuh Orang Tua dengan Anak Attention Deficit/Hyperactivity Disorder

This research study delves into the parenting styles employed by parents of children with Attention Deficit Hyperactivity Disorder (ADHD). ADHD is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity, potentially impacting a child's social, academic, and professional functioning. The research method used is qualitative. The study involved three pairs of parents cohabiting with their children aged 6-11 years old who have been diagnosed with ADHD by a specialist. The Parenting Styles and Dimensions Questionnaire (PSDQ) was employed to categorize the parenting styles of each couple. Screening results were further analyzed qualitatively, and semi-structured interviews were conducted to gather qualitative data. The findings revealed that parents do not adhere to a single parenting style, exhibiting varied responses and employing different styles depending on the situation and specific conditions. Mothers tend to be more involved in their child's daily activities, actively implementing strategies to manage ADHD symptoms, while fathers are more involved in disciplining their children through punishments aimed at promoting discipline.

Ortholog of autism candidate gene RBM27 regulates mitoribosomal assembly factor MALS-1 to protect against mitochondrial dysfunction and axon degeneration during neurodevelopment.

Mitochondrial dysfunction is thought to be a key component of neurodevelopmental disorders such as autism, intellectual disability, and attention-deficit hyperactivity disorder (ADHD). However, little is known about the molecular mechanisms that protect against mitochondrial dysfunction during neurodevelopment. Here, we address this question through the investigation of rbm-26, the Caenorhabditis elegans ortholog of the RBM27 autism candidate gene, which encodes an RNA-binding protein whose role in neurons is unknown. We report that RBM-26 (RBM26/27) protects against axonal defects by negatively regulating expression of the MALS-1 (MALSU1) mitoribosomal assembly factor. Autism-associated missense variants in RBM-26 cause a sharp decrease in RBM-26 protein expression along with defects in axon overlap and axon degeneration that occurs during larval development. Using a biochemical screen, we identified the mRNA for the MALS-1 mitoribosomal assembly factor as a binding partner for RBM-26. Loss of RBM-26 function causes a dramatic overexpression of mals-1 mRNA and MALS-1 protein. Moreover, genetic analysis indicates that this overexpression of MALS-1 is responsible for the mitochondrial and axon degeneration defects in rbm-26 mutants. These observations reveal a mechanism that regulates expression of a mitoribosomal assembly factor to protect against axon degeneration during neurodevelopment.

Mind-wandering when studying valuable information: The roles of age, dispositional traits, and contextual factors.

The factors that trigger lapses of attention (e.g., mind-wandering) during new learning remain unclear. The present study investigated whether the likelihood of experiencing an attentional lapse depends on (a) the importance of the material being studied and (b) the learner's age. In two experiments, younger and older adults completed a delayed free recall task in which to-be-remembered words were paired with point values. Thought probes were embedded into the encoding phase of each list to provide an index of one's ability to maintain attention on task and prevent recurrent lapses of attention (i.e., the consistency of attention). Experiment 1 revealed all individuals better remembered high-value information at the expense of low-value information, and older adults were more frequently focused on the task than younger adults. Participants were also less likely to remember an item at test if they experienced an attentional lapse while learning said item, and they were more consistently focused on the task when studying high-value information than when studying low-value information. Age did not moderate either of these effects. Experiment 2 replicated the findings from Experiment 1 and further revealed that the positive association between age and attentional consistency was explained by age-related differences in affect, motivation, personality, and attention-deficit hyperactivity disorder symptomology. Once these factors were accounted for, older age was associated with increased attentional inconsistency (less on-task focus). While future replication of this finding is needed, implications for education and theories of both mind-wandering and aging are discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Using Bifactor Twin Modeling to Assess the Genetic and Environmental Dimensionality of Adult ADHD Symptoms.

Attention Deficit Hyperactivity Disorder (ADHD) is a common and heritable neurodevelopmental condition that has been the subject of a wealth of genetics research. Because ADHD has an early age of onset, most of this work has focused on children, meaning that less is known about the genetics of ADHD in adults. Additionally, while much research has assessed the heritability of ADHD as a general dimension, less has assessed the heritability of individual subtypes (inattention, hyperactivity) or symptoms of ADHD. It therefore remains unclear whether the genetic factors underlying ADHD symptoms conform to a unidimensional or multidimensional structure. The aim of this study was to assess the genetic and environmental dimensionality of adult ADHD symptoms. We analyzed data from 10,454 twins of the Twins Early Development Study, who provided self-reports of ADHD symptoms using the Conners scale at age 21 years. The data conformed well to a psychometric bifactor model, providing support for a general dimension of ADHD in addition to secondary dimensions for inattention and hyperactivity. However, a bifactor independent pathway twin model provided support for a general dimension only at the level of non-shared environmental effects and not additive genetic or shared environmental effects. This suggests that symptoms of ADHD cluster together under a general dimension of non-shared environmental effects, although the two subtypes of ADHD (inattention and hyperactivity) are meaningfully genetically distinct. We found the overall heritability of ADHD to be 40%, comparable with previous estimates for adult ADHD symptoms. Our results provide useful insights into the genetic and environmental architecture of specific ADHD symptoms.

A cluster analysis of attachment styles in patients with borderline personality disorder, bipolar disorder and ADHD

BackgroundInsecure adult attachment has been associated with psychiatric disorders characterized by emotional dysregulation, such as borderline personality disorder (BPD), bipolar disorder (BD) and attention deficit/hyperactivity disorder (ADHD). However, little is known about the differences in attachment patterns between these diagnostic groups. The aim of this study was to identify clusters of adult attachment style in a cross-diagnostic group of patients with BDP and/or BD and/or ADHD and explore the characteristics of these clusters based on temperament profile, childhood trauma and psychiatric diagnoses.MethodsK-means cluster analysis was used to identify subgroups, based on the Attachment Style Questionnaire Short Form dimensions, in a clinical cohort of 150 young adults (113 women and 37 men, mean age ± SD = 23.3 ± 2.1) diagnosed with BPD, and/or BD, and/or ADHD.ResultsThree distinct clusters were identified: a secure, an insecure/avoidant-anxious and an insecure/avoidant cluster. These three clusters differed in temperament profile and related psychiatric diagnoses.ConclusionsThe three clusters of attachment in individuals with BPD, BD and/or ADHD could support differentiation between the disorders as well provide information usable for planning of treatment.