The mechanical behaviour of soils subjected to any stress path in which deviatoric stresses are present is heavily characterised by non-linearity, irreversibility and is strongly dependent on the initial state of stress. The latter, for the majority of geotechnical applications, is normally determined by the at-rest earth pressure coefficient K0, even though this state is valid, strictly speaking, for axisymmetric conditions and for zero-lateral deformations only. Many expressions are available in the literature for the determination of this coefficient for cohesive and granular materials both for normal consolidated and over-consolidated conditions. These relations are available for low to medium stress levels. Results of an extensive experimental investigation on two sands of different mineralogy up to very high stress (120 MPa) are reported in the paper. For reach very high vertical stresses, a special oedometer has been realised. In the loading phase (normal consolidated sands), the coefficient K0n depends on the stress level. It passes from values of about 0.8 to values of about 0.45 in the range of effective vertical stress σ′v = 0.5–4 MPa. Subsequently, K0n is about constant and varies between 0.45 to 0.55 up to very high vertical effective stresses (120 MPa). For the sands employed in the tests, Jaki’s relation did not lead to reliable results at relatively low pressures, while at high pressures, the same relationship seems to lead to reliable predictions if it refers to the constant volume angle of shear strength. For the over-consolidated sands, K0C strongly depends on the OCR, and for very high values of OCR, K0C could be greater than Rankine’s passive coefficient of earth pressure, Kp. This result is due to the very locked structure of the sands caused by the grain crushing, with intergranular contact of sutured and sigmoidal, concavo-convex and inter-penetrating type, that confer to the sand a sort of apparent cohesion and make it similar to weak sandstone.