Asymmetric Position Research Articles

Exploring horses' (Equus caballus) gaze and asymmetric ear position in relation to human attentional cues.

Studies have shown that horses are sensitive to human attentional cues. Also, there is some evidence that they might be able to infer the knowledge state of a human and communicate intentionally with us. However, this ability is not fully characterized and certain behaviors, like gaze, asymmetric ears position or vocalizations, which could work as attention-getting behaviors, have been scarcely studied in this context. The aim of the present study was to assess whether horses' gaze toward a person, asymmetric ears position and vocalizations are subject to audience effects and adjust to human attentional cues, which would suggest a communicative function. For this purpose, we adapted a protocol used with domestic dogs [Kaminski et al. 2017] and observed horses' spontaneous behavior (gaze, asymmetric ears position and vocalizations) in the presence of a human holding and not holding food in an attentive position (facing the horse with open eyes) and in a non-attentive position (with her back turned towards the horse). We found significant evidence of horses being sensitive to human attentional cues (reflected in the horses' gaze duration and asymmetric position of the ears), but not of intentional communication towards humans.

Left-Right Asymmetry in Invertebrates: From Molecules to Organisms.

Although most animals appear symmetric externally, they exhibit chirality within their body cavity, i.e., in terms of asymmetric organ position, directional organ looping, and lateralized organ function. Left-right (LR) asymmetry is determined genetically by intricate molecular interactions that occur during development. Key genes have been elucidated in several species. There are common mechanisms in vertebrates and invertebrates, but some appear to exhibit unique mechanisms. This review focuses on LR asymmetry formation in invertebrates, particularly Drosophila, ascidians, and mollusks. It aims to understand the role of the genes that are key to creating LR asymmetry and how chirality information is converted/transmitted across the hierarchies from molecules to cells and from cells to tissues.

Thermo-Mechanical Analysis of Masonry Brick Walls with Embedded Test Specimen Under Fire Exposure

AbstractThe present study is dealing with the heat transfer and deformation of masonry brick walls and an embedded fire safety steel door as well as their mechanical interaction when they were exposed to fire. A numerical approach based on the finite element method was applied to predict the temperatures and deformation. The heat transfer analysis of the wall considered the heat conduction and the radiative heat transfer within the voids of the brick. It was found that the thermal analysis predicted the temperature in the wall with high accuracy. The thermal analysis of the door was limited to the heat conduction and the water vapour transport within the door was neglected. However, the calculated temperatures were found to be reasonable and were further used for the structural analysis. When the door was placed in a central position in the wall, the predicted deformation of the wall was in close accordance to the measured data. The analysis of the door deformation showed that the pressure level and its time-dependency inside the steel door is a crucial factor for the simulation’s accuracy. When the door was placed in an asymmetric position, the wall deformation was increasing significantly. This phenomenon was also covered by the simulation, when the stiffness of the wall boundary condition was decreased. Although the numerical model was capable to calculate the deformation during the fire exposure, further research on the pressure inside the door and the mechanical conditions of the wall at the boundaries has to be done.

Влияние нарушений качества рентгенографических исследований органов грудной клетки на работу врачей-рентгенологов и диагностического искусственного интеллекта.

When performing radiographic studies, quality violations and errors periodically occur, making it difficult for an image to be interpreted and described by both a radiologist and software based on artificial intelligence technology. Incorrect filling of meta-information in DICOM format headers may be a separate problem for diagnostic artificial intelligence. Purpose: determination of quality violations of the chest x-ray examinations, which most strongly impede the work of radiologists and diagnostic software based on artificial intelligence in the conditions of the Moscow city health care system. Material and methods. To study the impact of the quality of x-ray examinations on the work of a radiologist, an online survey was conducted among radiologists, employees of the Moscow reference center for radiation diagnostics. To study the impact of the quality of x-ray examinations on the work of AI-based software, an analysis of the results of processing diagnostic studies according to the modalities chest x-ray and lung fluorography for the 4th quarter of 2023 by artificial intelligence services was carried out as part of an “Experiment on the use of innovative computer vision technologies for medical image analysis and subsequent applicability in the healthcare system of Moscow”. Results. The survey involved 172 radiologists. The most common quality violations by doctors are incompleteness of chest coverage and asymmetric position of the patient, as well as violations of image clarity / contrast. At the same time, the incompleteness of the chest coverage causes the greatest difficulties in interpreting the study for doctors with up to 5 years of experience. For more experienced doctors, the greatest difficulties are caused by violations of the clarity and contrast of images. The main problems hindering the description of studies by AI-services are non-filling or incorrect filling of meta-information about the study stored in DICOM format, as well as violations of the patient’s laying and positioning. Conclusion. The problems we have identified indicate the need for more careful adherence to the methodology of conducting diagnostic studies, especially with regard to filling out meta-information about the study. AI-based software developers need to evaluate the performance of their solutions based on the developed testing and monitoring methodology.

A Study of Asymmetric Hyperbolic Heat Storage Unit

ABSTRACTDue to the advantages of high energy density and constant temperature, phase change energy storage technology has attracted much attention in energy saving and efficient utilization of energy. In this paper, Fluent software is used to simulate and analyze the heat storage characteristics of six new thermal storage units: corrugated tube, hyperbolic‐shape, non‐hyperbolic‐shape, symmetric frustum‐shape, non‐frustum‐shape, and bow‐shape. The results show that the melting rate of the non‐hyperbolic‐shape phase change unit is significantly higher than that of the circular tube, the heat storage time is shortened by 22.52%, and Ra* reaches 0.0086. Second, the effects of the radius difference (δ) between the inlet and outlet of the non‐hyperbolic‐shape phase change unit and the asymmetric position (s) on the heat storage process are studied. The results show that when δ increases from 2 to 10 mm, the melting time of phase change material (PCM) is shortened by 22.89%, that is, the average heat transfer rate between PCM and heat transfer fluid increases with the increase of δ. On the other hand, the average heat storage rate of the heat storage unit decreases first and then increases with the increase of s. When δ = 10 mm, s = 35 mm is the best working condition, the average heat storage rate of the non‐hyperbolic‐shape thermal storage unit reaches 34.3 J/s. This study can provide new ideas and references for the optimization design of latent heat storage units and the progress of experiments.

Numerical Investigation of Cross Ventilation Flow in A Gable Roof Building with Asymmetric Opening Positions

Natural ventilation can be a suitable alternative to mechanical ventilation as it is cost-effective and environmentally friendly. Therefore, an effective design of the natural ventilation system is very crucial. In this work, an attempt has been made to investigate the impact of opening positions and roof pitch on the performance of wind-induced cross-ventilation in a gable roof building. Numerical simulations were carried out using the computational fluid dynamics (CFD) technique based on the steady Reynolds averaged Navier-Stokes equations (RANS) model. Six configurations with asymmetric openings on opposite facades were considered to evaluate the effect of opening positions. Further, for studying the influence of roof pitch on the flow properties, three roof pitches, viz. 3:10, 5:10 and 7.5:10 were considered. It is found that the configuration with a windward opening in the middle and a leeward opening at the bottom (Configuration D) has the highest flow rate. The configuration with a windward opening at the top and a leeward opening at the bottom (Configuration B) has the lowest flow rate. Furthermore, the investigation with different roof pitches reveals that buildings with lower roof pitches are more vulnerable to wind loading due to higher flow separation at the windward eave. The investigation concludes that the opening position and roof pitch significantly influences the indoor airflow characteristics thereby affecting the ventilation performance.

Caregivers and Babies in Interaction: A Study of Two Families in Wonosobo, Central Java

PParentese in each community has its own characteristics. This study aims to describe the interaction between caregivers and infants with a case study in two Javanese families living in the Wonosobo urban area (mother, babysitter, grandmother, and baby aged 0;4 [K1] and 1;6 [K2]), Central Java. This research used the ethnographic method through observation involving both families. The results showed that knowledge of the competence and cognition ability of the baby became the background for caregivers to adjust themselves so as to create an asymmetrical position. This places the caregiver as the party who "dominates" the interaction. In interaction, elements of caregiver contribution can be done by providing verbal stimuli to the baby, giving verbal responses to the baby's behavior, imitating the baby's behavior, shedding, role-playing as a baby, and inviting the baby to do simple games. Meanwhile, babies contribute to vocalizations and kinesic interactions. This study concluded that various interactions between caregivers and infants in two families in the urban environment of Wonosobo, Central Java are evidence that caregivers include babies in interaction activities. That is, caregivers do not wait for the baby to reach the verbal stage for them to start interacting verbally with the baby.

Digital Planning to Enhance Diagnosis and Precision in Correcting Excessive Gingival Display in the Presence of Asymmetrical Maxillary Position: A Case Report.

This case report addresses the treatment of excessive gingival display (EGD) in the context of maxillary asymmetry, zenith irregularities, and occlusal plane inclination. Digital planning was pivotal in formulating a precise treatment strategy by incorporating facial photographs, digital models, and cone-beam computed tomography data. Parameters, including occlusal plane inclination, teeth position, and lip-to-gingival margin relationships, were considered to ensure treatment alignment with the patient's facial characteristics. Notably, during the planning phase, it was evident that the conventional approach using the cementoenamel junction as the apical limit for incisions would result in asymmetry. Consequently, the gingival margin position was defined in accordance with facial and lip features. The chosen treatment, flapless crown lengthening, was tailored to the patient's thin phenotype and guided by measurements derived from digital planning. Postsurgery, the patient experienced a swift and painless recovery. A harmonious smile with a stable gingival margin position was achieved at the 1-year follow-up, seamlessly complementing the patient's facial attributes. This case underscores the importance of personalized EGD treatment and the value of digital planning in enhancing diagnostic accuracy and precise treatment planning, ultimately facilitating optimal treatment strategies.

Smart Sensing Chairs for Sitting Posture Detection, Classification, and Monitoring: A Comprehensive Review.

Incorrect sitting posture, characterized by asymmetrical or uneven positioning of the body, often leads to spinal misalignment and muscle tone imbalance. The prolonged maintenance of such postures can adversely impact well-being and contribute to the development of spinal deformities and musculoskeletal disorders. In response, smart sensing chairs equipped with cutting-edge sensor technologies have been introduced as a viable solution for the real-time detection, classification, and monitoring of sitting postures, aiming to mitigate the risk of musculoskeletal disorders and promote overall health. This comprehensive literature review evaluates the current body of research on smart sensing chairs, with a specific focus on the strategies used for posture detection and classification and the effectiveness of different sensor technologies. A meticulous search across MDPI, IEEE, Google Scholar, Scopus, and PubMed databases yielded 39 pertinent studies that utilized non-invasive methods for posture monitoring. The analysis revealed that Force Sensing Resistors (FSRs) are the predominant sensors utilized for posture detection, whereas Convolutional Neural Networks (CNNs) and Artificial Neural Networks (ANNs) are the leading machine learning models for posture classification. However, it was observed that CNNs and ANNs do not outperform traditional statistical models in terms of classification accuracy due to the constrained size and lack of diversity within training datasets. These datasets often fail to comprehensively represent the array of human body shapes and musculoskeletal configurations. Moreover, this review identifies a significant gap in the evaluation of user feedback mechanisms, essential for alerting users to their sitting posture and facilitating corrective adjustments.

Spatio-temporal control of asymmetric septum positioning during sporulation in Bacillus subtilis

During sporulation, Bacillus subtilis forms an asymmetric septum, dividing the cell into two compartments, a mother cell and a forespore. The site of asymmetric septation is linked to the membrane where FtsZ and SpoIIE initiate the formation of the Z-ring and the E-ring, respectively. These rings then serve as a scaffold for the other cell division and peptidoglycan synthesizing proteins needed to build the septum. However, despite decades of research, not enough is known about how the asymmetric septation site is determined. Here, we identified and characterized the interaction between SpoIIE and RefZ. We show that these two proteins transiently co-localize during the early stages of asymmetric septum formation when RefZ localizes primarily from the mother cell side of the septum. We propose that these proteins and their interplay with the spatial organization of the chromosome play a role in controlling asymmetric septum positioning.

EFFECT INITIAL FOOT POSITION HAS ON WEIGHT DISTRIBUTION SYMMETRY AND FORCE PRODUCTION DURING A SIT-TO-STAND TASK IN OLDER ADULTS

INTRODUCTION AND AIMS Transitioning from a seated position to standing is an important component to everyday living which can be affected by age-related muscle strength loss. Changing foot position has been found to affect a sit-to-stand transition in healthy younger populations however the effect it has on healthy older populations is unknown. The aim of this study was to provide clinicians with greater insight into the effect asymmetrical initial foot positions have on weight distribution symmetry and force production during a sit-to-stand transition in adults over 60 years of age. METHODS Three symmetrical and six asymmetrical initial foot positions were investigated on two separate testing sessions. The maximum vertical ground reaction forces collected from each foot placed on individual Kistler force platforms were used to calculate body weight symmetry percentage. RESULTS Body weight symmetry reduced when the dominant foot was moved posteriorly 1/3 and 2/3 participant’s foot length compared to the symmetrical positions (102-107%). When the non-dominant foot was moved posteriorly by 1/3 and 2/3 the participant’s foot length, body weight symmetry increased (99-102%) above the symmetrical positions. Maximum vertical ground reaction forces occurred (5.6-6.2N/kg) in the asymmetrical positions with the anterior foot positioned in neutral. CONCLUSIONS Asymmetrical foot positions which involved shifting one extremity posteriorly by 1/3 or 2/3 the participant’s foot length reduced transitional stability but increased force production. These results will help guide clinicians to scaffold progressions when prescribing sit-to-stand exercises to rehabilitate unilateral strength deficiencies within an older population.

Design of Muon Campus full flow purifier for varying operational conditions and horizontal shipping

Constant ingress of impurities in Muon Campus g-2 experiment at Fermilab has resulted in reduction of efficiency of cryogenic expanders and occasional undesired downtime to flush the impurities. Due to insufficiency of current 0.06 kg/s mobile purifier, a full flow purifier is designed to be used in Muon Campus which purifies 0.24 kg/s of Helium throughput of 4 compressors through charcoal bed at 80 K and returns ambient Helium back to the system. The purifier is designed to be operated near liquid Nitrogen temperature during cold operations and up to 400 K during regeneration. Both warm and cold operational range of the purifier has required use of appropriate clearances in design due to expansion and contraction. The vessel of around 5.5 m height which is designed to be operated vertically is to be shipped horizontally. The asymmetrical position of heavy stainless steel heat exchanger in the purifier support frame and 5g vertical load design consideration for shipping has required use of shipping supports and heat exchanger rotational stops to comply with design requirements. FEA of purifier system is performed in cold, warm and shipping cases to verify that the purifier satisfies the design requirements.

Filantropía comunitaria en México: Narrativas emergentes de lo común, el territorio y la memoria

In the relationships between foundations and communities, resources of different types are mobilized and those who receive them are seen in an asymmetrical position; this study seeks to identify and interpret the narrative elements that characterize the perceptions about philanthropic practices among communities in Mexico; as well as to characterize the narrative elements that question the hegemonic definitions of philanthropy. Based on three workshops, with the participation of 70 people from 19 Mexican states, we analyzed knowledge and perceptions regarding the definition of community philanthropy, the recognition of differentiated contributions between men and women, and the recognition of the types of resources and how they are mobilized. The people participating in the workshops do not identify with a generalized definition of Community Philanthropy, but rather different philanthropic practices were made visible related to the work carried out in the private and public spheres, the processes of memory recovery and attachment to the territory. It is concluded that the visibility of the resources contributed by the communities, mainly the intangible ones, promotes symmetrical relationships; as well as recognizing that external donations enhance the processes that are already taking place within the communities.

PLD1 promotes spindle assembly and migration through regulating autophagy in mouse oocyte meiosis

ABSTRACT PLD1 has been implicated in cytoskeletal reorganization and vesicle trafficking in somatic cells; however, its function remains unclear in oocyte meiosis. Herein, we found PLD1 stably expresses in mouse oocytes meiosis, with direct interaction with spindle, RAB11A+ vesicles and macroautophagic/autophagic vacuoles. The genetic or chemical inhibition of PLD1 disturbed MTOC clustering, spindle assembly and its cortical migration, also decreased PtdIns(4,5)P2, phosphorylated CFL1 (p-CFL1 [Ser3]) and ACTR2, and their local distribution on MTOC, spindle and vesicles. Furthermore in PLD1-suppressed oocytes, vesicle size was significantly reduced while F-actin density was dramatically increased in the cytoplasm, the asymmetric distribution of autophagic vacuoles was broken and the whole autophagic process was substantially enhanced, as illustrated with characteristic changes in autophagosomes, autolysosome formation and levels of ATG5, BECN1, LC3-II, SQSTM1 and UB. Exogenous administration of PtdIns(4,5)P2 or overexpression of CFL1 hyperphosphorylation mutant (CFL1S3E) could significantly improve polar MTOC focusing and spindle structure in PLD1-depleted oocytes, whereas overexpression of ACTR2 could rescue not only MTOC clustering, and spindle assembly but also its asymmetric positioning. Interestingly, autophagy activation induced similar defects in spindle structure and positioning; instead, its inhibition alleviated the alterations in PLD1-depleted oocytes, and this was highly attributed to the restored levels of PtdIns(4,5)P2, ACTR2 and p-CFL1 (Ser3). Together, PLD1 promotes spindle assembly and migration in oocyte meiosis, by maintaining rational levels of ACTR2, PtdIns(4,5)P2 and p-CFL1 (Ser3) in a manner of modulating autophagy flux. This study for the first time introduces a unique perspective on autophagic activity and function in oocyte meiotic development. Abbreviations: ACTR2/ARP2: actin related protein 2; ACTR3/ARP3: actin related protein 3; ATG5: autophagy related 5; Baf-A1: bafilomycin A1; BFA: brefeldin A; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GOLGA2/GM130: golgin A2; GV: germinal vesicle; GVBD: germinal vesicle breakdown; IVM: in vitro maturation; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MI: metaphase of meiosis I; MII: metaphase of meiosis II; MO: morpholino; MTOC: microtubule-organizing center; MTOR: mechanistic target of rapamycin kinase; PB1: first polar body; PLA: proximity ligation assay; PLD1: phospholipase D1; PtdIns(4,5)P2/PIP2: phosphatidylinositol 4,5-bisphosphate; RAB11A: RAB11A, member RAS oncogene family; RPS6KB1/S6K1: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; TUBA/α-tubulin: tubulin alpha; TUBG/γ-tubulin: tubulin gamma; UB: ubiquitin; WASL/N-WASP: WASP like actin nucleation promoting factor

Entangled dark state mediated by a dielectric cavity within epsilon-near-zero materials.

Two emitters can be entangled by manipulating them through optical fields within a photonic cavity. However, maintaining entanglement for a long time is challenging due to the decoherence of the entangled qubits, primarily caused by cavity loss and atomic decay. Here, we found the entangled dark state between two emitters mediated by a dielectric cavity within epsilon-near-zero (ENZ) materials, ensuring entanglement maintenance over an extended period. To obtain the entangled dark state, we derived an effective model with degenerate mode modulation. In the dielectric cavities within ENZ materials, the decay rate of emitters can be regarded as 0, which is the key to achieving the entangled dark state. Meanwhile, the dark state immune to cavity loss exists when two emitters are in symmetric positions in the dielectric cavity. Additionally, by adjusting the emitters to specific asymmetric positions, it is possible to achieve transient entanglement with higher concurrence. By overcoming the decoherence of the entangled qubits, this study demonstrates stable, long-term entanglement with ENZ materials, holding significant importance for applications such as nanodevice design for quantum communication and quantum information processing.

Parents and teachers collaborating to disrupt asymmetrical power positions in mathematics education

Parents and teachers collaborating to disrupt asymmetrical power positions in mathematics education

Asymmetrical positioning of cell organelles reflects the cell chirality of mouse myoblast cells.

Cell chirality is crucial for the chiral morphogenesis of biological tissues, yet its underlying mechanism remains unclear. Cell organelle polarization along multiple axes in a cell body, namely, apical-basal, front-rear, and left-right, is known to direct cell behavior such as orientation, rotation, and migration. Among these axes, the left-right bias holds significant sway in determining the chiral directionality of these behaviors. Normally, mouse myoblast (C2C12) cells exhibit a strong counterclockwise chirality on a ring-shaped micropattern, whereas they display a clockwise dominant chirality under Latrunculin A treatment. To investigate the relationship between multicellular chirality and organelle positioning in single cells, we studied the left-right positioning of cell organelles under distinct cell chirality in single cells via micropatterning technique, fluorescent microscopy, and imaging analysis. We found that on a "T"-shaped micropattern, a C2C12 cell adopts a triangular shape, with its nucleus-centrosome axis pointing toward the top-right direction of the "T." Several other organelles, including the Golgi apparatus, lysosomes, actin filaments, and microtubules, showed a preference to polarize on one side of the axis, indicating the universality of the left-right asymmetrical organelle positioning. Interestingly, upon reversing cell chirality with Latrunculin A, the organelles correspondingly reversed their left-right positioning bias, as suggested by the consistently biased metabolism and contractile properties at the leading edge. This left-right asymmetry in organelle positioning may help predict cell migration direction and serve as a potential marker for identifying cell chirality in biological models.

Appraisal of the historical impact of neglected, modernised small-scale architectural objects by Rudolf Frič

Abstract The context of interwar period Czechoslovakia lacks a formal on both the personality and built artefacts on the often overlooked Bratislava builder, Rudolf Frič. Small-scale architecture tends to be undervalued because of its size, utility, multiplicity, or related momentariness, and because of the automatic consideration of its banality. This paper aims to analyse their architectural qualities presented in concrete typologies and realisations. Tram shelters, gas stations, mausoleums, and small detached houses are thus researched. Their architectural values, both in construction and in form, are identified and clarified. On the other hand, it is noted that the scale and ephemerality conditioned by the utility character are the crucial reasons for their undervaluation. This is especially the case of traffic buildings, where the same dynamic that initiated their origin also resulted in their end, as they become obsolete rather soon. Some of these projects by Frič such as: Rybáček House, Polák Tram stop, the Zikmund Brothers’ gas station, as well as the Frič family tomb, are confronted with other relevant realisations, prove that small-scale architectural objects and peripheral typologies have the architectural qualities for which they would deserve the public and professional interest. Moreover, these objects reflect their variety, being situated in diverse urban situations, from the architecturally and historically intact city centre, through to newly urbanised dwelling area, urban periphery up to a provincial town. Additionally, they illustrate the asymmetric position of the Slovak situation compared to the Czech one, particularly in transport architecture. The presented works characterise the style of Frič based on the high-quality craftsmanship details rather than explicit architectural forms. This transfer of new typologies and structural forms with partial urban impacts, underscores the neglected and crucial contribution to architecture by Frič.

LOAD-BEARING TIMBER DSF ELEMENTS INFLUENCE ON RACKING STABILITY OF MULTI-STOREY PREFABRICATED TIMBER BUILDINGS

Application of double-skin façade (DSF) elements is an important approach in a designing process of contemporary multi-storey timber buildings. A double-skin facade is an envelope wall element that consists of two glass components separated by a cavity and can essentially improve building-physics properties of building envelope. In a sense to reduce global warming potential (GWP) an ecological solution with a timber frame is presented in this paper. Recently, many studies have analyzed thermal and acoustic performance of DSF elements, but practically none in a sense of structural behavior, especially in determination of racking resistance of such wall elements. Because costs of experiments performed on such full-scale DSF elements are very high and such experiments are also very time-consuming, a special mathematical model using a Finite Element Method (FEM) for analyzing the racking resistance and stiffness was further developed. Finally, a specially selected four-storey timber-framed building is subjected to a seismic analysis comparing the influence of the developed timber DSF elements on the overall racking behavior of that structure with non-resisting DSF function. It is demonstrated in the presented study on the selected case that the racking resistance (R) and a consequent seismic resistance of a whole building can be essentially improved if DSF elements are considered as lateral load-bearing wall elements. Consequently, such an approach by using DSF elements as additional bracing wall elements can essentially further increase a potential of designing also high-rise timber buildings with asymmetric position of transparent areas.

Shifting Trends in Regionalism

Regionalism is a movement that emerged after World War II. It involves countries that are geographically close and interdependent, collaborating with the help of governments and NGOs to achieve mutual benefits in a particular area of shared interest. Such regional clusters have evolved due to geographical proximity, economic interdependence, security issues, social and cultural background, and more. The end of the Cold War led to the rise of new regionalism shaped by factors such as globalization, the emergence of new players, shifts in global power dynamics, increased interdependence, alterations in security paradigms, the advent of multipolar, and various other influences. This shifting pattern has had a major impact on world politics and power dynamics. Traditional notions of security are evolving to encompass human security concerns, while economic collaboration and identity-based regionalism are gaining prominence. Asia's growing economic clout, new regional players' arrival, and smaller states' growing role are reshaping the global power landscape. Asymmetric positions and chequered history hinder the functioning of regionalism. In this context, the article seeks to analyze the changing dynamics of regionalism, the primary drivers of this shift, and its implications for global power dynamics. The article is presented from the perspectives of neo-realism, neo-liberalism, and constructivism in a descriptive, analytical, and exploratory format, where the necessary information is obtained from secondary qualitative data.