Association Of Serum Ferritin Levels Research Articles

Association of Serum Ferritin Level with Severity of COVID-19 Infection During Third Trimester of Pregnancy

Background: World has been passing through COVID-19 pandemic by a newly emergent coronavirus named SARS-CoV-2 since December 2019 and officially declared as a pandemic by WHO on 11th March 2020. Till mid-March 2022, around 460 million people already suffered from COVID-19, among them around 6 million people died and globally death rate was 2%. In Bangladesh till mid-March 2022, around 1.9 million people suffered from COVID-19 and around 29 thousand people had died. As pregnancy is a physiological immunosuppressive state, so pregnant women might be more susceptible to this infection. Studies on COVID-19 during pregnancy have showed, this infection occurred more during third trimester of pregnancy (about 64%). Reviewing several other studies on COVID-19 infection we found that, elevated serum ferritin level was associated with its severity; and ferritin could effectively discriminate severity and non-severity with sensitivity 96% and specificity 70%. We conducted this study to evaluate association of serum ferritin level with severity of COVID-19 infection during third trimester of pregnancy. Objectives: To evaluate association between rise of serum ferritin level and severity of COVID-19 infection during third trimester of pregnancy. Methods: This cross-sectional study was carried out in Department of Obstetrics and Gynaecology, COVID-19 Unit, BSMMU and DMCH. Sampling method was purposive. Total 77 cases were included in this study after matching eligibility criteria. After collecting intravenous blood, serum ferritin level was measured. Results: Among 77 cases of third trimester COVID-19, 19 cases (24.7%) were asymptomatic, 31 cases (40.3%) were mild, 19 cases (24.7%) were moderate and 8 cases (10.4%) were severe COVID-19. Non- severe COVID-19 group included 50 cases of asymptomatic & mild COVID-19; and their mean serum ferritin level was 51.48 ng/ml. Severe COVID-19 group included 27 cases of moderate & severe COVID-19; and their mean serum ferritin level ......

Association of Serum Ferritin Level in Women with Preeclampsia

Association of Serum Ferritin Level in Women with Preeclampsia

Association of serum ferritin with severity and clinical outcome in COVID-19 patients: An observational study in a tertiary healthcare facility

BackgroundFerritin, an intracellular protein, has a pivotal role in immune dysregulation. Hyperferritinemia has been associated with higher disease severity and adverse clinical outcomes in COVID-19, including mortality. We aimed to study the association of serum ferritin levels with disease severity and clinical outcomes and its severity prediction potential in COVID-19 patients. MethodsThis retrospective study included 870 adult patients with symptomatic COVID-19 infection hospitalized between July 1, 2020 to December 21, 2020. All the patients had a positive polymerase chain reaction test result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ResultsThe median age was 55 (IQR:40, 65) years with a male predominance [66.32% (n = 577)], among 870 COVID-19. Of these, 413 (47.47%) had mild COVID-19, and 457 (52.53%) had moderate plus severe COVID-19 disease. Median ferritin levels were significantly high in moderate to severe COVID-19 infection compared to mild [545.8 (326.0, 1046.0) vs 97.3 (52.65–155.5) (p = 0.001)], and in patients who developed a complication compared to without complications [380 (177.05, 863.15) vs 290 (110.9, 635) (p = 0.002). A slight elevation in median ferritin levels was observed in patients who had an ICU stay than non-ICU [326 (129.8, 655) vs 309 (119.1, 684) (p = 0.872)]. The cut-off for ferritin was identified at >287.4 ng/ml for mild versus moderate plus severe COVID-19 infections. ConclusionModerate to severe COVID-19 patients have elevated ferritin levels. Patients with more than 287.4 ng/ml ferritin value would have greater chances of developing moderate to severe COVID-19 infections.

Association of Serum Ferritin Level in Early Second Trimester of Pregnancy with Development of Gestational Diabetes Mellitus: A Prospective Observational Study.

Gestational diabetes mellitus (GDM) is associated with various maternal and perinatal morbidities. Serum ferritin is a major storage protein of iron and also acts as acute phase reactant which is increased in inflammatory conditions. GDM is a state of insulin resistance and associated with inflammation. The aim of this study was to find the correlation between serum ferritin and development of GDM. To determine the serum ferritin concentration in nonanemic pregnant women and its correlation with subsequent development of GDM. In this prospective observational study, 302 nonanemic pregnant women with singleton gestation between 14 and 20weeks, attending antenatal OPD, were enrolled. Serum ferritin was measured at the time of enrolment, and they were followed till 24-28weeks of gestation and subjected to blood glucose test by DIPSI method. A total of 92 women had blood glucose level ≥ 140mg/dl and were labeled as GDM, and 210 pregnant women with blood glucose level < 140mg/dl were labeled as non-GDM. Mean serum ferritin level of women with GDM (56.44 ± 19.19ng/ml) was found to be higher as compared to non-GDM (27.62 ± 12.11ng/ml), and this difference was found to be statistically significant (p < 0.001). The cutoff value of serum ferritin > 37.55ng/ml was found to be 85.9% sensitive and 81.9% specific. We can infer that serum ferritin is associated with development of GDM. Based on the findings of the current study, serum ferritin level can be used a predictive marker for the development of GDM.

A Comparative Study to Assess Parathyroid Hormone Status in Different Age Groups of b-Thalassaemia Major Individuals from Eastern India

Introduction: β-thalassaemia major, due to imbalance, missing or deficiency of β-globin chain synthesis pathway, is marked as a hereditary disorder. Homozygous state presents with severe anaemia. Regular blood transfusions and chelation therapy increase the life expectancy in thalassaemia patients. Due to recent advances in the treatment paradigm of β-thalassaemia major patients, there has been a significant increase in their lifespan but, due to the treatment related iron overload, endocrine defects like hypogonadism, diabetes mellitus, hypothyroidism and Hypoparathyroidism (HPT) have been seen to progress. Diverse studies state the occurrence of HPT to be from none upto almost 22.5% in patients. It has also been recognised that asymptomatic hypocalcaemia is much more common and can be overlooked unless precisely viewed. Aim: To estimate and compare the biochemical parameters related to bone turnover in regularly transfused thalassaemia patients in different age groups and to find out significant correlation among the biochemical markers. Materials and Methods: In this cross-sectional study conducted at Calcutta National Medical College, Kolkata, West Bengal, India, from January 2017 till January 2018, 100 β-thalassaemia major patients were enrolled. Serum Parathyroid Hormone (PTH), serum ferritin, ionic calcium (Ca2+), Alkaline Phosphatase (ALP), phosphorus (P) and 25-Hydroxy vitamin D (25-OHD) levels were estimated in these patients. Statistical evaluation was done by the Statistical Package for the Social Sciences (SPSS), version 12.0. Result was reported as mean±SD. Pearson correlation coefficient was used to determine the association of serum ferritin levels and parathormone levels. The p-value of &lt;0.05 was considered as statistically significant. Results: Out of 100 patients, 19 patients had HPT. The mean age was found to be 12.6 years on diagnosis, mean ionised calcium was 0.95 mmol/L, mean serum ferritin was 3045 μg/L (range 1209-10,000 µg/L) and mean serum phosphate was 1.88 mmol/L (range 1.50-2.73 mmol/L). Serum PTH values of 7.04 pg/mL was found to be low. Negative correlation serum PTH and ferritin levels were found. Significant higher values of mean serum ferritin (2789 μg/L) and lower values of parathormone (17.13 pg/mL) was found in the age group of 11-18 years as compared to the other age group of ≤10 years with serum ferritin and parathormones values being 1648 μg/L and 23.44 pg/mL, respectively. Conclusion: Regularly transfused β-thalassaemia major patients, inspite of receiving chelation therapy tend to develop altered calcium and vitamin D homeostasis once they enter second decade of life. Thereby, biochemical parameters related to bone profile which includes ionic calcium, vitamin D, phosphate and parathyroid hormones levels should stringently monitored once the patient crosses first decade of life to prevent any development of hypocalcaemia or overt HPT.

Cardiac magnetic resonance T2* mapping in patients with COVID-19 pneumonia is associated with serum ferritin level?

The coronavirus disease of 2019 (COVID-19)-related myocardial injury is an increasingly recognized complication and cardiac magnetic resonance imaging (MRI) has become the most commonly used non-invasive imaging technique for myocardial involvement. This study aims to assess myocardial structure by T2*-mapping which is a non-invasive gold-standard imaging tool for the assessment of cardiac iron deposition in patients with COVID-19 pneumonia without significant cardiac symptoms. Twenty-five patients with COVID-19 pneumonia and 20 healthy subjects were prospectively enrolled.Cardiac volume and function parameters, myocardial native-T1, and T2*-mapping were measured. The association of serum ferritin level and myocardial mapping was analyzed. There was no difference in terms of cardiac volume and function parameters. The T2*-mapping values were lower in patients with COVID-19 compared to controls (35.37 [IQR 31.67-41.20] ms vs. 43.98 [IQR 41.97-46.88] ms; p < 0.0001), while no significant difference was found in terms of native-T1 mapping value(p = 0.701). There was a positive correlation with T2*mapping and native-T1 mapping values (r = 0.522, p = 0.007) and negative correlation with serum ferritin values (r = -0.653, p = 0.000), while no correlation between cardiac native-T1 mapping and serum ferritin level. Negative correlation between serum ferritin level and T2*-mapping values in COVID-19 patients may provide a non-contrast-enhanced alternative to assess tissue structural changes in patients with COVID-19. T2*-mapping may provide a non-contrast-enhanced alternative to assess tissue alterations in patients with COVID-19. Adding T2*-mapping cardiac MRI in patients with myocardial pathologies would improve the revealing of underlying mechanisms. Further in vivo and ex vivo animal or human studies designed with larger patient cohorts should be planned.

The Association of Serum Ferritin Levels With Non-scarring Alopecia in Women.

Objective We designed this study to evaluate the association of serum ferritin levels with non-scarring alopecia in women. Methodology All patients were diagnosed by performing a clinical examination of the crown part width and occiput. Ludwig's classification was used to categorize the cases into grades I-III. Different laboratory tests were performed for the baseline investigation, including serum iron, total iron-binding capacity (TIBC), hemogram, and thyroid function tests. Of the 5 ml of venous blood drawn for routine biochemical tests, 3 ml was stored at -20°Cfor measuring serum ferritin, while the other 2 ml was sent for a complete blood count. Student's t-test, a chi-square test, and Fisher's exact test were used for comparing the variables. Results This study recruited 100 cases of alopecia. Out of them, 46% of patients were diagnosed with alopecia areata, 25% of cases reported androgenetic alopecia, and 29% of cases of telogen effluvium were also observed. We observed overall mean serum ferritin levels of 20.47±17.50 and 27.87±17.51 in the case versus the control group with a statistically significant difference of 0.005. Conclusion Our study shows that iron stores are one of the independent hazards of alopecia in non-menopausal women. Thus, proper laboratory examination is needed to manage the disease prevalence and prognosis.

Association between serum ferritin and bone mineral density in US adults

BackgroundThe association between serum ferritin and bone mineral density (BMD) is still controversial. This study aims to investigate the association of serum ferritin level with BMD in US adults.MethodsWe conducted a cross-sectional study consisting of 8445 participants from National Health and Nutrition Examination Survey. Serum ferritin and lumbar spine BMD were used as independent variables and dependent variables, respectively. We evaluated the association between serum ferritin and lumbar spine BMD through a weighted multivariable linear regression model. Subgroup and interaction analysis was also performed in this study.ResultsAfter adjusting for other confounding factors, serum ferritin was negatively correlated with lumbar spine BMD [β = − 0.090, 95% CI (− 0.135, − 0.045)]. Further subgroup analysis found that the strongest negative association mainly exists in females aged over 45 years [β = − 0.169, 95% CI (− 0.259, − 0.079)], and this association is not significant in other groups.ConclusionsThe results found that the association between serum ferritin and lumber spine BMD differed by gender and age. Increased level of serum ferritin may indicate a higher risk of osteoporosis or osteopenia in females aged over 45 years.

Serum Ferritin Increased the Predictive Value of the International Staging System/Revised International Staging System for Overall Survival

Background Multiple myeloma (MM) is a terminally differentiated plasma cell hematological malignancy. MM remained an incurable disease, accounting for 20% of deaths of hematological malignancies, despite continuous improvements in its treatment. The revised international staging system (RISS) is commonly used in patients with de novo MM, but it has limitations in predicting prognosis. Hence, better prognostic biomarkers and more optimized staging are yet to be explored. Methods This retrospective study reviewed 357 patients with MM at our institution from May 2013 to May 2018 and included a total of 302 patients. Differences in serum ferritin levels between patients with relapse/non-relapse and survival/death were assessed. Multivariate-adjusted Cox regression and K-M curve were conducted to analyze the effect of different serum ferritin levels on progression-free survival (PFS) and overall survival (OS) in 7 years. Further, the receiver operating characteristic (ROC) curve analysis was used to evaluate the role of serum ferritin level in increasing the international staging system (ISS) and RISS in prognosis prediction. Multivariate linear regression and binomial logistic regression assessed the association of serum ferritin level with optimal induction therapy response. Results The serum ferritin level of patients with MM with recurrence was significantly higher than that of patients without recurrence (P < 0.0001), and the serum ferritin level of patients with all-cause death was significantly higher than that of patients who were still alive during the 7-year follow-up period (P < 0.0001). Smooth curve fitting analysis showed that serum ferritin levels were associated with relapse and death occurrences. The K-M curve analysis indicated that MM patients with high ferritin levels (≥577.47 ng/ml) had shorter PFS (P < 0.0056) and OS (P = 0.0014) than those with ferritin levels of <577.47 ng/ml. Multivariate Cox regression analysis adjusted for potential variables showed that MM patients with high serum ferritin had poor PFS (hazard ratio [HR] = 2.07, 95% confidence interval [CI]: 1.33-3.23, P = 0.0012) and OS (HR = 1.84, 95%CI: 1.08-3.16, P = 0.0258), with independent correlation. The prediction model of ROC analysis based on Cox regression showed that ferritin had a predictive value for PFS (ORferritin = 2.158, Pferritin = 0.0219) and OS (ORferritin = 2.2480, Pferritin = 0.0196). Additionally, the ROC curve showed that serum ferritin could increase the predictive value of ISS and RISS for OS. Multivariate regression analysis showed that serum ferritin levels had no significant independently effect on the optimal response within induction therapy. Conclusion This retrospective study showed that baseline serum ferritin levels were associated with prognosis in patients with MM, and patients with higher serum ferritin have poorer PFS and OS. Serum ferritin could increase the prediction value of ISS and RISS for OS.

Association of Serum Ferritin with Gestational Diabetes Mellitus

Background: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder during pregnancy and is associated with increased maternal and neonatal morbidity. There are many serum markers known to be associated with Gestational Diabetes Mellitus (GDM). High serum ferritin level has been associated with the risk of developing gestational diabetes mellitus. The aim of the study was to investigate the association of serum ferritin levels with GDM.&#x0D; Materials and methods: This case control study was carried out in the Department of Obstetrics &amp; Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka, Bangladesh between February 2018 and January 2019. A total of 120 pregnant women between 18 and 35 years of age attending outdoor antenatal clinic in their second or third trimester of pregnancy were included in this study. Among them 60 diagnosed cases of GDM were consider as group A and rest 60 (Without GDM) were considered as group B. Serum ferritin concentration was measured in all of these patients. Statistical analysis of the results was obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-22).&#x0D; Results: The mean serum ferritin level was 124.1±14.7 ng/ml and 87.4±18.9 ng/ml in group A and group B respectively. The difference was statistically significant (p&lt;0.05) between two groups. More than half (55.0%) patients had serum ferritin level &gt;120 ng/ml in group A and 15(25.0%) in group B. Serum ferritin level &gt;120 ng/ml had 3.67 (95.0% C.I. 1.58 to 8.60) times significantly (p&lt;0.05) increase to developed gestational diabetes mellitus. There was a significant positive correlation between serum ferritin and fasting plasma glucose (r=0.445, p=0.001) in GDM patients. Similarly, a significant positive correlation between serum ferritin and 2-h after plasma glucose level following 75g oral glucose (r=0.427, p=0.001) in GDM patients. &#x0D; Conclusion: A significant positive association was found between GDM and maternal serum ferritin levels.&#x0D; JCMCTA 2022 ; 33 (1) : 154-159

Increased Serum Ferritin Levels in Type 2 Diabetes Mellitus Patients: A Hospital Based Cross-Sectional Study

INTRODUCTION: Type 2 diabetes mellitus is a metabolic disorder of multiple etiology characterized by chronic hyperglycemia with a derangement in carbohydrate, fat and protein metabolism resulting from defects in insulin secretion and action. Ferritin is a ubiquitous intracellular protein complex that reflects the iron stores of the body. Studies have shown that the increased body iron stores are associated with the development of glucose intolerance often leading to metabolic syndrome and type 2 diabetes (T2DM). The objective of the study was to find out association of serum ferritin level with T2DM and assess the correlation between serum ferritin and HbA1c. MATERIAL AND METHODS: A hospital based comparative cross-sectional study was conducted in 43 diabetic patients and 42 age and sex matched healthy controls. Fasting blood glucose (FBG), postprandial blood glucose (PBG), Glycated hemoglobin (HbA1c) and serum ferritin were estimated in cobas c311 autoanalyser using standard protocol. RESULTS: Mean age of healthy control and T2DM were found 54.83 ± 6.48 and 55.95±10.92 years respectively. Mean FBG (mg/dL) (170.41 ± 71.7 v/s 98.38 ± 9.7), PBG (mg/dL) (266.16 ± 110.09 v/s 123.20 ± 17.0), HbA1c (%) (8.17 ± 1.83 v/s 4.9 ± 0.29 and median ferritin (μg/L) 207.90 (138, 306.0) v/s 127.95 (85.75, 210.25) were significantly higher in T2DM compared to the healthy controls. Spearman’s correlation depicted that ferritin level was positively correlated with HbA1c level but the correlation was statistically insignificant. CONCLUSION: Serum ferritin level was found significantly higher in T2DM compared to healthy age and sex matched controls in our study.

A COMPARATIVE STUDY OF THE ASSOCIATION OF SERUM FERRITIN LEVEL WITH GESTATIONAL DIABETES MELLITUS IN THE DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY AT SMS MEDICAL COLLEGE &amp; ATTACHED GROUP OF HOSPITALS, JAIPUR

Background: The present study aimed to study the association of Serum Ferritin level with gestational diabetes mellitus&#x0D; Methods: All Pregnant Females in Gestational age of 16 to 32 weeks presenting to the Ante natal clinic of Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur. Based on Oral Glucose tolerance test, study participants were divided into two groups, Pregnant female with Gestational Diabetes (GDM group) and Pregnant female without Gestational Diabetes (Controls)&#x0D; Results: Mean ferritin level was significantly higher in GDM group (33.51 ng/ml)) as compared to control group (24.97 ng/ml). This difference in mean ferritin level among the two groups was found to be statistically significant (p&lt;0.001). This indicates that higher ferritin level is significantly associated with risk of GDM.&#x0D; Conclusion: Serum ferritin in this study had a significant correlation with development of GDM. High ferritin range was found in females with GDM. Routine use of monitoring of serum ferritin levels, during the antenatal visit in the mid trimester should be carried out, for early prediction of developing GDM.&#x0D; Keywords: GDM, Serum ferrtin, Metabolic conditions.

Association of Serum Ferritin Levels and Methylprednisolone Treatment With Outcomes in Nonintubated Patients With Severe COVID-19 Pneumonia

Serum ferritin, an acute phase marker of inflammation, has several physiologic functions, including limiting intracellular oxidative stress. Whether the effectiveness of corticosteroids differs according to serum ferritin level in COVID-19 has not been reported. To examine the association between admission serum ferritin level and methylprednisolone treatment outcomes in nonintubated patients with severe COVID-19. This retrospective cohort study included patients with severe COVID-19 admitted to an academic referral center in Stony Brook, New York, from March 1 to April 15, 2020, receiving high-flow oxygen therapy (fraction of inspired oxygen, ≥50%). The outcomes of treatment with methylprednisolone were estimated using inverse probability of treatment weights, based on a propensity score comprised of clinical and laboratory variables. Patients were followed up for 28 days. Data were analyzed from December 19, 2020, to July 22, 2021. Systemic methylprednisolone administered per the discretion of the treating physician. The primary outcome was mortality, and the secondary outcome was a composite of death or mechanical ventilation at 28 days. Among 380 patients with available ferritin data (median [IQR] age, 60 years [49-72] years; 130 [34.2%] women; 250 [65.8%] men; 310 White patients [81.6%]; 47 Black patients [12.4%]; 23 Asian patients [6.1%]), 142 patients (37.4%) received methylprednisolone (median [IQR] daily dose, 160 [120-240] mg). Ferritin levels were similar in patients who received methylprednisolone vs those who did not (median [IQR], 992 [509-1610] ng/mL vs 893 [474-1467] ng/mL; P = .32). In weighted analyses using tertiles of ferritin values (lower: 29-619 ng/mL; middle: 623-1316 ng/mL; upper: 1322-13 418 ng/mL), methylprednisolone was associated with lower mortality in patients with ferritin in the upper tertile (HR, 0.16; 95% CI, 0.06-0.45) and higher mortality in those with ferritin in the middle (HR, 2.46; 95% CI, 1.15-5.28) and lower (HR, 2.43; 95% CI, 1.13-5.22) tertiles (P for interaction < .001). Composite end point rates were lower with methylprednisolone in patients with ferritin in the upper tertile (HR, 0.45; 95% CI, 0.25-0.80) but not in those with ferritin in the middle (HR, 0.83; 95% CI, 0.50-1.39) and lower (HR, 0.89; 95% CI, 0.51-1.55) tertiles (P for interaction = .11). In this cohort study of nonintubated patients with severe COVID-19, methylprednisolone was associated with improved clinical outcomes only among patients with admission ferritin in the upper tertile of values.

The association of serum ferritin levels in predicting the outcome in GDM pregnancies

Background: The incidence of gestational diabetes mellitus has seen a rising trend. There is evidence that by estimation of serum ferritin levels in patients with gestational diabetes mellitus it is possible to predict the obstetric outcome.Methods: The incidence of gestational diabetes mellitus has seen a rising trend. There is evidence that by estimation of serum ferritin and GCT levels in patients with gestational diabetes mellitus it is possible to predict the obstetric outcome.Results: 248 cases into two groups 124 GDM and 124 Healthy non complicated pregnancies that served as controls. The mean age was 24.12years and 25.31 years (GDM and non - GDM). The mean serum ferritin levels in GDM was 68. 14 ng/ml ± 15. 63ng/ml which was significantly high compared to that of non GDM which was 30. 18 ng/ml ± 06. 02 ng/ml. Conclusion: In this study, we concluded that GDM is likely to be associated with high serum ferritin levels compared to non GDM mothers and by evaluation of serum ferritin levels it is possible to predict the outcome of the mother and the newborn.

Study on Association of Serum Ferritin With Thyroid Profile And Oral Glucose Tolerance Test in Thalassemia Major Children

Introduction: The free iron and haemosiderosis-induced damage of the endocrine glands cause endocrinopathies such as abnormal glucose tolerance and hypothyroidism in transfusion - dependent beta-thalassemia major patients. Our objective was to study the association of serum ferritin level with thyroid dysfunctions; abnormal blood glucose tolerance and to see if they appear in the earlier period of life.&#x0D; Methods: This cross-sectional study was done among thalassemia major children of two to 12 years in a tertiary care hospital, Kolkata, India. A pre-designed proforma was filled. Serum ferritin, fT4, TSH level, and oral glucose tolerance test (OGTT) were measured at presentation and noted in proforma.&#x0D; Results: A total of 80 thalassemic children were studied. Fiftieth percentile cut off value (1414 ng/ml) of serum ferritin was found to be significant with associated variables like normal fT4, TSH, and OGTT. Out of all study subjects, 39 (51.3%) of normal fT4, 39 (54.9%) of normal TSH and 39 (52.0%) of normal OGTT had ferritin &lt; 50th percentile (P &lt; 0.05). Nine (11.3%) children had abnormal thyroid profiles and five (6.3%) children had abnormal OGTT having ferritin &gt; 2000 ng/ml. At a cut off value of ferritin level &gt; 1414 ng/ml, fT4, TSH and OGTT showed significant abnormality (p &lt; 0.05 with df 1).&#x0D; Conclusions: Ferritin is a good indirect marker to assess the risk of endocrine abnormality in thalassemic children. Frequent monitoring should be done once ferritin level crosses 1000 ng/ml. This will help in early detection and timely management of thalassemia related endocrinopathies.

Abstract #806354: A Study of Association of Serum Ferritin Level with Thyroid Hormone Profile in Patients with Hypothyroidism

Abstract #806354: A Study of Association of Serum Ferritin Level with Thyroid Hormone Profile in Patients with Hypothyroidism

Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party.

Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. This prospective multicentric study aimed to study the association of ferritin serum levels before start of conditioning with alloSCT outcome. Patients with acute leukemia, lymphoma or MDS receiving a matched sibling alloSCT for the first time were considered for inclusion, regardless of conditioning. A comparison of outcomes between patients with high and low ferritin level was performed using univariate analysis and multivariate analysis using cause-specific Cox model. Twenty centers reported data on 298 alloSCT recipients. The ferritin cut off point was determined at 1500 μg/l (median of measured ferritin levels). In alloSCT recipients with ferritin levels above cut off measured before the start of conditioning, overall survival (HR = 2.5, CI = 1.5–4.1, p = 0.0005) and progression-free survival (HR = 2.4, CI = 1.6–3.8, p < 0.0001) were inferior. Excess mortality in the high ferritin group was due to both higher relapse incidence (HR = 2.2, CI = 1.2–3.8, p = 0.007) and increased non-relapse mortality (NRM) (HR = 3.1, CI = 1.5–6.4, p = 0.002). NRM was driven by significantly higher infection-related mortality in the high ferritin group (HR = 3.9, CI = 1.6–9.7, p = 0.003). Acute and chronic GVHD incidence or severity were not associated to serum ferritin levels. We conclude that ferritin levels can serve as routine laboratory biomarker for mortality risk assessment before alloSCT.

Association of serum ferritin level with the development of CKD in diabetic patients

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Association of serum ferritin level and depression with respect to the body mass index in Korean male adults.

BACKGROUND/OBJECTIVESObesity is globally a major public health issue. Evidence suggests that elevated ferritin levels are associated with obesity, dyslipidemia, insulin resistance, and metabolic syndrome. This study was undertaken to examine the relationship between the serum ferritin level and depression in Korean male adults with respect to classification of the prevailing obesity.SUBJECTS/METHODSThis was a case-control study; subjects were classified into obese group (≥ 25.0 kg/m2, 28 subjects) and normal group (18.5–22.9 kg/m2, 27 subjects). A survey was conducted to assess the depression levels as per the guidelines suggested by the Center program for Epidemiological Studies-Depression (CES-D). Blood was collected from each group for assessing biomarkers, and isolated plasma was evaluated for fasting glucose, insulin, quantitative insulin sensitivity check index, and ferritin levels. Data were analyzed, and groups were compared with respect to Body Mass Index (BMI), depression scale and biomarkers.RESULTSThe average depression score of the obesity group was 16.86, which was higher than the normal group (12.56). Subjects scoring more than 16 points comprised 53.6% of the population in the obese group, which was more than double that in the normal group, as assessed by the CES-D program. Furthermore, the serum ferritin level of the obesity group was 207.12 ng/mL, which was higher than that of the normal group (132.66 ng/mL). Lastly, the BMI appeared to be significantly correlated with both depression (r = 0.320, P = 0.017) and elevated ferritin levels (r = 0.352, P = 0.008).CONCLUSIONThis study provides evidence of existing correlation between ferritin and depression with obesity.

Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population.

Elevation of serum ferritin levels is frequently observed in non-alcoholic fatty liver disease (NAFLD) patients. Our study aims to examine the association between serum ferritin levels and NAFLD in Korean population. A total of 25,597 participants were selected from Korean National Health and Nutritional Examination Surveys 2007-2012. The NAFLD liver fat score (NLFS) was used to define NAFLD. Elevation of ALT levels was defined as ALT level > 40IU/L for male and ALT level > 31IU/L for female. Multiple logistic regression was used to examine the association of serum ferritin levels and NAFLD by sex. After adjusting for multiple covariates, the ORs (95% CI) of the elevated ALT levels were 1.56 (95% CI: 1.17-2.07), 1.84 (95% CI: 1.39-2.45), and 4.08 (95% CI: 3.08-5.40) for the second, third and fourth serum ferritin quartiles in male (p for trend < 0.01), 1.67 (95% CI: 1.24-2.23), 2.23 (95% CI: 1.68-2.96), and 5.72 (95% CI: 4.32-7.60) for the second, third and fourth serum ferritin quartiles in female (p for trend < 0.01). Serum ferritin levels were also significantly associated with NAFLD and liver fibrosis both in male and female. Elevation of serum ferritin level is significantly associated with NAFLD and blood ALT elevation in Korean general population.