Atrial Width Research Articles

Impact of Contact Force on Pulsed Field Ablation Outcomes Using Focal Point Catheter.

Conventional focal radiofrequency catheters may be modified to enable multiple energy modalities (radiofrequency or pulsed field [PF]) with the benefit of contact force (CF) feedback, providing greater flexibility in the treatment of arrhythmias. Information on the impact of CF on lesion formation in PF ablations remains limited. An in vivo study was performed with 8 swine using an investigational dual-energy CF focal catheter with local impedance. Experiment I: To evaluate atrial lesion formation, contiguity, and width, a point-by-point approach was used to create an intercaval line. The distance between the points was prespecified at 4±1 mm. Half of the line was created with radiofrequency energy, whereas the other half utilized PF (single 2.0 kV application with a proprietary waveform). Experiment II: To evaluate single application lesion dimensions with a proprietary waveform, discrete ventricular lesions were performed with PFA (single 2.0 kV application) with targeted levels of CF: low, 5 to 15 g; medium, 20 to 30 g; and high, 35 to 45 g. Following 1 week of survival, animals underwent endocardial/epicardial remapping, and euthanasia to enable histopathologic examination. Experiment I: Both energy modalities resulted in a complete intercaval line of transmural ablation. PF resulted in significantly wider lines than radiofrequency: minimum width, 14.9±2.3 versus 5.0±1.6 mm; maximum width, 21.8±3.4 versus 7.3±2.1 mm, respectively; P<0.01 for each. Histology confirmed transmural lesions with both modalities. Experiment II: With PF, lesion depth, width, and volume were larger with higher degrees of CF (depth: r=0.82, P<0.001; width: r=0.26, P=0.052; and volume: r=0.55, P<0.001), with depth increasing at a faster rate than width. The mean depths were as follows: low (n=17), 4.3±1.0 mm; medium (n=26), 6.4±1.2 mm; and high (n=14), 9.1±1.4 mm. Using the same focal point CF-sensing catheter, a novel PF ablation waveform with a single application resulted in transmural atrial lesions that were significantly wider than radiofrequency. Lesion depth showed a significant positive correlation with CF with depths of 6.4 mm at moderate CF.

Long-term results of ablation index guided atrial fibrillation ablation: insights after 5+ years of follow-up from the MPH AF Ablation Registry.

Catheter ablation (CA) for symptomatic atrial fibrillation (AF) offers the best outcomes for patients. Despite the benefits of CA, a significant proportion of patients suffer a recurrence; hence, there is scope to potentially improve outcomes through technical innovations such as ablation index (AI) guidance during AF ablation. We present real-world 5-year follow-up data of AI-guided pulmonary vein isolation. We retrospectively followed 123 consecutive patients who underwent AI-guided CA shortly after its introduction to routine practice. Data were collected from the MPH AF Ablation Registry with the approval of the institutional research board. Our patient cohort was older, with higher BMI, greater CHA2DS2-VASc scores, and larger left atrial sizes compared to similar previously published cohorts, while gender balance and other characteristics were similar. The probability of freedom from atrial arrhythmia with repeat procedures is as follows: year 1: 0.95, year 2: 0.92, year 3: 0.85, year 4: 0.79, and year 5: 0.72. Age >75 years (p = 0.02, HR: 2.7, CI: 1.14-6.7), BMI >35 kg/m2 (p = 0.0009, HR: 4.6, CI: 1.8-11.4), and left atrial width as measured on CT in the upper quartile (p = 0.04, HR: 2.5, CI: 1-5.7) were statistically significant independent predictors of recurrent AF. AI-guided CA is an effective treatment for AF, with 95.8% of patients remaining free from atrial arrhythmia at 1 year and 72.3% at 5 years, allowing for repeat procedures. It is safe with a low major complication rate of 1.25%. Age >75 years, BMI >35 kg/m2, and markedly enlarged atria were associated with higher recurrence rates.

Atrial fibrillation ablation in patients with arrhythmia-induced cardiomyopathy: a prospective multicentre study.

This study aims to investigate the clinical and biochemical characteristics of patients with atrial fibrillation (AF) referred for ablation who develop arrhythmia-induced cardiomyopathy (AiCM) as well as their long-term outcomes after catheter ablation (CA). A prospective multicentre study was conducted on consecutive AF patients who underwent CA. AiCM was defined as the development of heart failure in the presence of AF and an improvement of left ventricular fraction by at least 10% at 6months after ablation. A subgroup of patients underwent peripheral and left atrial blood samples [galectin-3, fatty acid-binding protein 4 (FABP4), and soluble receptor for advanced glycation end products (sRAGE)] at the time of the procedure. Of the 769 patients who underwent AF ablation, 135 (17.56%) met the criteria for AiCM. Independent predictors of AiCM included persistent AF, male gender, left atrial volume, QRS width, active smoking, and chronic kidney disease (CKD). Biomarker analysis revealed that sRAGE, FABP4, and galectin-3 levels were not predictive of AiCM development nor did they differ between groups or predict recurrence. There were no differences in AF recurrence between patients with and without AiCM (30.83% vs. 27.77%; P=0.392) during a median follow-up of 23.83months (inter-quartile range 9-36). In the subset of patients referred for AF ablation, the development of AiCM was associated with persistent AF and CKD. Biomarker analysis was not different between groups nor predicted recurrence. Patients with AiCM benefited from ablation, with a significant improvement in left ventricular ejection fraction and similar AF recurrence rates to those without AiCM.

PO-05-171 DOES LEFT ATRIAL DILATION PREDICT ATRIAL FIBRILLATION SEVERITY AND ABLATION EFFECTIVENESS?

Left atrium (LA) geometric changes with advancing chronicity and severity of atrial fibrillation (AF). During catheter ablation for AF, electroanatomical mapping (e.g. with CARTO) of the LA can be used to measure the LA volume and atrial width to heigh ratio to guide ablation procedures. To examine whether LA dilation measured by height-to-width ratio of posterior wall predicts paroxysmal AF vs persistent AF or one-year AF recurrence post ablation. CARTO procedural case files were loaded into CARTONET (a cloud-based artificial intelligence powered system) and linked to deidentified Mercy Health electronic health record (EHR) data among AF patients who underwent the first ablation. Machine learning was used for automatic segmentation of atria. Atrial dilation was calculated by height-to-width ratio, which was used to rank patients into thirds of high (>0.69), medium and low (<0.55) dilation. Patient demographic and clinical characteristics (AF type, BMI, age, Elixhauser Comorbidity Index score, and CHA2DS2-VASC score) at ablation were included in logistic regression examining the relationship of LA dilation with AF diagnosis at ablation. AF recurrence was measured by repeat ablation, electrical cardioversion, and AF rehospitalization within one-year post-ablation. Among 274 ablated AF patients, 146 (53.2%) patients had persistent AF and 58 (21.2%) experienced AF recurrence within one-year post-ablation. The high LA dilation group was 2.8 times more likely to have persistent AF than the low group (odds ratio (OR): 2.81, 95% confidence interval (CI): 1.42-5.67). The high LA dilation group was not associated with AF recurrence (OR: 0.64 95% CI: 0.30-1.35) compared with the low dilation group. Patients with high LA atrial dilation were more likely to have the persistent AF diagnosis. AF dilation may be useful to determine progression/chronicity of AF disease and assist physician to tailor the ablation procedures for AF treatment.

Medical record data-enabled machine learning can enhance prediction of left atrial appendage thrombosis in nonvalvular atrial fibrillation

BackgroundAs a major complication of non-valvular atrial fibrillation (NVAF), left atrial appendage (LAA) thrombosis is associated with cerebral ischemic strokes, as well as high morbidity. Due to insufficient incorporation of risk factors, most current scoring methods are limited to the analysis of relationships between clinical characteristics and LAA thrombosis rather than detecting potential risk. Therefore, this study proposes a clinical data-driven machine learning method to predict LAA thrombosis of NVAF. MethodsPatients with NVAF from January 2014 to June 2022 were enrolled from Southwest Hospital. We selected 40 variables for analysis, including demographic data, medical history records, laboratory results, and the structure of LAA. Three machine learning algorithms were adopted to construct classifiers for the prediction of LAA thrombosis risk. The most important variables related to LAA thrombosis and their influences were recognized by SHapley Addictive exPlanations method. In addition, we compared our model with CHADS2 and CHADS2-VASc scoring methods. ResultsA total of 713 participants were recruited, including 127 patients with LAA thrombosis and 586 patients with no obvious thrombosis. The consensus models based on Random Forest and eXtreme Gradient Boosting LAA thrombosis prediction (RXTP) achieved the best accuracy of 0.865, significantly outperforming CHADS2 score and CHA2DS2-VASc score (0.757 and 0.754, respectively). The SHAP results showed that B-type natriuretic peptide, left atrial appendage width, C-reactive protein, Fibrinogen and estimated glomerular filtration rate are closely related to the risk of LAA thrombosis in nonvalvular atrial fibrillation. ConclusionsThe RXTP-NVAF model is the most effective model with the greatest ROC value and recall rate. The summarized risk factors obtained from SHAP enable the optimization of the treatment strategy, thereby preventing thromboembolism events and the occurrence of cardiogenic ischemic stroke.

Comparison of fetal and neonatal sonographic measurements of ventricular size in second- and third-trimester fetuses with or without ventriculomegaly: cross-sectional three-dimensional ultrasound study.

To assess, in a population comprising normal fetuses and fetuses with primary or post-hemorrhagic ventriculomegaly, the reproducibility of measurement of neonatal ultrasound indices in the fetus and to compare the performance of various cut-offs of these parameters to diagnose ventriculomegaly and classify its severity. This was a retrospective cross-sectional study including 182 singleton fetuses assessed by transvaginal neurosonography. The sample populations included 116 normal fetuses and 66 fetuses with primary (n = 56) or post-hemorrhagic (n = 10) ventriculomegaly. In all cases, the atrial width (AW) was measured according to standard protocols and the findings were compared with four sonographic indices developed in the neonate: the anterior horn width (AHW), the ventricular index (VI), the thalamo-occipital distance (TOD) and the fronto-occipital horn ratio (FOHR). Reproducibility of measurements was assessed using the intraclass correlation coefficient (ICC) and diagnostic accuracy of the neonatal indices was assessed against AW using areas under the receiver-operating-characteristics curves (AUC). The intra- and interoperator reproducibility of measurement of AW and the neonatal measurements was excellent, with ICCs > 0.99 for all measures. The association in the fetus of all four variables developed in the neonate with the degree of ventriculomegaly as defined by the AW was strong for severe ventriculomegaly (AW > 15.0 mm; all AUC > 0.95), whereas the separation of cases with mild ventriculomegaly (AW, 10.0-15.0 mm) from those with normal AW (< 10.0 mm) was less effective. When applied in the fetus, all four indices of ventriculomegaly developed in neonates (AHW, VI, TOD, FOHR) were associated strongly with fetal AW when the AW measurement indicated severe fetal ventriculomegaly. However, for mild ventriculomegaly, the association was weaker, probably due to the fact that, in the fetus, mild ventriculomegaly is not caused by obstruction of the ventricular system. Considering the similar performance of the four neonatal variables and the technical issues involved in determination of TOD and FOHR in the fetus, use of VI and AHW is preferred. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.

Methods of Radiographic Measurements of Heart and Left Atrial Size in Dogs with and without Myxomatous Mitral Valve Disease: Intra- and Interobserver Agreement and Practicability of Different Methods

Simple SummaryIn the present study, different radiographic measurements for evaluating the cardiac size and left atrial size in dogs with and without myxomatous mitral valve disease were evaluated. Veterinarians applied these measurements with different levels of experience to identify heart enlargement in conventional and inverted radiographs. The repeatability and ease of application were evaluated. It was shown that radiographic measurements can identify cardiac enlargement reliably and even potentially stage dogs with myxomatous mitral valve disease if echocardiography is unavailable. The measurements can be performed in conventional and inverted radiographs with reliable results by veterinarians with different degrees of experience.Dogs suffering from Myxomatous Mitral Valve Disease (MMVD) show a potential heart enlargement, especially in the left atrium, detectable by radiography. Due to digital radiography, different radiographic measurements estimate cardiac size quite uncomplicatedly. The Vertebral Heart Size (VHS), Radiographic Left Atrial Dimension (RLAD), Left Atrial Width (LAWidth), and the Vertebral Left Atrial Size (VLAS) used anatomical landmarks for measuring cardiac size in relation to the vertebral column. This study aimed to compare VHS, RLAD, LAWidth, and VLAS measured in conventional and inverted radiographs by veterinarians with different levels of experience in healthy dogs and dogs with MMVD. The reliability and user-friendliness of these measurements were evaluated, and the staging was compared to the echocardiography staging. A total of 50 unaffected dogs and 150 dogs with MMVD in stages B1, B2, and C were assessed. Three veterinarians with different levels of experience examined 200 conventional radiographs and their corresponding inverted radiographs blinded to the echocardiographic and clinical examination results. Analyses were performed to compare the measurements’ grading and determine anatomical landmarks with measurement difficulties. Additionally, inter- and intraobserver agreement was assessed using intraclass correlation coefficient, and the agreement between radiographic and echocardiographic staging was compared using the kappa coefficient. The VHS, LAWidth, and VLAS were easier to define than the RLAD. The interobserver agreement was almost perfect for VHS (0.962) and good for the other radiographic measurements (RLAD: 0.778, LAWidth: 0.772, VLAS: 0.858). The VHS assigned the most dogs to the correct stage. However, VHS, RLAD, LAWidth, and VLAS presented an almost perfect intraobserver agreement. The dorsal left atrial margin of the RLAD was the most difficult measurement point to identify. The VHS is the most reproducible radiographic method for measuring the canine heart size and shows the highest agreement with echocardiography. An observer-related influence could be detected for RLAD, LAWidth, and VLAS.

Comparison of different radiographic scores with associated echocardiographic measurements and prediction of heart enlargement in dogs with and without myxomatous mitral valve disease

IntroductionStaging of myxomatous mitral valve disease (MMVD) requires an echocardiographic examination along with thoracic radiographs. The aims of this study were to calculate mean values for radiographic scores vertebral heart size (VHS), left atrial width (LAWidth), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) in conventional and grayscale inverted images in healthy dogs and dogs with different stages of MMVD, and to find cutoff values for a stage assignment. AnimalsOne hundred fifty dogs in different stages of MMVD and 50 unaffected dogs were evaluated. MethodsRadiographic scores, echocardiographic left atrium-to-aorta ratio and normalized left ventricular internal dimension at end-diastole, and results of a clinical examination were obtained. Analyses were performed to evaluate the correlation between radiographic scores and echocardiographic values, to determine cutoff values for a radiographic stage assignment, and to compare measurements in conventional and inverted radiographs. ResultsAfter excluding breed-specific higher VHS, the means of VHS, LAWidth, RLAD, and VLAS were similar in the control group and stage B1. All radiographic scores increased in stages B2 and C. The cutoff values identifying heart enlargement, and therefore differentiating stages B1 and B2, were 11.0 for VHS, 1.8 for LAWidth, 2.0 for RLAD, and 2.3 for VLAS. Besides RLAD, scores were similar in conventional and inverted radiographs. ConclusionCutoff values for the different radiographic scores for stage assignment were calculated. Radiographic cardiac scores using either conventional or inverted grayscale could be a tool to differentiate between different stages of MMVD when echocardiography is unavailable.

Diagnostic approach to fetal ventriculomegaly.

Ventriculomegaly (VM) is defined as an enlargement of the lateral ventricles of the developing fetal brain. The diagnosis is easily made by measuring the lateral ventricle width at the level of the atrium, which is normally <10mm. VM is defined as mild when the atrial width is 10-12mm, moderate 12-15mm, severe >15mm. VM is a non-specific sonographic sign which is common to different pathological entities and genetic conditions. When no associated anomaly can be found VM is defined as isolated. Since the prognosis of fetal VM mainly depends on the presence of associated anomalies, a careful diagnostic approach is necessary to rule out CNS and extra- CNS fetal anomalies. Magnetic Resonance Imaging can be a useful diagnostic tool complementary to ultrasound in order to recognize subtle brain anomalies, particularly cortical disorders. In this review the diagnostic approach to fetal VM will be discussed starting from ultrasound screening, moving to neurosonographic and MRI examination and genetic evaluation, in order to recognize the cause of VM and offer the appropriate counselling to the parents.

Effect of Sacubitril/Valsartan on renal function in patients with chronic kidney disease and heart failure with preserved ejection fraction: A real-world 12-week study

Patients with chronic kidney disease (CKD) are often complicated with heart failure with preserved ejection fraction (HFpEF). However, several drugs, including angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB), have not shown apparent benefits in terms of morbidity and mortality of HFpEF. PARAMOUNT and other studies have shown the potential benefits of Sacubitril/Valsartan on patients with HFpEF, but its effects on renal function and the effect of low-dose Sacubitril/Valsartan in actual clinical conditions have not been thoroughly evaluated. In our longitudinal and observational research, 353 patients were followed up for 12 weeks. We evaluated renal function [urinary protein, serum creatinine and estimated glomerular filtration rate (eGFR)] and cardiac function [NT-proBNP (brain natriuretic peptide), New York Heart Association (NYHA) classification, left ventricular ejection fraction (LVEF), left atrial width and left ventricular end-diastolic width] at baseline and during follow-up. Worsening renal function (WRF) was defined as an increased serum creatinine≥26.5umol/L or decreased eGFR≥20%. The decline of eGFR in the Sacubitril/Valsartan group was slower than that in the control group (p = 0.021). The outcome of proteinuria in the ACEI/ARB group was significantly better than that in the Sacubitril/Valsartan group (p = 0.001). In terms of echocardiogram, the average left atrial width in Sacubitril/Valsartan group decreased by 1.38 ± 3.02 mm, which was significantly lower than that in the ACEI/ARB group (p = 0.02). The increase of urine protein class in the ACEI/ARB group increased the risk of WRF with statistical significance (OR = 2.36, 95%CI 1.01–5.49, p = 0.047), but no statistical significance was found in all the patients or Sacubitril/Valsartan group. In conclusion, Sacubitril/Valsartan could more effectively slow down renal function decline and reverse myocardial remodeling in patients with CKD and HFpEF than ACEI/ARB, even at low doses, though its protective effect on urinary protein is not as good as that of ACEI/ARB.

Role of fetal MRI to diagnose abnormal cerebral ventricular system and associated fetal brain anomalies

BackgroundAbnormal cerebral ventricular system is one of the most common clinical indications for fetal MRI, mainly to detect other associated abnormalities that can be occult on prenatal ultrasonography. Although using ultrasound can identify most anomalies, MRI is known to be superior in identifying CNS anomalies as it has higher contrast resolution for brain parenchymal assessment added to the fact of being less affected by fetal positioning, oligohydramnios, maternal obesity, and reverberation artifacts. Fetal brain ventriculomegaly is defined as atrial width of > 10 mm on sonography, measured in the axial plane, at the level of the frontal horns, cavum septi pellucidi, and glomus of the choroid plexus perpendicular to the long axis of the lateral ventricle. One of the most important factors determining the fetal neurological outcome is the presence and severity of additional CNS anomalies that are better clarified by MRI. The aim of this study is to establish the role of fetal MRI in detecting the association between abnormal cerebral ventricular system and other CNS anomalies, correlation with the severity of ventriculomegaly and ventricle asymmetry.ResultsThirty pregnancies with fetal brain abnormal ventricular system were included in this study, 5 cases with isolated corpus callosum (CC) agenesis (16.666%); 2 cases with cystic lesions [one interhemispheric and the other dorsal] (6.666%) both associated with CC agenesis; 1 case with alobar holoprosencephaly (3.333%) associated with CC agenesis; 2 cases with semi-lobar holoprosencephaly (6.666%) [associated with CC agenesis and one of them is also associated with lissencephaly]; 3 cases with Dandy–Walker Malformation (DWM) (10%) [2 isolated and 1 associated with CC agenesis]; 3 cases with Dandy–Walker Variants (DWV) (10%) [1 isolated and 2 associated with CC agenesis]; 2 cases with Joubert syndrome (6.666%); 1 case isolated lissencephaly (3.333%); 4 cases of obstructive ventriculomegaly (13.333%) (1 of which associated with CC agenesis); 1 case of Arnold Chiari malformation type II (3.333%) associated with CC agenesis; 2 cases with meningoceles (6.666%) (occipital and parieto-occipital); 1 case with Mega cisterna Magna (3.333%); 1 case with anencephaly (3.333%); 1 case with right hemimegalencephaly (3.333%) (associated with frontal meningocele and CC agenesis); and 1 case with grade IV germinal matrix hemorrhage (3.333%). The pregnancies resulted in 20 births (66.66%), 2 died directly after birth (6.66%), 5 terminations (16.66%), and 3 intrauterine fetal deaths (IUFD) (10%). We found that the frequency of associated CNS anomalies was strongly related to the width of the ventricle. The association between CNS findings and ventricle width was particularly evident in sever ventriculomegaly. The greater the width of the ventricular system, the more the risk of associated CNS anomalies. Only one case showed diffusion restriction and was diagnosed to be of hemorrhagic nature. The relation between symmetry and degree of ventriculomegaly was found to be statistically insignificant (P = 0.115). Assessment of different fetal brain congenital anomalies was not significantly affected by the using of DWI sequence as it is a functional modality rather than being a tool for assessment of anatomical gross abnormalities.ConclusionsFetal MRI is an important adjuvant to US in cases of ventriculomegaly particularly those associated with complex CNS anomalies. The association between CNS findings and ventricular dilatation was particularly evident in sever ventriculomegaly. The greater the width of the ventricular system, the more the risk of associated CNS anomalies. Fetal MRI may also be helpful in doubtful cases that could be misdiagnosed as ventriculomegaly including holoprosencephaly, hydranencephaly, porencephaly, and various supratentorial cystic lesions. DWI confirms the diagnosis of hemorrhage.

Speckle Tracking Analysis to Evaluate the Size, Shape, and Function of the Atrial Chambers in Normal Fetuses at 20-40 Weeks of Gestation.

The purpose of this study was to use speckle tracking analysis to evaluate the size, shape, and function of the atrial chambers in normal fetuses and develop a z-score calculator that can be used in future studies in fetuses at risk for cardiovascular disease. The control group consisted of 200 normal fetuses examined between 20 and 40 weeks of gestation in which speckle tracking analysis of right (RA) and left (LA) atrial chambers was performed. The atrial end-diastolic and end-systolic endocardial borders for each chamber were identified from which measurements of atrial length, width, area, and volume were computed. Equations were derived using fractional polynomial regression analysis to compute z-score equations. The LA end-diastolic volume, RA and LA end-diastolic area, length, base width, and mid-chamber widths increased with gestational age and fetal size. Left atrial emptying and ejection volumes increased with gestational age and fetal size. The fractional area change was significantly less for the RA than the LA. The LA base and mid-chamber fractional shortening were significantly greater than the RA. There was a significant difference between the RA and LA global contractile strain. Mean and standard deviation equations for each of the measurements described in this study were computed to create a z-score calculator that can be utilized in the clinical environment when evaluating fetuses with suspected atrial pathology that could alter the size, shape, and function of the atrial chambers.

Is ventriculomegaly and hindbrain herniation seen before and after prenatal neural tube defect repair associated with a worse functional level than anatomical level at birth?

To determine if the evaluation of the fetal ventricular system and hindbrain herniation (HBH) is associated with motor outcome at birth in prenatally repaired open neural tube defect (NTD). Retrospective cohort study of 47 patients with NTD who underwent prenatal repair (17 fetoscopic; 30 open-hysterotomy). At referral and 6weeks postoperatively, the degree of HBH, ventricular atrial widths and ventricular volume were evaluated by MRI. Head circumference and ventricular atrial widths were measured on ultrasound at referral and during the last ultrasound before delivery. Anatomic level of the lesion (LL) was determined based on the upper bony spinal defect detected by ultrasound. We considered the functional level as worse than anatomical level at birth when the motor level was equal or worse than the anatomical LL. 26% (12/47) of the cases showed worse functional level than anatomical level at birth. Having a HBH below C1 at the time of referral was associated with a worse functional level than anatomical level at birth (OR=9.7, CI95 [2.2-42.8], p<0.01). None of the other brain parameters showed a significant association with motor outcomes at birth. HBH below C1 before surgery was associated with a worse functional level than anatomical level at birth.

ISUOG Practice Guidelines (updated): sonographic examination of the fetal central nervous system. Part 2: performance of targeted neurosonography.

ISUOG Practice Guidelines (updated): sonographic examination of the fetal central nervous system. Part 2: performance of targeted neurosonography.

Factors Associated with Prolonged Impairment of Consciousness in Adult Patients Admitted for Seizures: A Comprehensive Single-center Study.

Seizures are common neurological emergencies that occasionally cause prolonged impairment of consciousness. The aim of this retrospective single-center study is to clarify factors associated with prolonged impairment of consciousness for admitted adult patients investigating patient backgrounds, blood tests, electroencephalographic patterns, and MRI findings. The patients who were admitted to the hospital due to epileptic seizures were classified into two groups: (1) early recovery group, in which patients recovered their consciousness within 6 hr, and (2) delayed recovery group, in which patients showed impairment of consciousness more than 6 hr. Factors associated with prolonged impairment of consciousness were compared between these groups. In this study, 42 cases (33 patients), with a mean age of 67.8 years, were included. Fifteen cases (13 patients) and 27 cases (20 patients) were classified into the early and delayed recovery groups, respectively. The populations of older patients and patients from a nursing home were significantly higher in the delayed recovery group. With regard to radiological analyses, a high grade of periventricular hyperintensity (PVH), high Evans index score, and enlarged bilateral atrial widths were significantly associated with prolonged impairment of consciousness. Multivariable analyses showed that a high grade of PVH was significantly associated with delayed recovery of consciousness independent of age and status epilepticus. In conclusion, we proposed that diffuse white matter degeneration around the lateral ventricles contributes to prolonged impairment of consciousness.

The tracheal system of scutigeromorph centipedes and the evolution of respiratory systems of myriapods

The tracheal system of scutigeromorph centipedes (Chilopoda) is special, as it consists of dorsally arranged unpaired spiracles. In this study, we investigate the tracheal systems of five different scutigeromorph species. They are strikingly similar to each other but depict unique characters compared to the tracheal systems of pleurostigmophoran centipedes, which has engendered an ongoing debate over a single versus independent origin of tracheal systems in Chilopoda. Up to now, only the respiratory system of Scutigera coleoptrata was investigated intensively using LM-, TEM-, and SEM-techniques. We supplement this with data for species from all three families of Scutigeromorpha. These reveal interspecific differences in atrial width and the shape and branching pattern of the tracheal tubules. Further, we investigated the tracheal system of Scutigera coleoptrata with three additional techniques: light sheet microscopy, microCT and synchrotron radiation based microCT analysis. This set of techniques allows a comparison between fresh versus fixed and dried material. The question of a unique vs. multiple origin of tracheal systems in centipedes and in Myriapoda as a whole is discussed with regard to their structural similarities and differences and the presence of hemocyanin as an oxygen carrier. We used morphological and molecular data and the fossil record to evaluate the alternative hypotheses.

Assessment of Structure, Function, and Rhythm of the Heart with Echocardiography and Electrocardiography in Adolescent Swimmers.

The aim of this study was to evaluate the cardiac parameters by using electrocardiography and echocardiography in adolescent swimmers. Twenty-two adolescent swimmers and 22 gender- and age-matched sedentary controls admitted to our center between November 2018 and May 2019 were included in this study. In addition to demographical characteristics, participants were assessed via a 12-lead electrocardiography and two-dimensional echocardiography for cardiac function. On the echocardiography, end-systolic and end-diastolic interventricular septum, end-systolic and end-diastolic left ventricular posterior wall thicknesses, left atrial width, Tricuspid E, left ventricular mass and left ventricular mass index were higher in the swimmers when compared to the sedentary controls (P < 0.05). On the electrocardiography, Tp-e duration which reflects ventricular transmural repolarization, and Tp-e/QT and Tp-e/corrected QT ratios were higher in the swimmers than the sedentary controls (P < 0.05). In conclusion, swimming exercise in children leads to concentric thickening of left ventricle and induces an increase in Tp-e duration, and Tp-e/QT and Tp-e/corrected QT ratios, which are the novel markers for risk of ventricular arrhythmias.

Use of radiographic measurements to diagnose stage B2 preclinical myxomatous mitral valve disease in dogs.

To investigate the usefulness of radiographic measures of the left atrium and ventricle as surrogates for echocardiographic criteria in identifying dogs with stage B2 preclinical myxomatous mitral valve disease (MMVD). 56 client-owned dogs with preclinical mitral regurgitation attributed to MMVD examined between April 19, 2016, and November 22, 2017. Medical records were retrospectively searched, and data collected included age, body weight, heart murmur grade, and echocardiographic and radiographic measurements. Dogs were grouped according to whether they did (case dogs) or did not (control dogs) meet echocardiographic criteria used to identify dogs with stage B2 MMVD. Measurements for lateral thoracic radiographic variables normalized to vertebral body units (VBUs) were obtained, and results were analyzed to identify variables that could best discriminate between case and control dogs. Three radiographic variables of left atrial size (vertebral left atrial size [VLAS], left atrial width, and the combined variable of VLAS + left atrial width) most accurately distinguished control dogs from case dogs, and the VLAS was the simplest and fastest to perform in a clinical setting. The optimal cutoff for VLAS was 2.5 VBUs (sensitivity, 70%; specificity, 84%; and likelihood ratio, 4.38), with VLAS ≥ 2.5 VBUs for case dogs. The maximum specificity cutoff for VLAS was 3.0 VBUs (sensitivity, 40%; specificity, 96%; and likelihood ratio, 10.0), with VLAS ≥ 3.0 VBUs for case dogs. Results indicated that when echocardiography is unavailable, radiographic VLAS ≥ 3 VBUs could be used with minimal risk of false-positive diagnosis of stage B2 MMVD in dogs.

Multiple paravalvular leak closures

Introduction 70 year old man with paroxysmal atrial fibrillation and heart failure with preserved ejection fraction with previous bioprosthetic aortic and mitral valve replacement in 2003 and 2008 presented for fatigue and dyspnea. He was an unsuitable candidate for surgery due a EuroSCORE II of 7.27%. Preoperative TEE showed posterior mitral periprosthetic regurgitation (peak gradient 73.3 mmHg) for which he underwent a transcatheter closure using an Amplatzer Vascular Plug (AVP) 2 size 12 mm and 18 mm with improved regurgitation. Methods Arterial line was placed and general anesthesia induced. Using a 6 french and 14 french catheters, the left femoral artery and right femoral vein were accessed, respectively. The septum was crossed posteriorly in order to avoid the aortic valve. TEE demonstrated a 1.4cm by 0.6cm mitral leak – almost 1/3 the circumference of the biopresthesis, as well as a left atrial width of 5.8cm. After placement of device, TEE demonstrated coverage of 2/3 of the original paravalvular orifice with regurgitation decreased significantly, as well as S wave blunting on pulmonary vein flow. Results A month postoperatively, the patient returned with worsening fatigue, shortness of breath, and weakness. In addition to anemia, patient showed hemolysis. Hematology was consulted and they believed that his PVL was again the etiology. Thus, he underwent repeat attempt at closure of the mitral in addition to early closure of the aortic paravalvular leak. Of note, TEE showed previously closed leak measuring 9mm by 9mm. There were no immediate postoperative complications. Several days later however, the patient suffered decompensated heart failure leading to multisystem organ failure. Discussion Transcatheter leak closure results in significant decrease in regurgitation. Moreover, mortality rate within 30 days averages 1.4-2.0% and 3-year survival rate is 64.5%. When both aortic and mitral prosthesis are involved, it is generally accepted to close the most regurgitant lesion and return in about 6 months for closure of the second lesion. Followup TTE/TEE and labs with close attention to hemolysis is also warranted for possible recurrence.

Oral Communication Abstracts

Results: There were 31 cases of cACC and 23 cases of pACC. Mean gestational age was lower in the cases referred because of anomalies other than ACC than in those referred because of ventriculomegaly and/or suspicion of ACC (p < 0.05). Atrial width showed a positive linear correlation with advancing gestational age (p < 0.0001). Colpocephaly was present in 20.6% (7/34) of cases < 24 weeks of gestation and in 68.6% (24/35) of cases after 23 weeks (P < 0.05). The CSP was visible in 17/25 (68%) of pACC cases. In 9/25 (36.0%) cases of pACC, there was nor ventriculomegaly nor absence of the cavum septi pellucidi. Associated anomalies were present in 25/54 (46.3%) cases. Karyotype was abnormal in 7/40 (17.5%) cases in which it was available. Conclusions: Most of the indirect signs of ACC are either absent or barely visible at the time of the mid-trimester screening ultrasound in a significant proportion of cases. Therefore, ACC may escape diagnosis at mid-trimester screening ultrasound. In particular, pACC may not show any abnormality of the trans-ventricular screening view < 24 gestational weeks in 43.5% of cases. The medico-legal implications of such findings are important and should be considered.