Increasing regulatory pressure is being placed on the environmental storage conditions of perishable products during manufacture, storage, and transportation. These requirements are established by, the Food and Drug Administration (FDA), Center for Disease Control and Prevention (CDC), Code of Federal Regulations (CFR), United States Pharmacopoeia (USP), American Association of Tissue Banks (AATB), as well as other US and non-US counterparts. Compliance with agency regulations may be reactive or proactive. A reactive response would follow the proper and accurate monitoring methodologies and only occurs after an alert or other notification. In contrast, proactive compliance would employ data analytics that provides the user with methods by which monitoring and management of the collected storage data may be accomplished. These methods would show strengths and weaknesses in monitoring and managing overall compliance, thus allowing the user to focus on addressing any potential liability and preventing loss due to non-compliance. Critical-temperature monitoring drives the requirement for thermal buffering. The lack of specification associated with the guidance to this practice leaves the size, material, and geometry up to the user's discretion. This practice results in errors in representing the temperature of the contents and will, at a point, lead to improper notification alerts. These shortcomings and inaccuracies are overcome using Virtual Temperature Buffering™ (VTB). VTB is a mathematical algorithm that operates on air temperature. This highly accurate model preserves the air temperature while computing the buffered temperature in real-time. The measurement and recording of the air temperature are accomplished per the CDC guidance [1] by placing the measurement probe in the center of the storage unit. The buffered temperature value may be calculated for any volume and geometry desired. If desired, the air temperature will be available for post-process for a specific geometry.