Introduction: Laterognathia is characterized by the mandibular deviation to one of the sides affected which often caused by unilateral overgrowth of the mandible and age-related adaptive remodeling changes in the temporomandibular joint (TMJ) that affected masticatory function and aesthetics. The aim of this serial case report is to discuss the surgical management for laterognathia with bilateral sagittal split osteotomy (BSSO) on a clinical case of asymmetrical dentofacial deformity due to an excessive mandibular unilateral laterognathia. Case Report: This case report contains two cases of mandibular laterognathia. Both of our patients underwent a corrective procedure with bilateral sagittal split ramus osteotomy (BSSO) that performed mandibular setback and rotation. Post-operative follow-up showed the patient was in good condition and no complications were noted. Conclusion: The mandibular setback and rotation procedure can be performed with a bilateral sagittal split ramus osteotomy (BSSO). Significant improvement of laterognathia in occlusion, masticatory function, and facial appearance was achieved by surgical management with BSSO procedure. Keywords: laterognathia, bilateral sagittal split osteotomy, mandibular setback.