Atropine For Prevention Research Articles

Effect of Atropine as Premedication to Prevent Vasovagal Attack in Male Patients Undergoing Spinal Anaesthesia

Background: Spinal anaesthesia (SA) is associated with many complications among which the most common side effects are hypotension and bradycardia, The aim of the current study was to assess the effects of prophylactic atropine in prevention of spinal anaesthesia induced hypotension and bradycardia in male. Aim of the Study: The aim of the current study was to assess the effects of prophylactic atropine in prevention of spinal anaesthesia induced hypotension and bradycardia in male. Method: Seventy (70) patients aged 25-60 years old, they had more than one type of surgery. the patients were monitored by the anaesthesiologist, and we monitored the patient’s vital sign related to the operation period, such as blood pressure, heart rate, body temperature, and oxygen saturation, for patients who received atropine before the operation and patients who received atropine during the operation. Results: There were statistically significant differences in the results of the men who received atropine at the beginning of the operation, while for the people who did not receive atropine at the beginning of the operation, there were values that were not statistically significant in the variables of systolic and diastolic blood pressure and heart rate within 5 minutes of receiving spinal anaesthesia. Conclusion: Prophylactic atropine within 1 min of induction of spinal anaesthesia in male patients undergoing surgery reduce the incidence of hypotension and bradycardia.

阿托品在青少年近视防控中的应用

阿托品在青少年近视防控中的应用

Compliance in usage of low-dose atropine for prevention of progression of myopia in Indian children

Compliance in usage of low-dose atropine for prevention of progression of myopia in Indian children

Effects of prophylactic atropine in prevention of spinal anesthesia induced hypotension and bradycardia in geriatrics undergoing urological surgeries at a resource limited setting in central Ethiopia, 2018; prospective cohort study

BackgroundSpinal anesthesia induced hypotension and bradycardia are common and hazardous in elderly patients. Many techniques are being tried to prevent and treat these problems even if there is a controversy. The effects of prophylactic atropine on prevention of spinal anesthesia induced hypotension and bradycardia in geriatrics for urologic surgeries are not well-established. ObjectiveTo assess the effects of prophylactic atropine in prevention of spinal anesthesia induced hypotension and bradycardia in geriatrics undergoing urological surgeries at a resource limited setting in Central Ethiopia from December 1, 2017 to February 28, 2018 G C. MethodsThis is a prospective cohort study that recruits 76 patients who underwent elective urological surgeries. Independent t-test and Manny Whitney tests were used for numeric data while Chi-Square or Fisher exact test was used for categorical variables. P-values < 0.05 were considered as statistically significant. ResultsThere was no significant difference in baseline heart rate, mean arterial pressure, type & duration of surgery and total fluid administrations. There was a statistically significant difference in mean heart rate and mean arterial pressure at different times of measurement between the exposed and un-exposed groups. Total 1 h vasopressor consumption was minimal in the exposed group (P = 0.038). ConclusionProphylactic atropine with in 1 min of induction of spinal anesthesia in elderly patients undergoing urological surgery might reduce the incidence of hypotension and bradycardia.

Use of atropine-diphenoxylate compared with hyoscyamine to decrease rates of irinotecan-related cholinergic syndrome.

Cholinergic syndrome is a well established acute adverse reaction associated with irinotecan. Cholinergic side effects can be ameliorated or prevented with anticholinergic agents. To date, no formal studies have compared atropine-diphenoxylate and hyoscyamine as premedications for prophylaxis of the cholinergic syndrome with irinotecan infusion. To compare the incidence of cholinergic syndrome with irinotecan using atropine-diphenoxylate or hyoscyamine as premedication. We conducted a retrospective, single-center, nonrandomized, cohort study of adult patients treated with atropine-diphenoxylate or hyoscyamine as premedication before receiving irinotecan. For all irinotecan infusions, intravenous atropine was administered for patients experiencing any cholinergic reaction. A total of 532 irinotecan cycles (354 cycles for atropine-diphenoxylate group; 178 cycles for hyoscyamine group) were analyzed in 80 patients. Overall incidence of cholinergic syndrome did not differ between atropine-diphenoxylate (8.2%) and hyoscyamine (9.0%) groups (P = .76). The incidence of cholinergic syndrome after the £rst cycle of irinotecan was similar between the 2 arms, atropine-diphenoxylate (14.6%) and hyoscyamine (10.7%), with P = .74. The most common cholinergic symptoms documented were abdominal pain or cramping, and diarrhea. This study was subjected to vulnerabilities to bias and random error because of its observational retrospective design and small number of participants. Lack of difference in the incidence of cholinergic syndrome observed in irinotecan-treated patients suggests atropinediphenoxylate and hyoscyamine may both be effective prophylactic options. The findings support the need for a larger, randomized study to assess and compare these agents with other potential premedications such as scopolamine and atropine in prevention of irinotecan-related cholinergic syndrome.

Prophylactic use of IV atropine for prevention of spinal anesthesia induced hypotension and bradycardia in elderly: a randomized controlled trial

Abstract Background: Spinal anesthesia induced hypotension is common and hazardous in elderly patients. Reversal of the blunted reflexes of tachycardia following hypotension in elderly with atropine helps in prevention

Role of atropine in prevention of reflex bradycardia in response to awaked intubation in neonatal anesthesia

Background: Neonates (0–1 months) have different anesthetic requirements. Safe anesthetic management depends on full appreciation of the physiological, anatomic, and pharmacological characteristics of this age group. One of important difference in neonates is easy development of reflex bradycardia and cardiac standstill during anesthesia. These characteristics, differentiate them from adults, and necessitate modification of anesthetic equipment, medications, and techniques.&#x0D; Objectives: To evaluate the role of atropine in prevention of reflex bradycardia in neonatal anesthesia.&#x0D; Patients and methods: This is a prospective study done on 30 neonate patients in Baghdad teaching hospital/Baghdad /Iraq during the period from January - July/ 2009. Neonates that underwent major surgical operations, were randomly allocated into two groups, group (A) received atropine(0.015mg/kg) 5 minutes before awake intubation and group (B) (control group) received no atropine. Heart rate was recorded at pre-induction and during intubation then anesthesia was maintained in a similar way in both groups.&#x0D; Result: the results reported in this study indicate that the pre-induction with i.v. atropine was associated with a statistically significant decrease in the incidence rate of reflex bradycardia (below 100 beat/min or reduction in HR &gt; 20% of basal heart rate) during intubation from 96.65% in the group (B) (control group) to 26.6 % in the group (A) (atropine group) In addition the magnitude of reduction in heart rate was lower by a mean of 22% in the atropine group compared to the mean reduction 41% in group (B&#x0D; Conclusion: Pre-induction with IV atropine decrease in the incidence of reflex bradycardia during intubation from 96.65% in the control group (B) to 26.6% in the atropine group (A). Pre-induction of atropine reduces the magnitude of heart rate reduction during intubation by a mean of 22% compared to 41% in control group.

Role of atropine in prevention of reflex bradycardia in response to awaked intubation in neonatal anesthesia

Role of atropine in prevention of reflex bradycardia in response to awaked intubation in neonatal anesthesia

Is Premedication With Oral Glycopyrrolate as Effective as Oral Atropine in Attenuating Cardiovascular Depression in Infants Receiving Halothane for Induction of Anesthesia?

The authors conducted a double-blind study to compare premedication with oral glycopyrrolate and oral atropine in prevention of bradycardia and hypotension during induction of anesthesia with halothane-N2O in 90 outpatient infants and children aged 1-18 mo who were randomized into three groups to receive either an oral placebo, oral atropine (0.02 mg/kg), or oral glycopyrrolate (0.05 mg/kg) approximately 1 h before induction of anesthesia. Heart rate and mean arterial pressure were measured before drug administration, just before induction of anesthesia, and every minute until surgical stimulation occurred. Glycopyrrolate, at the dose used, was significantly less effective than atropine in attenuating bradycardia during induction; neither glycopyrrolate nor atropine altered the incidence or degree of hypotension. Antisialagogic activity and side effects were comparable, except for significantly more flushing with atropine.

Glycopyrrolate compared with atropine in prevention of the oculocardiac reflex during eye-muscle surgery.

Glycopyrrolate compared with atropine in prevention of the oculocardiac reflex during eye-muscle surgery.