Asthmatic Pneumonia Research Articles

IL6 receptor inhibitors: exploring the therapeutic potential across multiple diseases through drug target Mendelian randomization.

High interleukin-6 levels correlate with diseases like cancer, autoimmune disorders, and infections. IL-6 receptor inhibitors (IL-6Ri), used for rheumatoid arthritis and COVID-19, may have wider uses. We apply drug-target Mendelian Randomization (MR) to study IL-6Ri's effects. To simulate the effects of genetically blocking the IL-6R, we selected single nucleotide polymorphisms (SNPs) within or near the IL6R gene that show significant genome-wide associations with C-reactive protein. Using rheumatoid arthritis and COVID-19 as positive controls, our primary research outcomes included the risk of asthma, asthmatic pneumonia, cor pulmonale, non-small cell lung cancer, small cell lung cancer, Parkinson's disease, Alzheimer's disease, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, type 1 diabetes, and type 2 diabetes. The Inverse Variance Weighted (IVW) method served as our principal analytical approach, with the hypotheses of MR being evaluated through sensitivity and colocalization analyses. Additionally, we conducted Bayesian Mendelian Randomization analyses to minimize confounding and reverse causation biases to the greatest extent possible. IL-6 inhibitors significantly reduced the risk of idiopathic pulmonary fibrosis (OR= 0.278, 95% [CI], 0.138-0.558; P <0.001), Parkinson's disease (OR = 0.354, 95% CI, 0.215-0.582; P <0.001), and positively influenced the causal relationship with Type 2 diabetes (OR = 0.759, 95% CI, 0.637-0.905; P = 0.002). However, these inhibitors increased the risk for asthma (OR = 1.327, 95% CI, 1.118-1.576; P = 0.001) and asthmatic pneumonia (OR = 1.823, 95% CI, 1.246-2.666; P = 0.002). The causal effect estimates obtained via the BWMR method are consistent with those based on the IVW approach. Similarly, sIL-6R also exerts a significant influence on these diseases.Diseases such as Alzheimer's disease, Crohn's disease, pulmonary heart disease, systemic lupus erythematosus, Type 1 diabetes, Non-small cell lung cancer and ulcerative colitis showed non-significant associations (p > 0.05) and were excluded from further analysis. Similarly, Small cell lung cancer were excluded due to inconsistent results. Notably, the colocalization evidence for asthmatic pneumonia (coloc.abf-PPH4 = 0.811) robustly supports its association with CRP. The colocalization evidence for Parkinson's disease (coloc.abf-PPH4 = 0.725) moderately supports its association with CRP. IL-6Ri may represent a promising therapeutic avenue for idiopathic pulmonary fibrosis, Parkinson's disease, and Type 2 diabetes.

Diagnosis of asthmatic pneumonia in children by lung ultrasound vs. chest X-ray: an updated systematic review and meta-analysis.

Chest X-ray (CXR) is used as the standard diagnostic method in lung diseases, especially in pneumonia, but unfortunately, despite the high risk of receiving radiation, it also has a high false negative rate. Therefore, some researchers recommend ultrasound to diagnose pneumonia. To investigate the accuracy of lung ultrasound compared to CXR for the diagnosis of pneumonia children by meta-analysis method. Original articles which evaluated accuracy of lung ultrasound compared to chest X-ray for the diagnosis of pneumonia in children, published between 1 January 2010 and 20 March 2021, were identified in the PubMed, Web of Science, Embase, Scopus and Cochrane Library databases. Data synthesis and statistical analysis were carried out using STATA software. Odds ratios with 95% confidence interval (CI), fixed effect model and mean difference with 95% CI, random effect model (REM) were calculated. At the first step, 1016 potentially important research abstracts and titles were discovered in our electronic searches, 8 papers were in agreement with our inclusion criteria. The statistical analysis showed sensitivity of 95.5% (95% CI: 93.6-97.1%) and specificity of 96.3% (95% CI: 92.1-98.4%) for the lung ultrasound, and CXR sensitivity and specificity were 87.4% (95% CI: 84.3-90.0%) and 98.6% (95% CI: 95.8-99.6%), respectively. The present study showed that ultrasound can be useful in diagnosing pneumonia in children, and due to the lack of risk of receiving radiation, this method is even more preferred.

Inhaled Corticosteroids as an Associated Risk Factor for Asthmatic Pneumonia: A Literature Review.

Asthma patients have commonly been prescribed inhaled corticosteroids (ICSs) as the first line of control therapy. ICSs are associated with an increased risk of pneumonia in chronic obstructive airway disease (COPD) patients. However, the evidence remains controversial in asthma patients. Several observational studies reported an increased risk of pneumonia; however, COPD patients were not excluded clearly in these studies. In observational studies that excluded COPD patients and in randomized controlled trials, ICS use was not found to be associated with the risk of pneumonia. Hence, COPD patients should be excluded in future studies, and the currently available evidence demonstrates that ICS use is not associated with an increased risk of pneumonia in asthma patients.

Effect of pulmicort respules inhalation combined with tulobuterol in treating infantile asthmatic pneumonia and its effect on serum inflammatory factors

Objective To study the effect of atomized inhalation of pulmicort respules combined with tulobuterol in the treatment of children with wheezing pneumonia and its influence on serum inflammatory factors. Methods 90 children with asthmatic bronchopneumonia were selected, and they were randomly divided into observation group and control group, 45 cases in each group.The control group received routine western medicine and atomized inhalation of ambroxol hydrochloride.The observation group was treated with pulmicort respules inhalation combined with tulobuterol paste service on the basis of the control group.After 1 course of treatment, the efficacy was evaluated.The improvement of clinical symptoms, clinical efficacy, serum cytokine level, inflammatory index and adverse reaction were compared between the two groups. Results The disappearance time of clinical signs such as shortness of breath, cough, wheezing and pulmonary rales in the observation group were significantly shorter than those in the control group [(7.58±0.72)d, (8.42±1.33)d, (5.66±0.74)d, (7.76±0.75)d vs.(4.21±0.29)d, (2.59±0.71)d, (3.41±0.69)d, (5.29±0.71)d, P 0.05). The ECP and Eos in the peripheral blood of the two groups were significantly lower than those before treatment(t=8.363, 4.307, 13.431, 12.949, all P 0.05). After treatment, the levels of IL-4, IL-6 and IL-10 were significantly decreased and the IFN-γ level was significantly higher than before treatment(t=17.216, 20.051, 17.891, 15.417, 32.724, 26.709, 28.112, 26.708, all P<0.05). The levels of inflammatory cytokines in the peripheral blood of the observation group were significantly better than those of the control group(t=9.306, 4.150, 5.117, 4.124, all P<0.05). No serious adverse events occurred in the two groups during the treatment. Conclusion Pulmicort respules combined with tulobuterol is effective in the treatment of children with wheezing pneumonia.It can relieve the symptoms of cough and wheezing.The mechanism may be related to the imbalance of Th1/Th2 imbalance and the reduction of airway inflammation. Key words: Pneumonia; Administration, inhalation; Child; Pulmicort respules; Trotolol

Study of viral etiology in children with wheezing disease in Pediatric Intensive Care Unit

Objective To investigate the viral pathogen spectrums in children with wheezing disease in Pedia-tric Intensive Care Unit(PICU). Methods Nasopharyngeai aspirates specimens (NPA) specimens were collected from 70 children with wheezing disease who were admitted to PICU in the Second Affiliated Hospital of Shantou University Medical College from Jun.2010 to Dec.2011.Multiplex PCR was applied to detect the respiratory viruses, the clinical data of the positive cases were analyzed. Results Seventy throat swab specimens tested positive in 54 cases of respiratory viruses (77%), of which a single virus-positive in 34 cases, 20 cases of mixed infection.For the specimens tested positive for the virus, the most common was respiratory syncytial virus(RSV), and there were 23 copies of them, followed by the human rhinovirus (HRV) 21 copies, adenovirus 8 copies, human Bocavirus 4 copies, 4 copies with parainfluenza virus type 3, 3 copies with parainfluenza virus type 4, there were 1 copy positive for human metapneumovirus, 1 copy positive for WU polyomavirus, 1 copy positive for seasonal flu and 1 copy positive for swine H1N1.Mixed infection in 19 copies with 2 kinds of viruses mixed, 1 copy with 3 kinds of viruses mixed, and hybrid virus was detected in most RSV mixed HRV (6 copies). For the specimens tested positive for the virus, their clinical diagnosis: 39 cases of asthmatic pneumonia, 11 cases of bronchiolitis, 3 cases of asthmatic bronchitis and 1 case of status asthmaticus. Conclusions There was a high rate of detection of viral pathogens in children with wheezing disease in PICU in the Second Affiliated Hospital of Shantou University Medical College, and the most common viruses were respiratory syncytial virus and rhinovirus. Key words: Respiratory infection; Pediatric intensive care unit; Child; Rhinovirus; Respiratory syncytial virus

Study on correlation between mycoplasma pneumonia (MP), chlamydia pneumoniae (CP) and asthma index as a predictor of positive

Objective To explore the correlation between mycoplasma pneumonia (MP),chlamydia pneumoniae (CP) and asthma index as a predictor of positive.Methods We separated 120 received infants who suffered from the asthmatic respiratory disease (included the bronchitis convulsive and asthmatic pneumonia).We separated the infants into experimental group i.e.predictive index for positive group (62 infants) and control group i.e.predictive index of negative group (58 infants),and we checked the MP-IgM,CP-IgM of the two groups of infants and compared the groups.Results 15 infants of the experimental group had the positive MP-IgM and the positive rate was 24.2%.18 infants of the experimental group had the positive CP-IgM and the positive rate was 29%.And the relative positive rate of the control group was 8.6% and 12.1%.The discrepancy of two group had statistical significant difference (P＜0.05).Conclusion MP,CP have some relation with the asthma index as a predictor of positive.We need to improve the related specific antibody detection,and to macrolides in treatment of acute asthmatic attack in order to decrease incidence of asthma disease in school age children. Key words: Mycoplasma pneumonia(MP); Chlamydia pneumoniae(CP); Predictive index for positive children asthma

Clinical curative effect analysis of α-asarone injection in infants with asthmatic pneumonia

目的 观察α-细辛脑注射液治疗小儿喘息性肺炎的临床疗效及不良反应.方法142例年龄4个月至6岁的本科住院的喘息性肺炎患儿采取随机抽取治疗组78例,对照组64例,两组均给予综合治疗,治疗组在此基础上给予α-细辛脑注射液按每次0.5 mg/kg(最大剂量＜8 mg/次)用5%或10%葡萄糖注射液稀释成0.01%～0.02%的溶液,静脉滴注,每日1～2次,直至症状消失或减轻1～2 d停药.结果治疗组与对照组治愈率比较:治疗组94.9%,对照组81,0%,治疗组明显优于对照组(χ2=5.514,P＜0.05);治疗组气促缓解、咳嗽消失、肺部喘(哮)鸣音及湿罗音消失与对照组比较明显缩短(均P＜0.01).住院时间与对照组比较明显缩短(P＜0.05).结论α-细辛脑注射液佐治喘息性肺炎临床疗效肯定,能有效地缓解患儿的咳嗽、喘息,可促进肺部罗音吸收,临床疗效肯定可靠,在上述剂量下安全,在我们的临床应用中未发现明显的毒副作用。