Integrating diverse techniques and datasets, significantly enhances the accurate identification of various mineral deposits. This work aims to determine different types of mineral deposits in the Hamash district (Southern Eastern Desert, Egypt) by combining structural features (derived from ALOS PALSAR DEM), alteration zones (detected using ASTER and Sentinel-2), and ore mineralogy. Multispectral imaging, such as ASTER and Sentinel-2 satellite data, provides a cost-effective and efficient tool for lithological and hydrothermal alteration mapping utilizing selective band ratios (SBR), directed principal component analysis (DPCA), feature-oriented false-color composites (FFCC), and constrained energy minimization (CEM). The deductions drawn from the analysis of ASTER and Sentinel 2 satellite data are solidly corroborated through meticulous investigations of pre-existing lithological maps in the study area, on-site validation via fieldwork, and robust laboratory analysis, attesting to reliable results. Validation of remote sensing results was performed through field observations, petrographic investigations, X-ray diffraction technique (XRD), and SEM–EDX analyses. Based on ore mineralogy derived from XRD and SEM results the quartz-vein-associated ore minerals in the Hamash district include chalcopyrite, pyrite, hematite, goethite, bornite, covellite, and gold. According to the present paragenesis, the mineralization in the study area is classified into three types: sulfide mineralized zone, transitional zone, and supergene zone. Using an ore microscope, our studies identified that the alteration zones include gold-bearing sulfide minerals as well as the minerals goethite and malachite. In gold-bearing quartz samples, the concentrations of Cu, As, Ag, and Sb are positively correlated with Au at the degree of shear deformation. According to data gathered from the fire assay results, Au content varied from 0.027 to 57.20 ppm, along with Cu (10–6484 ppm), Ag (0.5–20.5 ppm), As (5–2046 ppm), Zn (3–1095 ppm), Pb (2–1383 ppm), and Sb (5–23). Our results confirmed that the Hamash region is one of the most important gold-bearing sites, with gold concentrations ranging from 0.027 up to 57.20 ppm. Furthermore, the current contribution highlighted four stages in the paragenetic sequence of the recorded ores, including magmatic, metamorphic, hydrothermal, and supergene by origin, indicating a considered similarity with the known Egyptian gold sites regarding host rocks, mineralization style, alteration assemblage, and several ore mineral conditions.
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