Cache prefetching is a traditional way to reduce memory access latency. In multi-core systems, aggressive prefetching may harm the system. In the past, prefetching throttling strategies usually set thresholds through certain factors. When the threshold is exceeded, prefetch throttling strategies will control the aggressive prefetcher. However, these strategies usually work well in homogeneous multi-core systems and do not work well in heterogeneous multi-core systems. This paper considers the performance difference between cores under the asymmetric multi-core architecture. Through the improved hill-climbing method, the aggressiveness of prefetching for different cores is controlled, and the IPC of the core is improved. Through experiments, it is found that compared with the previous strategy, the average performance of big core is improved by more than 3%, and the average performance of little cores is improved by more than 24%.